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Magnetic resonance imaging for diagnosis of early Alzheimer's disease

O. Colliot, L. Hamelin, M. Sarazin
2013 Revue neurologique (Paris)  
A major challenge for neuroimaging is to contribute to the early diagnosis of Alzheimer's disease (AD).  ...  In particular, magnetic resonance imaging (MRI) allows detecting different types of structural and functional abnormalities at an early stage of the pathology.  ...  Introduction The increasing global prevalence and societal cost of Alzheimer's disease (AD) explains the need for early diagnosis, in order to develop effective treatments able to stop the pathophysiological  ... 
doi:10.1016/j.neurol.2013.07.013 pmid:24011982 fatcat:nopub2pisvg3letsnf3y6tzc4a

A Focus on Structural Brain Imaging in the Alzheimer's Disease Neuroimaging Initiative

Meredith N. Braskie, Paul M. Thompson
2014 Biological Psychiatry  
In recent years, there has been a wealth of laboratories and consortia that use neuroimaging to evaluate the risk for and progression of Alzheimer's disease (AD).  ...  One such consortium is the Alzheimer's Disease Neuroimaging Initiative (ADNI) -a longitudinal, multi-center study that evaluates a range of biomarkers for use in AD diagnoses, predicting patient outcomes  ...  This suggests that, as in purely genetic early onset forms of AD, abnormal CSF Aβ may be detectable earlier in the disease process than is brain amyloid (32) .  ... 
doi:10.1016/j.biopsych.2013.11.020 pmid:24367935 pmcid:PMC4019004 fatcat:jvqdma4yabfbdhutrzmqnuhszq

Diagnostic Utility of Cerebral White Matter Integrity in Early Alzheimer's Disease

David K. Johnson, Willis Barrow, RaeAnn Anderson, Amith Harsha, Robyn Honea, William M. Brooks, Jeffrey M. Burns
2010 International Journal of Neuroscience  
Very mildly demented patients showed expected disease-related patterns of brain atrophy with reductions in whole-brain and hippocampal volumes most prominent.  ...  We compared white matter integrity with brain atrophy in healthy controls and participants with very mild dementia (Clinical Dementia Rating 0 vs. 0.5) from the Brain Aging Project, a longitudinal study  ...  Jeffrey Burns has received honoraria from Novartis in the last year for speaking. These financial disclosures are not relevant to the current study. All other coauthors have no disclosures.  ... 
doi:10.3109/00207454.2010.494788 pmid:20615058 pmcid:PMC3108435 fatcat:fzqpb7z44jebtbvaphssgn6v7e

Tract-based analysis of white matter degeneration in Alzheimer's disease

S.-H. Lee, J.-P. Coutu, P. Wilkens, A. Yendiki, H.D. Rosas, D.H. Salat
2015 Neuroscience  
automated diffusion tractography procedures in the Alzheimer's disease Neuroimaging Initiative (ADNI) dataset.  ...  Although much prior work has focused on the known cortical pathology that defines Alzheimer's disease (AD) histologically, recent work has additionally demonstrated substantial damage to the cerebral white  ...  Data collection and sharing for this project was funded by the Alzheimer's Disease Neuroimaging Initiative (ADNI) (National Institutes of Health Grant U01 AG024904) and DOD ADNI (Department of Defense  ... 
doi:10.1016/j.neuroscience.2015.05.049 pmid:26026680 pmcid:PMC4505932 fatcat:rzh46fuokbadrh4dgui7stkczq

Localized hippocampus measures are associated with Alzheimer pathology and cognition independent of total hippocampal volume

Owen Carmichael, Jing Xie, Evan Fletcher, Baljeet Singh, Charles DeCarli
2012 Neurobiology of Aging  
Hippocampal injury in the Alzheimer's disease (AD) pathological process is region-specific and magnetic resonance imaging (MRI)based measures of localized hippocampus (HP) atrophy are known to detect region-specific  ...  imaging of participants in the Alzheimer's Disease Neuroimaging Initiative (ADNI).  ...  Early efforts measured areas of slices oriented perpendicular to the longitudinal HP axis (Laakso et al., 2000) .  ... 
doi:10.1016/j.neurobiolaging.2011.08.016 pmid:22169204 pmcid:PMC3323681 fatcat:tbc5h5dg6rgcrmzq3gv6hayfhe

Quantitative multi-modal MRI of the Hippocampus and cognitive ability in community-dwelling older subjects

