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5th International Symposium on Focused Ultrasound

Menashe Zaaroor, Alon Sinai, Dorit Goldsher, Ayelet Eran, Maria Nassar, Ilana Schlesinger, Jonathon Parker, Vinod Ravikumar, Pejman Ghanouni, Sherman Stein, Casey Halpern, Vibhor Krishna (+1008 others)
2016 Journal of Therapeutic Ultrasound  
Our studies indicate that delivery of GDNF-BPN with FUS may provide a powerful, non-invasive and highly tailorable gene therapy approach to slow or stop the neurodegenerative process in PD.  ...  Here, we tested whether the FUS-mediated delivery of GDNF plasmid-bearing BPN (GDNF-BPN) reverses neurodegeneration in the rat 6-OHDA PD model.  ...  of lipid microbubbles can induce non-invasive, transient and reversible Blood-Brain Barrier (BBB) opening.  ... 
doi:10.1186/s40349-016-0076-5 fatcat:4vm7i5mt6vheni3hflxd3pwl2i

Photoacoustic imaging for monitoring of stroke diseases: A review

Xi Yang, Yun-Hsuan Chen, Fen Xia, Mohamad Sawan
2021 Photoacoustics  
In this manuscript, we review the achievements and progress of this technology and its applications in stroke and related diseases in small animal models as well as for human brain imaging.  ...  Stroke is the leading cause of death and disability after ischemic heart disease. However, there is lacking a non-invasive long-time monitoring technique for stroke diagnosis and therapy.  ...  As a non-invasive imaging method, the modality of transcranial PAI has enormous advantages for brain imaging.  ... 
doi:10.1016/j.pacs.2021.100287 fatcat:rxxyz36w2nfelbz6zjesziaili

Quantification of Atherosclerotic Plaque Elasticity using Ultrasonic Texture Matching

Hongyu Kang, Yanling Zhang, Xiaowei Huang, Lili Niu, Hui Zhang, Lisheng Xu, Derek Abbott
2020 IEEE Access  
In the phantom experiment, the mean elastic moduli of two component phantoms were 60.4 ± 7.6 kPa (soft tissue) and 198.5 ± 12.5 kPa (surrounding tissue), respectively.  ...  The cine-loop data in vitro study and in vivo study were acquired by an ultrasound micro-imaging system (VisualSonics Vevo2100).  ...  The B-mode data can be acquired easily in clinical ultrasound equipment and is inexpensive and non-invasive.  ... 
doi:10.1109/access.2020.2996432 fatcat:o6y6ytldnfdknjlfycd24jdh3i

Fiber Optics for Thermometry in Hyperthermia Therapy [chapter]

Mario Francisco Jess Cepeda Rubio, Arturo Vera, Lorenzo Leija
2012 Fiber Optic Sensors  
The measurement of temperatures is carried out with thermometry systems that can be invasive, or non invasive.  ...  Intelligent Optical Systems, Inc., has reported in 2009 an Optical Fiber Temperature (OFT) probe that will provide 10 points of high-resolution temperature data in a single fiber.  ...  It consists of 21 chapters encompassing the recent progress in the subject, basic principles of various sensor types, their applications in structural health monitoring and the measurement of various physical  ... 
doi:10.5772/28184 fatcat:34evjq7kprh6ndf6xiehfpvtcy

Simulation techniques in hyperthermia treatment planning

Margarethus M. Paulides, Paul R. Stauffer, Esra Neufeld, Paolo F. Maccarini, Adamos Kyriakou, Richard A.M. Canters, Chris J. Diederich, Jurriaan F. Bakker, Gerard C. Van Rhoon
2013 International Journal of Hyperthermia  
Clinical trials have shown that hyperthermia (HT), i.e. an increase of tissue temperature to 39-44°C, significantly enhance radiotherapy and chemotherapy effectiveness (1).  ...  In this paper, we review the simulation tools and techniques developed for clinical hyperthermia, and evaluate their current status on the path from "model" to "clinic".  ...  Acknowledgments The authors of Erasmus MC are financially supported by the Dutch Cancer Society and Technology Foundation STW, the authors of Duke University hospital by NIH (grant PO1-CA42745), and IT'IS  ... 
doi:10.3109/02656736.2013.790092 pmid:23672453 pmcid:PMC3711016 fatcat:dklawixdtvhhbk23riss3ueoke

