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Joint Impact of Early Life Adversity and COMT Val158Met (rs4680) Genotypes on the Adult Cortisol Response to Psychological Stress

William R. Lovallo, Mary-Anne Enoch, Kristen H. Sorocco, Andrea S. Vincent, Ashley Acheson, Andrew J. Cohoon, Colin A. Hodgkinson, David Goldman
<span title="">2017</span> <i title="Ovid Technologies (Wolters Kluwer Health)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/ghxpuog4gfeq7gv4x6zuxsffqa" style="color: black;">Psychosomatic Medicine</a> </i> &nbsp;
Val-allele carriers of a common polymorphism of the COMT gene (Val158Met, rs4680) have rapid removal of catecholamines in the prefrontal cortex, limbic system, and reward centers.  ...  Val158Met polymorphism.  ...  The COMT Val158Met (rs4680) polymorphism appears to represent one source of genetic vulnerability to childhood adversity.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1097/psy.0000000000000481">doi:10.1097/psy.0000000000000481</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/28452825">pmid:28452825</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC5489380/">pmcid:PMC5489380</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/7wtiyvtvqrbk7dg33nmlsh65zq">fatcat:7wtiyvtvqrbk7dg33nmlsh65zq</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20191113113611/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC5489380&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/3e/df/3edf391f8c401641003ccad4d13025e74770240d.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1097/psy.0000000000000481"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5489380" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Interactions Between Variation in Candidate Genes and Environmental Factors in the Etiology of Schizophrenia and Bipolar Disorder: a Systematic Review

Błażej Misiak, Filip Stramecki, Łukasz Gawęda, Katarzyna Prochwicz, Maria M. Sąsiadek, Ahmed A. Moustafa, Dorota Frydecka
<span title="2017-08-18">2017</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/loozxa5zw5ftrmskw74knpnku4" style="color: black;">Molecular Neurobiology</a> </i> &nbsp;
Almost consistently, these studies revealed that polymorphisms in COMT, BDNF, and FKBP5 genes might interact with early life stress and cannabis abuse or dependence, influencing various outcomes of schizophrenia  ...  In addition, future studies should address the direction of causality and potential mechanisms of the relationship between gene × environment interactions and various categories of outcomes in schizophrenia  ...  There was also no moderating effect of the MTHFR A1298C polymorphism on the interaction between the COMT Val158Met polymorphism and stress.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s12035-017-0708-y">doi:10.1007/s12035-017-0708-y</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/28822116">pmid:28822116</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC5948257/">pmcid:PMC5948257</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/upurhkpasrcftffudfxqhp2gcm">fatcat:upurhkpasrcftffudfxqhp2gcm</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20180730135724/https://link.springer.com/content/pdf/10.1007%2Fs12035-017-0708-y.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/29/27/29274fa4592aee622677aee0fbe7cbca92c756f0.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s12035-017-0708-y"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> springer.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5948257" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Psychopathological aspects of dopaminergic gene polymorphisms in adolescence and young adulthood

Zsofia Nemoda, Anna Szekely, Maria Sasvari-Szekely
<span title="">2011</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/bphxj3vvszarjlpalo447rq3nm" style="color: black;">Neuroscience and Biobehavioral Reviews</a> </i> &nbsp;
Meta-analyses also support the association between substance abuse and the D2 receptor gene.  ...  The aim of this review is to survey the most important findings concerning dopaminergic gene polymorphisms in attention deficit hyperactivity disorder (ADHD), Tourette syndrome, obsessive compulsive disorder  ...  Acknowledgments This work was supported by the NIH R03 TW007656 Fogarty International Research grant awarded to Maria Sasvari-Szekely and by the Hungarian fund OTKA F67784, awarded to Zsofia Nemoda.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.neubiorev.2011.04.002">doi:10.1016/j.neubiorev.2011.04.002</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/21527290">pmid:21527290</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3133854/">pmcid:PMC3133854</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/yhgh3xg55vcrbgyhjzah7edjfu">fatcat:yhgh3xg55vcrbgyhjzah7edjfu</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200506013829/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC3133854&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/05/94/05947697c5186a1176b8e0708617ba9e31c8905d.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.neubiorev.2011.04.002"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> elsevier.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3133854" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Epigenetics in Developmental Disorder: ADHD and Endophenotypes

