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Interactive Visual Exploration of Metabolite Ratios in MR Spectroscopy Studies

Laura Garrison, Jakub Vašíček, Alexander R. Craven, Renate Grüner, Noeska N. Smit, Stefan Bruckner
2020 Computers & graphics  
Our resulting tool, SpectraMosaic, links with upstream spectroscopy quantification software to provide a means for precise interactive visual analysis of metabolites with both single-and multi-peak spectral  ...  Using a layered visual approach, SpectraMosaic allows researchers to analyze any permutation of metabolites in ratio form for an entire cohort, or by sample region, individual, acquisition date, or brain  ...  This work is supported by the University of Bergen and the Trond Mohn Foundation in Bergen, Norway (#813558, Visualizing Data Science for Large Scale Hypothesis Management in Imaging Biomarker Discovery  ... 
doi:10.1016/j.cag.2020.08.001 fatcat:n2md2g533jf4tfsolxfuyc2xri

A Visual Encoding System for Comparative Exploration of Magnetic Resonance Spectroscopy Data

Laura Garrison, Jakub Vasicek, Renate Grüner, Noeska Natasja Smit, Stefan Bruckner
2019 Eurographics Conference on Visualization  
In this work we present a novel, tiered visual encoding system for multidimensional MRS data to aid in the visual exploration of metabolite concentration ratios.  ...  This visual encoding system was subsequently realized as part of an interactive insight-generation tool for rapid exploration and comparison of metabolite ratio variation for deeper insights to these complex  ...  We realized this visual encoding system in a novel web-based visualization tool for the interactive exploration of MRS metabolite concentration ratios using HTML, CSS, p5.js and gridster.js.  ... 
doi:10.2312/eurp.20191137 dblp:conf/vissym/GarrisonVGSB19 fatcat:zjp3mv3kbbbn5d3kxpaz3k24ju

SpectraMosaic: An Exploratory Tool for the Interactive Visual Analysis of Magnetic Resonance Spectroscopy Data

Laura Garrison, Jakub Vašíček, Renate Grüner, Noeska N. Smit, Stefan Bruckner
2019 Eurographics Workshop on Visual Computing for Biomedicine  
In this design study, we collaborated with domain experts to design a novel visualization tool for the exploration of tissue metabolite concentration ratios in MRS clinical and research studies.  ...  Our result is SpectraMosaic (Figure 1), an interactive insight-generation tool for rapid exploration and comparison of metabolite ratios.  ...  This work is part of the project Visualizing Data Science for Large Scale Hypothesis Management in Imaging Biomarker Discovery (VIDI) funded by the University of Bergen and the Trond Mohn Foundation in  ... 
doi:10.2312/vcbm.20191225 dblp:conf/vcbm/GarrisonVGSB19 fatcat:qrvmjjwrxfhohj2qv3fqx6wwq4

Altered posterior cingulate brain metabolites and cognitive dysfunction in preterm adolescents

Jeanie L. Y. Cheong, Alan Bainbridge, Peter J. Anderson, Katherine J. Lee, Alice C. Burnett, Deanne K. Thompson, Gehan Roberts, Stephen J. Wood, Lex W. Doyle, Nicola J. Robertson
2016 Pediatric Research  
Cerebral metabolites were measured using proton magnetic resonance spectroscopy (MRS) obtained from a left posterior cingulate voxel.  ...  We aimed to compare brain metabolite ratios of neurons and cell membranes between EP 18-y olds and controls, and explore the association between metabolite ratios and cognitive outcomes.  ...  Brain metabolites measured using magnetic resonance spectroscopy (MRS) may provide insights into the structural changes observed in volumetric and diffusion MRI studies.  ... 
doi:10.1038/pr.2015.272 pmid:26821169 fatcat:3yp6j6xpirg37pzbo5b5zaeqme

A Survey on Visualizing Magnetic Resonance Spectroscopy Data [article]

Miguel Nunes, Andrea Laruelo, SoleaKhena Ken, Anne Laprie, Katja Bühler
2014 Eurographics Workshop on Visual Computing for Biomedicine  
In clinical environment, the lack of appropriate methods and tools to visualize MRSI has made this imaging technique information hard to interpret and include in treatment planning workflows.  ...  These support doctors in identifying and treat diseases as well as better defining regions of interest.  ...  Acknowledgments This work is part of the SUMMER Marie Curie Research Training Network (PITN-GA-2011-290148), which is funded by the 7th Framework Programme of the European Commission (FP7-PEOPLE-2011-ITN  ... 
doi:10.2312/vcbm.20141180 fatcat:w2w6kbv5c5dsvc3oae2rpf7thi