Chronicle. 59th Open Seminar on Acoustics Boszkowo, Poland, September 10–14, 2012

Arkadiusz Józefczak
2012 Archives of Acoustics  
The aim of the conference is to exchange scientific experience in the field of acoustics, promote science and integrate specialists from various fields.  ...  It is organized sequentially by different departments of Polish Acoustical Society (PTA) – in 2012 by the Poznań Division.  ...  preliminary results of measuring the temperature inside the tissue in vitro during the process of heating by the ultrasound beam with low power and measuring the acoustic properties of soft tissue phantoms  ... 
doi:10.2478/v10168-012-0047-y fatcat:5wzt63vlwjegvpz4ghskcfa27y

Possible Patient Early Diagnosis by Ultrasonic Noninvasive Estimation of Thermal Gradients into Tissues Based on Spectral Changes Modeling

I. Bazan, A. Ramos, H. Calas, A. Ramirez, R. Pintle, T. E. Gomez, C. Negreira, F. J. Gallegos, A. J. Rosales
2012 Computational and Mathematical Methods in Medicine  
In this paper, approaches for non-invasive spectral ultrasonic detection are analyzed.  ...  tool in scattered tissues like liver.  ...  Models and Methods On Computer Modeling of Thermally Induced Alteration in Multiscattering Echoes from Patient Tissues.  ... 
doi:10.1155/2012/275405 pmid:22654958 pmcid:PMC3359682 fatcat:irtlpxj3zfegbnmogaoumfxmwe

Thermal modelling using discrete vasculature for thermal therapy: A review

H. Petra Kok, Johanna Gellermann, Cornelis A.T. van den Berg, Paul R. Stauffer, Jeffrey W. Hand, Johannes Crezee
2013 International Journal of Hyperthermia  
Since blood perfusion is such an important factor in thermal redistribution of energy in in vivo tissue, thermal simulations are most accurately performed by modelling discrete vasculature.  ...  This review describes the progress in thermal modelling with discrete vasculature for the purpose of hyperthermia treatment planning and thermal ablation.  ...  Non-uniform heat removal by blood flow further aggravates the temperature heterogeneity. Non-invasive 3D thermometry techniques are under development.  ... 
doi:10.3109/02656736.2013.801521 pmid:23738700 pmcid:PMC3684078 fatcat:tlm3u4jwibbpbn4rt6cn66lfmy

Monitoring Microwave Ablation Using Ultrasound Echo Decorrelation Imaging: An ex vivo Study

Zhuhuang Zhou, Yue Wang, Shuang Song, Weiwei Wu, Shuicai Wu, Po-Hsiang Tsui
2019 Sensors  
In this study, a microwave-induced ablation zone (thermal lesion) monitoring method based on ultrasound echo decorrelation imaging was proposed.  ...  Experimental results showed that the instantaneous echo decorrelation images outperformed conventional B-mode images in monitoring microwave-induced thermal lesions.  ...  The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.  ... 
doi:10.3390/s19040977 fatcat:7txsig5tojhdtblu3h4cob7glq

Cardiac and Thoracic-Abdominal Surgery

2006 International Journal of Computer Assisted Radiology and Surgery  
Keywords Robotic surgery AE Heartbeat synchronization AE System identification AE Model reference control Dynamic planning in single needle brachytherapy systems Abstract A semi-automatic non-rigid registration  ...  technique is applied to assist and improve the open magnetic resonance (Open-MR) imaging guided liver cancer surgery in which cancer tissues are coagulated by microwave ablation.  ...  The proposed force-depth/deflection model was used in conjunction with a force model of tissue.  ... 
doi:10.1007/s11548-006-0021-0 fatcat:7girlkxijner7ay3zih4jrzugq