Trevor Archer, Marlene Oscar Berman
<span title="">2011</span> <i title="OMICS Publishing Group"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/crlnpfwt25c4xkratd2236itua" style="color: black;">Journal of genetic syndrome &amp; gene therapy</a> </i> &nbsp;
factor (BDNF), associations between symptoms-profiles endophenotypes and single nucleotide polymorphisms appear reassuring.  ...  Parent-of-origin effects seem to support the notion that genetic risks for disease process debut often interact with the social environment, i.e., the parental environment in infants and young children  ...  Acknowledgements The writing of this paper was supported in part by the US Department of Health and Human Services, NIAAA (R01 AA 07112, K05 AA 00219), and by the Medical Research Service of the US Department  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.4172/2157-7412.1000104">doi:10.4172/2157-7412.1000104</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/whee456xtnfztkfjvg75zcurni">fatcat:whee456xtnfztkfjvg75zcurni</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20170620105947/https://www.omicsonline.org/epigenetics-in-developmental-disorder-adhd-and-endophenotypes-2157-7412.1000104.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/b0/8e/b08e866865fd94615c5f6548dd7a71d602ff973e.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.4172/2157-7412.1000104"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a>

Borderline personality disorder and childhood trauma: exploring the affected biological systems and mechanisms

Nadia Cattane, Roberta Rossi, Mariangela Lanfredi, Annamaria Cattaneo
<span title="2017-06-15">2017</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/bxgog22cfjhmzpzfdp5bafzzf4" style="color: black;">BMC Psychiatry</a> </i> &nbsp;
We have searched for studies reporting possible alterations in several biological processes and brain morphological features in relation to childhood trauma experiences and to BPD.  ...  A better comprehension of the biological and epigenetic mechanisms, affected by childhood trauma and altered in BPD patients, could allow to identify "at high risk" subjects and to prevent or minimize  ...  (Inflame-D project) and by funding from the Italian Ministry of Health (MoH) to A.C.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/s12888-017-1383-2">doi:10.1186/s12888-017-1383-2</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/28619017">pmid:28619017</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC5472954/">pmcid:PMC5472954</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/qw27wwxytbbhfagyqdrt7vw2wi">fatcat:qw27wwxytbbhfagyqdrt7vw2wi</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20180719040657/https://bmcpsychiatry.biomedcentral.com/track/pdf/10.1186/s12888-017-1383-2?site=bmcpsychiatry.biomedcentral.com" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/f9/18/f91830254188d085c5f178acea63902984a3cfe7.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/s12888-017-1383-2"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> springer.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472954" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Gene-Environment Studies and Borderline Personality Disorder: A Review

Ryan W. Carpenter, Rachel L. Tomko, Timothy J. Trull, Dorret I. Boomsma
<span title="2012-12-13">2012</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/dvpogvvzjzfbzasqb3rjxj5unm" style="color: black;">Current Psychiatry Reports</a> </i> &nbsp;
We provide suggestions regarding future research on GxE interaction and rGE effects in borderline personality.  ...  The best evidence to date supports a gene-environment correlation (rGE) model for borderline personality traits and a range of adverse life events, indicating that those at risk for BPD are also at increased  ...  [33] examined the effects of 5-HTTLPR l/s and COMT Val158Met and emotional abuse on distress intolerance in a sample of 218 adolescents.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s11920-012-0336-1">doi:10.1007/s11920-012-0336-1</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/23250817">pmid:23250817</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3973430/">pmcid:PMC3973430</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/ylq2xoybtzdrzmj6rz2idk55dq">fatcat:ylq2xoybtzdrzmj6rz2idk55dq</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20170812040648/http://www.tweelingenregister.org/fileadmin/user_upload/publicaties/verslaggeving/NTR-publicaties_2013/Carpenter_CPR_2013.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/c9/4b/c94b7ba81aa0b8c9fa1bfe00555f20bc98c868f1.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s11920-012-0336-1"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> springer.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973430" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Epigenetics in Developmental Disorder: ADHD and Endophenotypes