Benjamin S. Aribisala, Natalie A. Royle, Susana Muñoz Maniega, Maria C. Valdés Hernández, Catherine Murray, Lars Penke, Alan Gow, John M. Starr, Mark E. Bastin, Ian J. Deary, Joanna M. Wardlaw
2014 Cortex  
Longitudinal relaxation time (T1), magnetization transfer ratio (MTR), fractional anisotropy (FA) and mean diffusivity (MD) were measured in the hippocampus.  ...  Quantitative multi-modal MRI assessments were more sensitive at detecting cognitionhippocampal integrity associations than volumetric measurements, resulting in stronger associations between MRI biomarkers  ...  Hippocampal volume reduction is associated with the development of Alzheimer's disease and other disorders of memory, with findings showing links between poor cognitive performance and smaller hippocampal  ... 
doi:10.1016/j.cortex.2013.12.012 pmid:24561387 pmcid:PMC3979658 fatcat:3le23cl4jrdtdgthcaipe5jd3y

Biomarker clusters are differentially associated with longitudinal cognitive decline in late midlife

Annie M. Racine, Rebecca L. Koscik, Sara E. Berman, Christopher R. Nicholas, Lindsay R. Clark, Ozioma C. Okonkwo, Howard A. Rowley, Sanjay Asthana, Barbara B. Bendlin, Kaj Blennow, Henrik Zetterberg, Carey E. Gleason (+2 others)
2016 Brain  
The ability to detect preclinical Alzheimer's disease is of great importance, as this stage of the Alzheimer's continuum is believed to provide a key window for intervention and prevention.  ...  As Alzheimer's disease is characterized by multiple pathological changes, a biomarker panel reflecting co-occurring pathology will likely be most useful for early detection.  ...  at the Wisconsin Alzheimer's Disease Research Center, the Wisconsin Alzheimer's Institute, and the University of Wisconsin-Madison for their assistance in recruitment, data collection, and data analysis  ... 
doi:10.1093/brain/aww142 pmid:27324877 pmcid:PMC4958904 fatcat:nm46g7tz2rg7ra66ljp4cpb5ry

Longitudinal neuroanatomical and cognitive progression of posterior cortical atrophy

2019 Brain  
The ordering of disease events both motivates investigation of biological factors underpinning phenotypic heterogeneity, and informs the selection of measures for clinical trials in posterior cortical  ...  Patients with typical Alzheimer's disease showed early hippocampal atrophy, with subsequent higher rates of temporal atrophy and ventricular expansion.  ...  Acknowledgements We are deeply indebted to all the research participants and their supporters without whom this work would not have been possible.  ... 
doi:10.1093/brain/awz136 pmid:31219516 pmcid:PMC6598737 fatcat:f2vxhaiz55aa5lnhgzbszq5wna

T2 heterogeneity: a novel marker of microstructural integrity associated with cognitive decline in people with mild cognitive impairment

Alfie R. Wearn, Volkan Nurdal, Esther Saunders-Jennings, Michael J. Knight, Hanna K. Isotalus, Serena Dillon, Demitra Tsivos, Risto A. Kauppinen, Elizabeth J. Coulthard
2020 Alzheimer's Research & Therapy  
Background Early Alzheimer's disease (AD) diagnosis is vital for development of disease-modifying therapies.  ...  T2 heterogeneity in the brain may present a sensitive early marker of AD pathology.  ...  MRI scans, and all the volunteers who gave up their time to take part in our studies.  ... 
doi:10.1186/s13195-020-00672-9 pmid:32912337 fatcat:yfvqsvx6drdmtl6exk2r7wdaqu

Diffusion imaging changes in grey matter in Alzheimer's disease: a potential marker of early neurodegeneration

Philip S.J. Weston, Ivor J.A. Simpson, Natalie S. Ryan, Sebastien Ourselin, Nick C. Fox
2015 Alzheimer's Research & Therapy  
Initial studies identified changes in diffusion measures in the hippocampi of patients with mild cognitive impairment, which predated macroscopic volume loss, with positive predictive value for progression  ...  The ability to identify presymptomatic individuals with evidence of neurodegenerative change, to stage their disease, and to track progressive changes will be important for early diagnosis and for prevention  ...  Acknowledgements The authors would like to acknowledge support from the NIHR Queen Square Dementia  ... 
doi:10.1186/s13195-015-0132-3 pmid:26136857 pmcid:PMC4487800 fatcat:yyrf5b7kfjampntywzueoksro4

