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Applications of Radiotracer Imaging Poster Abstracts

2012 Journal of Cerebral Blood Flow and Metabolism  
Regional distributions of [ 11 C]PIB and [ 18 F]FDG (both p for interaction < 0.05) differed between groups, however, largely due to increased [ 11 C]PIB binding and decreased [ 18 F]FDG uptake in the  ...  Linear regression analyses showed negative associations between visuo-spatial functioning and parietal [ 11 C]Pittsburgh compound-B binding for younger patients (standardized b: À0.37) and between visuo-spatial  ...  Figure Partial regression plots between 5-HT1A and 5-HT2A binding potential controlled for 5-HT1B and 5-HTT (left), 5-HT1A and 5-HT1B binding potential controlled for 5-HT2A and 5-HTT (middle), and 5-HT1B  ... 
doi:10.1038/jcbfm.2012.78 fatcat:2uvqdqlwsfgexhr5qno2gjfmqe

Abstracts from the XXIII CINP Congress, Montréal, June 23–27, 2002

2002 International Journal of Neuropsychopharmacology  
G-protein coupled receptors interact with heterotrimeric guanine-nucleotide-binding regulatory proteins (G-proteins) and transduce intracellular signals.  ...  Delta and kappa opioid receptors exist as homodimers that have distinct physical and structural properties.  ...  S.21.3 CONTRIBUTIONS OF 5-HT1A AND 5-HT1B RECEPTORS TO THE BEHAVIORAL EFFECTS OF ANTIDEPRESSANT DRUGS R. Hen.  ... 
doi:10.1017/s1461145702003176 fatcat:25u2fa2qmve7zpljmks4tqinge

Function and dysfunction of monoamine interactions in children and adolescents with AD/HD

Robert D Oades
2006 EXS  
Two of the most studied 5-HT binding sites in the CNS are the 5-HT1a and 5-HT2a receptors.  ...  Thus, the nature of the 5-HT transporter (5-HTTLPR) will affect the expression of 5-HT binding sites: for example the short allele is associated with a lower binding potential of the HT1a site (180) .  ... 
pmid:17019890 fatcat:6vw5n6wf2ve7foyochyolhbboy

Poster Session II

2005 Neuropsychopharmacology  
All 7 segments of the corpus callosum were compared between cocaine users and controls for using a Mixed Model ANOVA for λ1 and λ2.  ...  Within cocaine dependent subjects there was a significant positive correlation between years of cocaine use and λ2. There was no significant difference between groups for λ 1.  ...  Rather than Limbic Regions of the Striatum Marc Laruelle*, Lawrence S Kegeles, Gordon W Frankle, Raj Narendran, Roberto Gil, Peter S Talbot, Dah-Ren Hwang, Yiyun Huang, Thomas Cooper, Slifstein Mark and  ... 
doi:10.1038/sj.npp.1300970 fatcat:ikayo4dkwrdrthgopr2hltn2hi

Sex hormones affect neurotransmitters and shape the adult female brain during hormonal transition periods

Claudia Barth, Arno Villringer, Julia Sacher
2015 Frontiers in Neuroscience  
Here we review the evidence from animal experiments and human studies reporting interactions between sex hormones and the dominant neurotransmitters, such as serotonin, dopamine, GABA and glutamate.  ...  Many brain regions have been demonstrated to express high densities for estrogen-and progesterone receptors, such as the amygdala, the hypothalamus, and the hippocampus.  ...  5-HT to the density and binding of 5-HT receptors .  ... 
doi:10.3389/fnins.2015.00037 pmid:25750611 pmcid:PMC4335177 fatcat:3rxysonlqrh6zliqrdujz7boae

Genetic and biochemical changes of the serotonergic system in migraine pathobiology

Claudia Francesca Gasparini, Robert Anthony Smith, Lyn Robyn Griffiths
2017 The Journal of Headache and Pain  
Genetic and biochemical studies have primarily focused on the neurotransmitter serotonin, considering receptor binding, transport and synthesis of serotonin and have investigated serotonergic mediators  ...  Attempts to study the biochemistry of migraine began as early as the 1960s and were primarily directed at serotonin metabolism after an increase of 5-hydroxyindoleacetic acid (5-HIAA), the main metabolite  ...  At the cellular level triptans alleviate migraine symptoms by binding to serotonin 5-HT1b, d and f receptors along pain signaling circuits and are effective due to high receptor specificity and disease  ... 
doi:10.1186/s10194-016-0711-0 pmid:28194570 pmcid:PMC5307402 fatcat:jurfhidqpbemlhwxmsfo2sexa4

Annual Research Review: New frontiers in developmental neuropharmacology: can long-term therapeutic effects of drugs be optimized through carefully timed early intervention?

Susan L. Andersen, Carryl P. Navalta
2011 Journal of Child Psychology and Psychiatry and Allied Disciplines  
The immature brain undergoes significant changes during the transitions between childhood, adolescence, and adulthood.  ...  Such changes in innervation, neurotransmitter levels, and their respective signaling mechanisms have profound and observable changes on typical behavior, but also increase vulnerability to psychiatric  ...  Acknowledgments The authors gratefully acknowledge the support of NIH (DA-15403), the Simches and Rosenberg families.  ... 
doi:10.1111/j.1469-7610.2011.02376.x pmid:21309771 pmcid:PMC3115525 fatcat:t3xzowncnzbnrnx3jngderskiu