Trevor Archer, Marlene Oscar-Berman, Kenneth Blum
<span title="2011-06-30">2011</span> <i title="OMICS Publishing Group"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/crlnpfwt25c4xkratd2236itua" style="color: black;">Journal of genetic syndrome &amp; gene therapy</a> </i> &nbsp;
factor (BDNF), associations between symptoms-profiles endophenotypes and single nucleotide polymorphisms appear reassuring.  ...  Parent-of-origin effects seem to support the notion that genetic risks for disease process debut often interact with the social environment, i.e., the parental environment in infants and young children  ...  Acknowledgements The writing of this paper was supported in part by the US Department of Health and Human Services, NIAAA (R01 AA 07112, K05 AA 00219), and by the Medical Research Service of the US Department  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/22224195">pmid:22224195</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3250517/">pmcid:PMC3250517</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/svilvlucvjdaxnjlmxaa4zwaoy">fatcat:svilvlucvjdaxnjlmxaa4zwaoy</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190426071748/https://www.longdom.org/open-access/epigenetics-in-developmental-disorder-adhd-and-endophenotypes-2157-7412.1000104.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/98/b7/98b7fc6a00213de4e20b455885ff3f33a3f556f1.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3250517" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Animal models of gene–environment interaction in schizophrenia: A dimensional perspective

Yavuz Ayhan, Ross McFarland, Mikhail V. Pletnikov
<span title="">2016</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/fptky5bef5gmpjh2fugyz6i3yq" style="color: black;">Progress in Neurobiology</a> </i> &nbsp;
Conte Center and the Brain and Behavior Research Foundation (MVP).  ...  Peerbooms et al. (2012) studied an interaction between stress and the polymorphisms in the COMT gene (Val158Met) and in the methylenetetrahydrofolate reductase (MTHFR) gene (C677T and MTHFR A1298C) known  ...  This MRI study investigated interaction effects on hippocampal volume between functional genetic variants (COMT Val158Met, BDNF Val66Met, 5-HTTLPR) and environmental adversity in 153 healthy subjects.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.pneurobio.2015.10.002">doi:10.1016/j.pneurobio.2015.10.002</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/26510407">pmid:26510407</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC4707068/">pmcid:PMC4707068</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/cqjhmzta6bhf7hpidatgnytroq">fatcat:cqjhmzta6bhf7hpidatgnytroq</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210428205209/http://openaccess.hacettepe.edu.tr:8080/xmlui/bitstream/handle/11655/16005/Animal%20Models%20Of%20Gene-Environment%20Interaction%20In.pdf;jsessionid=5DC5D264A777928FA6269FA2DE8FBAEB?sequence=2" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/20/a3/20a3e17df05e445fbd37055a33bef78039b09686.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.pneurobio.2015.10.002"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> elsevier.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4707068" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Low Dopamine Function in Attention Deficit/Hyperactivity Disorder: Should Genotyping Signify Early Diagnosis in Children?

Mark S. Gold, Kenneth Blum, Marlene Oscar–Berman, Eric R. Braverman
<span title="">2014</span> <i title="Informa UK Limited"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/5qnfxgcowfcb3avo3a2e3xzyyu" style="color: black;">Postgraduate medicine</a> </i> &nbsp;
Attention deficit/hyperactivity disorder (ADHD) is present in 8% to 12% of children, and 4% of adults worldwide.  ...  With the goals of improving treatment of patients with ADHD and SUD prevention, we encourage further work in both genetic diagnosis and novel treatment approaches.  ...  with personality traits. 99 Val158Met Polymorphism A common normal variant of the COMT gene, Val158Met (rs4680) is a functional singlenucleotide polymorphism that has been shown to affect cognitive  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3810/pgm.2014.01.2735">doi:10.3810/pgm.2014.01.2735</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/24393762">pmid:24393762</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC4074363/">pmcid:PMC4074363</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/iodmvd5hanaftmrbutlxvbmjn4">fatcat:iodmvd5hanaftmrbutlxvbmjn4</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200211133242/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC4074363&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/bd/fa/bdfa260cdb7bf8bc24ded4251a9fec4b5cbfec84.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3810/pgm.2014.01.2735"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074363" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Imaging Genetics

