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Integrated computational and Drosophila cancer model platform captures previously unappreciated chemicals perturbing a kinase network [article]

Peter Man-Un Ung, Masahiro Sonoshita, Alex P Scopton, Arvin C Dar, Ross L Cagan, Avner Schlessinger
<span title="2018-06-11">2018</span> <i title="Cold Spring Harbor Laboratory"> bioRxiv </i> &nbsp; <span class="release-stage" >pre-print</span>
We demonstrate this platform by developing chemicals targeting a Drosophila model of Medullary Thyroid Cancer (MTC) with disease-promoting kinase network activated by mutant dRet M955T .  ...  Here, we present a unique discovery platform integrating structure-based modeling with Drosophila biology and organic synthesis.  ...  We demonstrate this platform by developing chemicals targeting a Drosophila 25 model of Medullary Thyroid Cancer (MTC) with disease-promoting kinase network acti-26 vated by mutant dRet M955T .  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1101/344192">doi:10.1101/344192</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/ltcrro7jsjcf5j726e7goqoqqq">fatcat:ltcrro7jsjcf5j726e7goqoqqq</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190430131714/https://www.biorxiv.org/content/biorxiv/early/2018/07/03/344192.full.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/cb/db/cbdbea46f8b5ca437b7b04ed81257bdf4f623c9c.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1101/344192"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> biorxiv.org </button> </a>

Integrated computational and Drosophila cancer model platform captures previously unappreciated chemicals perturbing a kinase network

Peter M. U. Ung, Masahiro Sonoshita, Alex P. Scopton, Arvin C. Dar, Ross L. Cagan, Avner Schlessinger, Feilim Mac Gabhann
<span title="2019-04-26">2019</span> <i title="Public Library of Science (PLoS)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/ch57atmlprauhhbqdf7x4ytejm" style="color: black;">PLoS Computational Biology</a> </i> &nbsp;
Here, we present a unique discovery platform integrating structure-based modeling with Drosophila biology and organic synthesis.  ...  We demonstrate this platform by developing chemicals targeting a Drosophila model of Medullary Thyroid Cancer (MTC) characterized by a transformation network activated by oncogenic dRetM955T.  ...  This work was supported in part through the computational resources and staff expertise provided by the Department of Scientific Computing at the Icahn School of Medicine at Mount Sinai.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1371/journal.pcbi.1006878">doi:10.1371/journal.pcbi.1006878</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/31026276">pmid:31026276</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC6506148/">pmcid:PMC6506148</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/chjsjiirgzcanmhm7m56jvft7q">fatcat:chjsjiirgzcanmhm7m56jvft7q</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20191214190250/https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1006878&amp;type=printable" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/b2/79/b27979daca268f4f97b83bb2c2a19b7ff7061a24.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1371/journal.pcbi.1006878"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> plos.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6506148" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Crowdsourced identification of multi-target kinase inhibitors for RET- and TAU-based disease: the Multi-Targeting Drug DREAM Challenge [article]

Zhaoping Xiong, Minji Jeon, Robert J Allaway, Jaewoo Kang, Donghyeon Park, Jinhyuk Lee, Hwisang Jeon, Miyoung Ko, Hualiang Jiang, Minyue Zheng, Aik Choon Tan, Xindi Guo (+10 others)
<span title="2021-02-17">2021</span> <i title="Cold Spring Harbor Laboratory"> bioRxiv </i> &nbsp; <span class="release-stage" >pre-print</span>
cancer and neurodegenerative disease.  ...  unrelated diseases: RET-based tumors and a common form of inherited Tauopathy.  ...  unappreciated chemicals perturbing a kinase network.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1101/2021.02.15.430538">doi:10.1101/2021.02.15.430538</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/4ihbouza6vfbvg6bsibmaa5p64">fatcat:4ihbouza6vfbvg6bsibmaa5p64</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210718083945/https://www.biorxiv.org/content/biorxiv/early/2021/02/17/2021.02.15.430538.1.full.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/c8/28/c8284348f2ea76e560639cc502734e59dbf6f44c.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1101/2021.02.15.430538"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> biorxiv.org </button> </a>

