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Integrated Cantilever-Based Flow Sensors with Tunable Sensitivity for In-Line Monitoring of Flow Fluctuations in Microfluidic Systems

Nadine Noeth, Stephan Keller, Anja Boisen
2013 Sensors  
Finally, we demonstrate the ability to perform in-line monitoring of flow fluctuations in a microfluidic system using the integrated cantilever-like sensor.  ...  In-line measurement of flow fluctuations in the microfluidic system with an integrated flow sensor allows the characterization of the fluidic noise.  ...  Conflicts of Interest The authors declare no conflict of interest.  ... 
doi:10.3390/s140100229 pmid:24366179 pmcid:PMC3926555 fatcat:qodwnjuepbagpdodtnhypdeny4

Microfluidic and Micromachined/MEMS Devices for Separation, Discrimination and Detection of Airborne Particles for Pollution Monitoring

Daniel Puiu Poenar
2019 Micromachines  
Most of the microfluidics-related literature describes devices handling liquids, with only a small part dealing with gas-based applications, and a much smaller number of papers are devoted to the separation  ...  due to their inherent capability of being integrated in lab-on-chip (LOC) type of smart microsystems with increased functionalities that can be portable and are easy to use.  ...  Capacitive sensors have the advantage that they can be easily integrated with circuits in CMOS ICs to provide a much more performant system in terms of sensitivity.  ... 
doi:10.3390/mi10070483 pmid:31323826 pmcid:PMC6681025 fatcat:oypxrhks6rdenho3c5sukm4o4u

Suspended microchannel resonators for biomolecular detection

T. P. Burg, S. R. Manalis
2003 Applied Physics Letters  
Microfabricated resonant mass sensors are among the most sensitive devices for chemical detection, but degradation of the sensitivity in liquid has so far hindered their successful application in biology  ...  Integrating microfluidic detect ion and sample-preparat ion can greatly leverage experimental efforts in systems biology and pharmaceutical research by increasing analysis throughput while dramatically  ...  The influence of flow rate, diffusivity, and sensor geometry on kinetic measurements has been studied extensively for commercial surface plasmon resonance based instruments whose flow chamber is a microfluidic  ... 
doi:10.1063/1.1611625 fatcat:t5tabhmd35fcdnsffvrb3rfwxu

Label-free biological and chemical sensors

Heather K. Hunt, Andrea M. Armani
2010 Nanoscale  
Highly sensitive, label-free biodetection methods have applications in both the fundamental research and healthcare diagnostics arenas.  ...  Additionally, a more in-depth discussion of optical devices, surface functionalization methods to increase device specificity, and fluidic techniques to improve sample delivery will be reviewed.  ...  sensors with parylene microfluidics. 169 Using this type of integrated device, changes in cellular behavior in response to fluid shear stress were detected by monitoring the change in the mechanical  ... 
doi:10.1039/c0nr00201a pmid:20820687 fatcat:5fi4xzbwgzgdlpochxb2ir6wdi

Microfluidic approaches for isolation, detection, and characterization of extracellular vesicles: Current status and future directions

Shima Gholizadeh, Mohamed Shehata Draz, Maryam Zarghooni, Amir Sanati-Nezhad, Saeid Ghavami, Hadi Shafiee, Mohsen Akbari
2017 Biosensors & bioelectronics  
This review will also highlight the integrated on-chip systems for isolation and characterization of EVs.  ...  Advances in microfluidics allow for chemical sampling with increasingly high spatial resolution and under precise manipulation down to single molecule level.  ...  Mohsen Akbari acknowledges Natural Sciences and Engineering Research Council of Canada (NSERC) for funding.  ... 
doi:10.1016/j.bios.2016.12.062 pmid:28088752 pmcid:PMC5323331 fatcat:edr5hed6dvaijapwffq5rkudva

Integrating Biosensors in Organs-on-Chip Devices: A Perspective on Current Strategies to Monitor Microphysiological Systems

Erika Ferrari, Cecilia Palma, Simone Vesentini, Paola Occhetta, Marco Rasponi
2020 Biosensors  
However, the urgent demand for continuous, noninvasive, and real-time monitoring of tissue constructs requires the direct integration of biosensors.  ...  Biosensors for monitoring biological models with metabolic activities, models with tissue barrier functions, as well as models with electromechanical properties will be described and critically evaluated  ...  [92] developed a microfluidic device integrated with aptamer-based sensors for continuous monitoring of transforming growth factor-beta (TGF-β) signaling in hepatocytes and stellate cells coculture  ... 
doi:10.3390/bios10090110 pmid:32872228 fatcat:vrbvsqzxrzf4xizsvav7hx6ihy

Table of Contents

2019 Journal of Physics, Conference Series  
This work is being conducted in the NSF funded ERC Center on Advanced Self-Powered Systems of Integrated Sensors and Technologies (ASSIST).  ...  Active AFC-MEAs were combined by integrating OH--permeable electrolyte into micro-channels of MEMS-based membranes.  ...  The device consists of two cantilever-type sensors for the forces monitoring.  ... 
doi:10.1088/1742-6596/1407/1/011002 fatcat:5ttgm2jqtfgr3jf55i22inzuq4

Microelectromechanical Systems and Nephrology: The Next Frontier in Renal Replacement Technology

Steven Kim, Shuvo Roy
2013 Advances in Chronic Kidney Disease  
Next, a survey of MEMS devices being developed for various biomedical applications will be illustrated with current examples.  ...  The future landscape of clinical medicine and research will only see further expansion of MEMS based technologies in device designs and applications.  ...  Cheong et al. have designed a MEMS based pressure sensor for monitoring blood flow in prosthetic vascular grafts. 104 The implantable device uses a silicon nanowire sensor with tunable piezoresistivity  ... 
doi:10.1053/j.ackd.2013.08.006 pmid:24206604 pmcid:PMC3866020 fatcat:5hqtwigv6bbl5e5wr7to6pe2ei