Intelligent magnetic manipulation for gastrointestinal ultrasound

Joseph C. Norton, Piotr R. Slawinski, Holly S. Lay, James W. Martin, Benjamin F. Cox, Gerard Cummins, Marc P.Y. Desmulliez, Richard E. Clutton, Keith L. Obstein, Sandy Cochran, Pietro Valdastri
2019 Science Robotics  
We demonstrated the functionality of an autonomous servoing algorithm that uses μUS feedback, both on benchtop trials and in vivo in a porcine model.  ...  We have validated this magnetic μUS servoing in instances of autonomous linear probe motion and were able to locate markers in an agar phantom with 1.0 ± 0.9 mm position accuracy using a fusion of robot  ...  In-situ histology that is both non-invasive and facilitates rapid diagnosis would therefore be extremely beneficial (17) .  ... 
doi:10.1126/scirobotics.aav7725 pmid:31380501 pmcid:PMC6677276 fatcat:knxdpdmk7vbcvaxgbz4vjjopfm

Shape Reconstruction Processes for Interventional Application Devices: State of the Art, Progress, and Future Directions

Sujit Kumar Sahu, Canberk Sozer, Benoit Rosa, Izadyar Tamadon, Pierre Renaud, Arianna Menciassi
2021 Frontiers in Robotics and AI  
Thus, in recent years lots of efforts have been devoted for the development of shape reconstruction methods, with the advancement of different kinematic models, sensors, and imaging techniques.  ...  Yet, the problem of electromagnetic interference in the case of EM sensors, and poor response to high strains in the case of FBG sensors need to be considered.  ...  ACKNOWLEDGMENTS The authors wish to thank the ATLAS project team; in particular Selene Tognarelli, and Mohammad Hasan Dad Ansari from the BioRobotics Institute, Scuola Superiore Sant'Anna for their suggestions  ... 
doi:10.3389/frobt.2021.758411 pmid:34869615 pmcid:PMC8640970 fatcat:ai5dvdz42bg77bkdkltc7u4x3i

Smart sealants for prevention and monitoring of gastrointestinal anastomotic leaks using portable smartphone-controlled ultrasound transducers [article]

Alexandre H.C. Anthis, Maria Paulene Abundo, Anna L. Neuer, Elena Tsolaki, Jachym Rosendorf, Thomas Rduch, Fabian H.L. Starsich, Vaclav Liska, Andrea A. Schlegel, Mikhail G. Shapiro, Inge K. Herrmann
2022 biorxiv/medrxiv   pre-print
sensing elements, which can be read out by non-invasive point-of-need ultrasound imaging.  ...  Reliable detection of the breaching of sutures in as little as 3 hours in intestinal leak and 15 minutes in gastric leak conditions, and before an actual leak develops, is demonstrated.  ...  We thank Apolline Anthis for her contributions towards the development of the layer-by-layer incorporation of sensing and therapeutic elements in model patches.  ... 
doi:10.1101/2022.01.24.477460 fatcat:gwl7bh5ljbbk3iiora22iim3ry

Advances in Computational Human Phantoms and Their Applications in Biomedical Engineering—A Topical Review

Wolfgang Kainz, Esra Neufeld, Wesley E. Bolch, Christian G. Graff, Chan Hyeong Kim, Niels Kuster, Bryn Lloyd, Tina Morrison, Paul Segars, Yeon Soo Yeom, Maria Zankl, X. George Xu (+1 others)
2019 IEEE Transactions on Radiation and Plasma Medical Sciences  
Over the past decades, significant improvements have been made in the field of computational human phantoms (CHPs) and their applications in biomedical engineering.  ...  The article is organized into two main sections: the first section reviews the different modeling techniques used to create CHPs, whereas the second section discusses various applications of CHPs in biomedical  ...  In this case, non-invasive means, e.g., surface temperature and MRI-based in vivo magnetic field measurements, have been used.  ... 
doi:10.1109/trpms.2018.2883437 pmid:30740582 pmcid:PMC6362464 fatcat:p4kq6sj2wbalxdhsfiyhw4bimi

MRI-Guided Focused Ultrasound Surgery

Ferenc A. Jolesz
2009 Annual Review of Medicine  
A wide variety of references are listed.  ...  Reasonable efforts have been made to publish reliable data and information, but the author and the publisher cannot assume responsibility for the validity of all materials or for the consequence of their  ...  This can happen in the ultrasound field when temperatures in excess of 100˚C are induced and cause tissue boiling.  ... 
doi:10.1146/annurev.med.60.041707.170303 pmid:19630579 pmcid:PMC4005559 fatcat:7ojh6xtfc5ckvloxhnfb5dxtmi
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