Tension, contraction and tissue morphogenesis

Natalie C. Heer, Adam C. Martin
<span title="2017-11-28">2017</span> <i title="The Company of Biologists"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/p74htnr5yvfmxn6hgfmprxrxiq" style="color: black;">Development</a> </i> &nbsp;
Indeed, the recent integration of quantitative experimental data, force measurements and mathematical modeling has changed our understanding of morphogenesisthe shaping of an organism during development  ...  Emerging evidence suggests that the subcellular organization of contractile cytoskeletal networks plays a key role in force generation, while on the tissue level the spatial organization of forces determines  ...  Davidson for generous feedback; and the anonymous reviewers and the editor for their helpful comments.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1242/dev.151282">doi:10.1242/dev.151282</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/29183938">pmid:29183938</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/cwuafzfwz5f6rbjdsaglosdfse">fatcat:cwuafzfwz5f6rbjdsaglosdfse</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190426220119/http://dev.biologists.org/content/develop/144/23/4249.full.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/38/8d/388dd6fe7f273befb80f72943ea1a7f9cd67c67e.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1242/dev.151282"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a>

2017 ASCB Annual Meeting Abstracts

David G. Drubin
<span title="2017-12-15">2017</span> <i title="American Society for Cell Biology (ASCB)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/btmjitlxs5by3dntmzk67gakxi" style="color: black;">Molecular Biology of the Cell</a> </i> &nbsp;
Maintenance of proper PM proteostasis is crucial to prevent loss of PM integrity and dissipation of essential ion and chemical gradients.  ...  We have used the single-cell yeast Saccharomyces cerevisiae as a genetic model system to discover and isolate the complex machinery that ORAL PRESENTATIONS-SUNDAY Sunday-2 sorts and delivers proteins and  ...  Surface-tethered and soluble RGD-containing ligands engage the integrin receptor and activate FAK-src kinases and the RhoGTPase, RhoA.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1091/mbc.e17-10-0618">doi:10.1091/mbc.e17-10-0618</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/29237772">pmid:29237772</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC5739290/">pmcid:PMC5739290</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/3msjrn3omzcybfanlagykayauy">fatcat:3msjrn3omzcybfanlagykayauy</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190224160426/http://pdfs.semanticscholar.org/5a74/07e4c866dc8005eabe38e962d545388aa88b.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/5a/74/5a7407e4c866dc8005eabe38e962d545388aa88b.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1091/mbc.e17-10-0618"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739290" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

A live-cell screen for altered Erk dynamics reveals principles of proliferative control [article]

Alexander G Goglia, Maxwell Z Wilson, Jillian Silbert, Siddhartha Jena, Danelle Devenport, Jared E Toettcher
<span title="2019-06-19">2019</span> <i title="Cold Spring Harbor Laboratory"> bioRxiv </i> &nbsp; <span class="release-stage" >pre-print</span>
We screened a library of 429 kinase inhibitors, monitoring Erk activity over 5 h in more than 80,000 single live cells.  ...  The screen revealed both known and uncharacterized modulators of Erk dynamics, including inhibitors of non-EGFR receptor tyrosine kinases (RTKs) that increased Erk pulse frequency and overall activity.  ...  Gary Laevsky and the Princeton Molecular Biology Microscopy Core, which is a Nikon Center of Excellence, for microscopy support; and Hahn Kim and the Princeton Small Molecule Screening Facility for support  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1101/675736">doi:10.1101/675736</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/4tn7ad5oync6bnb7tsckwmgbz4">fatcat:4tn7ad5oync6bnb7tsckwmgbz4</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200309172728/https://www.biorxiv.org/content/biorxiv/early/2019/07/31/675736.full.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/39/97/399715a29990a418fb5b34e403909e1d4e6d830d.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1101/675736"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> biorxiv.org </button> </a>

Society for Development Biology 64th Annual Meeting

<span title="">2005</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/2ojtrdr5enbotexnfakgsvrhai" style="color: black;">Developmental Biology</a> </i> &nbsp;
These studies reveal a previously unknown mechanism for transcription factor regulation in vertebrate limb and heart development and provide a better understanding of the molecular basis of hand/heart  ...  We are using molecular and computational approaches to identify micro-RNAs in plants and animals and then investigate their functions.  ...  Computational models of the interaction network suggest new experiments, and realtime analysis of meristem activities after changes in gene activity tests the computational models, leading iteratively  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.ydbio.2005.04.040">doi:10.1016/j.ydbio.2005.04.040</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/jj63lzrujnfx7pt3uxl57spp4i">fatcat:jj63lzrujnfx7pt3uxl57spp4i</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190412105116/https://core.ac.uk/download/pdf/82374310.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.ydbio.2005.04.040"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> elsevier.com </button> </a>

Kinetochore structure and spindle assembly checkpoint signaling in the budding yeast, Saccharomyces Cerevisiae