Micro Total Analysis Systems: Fundamental Advances and Applications in the Laboratory, Clinic, and Field

Michelle L. Kovarik, Douglas M. Ornoff, Adam T. Melvin, Nicholas C. Dobes, Yuli Wang, Alexandra J. Dickinson, Philip C. Gach, Pavak K. Shah, Nancy L. Allbritton
2012 Analytical Chemistry  
or in environmental monitoring.  ...  Another strength of μTAS lies in the creation of multicellular communities, for example, the combination of many cell types into an interacting system to explore intercellular communication.  ...  Acknowledgments The authors thank Jessica Park Lindsey for preparing the table of contents graphic.  ... 
doi:10.1021/ac3031543 pmid:23140554 pmcid:PMC3546124 fatcat:6zpniz3pkbasveawfmooodsvk4

MEMS Resonant Mass Sensor With Integrated Optical Manipulation

Ethan G. Keeler, Peifeng Jing, Jingda Wu, Chen Zou, Lih Y. Lin
2018 IEEE transactions on nanotechnology  
We investigate optical manipulation of particles in fluid as a viable method to achieve better experimental fidelity and extend the application of integrated-fluidic resonant-mass sensing.  ...  Fluctuations in sample position or trajectory can lead to measurement error, thereby degrading the resolution with which these devices can accurately characterize mass.  ...  CONCLUSION The sensor described in this letter unites the techniques of optical trapping and MEMS resonant mass sensing in a microfluidic-enabled device.  ... 
doi:10.1109/tnano.2018.2819939 fatcat:4hm47geknzaita4yptmvjls3fi

Opto-Mechanical Photonic Crystal Cavities for Sensing Application

Ji Xia, Qifeng Qiao, Guangcan Zhou, Fook Siong Chau, Guangya Zhou
2020 Applied Sciences  
In this review, we introduce basic physical concepts of opto-mechanical PhC system and describe typical experimental systems for sensing applications.  ...  On account of their high-quality factors and small mode volumes as well as good on-chip integrability with waveguides/circuits, photonic crystal (PhC) cavities have attracted great attention in sensing  ...  Conflicts of Interest: The authors declare no conflict of interest.  ... 
doi:10.3390/app10207080 fatcat:52kvkq3kfvfy7i5j5a4h5ohghm

Ultrafine Aerosol Particle Sizer Based on Piezoresistive Microcantilever Resonators with Integrated Air-Flow Channel

Maik Bertke, Ina Kirsch, Erik Uhde, Erwin Peiner
2021 Sensors  
To monitor airborne nano-sized particles (NPs), a single-chip differential mobility particle sizer (DMPS) based on resonant micro cantilevers in defined micro-fluidic channels (µFCs) is introduced.  ...  Mobility sizing in 4 bins of a nebulized carbon aerosol NPs is demonstrated based on finite element modelling (FEM) combined with a-priori knowledge of particle charge state.  ...  Conflicts of Interest: The authors declare no conflict of interest.  ... 
doi:10.3390/s21113731 pmid:34072041 fatcat:hmxnavg5tbdy5dgxahykrtzjdu

Recent Advances in Application of Biosensors in Tissue Engineering

Anwarul Hasan, Md Nurunnabi, Mahboob Morshed, Arghya Paul, Alessandro Polini, Tapas Kuila, Moustafa Al Hariri, Yong-kyu Lee, Ayad A. Jaffa
2014 BioMed Research International  
In this review, we provide an overview of the recent advancements in biosensors for tissue engineering applications.  ...  In recent years, there has been a growing interest in application of novel biosensors in cell culture and tissue engineering, for example, real-time detection of small molecules such as glucose, lactose  ...  Conflict of Interests The authors declare that there is no conflict of interests regarding the publication of this paper.  ... 
doi:10.1155/2014/307519 pmid:25165697 pmcid:PMC4140114 fatcat:e4ipgwnyvja4holnq75zefvpdm

Progress of infrared guided-wave nanophotonic sensors and devices

Yiming Ma, Bowei Dong, Chengkuo Lee
2020 Nano Convergence  
Guided-wave nanophotonics paves the way to miniaturize the sensors and realize on-chip integration of various photonic components, so as to realize chip-scale sensing systems for the future realization  ...  Starting from the popular CMOS-compatible silicon nanophotonics in the infrared, many infrared guided-wave nanophotonic sensors have been developed, showing the advantages of high sensitivity, low limit  ...  Authors' contributions YM, BD, and CL contributed to the preparation of the manuscript. YM and BD contributed equally to this work. CL supervised the overall conception.  ... 
doi:10.1186/s40580-020-00222-x pmid:32239361 fatcat:zxljikq4afa7ravknpul42hp5a

Single nanoparticle detectors for biological applications

Abdulkadir Yurt, George G. Daaboul, John H. Connor, Bennett B. Goldberg, M. Selim Ünlü
2012 Nanoscale  
In this article, we discuss the recent progress and future directions in the area of single nanoparticle detectors with an emphasis on their biological applications.  ...  Development of novel detection and characterization tools for nanoparticles will impact a broad range of disciplines in biological research from nanomedicine to nanotoxicology.  ...  Acknowledgements This work was supported in part by US Army Research Laboratories (ARL) grant W911NF-06-2-0040.  ... 
doi:10.1039/c2nr11562j pmid:22214976 pmcid:PMC3759154 fatcat:sflcjeljsje4vj5w64cmiac45a
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