Andrew J. Gerber, Bradley S. Peterson, Karen E. Muñoz, Luke W. Hyde, Ahmad R. Hariri
<span title="">2009</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/6d7ts6uklvgtdeehycjfym2nhm" style="color: black;">Journal of the American Academy of Child and Adolescent Psychiatry</a> </i> &nbsp;
Whereas most human behaviors cannot be explained by genes alone, and certainly much of the variance in aspects of brain information processing will not be genetically determined directly, variations in  ...  As research in developmental and clinical sciences has progressed in the last decades, there have been many important technological and methodological advances in the increasingly complimentary fields  ...  Additionally, structural imaging studies have shown that cortical development continues into adulthood. 35 Therefore, examining the links between genetic polymorphisms and alterations in brain function  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1097/chi.0b013e31819aad07">doi:10.1097/chi.0b013e31819aad07</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/19318879">pmid:19318879</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC2891750/">pmcid:PMC2891750</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/74melzxyrnaxnjckaehgihyoju">fatcat:74melzxyrnaxnjckaehgihyoju</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190302175633/http://pdfs.semanticscholar.org/9fbe/7d9d312eed5416279d50a6246b8b0d3469a8.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/9f/be/9fbe7d9d312eed5416279d50a6246b8b0d3469a8.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1097/chi.0b013e31819aad07"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2891750" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Adapting to Stress: Understanding the Neurobiology of Resilience

Carlos Osório, Thomas Probert, Edgar Jones, Allan H. Young, Ian Robbins
<span title="2016-04-21">2016</span> <i title="Informa UK Limited"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/u6pdubfw55ayjgsetdr2w4hsxu" style="color: black;">Behavioral Medicine</a> </i> &nbsp;
There is significant variation in the way individuals react and respond to extreme stress and adversity.  ...  To understand why some individuals exhibit characteristics of a resilient profile, the interplay between neurochemical, genetic and epigenetic processes over time needs to be explained.  ...  For example, in a human study evaluating traumatic load, diagnosis of PTSD and COMT Val158Met polymorphism, results showed that a gene environment interaction among the human COMT Val158 Met polymorphism  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1080/08964289.2016.1170661">doi:10.1080/08964289.2016.1170661</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/27100966">pmid:27100966</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/ctt6vu6panfpnieh6xsp6ucrzq">fatcat:ctt6vu6panfpnieh6xsp6ucrzq</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200321153000/https://kclpure.kcl.ac.uk/portal/files/79974959/Adapting_to_Stress_OSORIO_Publishedonline21April2017_GREEN_AAM.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/6f/8d/6f8d8d7573899d3f7702b5908655b4c8440904ab.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1080/08964289.2016.1170661"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> tandfonline.com </button> </a>

Resilience in mental health: linking psychological and neurobiological perspectives

B. P. F. Rutten, C. Hammels, N. Geschwind, C. Menne-Lothmann, E. Pishva, K. Schruers, D. van den Hove, G. Kenis, J. van Os, M. Wichers
<span title="2013-03-14">2013</span> <i title="Wiley"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/yqfo4bjnbbf2vnssiklty5qvk4" style="color: black;">Acta Psychiatrica Scandinavica</a> </i> &nbsp;
Overlap between psychological and biological findings on resilience in the literature is most apparent for the topic of stress sensitivity, although recent results suggest a crucial role for reward experience  ...  successfully adapt to severe adversity over the life course. • Resilience entails both the process of preventing or attenuating health disturbance after adversity, and the process of swift recovery from  ...  Consistent with this proposition, a recent study found that daily life reward experience increased proportionally with the number of Met alleles on the COMT Val158Met polymorphism (90) .  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1111/acps.12095">doi:10.1111/acps.12095</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/23488807">pmid:23488807</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3746114/">pmcid:PMC3746114</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/umt47xfpabbsrjjjgdagn7o6pq">fatcat:umt47xfpabbsrjjjgdagn7o6pq</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20191016053821/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC3746114&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/d5/b3/d5b332e9686659538fc9bf068d58ae63d46b30b8.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1111/acps.12095"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3746114" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Neurogenetics and Pharmacology of Learning, Motivation and Cognition