Cingulate metabolites during pain and morphine treatment as assessed by magnetic resonance spectroscopy

Hansen TM, Olesen AE, Simonsen CW, Drewes AM, Frøkjær JB
2014 Journal of Pain Research  
The aim of the current study was to explore brain metabolites in response to pain and treatment with morphine.Methods: Proton magnetic resonance spectroscopy of the anterior cingulate cortex was performed  ...  the pain-evoked N-acetylaspartate/creatine concentration (F=6.1, P=0.04) was seen during treatment with placebo.Conclusion: This explorative study indicates that neuronal metabolites in the anterior cingulate  ...  . 2 In line with previous studies using spectroscopy, we chose to analyze changes in metabolite concentration as ratios to creatine. 5,24 Using ratios compared with absolute values of metabolite concentrations  ... 
doaj:ee6440a929694fc6bd31902e9f840b32 fatcat:w7r7bmv7wfgkpakwo4tyhemfy4

Linked exploratory visualizations for uncertain MR spectroscopy data

David Feng, Lester Kwock, Yueh Lee, Russell M. Taylor II, Chaomei Chen, Jinah Park, Ming C. Hao, Pak C. Wong
2010 Visualization and Data Analysis 2010  
We present a system for visualizing magnetic resonance spectroscopy (MRS) data sets.  ...  Using MRS, radiologists generate multiple 3D scalar fields of metabolite concentrations within the brain and compare them to anatomical magnetic resonance imaging.  ...  CISMM is supported by the NIH National Institute of Biomedical Imaging and Bioengineering (NIH P41-EB002025).  ... 
doi:10.1117/12.839818 pmid:21152337 pmcid:PMC2997734 dblp:conf/vda/FengKLT10 fatcat:2drqp2i6irbstol7zf7pjr7xk4

GABA Concentration in Posterior Cingulate Cortex Predicts Putamen Response during Resting State fMRI

Jorge Arrubla, Desmond H. Y. Tse, Christin Amkreutz, Irene Neuner, N. Jon Shah, Yu-Feng Zang
2014 PLoS ONE  
The role of neurotransmitters in the activity of resting state networks has been gaining attention and has become a field of research with magnetic resonance spectroscopy (MRS) being one of the key techniques  ...  In this study GABA concentration in the posterior cingulate cortex (PCC) was measured using single voxel spectra acquired with standard point resolved spectroscopy (PRESS) from 20 healthy male volunteers  ...  In a MRS study, Epperson et al.  ... 
doi:10.1371/journal.pone.0106609 pmid:25184505 pmcid:PMC4153676 fatcat:6didluzjwzfp3pzrorfz2o77vi

Proton magnetic resonance spectroscopy in frontotemporal lobar degeneration-related syndromes [article]

Alexander G Murley, Kamen A Tsvetanov, Matthew A Rouse, P Simon Jones, Katrine Sværke, Win Li, T Adrian Carpenter, James B Rowe
2021 medRxiv   pre-print
We measured nine metabolites in the right inferior frontal gyrus, superior temporal gyrus and right primary visual cortex using 3T semi-laser magnetic resonance spectroscopy.  ...  The reduction of these metabolites was associated with executive dysfunction and behavioral impairment (canonical correlation analysis R=0.95, p<0.001).ConclusionMagnetic resonance spectroscopy confirms  ...  This has important implications for the clinical use of MRS as some correction methods, e.g. creatine ratios, may be less accurate in measuring metabolite levels in residual brain tissue.  ... 
doi:10.1101/2021.01.11.21249589 fatcat:cajibk4wufavho3omxum5fldua

Proton magnetic resonance spectroscopy in substance use disorder: recent advances and future clinical applications

Tianzhen Chen, Haoye Tan, Huiting Lei, Hang Su, Min Zhao
2020 Science China Information Sciences  
Recently, there are many studies on substance use disorders utilizing 1H-MRS to explore the mechanism of brain metabolites.  ...  Proton magnetic resonance spectroscopy (1H-MRS) now is widely used in clinical researches for the measurement of compounds or metabolites in vivo, especially in neuropsychiatric diseases/disorders.  ...  Exploration of other spectroscopy methods 1H-MRS is a common method for neurometabolites detecting.  ... 
doi:10.1007/s11432-019-2818-5 fatcat:uzz3gexf4vbwfeebmq6a4ekkfy