Duncan, J. Clarke
<span title="">2008</span> <i title="Frontiers in Bioscience"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/mfwufqll45bepinkdxuteuecia" style="color: black;">Frontiers in Bioscience</a> </i> &nbsp;
This might form part of a platform for recruitment of other components such as Mad1 and Mad2.  ...  Figure 2 . 2 Microtubule Capture and Error Correction. Microtubule (MT) capture is achieved by interaction of a kinetochore microtubule (KMT) with KNL-1 and Ndc80 complexes.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.2741/3189">doi:10.2741/3189</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/18508695">pmid:18508695</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/2mubnakobrbexpa6w5vxcecy2y">fatcat:2mubnakobrbexpa6w5vxcecy2y</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190304172535/http://pdfs.semanticscholar.org/c9a2/b20c54efbae860041150c25f3d9fb46d1967.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/c9/a2/c9a2b20c54efbae860041150c25f3d9fb46d1967.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.2741/3189"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a>

ISEV2020 Abstract Book

<span title="2020-07-06">2020</span> <i title="Informa UK Limited"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/54x42hzx4zg67l77khyvk7qopm" style="color: black;">Journal of Extracellular Vesicles</a> </i> &nbsp;
a Faculty of Dentistry, National University of Singapore, Singapore, Singapore, Singapore; b Institute of Medical Biology, Agency for Science, Technology and Research, Singapore, Singapore, Singapore;  ...  Here we introduce the use of membrane sensing peptides as new, highly efficient ligands to directly integrate sEV capturing and analysis on a microarray platform.  ...  platform (LEUKOBIOPSY) in cancer.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1080/20013078.2020.1784511">doi:10.1080/20013078.2020.1784511</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/xbxp2qizdre7lesxfhhd4ox6ga">fatcat:xbxp2qizdre7lesxfhhd4ox6ga</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210718085050/https://onlinelibrary.wiley.com/doi/pdfdirect/10.1080/20013078.2020.1784511" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1080/20013078.2020.1784511"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> tandfonline.com </button> </a>

The Heart as a Model Organ

<span title="">1999</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/iwommhyo5bdk7c3u37mhjzexfe" style="color: black;">Cell</a> </i> &nbsp;
A tant print source, and probably the most respected model of candor is the comment from a leading investisource, of news about biology.  ...  magnum opus and remains the ultimate resource for anyone interested in aging as the teeth of herbivores or the ragged wings of aged Drosophila.  ...  "snapshot" (p. vi) capturing current views of chemokines Furthermore, over 70,000 chemicals are currently used and cancer.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/s0092-8674(00)81499-3">doi:10.1016/s0092-8674(00)81499-3</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/lpbcm6kx2rgsxp2ew7kenxzv5e">fatcat:lpbcm6kx2rgsxp2ew7kenxzv5e</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20170927111156/http://publisher-connector.core.ac.uk/resourcesync/data/elsevier/pdf/518/aHR0cDovL2FwaS5lbHNldmllci5jb20vY29udGVudC9hcnRpY2xlL3BpaS9zMDA5Mjg2NzQwMDgxNDk5Mw%3D%3D.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/f5/08/f508cbaabe4fdcf56bf6d36117b10fbc13cbd706.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/s0092-8674(00)81499-3"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> elsevier.com </button> </a>

Using Genes to Cure Cancer

<span title="">1999</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/iwommhyo5bdk7c3u37mhjzexfe" style="color: black;">Cell</a> </i> &nbsp;
A tant print source, and probably the most respected model of candor is the comment from a leading investisource, of news about biology.  ...  magnum opus and remains the ultimate resource for anyone interested in aging as the teeth of herbivores or the ragged wings of aged Drosophila.  ...  "snapshot" (p. vi) capturing current views of chemokines Furthermore, over 70,000 chemicals are currently used and cancer.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/s0092-8674(00)81506-8">doi:10.1016/s0092-8674(00)81506-8</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/qlw4msbz7vht5psfzufg5ykgo4">fatcat:qlw4msbz7vht5psfzufg5ykgo4</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190330123800/https://core.ac.uk/download/pdf/82577500.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/8d/2e/8d2edd83753a86a66ad4952084875a8694d0ccb9.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/s0092-8674(00)81506-8"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> elsevier.com </button> </a>

What Makes Breast Cancer Cells Tick?