Alzheimer Disease Biomarkers as Outcome Measures for Clinical Trials in MCI

Anna Caroli, Annapaola Prestia, Sara Wade, Kewei Chen, Napatkamon Ayutyanont, Susan M. Landau, Cindee M. Madison, Cathleen Haense, Karl Herholz, Eric M. Reiman, William J. Jagust, Giovanni B. Frisoni
2014 Alzheimer Disease and Associated Disorders  
CSF Aβ1-42 concentration -ABETA+) or MRI evidence of Alzheimer's Disease (AD) (positivity to hippocampal atrophy -HIPPO+).  ...  Background-Aim of this study was to compare the performance and power of the bestestablished diagnostic biological markers as outcome measures for clinical trials in patients with mild cognitive impairment  ...  is the Northern California Institute for Research and Education, and the study is coordinated by the Alzheimer's Disease Cooperative Study at the University of California, San Diego.  ... 
doi:10.1097/wad.0000000000000071 pmid:25437302 pmcid:PMC4437812 fatcat:sm42dd2ek5gwjakk6r4yhgpowy

Tracking Alzheimer's Disease

P. M THOMPSON, K. M HAYASHI, R. A DUTTON, M.-C. CHIANG, A. D LEOW, E. R SOWELL, G. DE ZUBICARAY, J. T BECKER, O. L LOPEZ, H. J AIZENSTEIN, A. W TOGA
2007 Annals of the New York Academy of Sciences  
We describe three novel brain mapping techniques, cortical thickness mapping, tensor-based morphometry, and hippocampal surface modeling, that offer enormous power for measuring disease progression in  ...  drug trials, and shed light on the neuroscience of brain degeneration in Alzheimer's Disease (AD) and Mild Cognitive Impairment (MCI).  ...  This research was supported by the National Institute on Aging, the National Library of Medicine, the National Institute for Biomedical Imaging and Bioengineering, the National Center for Research Resources  ... 
doi:10.1196/annals.1379.017 pmid:17413023 pmcid:PMC3197831 fatcat:ztx5gpereze5fiujthiwuktr5q

Role of structural MRI in Alzheimer's disease

Prashanthi Vemuri, Clifford R Jack
2010 Alzheimer's Research & Therapy  
A plausible model for the development of AD posits that amyloid deposition occurs early in the process but by itself does not directly cause clinical symptoms [1, 2] .  ...  and intensity of the neurodegenerative aspect of Alzheimer's disease (AD) pathology.  ...  Early diagnosis of Alzheimer's disease and mild cognitive impairment Th e typical reductions of hippocampal volume in MCI with an average Mini-Mental State Exam (MMSE) score of 25 are 10% to 15% and in  ... 
doi:10.1186/alzrt47 pmid:20807454 pmcid:PMC2949589 fatcat:ua2c6ky2prdzpp42kxq4rlmp2q

Impact of the Alzheimer's Disease Neuroimaging Initiative, 2004 to 2014

Michael W. Weiner, Dallas P. Veitch, Paul S. Aisen, Laurel A. Beckett, Nigel J. Cairns, Jesse Cedarbaum, Michael C. Donohue, Robert C. Green, Danielle Harvey, Clifford R. Jack, William Jagust, John C. Morris (+6 others)
2015 Alzheimer's & Dementia  
Introduction-The Alzheimer's Disease Neuroimaging Initiative (ADNI) was established in 2004 to facilitate the development of effective treatments for Alzheimer's disease (AD) by validating biomarkers for  ...  A competitive renewal of the project in 2015 would see the use of newly developed tau imaging ligands, and the continued development of recruitment strategies and outcome measures for clinical trials.  ...  Table 1 Major findings using ADNI data Area of research Major findings using ADNI data References Conflicts of Interest  ... 
doi:10.1016/j.jalz.2015.04.005 pmid:26194320 pmcid:PMC4659407 fatcat:ba7v6zu5pvhqjf6ovuvwa7acl4

Whole-brain analysis reveals increased neuroanatomical asymmetries in dementia for hippocampus and amygdala

Christian Wachinger, David H. Salat, Michael Weiner, Martin Reuter
2016 Brain  
are associated with disease progression and can yield a powerful imaging biomarker for the early presymptomatic classification and prediction of Alzheimer's disease.  ...  Most contemporary imaging biomarkers are scalar values, such as the volume of a structure, and may miss the localized morphological variation of early presymptomatic disease progression.  ...  A more accurate prediction of the likelihood for progression and the early detection of the disease requires a better understanding of disease trajectories.  ... 
doi:10.1093/brain/aww243 pmid:27913407 pmcid:PMC5840883 fatcat:ug3lsuyx5fb2jnvrt7tfiqcrme
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