Michael J Frank, John A Fossella
<span title="2010-07-14">2010</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/zscwnf3bera7vcvkm7bgnh2sbu" style="color: black;">Neuropsychopharmacology</a> </i> &nbsp;
COMT, DARPP-32, DAT1, DRD2, and DRD4.  ...  Many of the individual differences in cognition, motivation, and learningFand the disruption of these processes in neurological conditionsFare influenced by genetic factors.  ...  We thank Naomi Friedman for helpful comments and discussion.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1038/npp.2010.96">doi:10.1038/npp.2010.96</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/20631684">pmid:20631684</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3055524/">pmcid:PMC3055524</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/gzyrkzmpuvhm3bel72uywwj7sq">fatcat:gzyrkzmpuvhm3bel72uywwj7sq</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20170812080829/http://ski.cog.brown.edu/papers/FrankFossella_NPP.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/03/09/03095dc5de7e46b4546192b9597f7ec5f9cfba10.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1038/npp.2010.96"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3055524" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

[EXPRESS] Fibromyalgia: genetics and epigenetics insights may provide the basis for the development of diagnostic biomarkers

Simona D'Agnelli, Lars Arendt-Nielsen, Maria Carla Gerra, Lorenzo Boggiani, Marco Baciarello, Elena Bignami
<span title="2018-11-29">2018</span> <i title="SAGE Publications"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/os3hp2ohsveevbz2eccp2pu7sa" style="color: black;">Molecular Pain</a> </i> &nbsp;
Differences in the genome-wide expression profile of microRNAs were found among multiple tissues, indicating the involvement of distinct processes in FM pathogenesis.  ...  Furthermore, a gene-environmental interaction has been proposed as triggering mechanism, through epigenetic alterations: in particular, FM appears to be characterized by a hypomethylated DNA pattern, in  ...  (1A)-AR-rs1048101 SNP and FIQ disability, 29 and T102C polymorphism of the 5-HT2A receptor gene and FM onset. 30 In order to clarify the potential association between gene polymorphisms in 5-HTT, COMT  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1177/1744806918819944">doi:10.1177/1744806918819944</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/30486733">pmid:30486733</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC6322092/">pmcid:PMC6322092</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/o3k3mzmjy5atbpjim27tks3pa4">fatcat:o3k3mzmjy5atbpjim27tks3pa4</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190429163457/https://vbn.aau.dk/ws/files/292956444/1744806918819944.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/d1/57/d1574ee9a715383dae1b293854ba618874f7cb1a.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1177/1744806918819944"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> sagepub.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322092" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Early life adversity reduces stress reactivity and enhances impulsive behavior: Implications for health behaviors

William R. Lovallo
<span title="">2013</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/efcewkjpgrbuvptv4j3naansru" style="color: black;">International Journal of Psychophysiology</a> </i> &nbsp;
One source of diminished cortisol and autonomic reactivity is the experience of adverse rearing during childhood and adolescence.  ...  capacity, and unstable regulation of affect, leading to behavioral impulsivity and antisocial tendencies.  ...  Acknowledgments This is supported by the Department of Veterans Affairs Medical Research Service, the National Institutes of Health, and NIAAA, grants AA12207 and AA19691.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.ijpsycho.2012.10.006">doi:10.1016/j.ijpsycho.2012.10.006</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/23085387">pmid:23085387</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3587283/">pmcid:PMC3587283</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/3wz2uqbomnh6rohnk4gshvrisa">fatcat:3wz2uqbomnh6rohnk4gshvrisa</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20170420185800/http://mindbody1.org/pdf/Lovallo%202013%20final.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/44/7f/447fdd3c92643d40bc7a748ac701e2b6b7bbd359.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.ijpsycho.2012.10.006"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> elsevier.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3587283" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>
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