<span title="">1999</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/iwommhyo5bdk7c3u37mhjzexfe" style="color: black;">Cell</a> </i> &nbsp;
A tant print source, and probably the most respected model of candor is the comment from a leading investisource, of news about biology.  ...  magnum opus and remains the ultimate resource for anyone interested in aging as the teeth of herbivores or the ragged wings of aged Drosophila.  ...  "snapshot" (p. vi) capturing current views of chemokines Furthermore, over 70,000 chemicals are currently used and cancer.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/s0092-8674(00)81507-x">doi:10.1016/s0092-8674(00)81507-x</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/hzyd3c3iirdn5oif5qdyxfzr6i">fatcat:hzyd3c3iirdn5oif5qdyxfzr6i</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190329184256/https://core.ac.uk/download/pdf/81962163.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/9f/3a/9f3a1526dd139df879d9e30e783e048d25b5feaf.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/s0092-8674(00)81507-x"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> elsevier.com </button> </a>

Origin of Life and RNA; Achievements and Disillusions

<span title="">1999</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/iwommhyo5bdk7c3u37mhjzexfe" style="color: black;">Cell</a> </i> &nbsp;
A tant print source, and probably the most respected model of candor is the comment from a leading investisource, of news about biology.  ...  magnum opus and remains the ultimate resource for anyone interested in aging as the teeth of herbivores or the ragged wings of aged Drosophila.  ...  "snapshot" (p. vi) capturing current views of chemokines Furthermore, over 70,000 chemicals are currently used and cancer.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/s0092-8674(00)81489-0">doi:10.1016/s0092-8674(00)81489-0</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/bxgxdzvkhjgd5ixra3g2xpqgnu">fatcat:bxgxdzvkhjgd5ixra3g2xpqgnu</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20170926203545/http://publisher-connector.core.ac.uk/resourcesync/data/elsevier/pdf/44e/aHR0cDovL2FwaS5lbHNldmllci5jb20vY29udGVudC9hcnRpY2xlL3BpaS9zMDA5Mjg2NzQwMDgxNDg5MA%3D%3D.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/b6/6b/b66b6813770cc406b27955e2db31b5495d4da5dc.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/s0092-8674(00)81489-0"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> elsevier.com </button> </a>

Why Mutton Doesn't Taste Like Lamb

<span title="">1999</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/iwommhyo5bdk7c3u37mhjzexfe" style="color: black;">Cell</a> </i> &nbsp;
A tant print source, and probably the most respected model of candor is the comment from a leading investisource, of news about biology.  ...  magnum opus and remains the ultimate resource for anyone interested in aging as the teeth of herbivores or the ragged wings of aged Drosophila.  ...  "snapshot" (p. vi) capturing current views of chemokines Furthermore, over 70,000 chemicals are currently used and cancer.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/s0092-8674(00)81486-5">doi:10.1016/s0092-8674(00)81486-5</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/4n2y5k5c6zc4zlrviemw7b6gj4">fatcat:4n2y5k5c6zc4zlrviemw7b6gj4</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20170930091729/http://publisher-connector.core.ac.uk/resourcesync/data/elsevier/pdf/8c2/aHR0cDovL2FwaS5lbHNldmllci5jb20vY29udGVudC9hcnRpY2xlL3BpaS9zMDA5Mjg2NzQwMDgxNDg2NQ%3D%3D.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/a8/38/a838b953a39752b822c292794f65368a363f4eef.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/s0092-8674(00)81486-5"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> elsevier.com </button> </a>

And Still It Moves (E Pur Si Muove)

<span title="">1999</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/iwommhyo5bdk7c3u37mhjzexfe" style="color: black;">Cell</a> </i> &nbsp;
A tant print source, and probably the most respected model of candor is the comment from a leading investisource, of news about biology.  ...  magnum opus and remains the ultimate resource for anyone interested in aging as the teeth of herbivores or the ragged wings of aged Drosophila.  ...  "snapshot" (p. vi) capturing current views of chemokines Furthermore, over 70,000 chemicals are currently used and cancer.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/s0092-8674(00)81494-4">doi:10.1016/s0092-8674(00)81494-4</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/dev7zmrojbfqrb63twbxuwdi3u">fatcat:dev7zmrojbfqrb63twbxuwdi3u</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20170930235920/http://publisher-connector.core.ac.uk/resourcesync/data/elsevier/pdf/98b/aHR0cDovL2FwaS5lbHNldmllci5jb20vY29udGVudC9hcnRpY2xlL3BpaS9zMDA5Mjg2NzQwMDgxNDk0NA%3D%3D.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/94/ff/94ff828722307b079145639022e74dcc916e1dac.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/s0092-8674(00)81494-4"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> elsevier.com </button> </a>
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