Relationships between dorsolateral prefrontal cortex metabolic change and cognitive impairment in first-episode neuroleptic-naive schizophrenia patients

Man-Li Huang, Thong-Teck Khoh, Shao-Jia Lu, Fen Pan, Jin-Kai Chen, Jian-Bo Hu, Shao-Hua Hu, Wei-Juan Xu, Wei-Hua Zhou, Ning Wei, Hong-Li Qi, De-Sheng Shang (+1 others)
2017 Medicine  
The present study aimed to explore the possible associations between the dorsolateral prefrontal cortex (DLPFC) metabolites and the cognitive function in first-episode schizophrenia (FES).This study included  ...  The ratios of metabolites to creatine (Cr) were calculated.  ...  Acknowledgment The authors thank Yi Shen, PhD (College of Medicine, Zhejiang University, Hang Zhou, China), for his statistical advice throughout the study.  ... 
doi:10.1097/md.0000000000007228 pmid:28640119 pmcid:PMC5484227 fatcat:6oynyukaxrgdjowltuujurwo34

Decreased in vivo glutamate/GABA ratio correlates with the social behavior deficit in a mouse model of autism spectrum disorder

Gaeun Park, Se Jin Jeon, In Ok Ko, Ji Hwan Park, Kyo Chul Lee, Min-Sik Kim, Chan Young Shin, Hyeonjin Kim, Yong-Seok Lee
2022 Molecular Brain  
Here, using proton magnetic resonance spectroscopy (1H-MRS) at 9.4T, we found significant differences in the levels of different metabolites or their ratios in the prefrontal cortex and hippocampus of  ...  Moreover, there are controversies in the directions of E/I ratio alterations even in extensively studied ASD animal models.  ...  Therefore, we examined the E/I ratio and other metabolites in multiple brain regions of Cntnap2 −/− mice using the MRS technique in the present study.  ... 
doi:10.1186/s13041-022-00904-z pmid:35183218 pmcid:PMC8858545 fatcat:gdxcz7dhrjajza4wnro7y3xgqi

Common processing ofin vivo MR spectra

HJA in 't Zandt, M van der Graaf, A Heerschap
2001 NMR in Biomedicine  
This introductory article addresses approaches currently in use to process in vivo spectra. First, a brief overview is given of the information content represented by the parameters of MR signals.  ...  Subsequently, common steps in the processing of MR spectra such as pre-processing, normalisation and quantification and the use of prior knowledge are described.  ...  We thank the EU for support (IST project -1999-10310 (INTERPRET) and TMR project ERBFMRXCT970160 (Advanced Signal Processing for Medical MRI/MRS)).  ... 
doi:10.1002/nbm.707 pmid:11410940 fatcat:zeqssptltzditfzsi4iijto22y

Matching Visual Saliency to Confidence in Plots of Uncertain Data

David Feng, Lester Kwock, Yueh Lee, Russell M Taylor
2010 IEEE Transactions on Visualization and Computer Graphics  
These techniques have been useful for identifying brain tumors in multivariate magnetic resonance spectroscopy data and we describe how to extend them to visualize ensemble data sets.  ...  Conveying data uncertainty in visualizations is crucial for preventing viewers from drawing conclusions based on untrustworthy data points.  ...  Acknowledgments The authors would like to thank the staff of the UNC Departments of Computer Science and Radiology for supporting this work.  ... 
doi:10.1109/tvcg.2010.176 pmid:20975135 pmcid:PMC3179257 fatcat:zkewgfr5wzhtlfvt3ercy2hoqu

The medical food Souvenaid affects brain phospholipid metabolism in mild Alzheimer's disease: results from a randomized controlled trial

Anne Rijpma, Marinette van der Graaf, Marieke M. Lansbergen, Olga Meulenbroek, Aysun Cetinyurek-Yavuz, John W. Sijben, Arend Heerschap, Marcel G. M. Olde Rikkert
2017 Alzheimer's Research & Therapy  
In this study, we explored whether the medical food Souvenaid affects brain phospholipid metabolism in patients with Alzheimer's disease.  ...  Conclusions: MRS reveals that Souvenaid affects brain phospholipid metabolism in mild Alzheimer's disease, in line with findings in preclinical studies.  ...  Acknowledgements We thank all participants and their caregivers for participating in this study.  ... 
doi:10.1186/s13195-017-0286-2 pmid:28747210 pmcid:PMC5530581 fatcat:vaa4o3ufovhkfk5s3knqy4775y
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