Poster Session I

2015 Neuropsychopharmacology  
risk factor for psychopathology and is associated with altered functional connectivity within-and between neural networks.  ...  . rs-fMRI was used to map correlations between brain network and memory performance changes over time.  ...  Eleven healthy controls, matched for sex, age, and binding status, were also imaged with [11C] PBR28 PET.  ... 
doi:10.1038/npp.2015.325 pmid:26632286 pmcid:PMC4672310 fatcat:cqqyl6zydfeuxltv6zkqhn7qry

Poster Session III

2004 Neuropsychopharmacology  
These data suggest a significant role for glutamate receptors in the enduring effects of social defeat stress, but the interactions between glutamate receptor subtypes have to await further characterization  ...  Consistent with our studies of a neurotensin receptor agonist and contrary to studies with a neurotensin receptor antagonist, mice lacking NTS1 showed sensitization to D-amphetamine, which was enhanced  ...  Serotonergic candidates included the 5HT1B and 5-HT1A receptor genes, and both the VNTR and promoter-region (5-HTTLPR) polymorphisms for the serotonin transporter.  ... 
doi:10.1038/sj.npp.1300648 fatcat:vw22deytbbeyrpwv7zwkwotqgm

Transcriptional regulation of the 5-HT1A receptor gene by deformed autosomal regulatory factor 1

Margaret Czesak, Université D'Ottawa / University Of Ottawa, Université D'Ottawa / University Of Ottawa
2013
Deaf-1 was shown to bind the mouse 5-HT1A promoter sequence and mediate cell-type specific transcriptional repression or enhancement of 5-HT1A receptor gene expression, similar to that obs [...]  ...  The 5-HT1A receptor is a powerful regulator of both pre and post-synaptic 5-HT neurotransmission, and becomes compromised in depression.  ...  In addition, interaction between the 5-HT1A genotype and stressful life conditions may also enhance the results of some studies.  ... 
doi:10.20381/ruor-20076 fatcat:yu6bltg7ffca7dedqqm4c2gbze

ORAL PRESENTATIONS

2006 The Journal of Headache and Pain  
Expectation will play a major role, when the randomisation ratio between placebo and verum is known. The quality of a trial has no influence on the placebo responder rate.  ...  Objective To analyze the importance of genetic and environmental factors in tension-type headache. Subjects and methods Review of literature.  ...  Triptans are commonly used anti-migraine drugs and show agonist action mainly at serotonin 5-HT1B/1D/1F receptors.  ... 
doi:10.1007/s10194-006-0313-3 fatcat:qkedhloc7ngsvebivfwado32g4

Transcriptional regulation of 5-HT(1A) receptor gene; Freud-2 a novel repressor of 5-HT(1A) receptor gene

Mahmoudreza Hadjighassem, Université D'Ottawa / University Of Ottawa, Université D'Ottawa / University Of Ottawa
2013
Alteration in expression and function of 5-HT1A receptors is believed play an important role in etiopathology and treatment of mood disorders such as major depression. 5-HT1A receptor gene regulation was  ...  The serotonin 1A receptor (5-HT1A) is expressed presynaptically on raphe neurons and works as an inhibitory autoreceptor.  ...  So, 5-HTTLPR has triple allele, S and LG representing low functional variant and LA shows higher functiona. 5-HT1A receptor gene polymorphism 5-HT1A receptors are expressed presynaptically as autoreceptors  ... 
doi:10.20381/ruor-13028 fatcat:3yqnninzdbgzxdl6tcfwbciyke

ACNP 55th Annual Meeting: Poster Session III

2016 Neuropsychopharmacology  
Both 11C-PS13 and 11C-MC1 showed good uptake in monkey brain (peak concentrations of 3-5 SUV) and washed out relatively quickly (demonstrating that the binding was reversible, as expected).  ...  Our laboratory recently developed two PET radioligands: 11C-PS13 for COX-1 and 11C-MC1 for COX-2, each of which potently and selectively inhibits the cognate enzyme in whole blood assays from monkey and  ...  For the serotonin transporter, we saw no significant associations of rs25531/5-HTTLPR and 5-HTTVNTR genotypes with our outcomes of interest in any of the ethnic samples (p4 0.05).  ... 
doi:10.1038/npp.2016.242 fatcat:4efd43swjbboranfrcs3pp32h4

Meta-analysis of hippocampal volume changes following electroconvulsive therapy in major depression

Karolin Elke Einenkel
2018 unpublished
The relationship between hippocampal volume alterations and changes in depressive symptomatology should be evaluated in more homogeneous [...]  ...  Alterations in hippocampal volume and changes in depressive symptom scores were not correlated.  ...  This control is mediated through auto-receptors at the presynaptic neuron: serotonin-1A (5-HT1A) receptor and serotonin-1B (5-HT1B) receptor, for instance, for serotonin and α2-noradrenergic ones for norepinephrine  ... 
doi:10.25365/thesis.52406 fatcat:xehqhx4hyfbbzkjdxsqeedhvny

Migraine and its chronicization to medication overuse headache: a pharmacogenetic-pharmacoepidemiologic approach

Sarah CARGNIN
2016
The overlapping between premonitory and postdrome symptoms fostered the hypothesis that postdromal signs could be present throughout the attack, probably disguised by headache, nausea or, if present, aura  ...  Photophobia, phonophobia, nausea and vomit can frequently accompany headache pain [17].  ...  Aknowledgements This work was funded by grants from Regione Piemonte, Ricerca Sanitaria Finalizzata to AAG (2006) and to PLC (2003PLC ( , 2007PLC ( , and 2008, from the Italian Ministry of Health (RC2010  ... 
doi:10.20373/uniupo/openthesis/115176 fatcat:3isouhvrxfbdpfn2vi56haqpva