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Spike-timing computation properties of a feed-forward neural network model

Drew B. Sinha, Noah M. Ledbetter, Dennis L. Barbour
2014 Frontiers in Computational Neuroscience  
When background activity was correlated or parallel disynaptic pathways were added, however, robust polysynaptic spike timing relationships were observed, and application of STS yielded predictable changes  ...  We investigated how activity varied when dynamics were perturbed by an activity-dependent electrical stimulation protocol (spike-triggered stimulation; STS) in networks of different topologies and background  ...  ACKNOWLEDGMENTS We would like to thank Jeffery Gamble, Ruiye Ni, Xinyu Song, and Wensheng Sun for helpful comments on early drafts of this manuscript. Drew B.  ... 
doi:10.3389/fncom.2014.00005 pmid:24478688 pmcid:PMC3904091 fatcat:stlcp57l2fbibjrxh5b2ggwgpy

Evolving networks of integrate-and-fire neurons

Francisco J. Veredas, Francisco J. Vico, José M. Alonso
2006 Neurocomputing  
The search for answers to that question has been tackled in two steps: (1) we incorporated into an integrate-and-fire (IAF) neuron model those aspects of neuronal physiology that can influence cross-correlated  ...  activity; (2) we evolved networks of biologically realistic neurons towards circuits that are able to generate a monosynaptic correlogram between two neurons.  ...  Acknowledgments This research has been partially funded by NIH-EY 05253, and by the Spanish Ministerio de Ciencia y Tecnologı´a (projects PTR95.0734.OP and OTRI-PAI 03-18).  ... 
doi:10.1016/j.neucom.2005.06.013 fatcat:jm54fvufuberlchlqgjrpnbuhe

A computational tool to simulate correlated activity in neural circuits

F.J. Veredas, F.J. Vico, J.M. Alonso
2004 Journal of Neuroscience Methods  
A new computational approach to study correlated neural activity is presented.  ...  The model neuron that it implements can reproduce a wide scope of integrate-and-fire models by simply adjusting the parameter set.  ...  This research has been supported by NIH-EY 05253, and by the Spanish Ministerio de Ciencia y Tecnología (project PTR95.0734.OP).  ... 
doi:10.1016/j.jneumeth.2003.12.026 pmid:15126042 fatcat:gh7aemomirdyzp7yuzicsteai4

Monosynaptic functional connectivity in cerebral cortex during wakefulness and under graded levels of anesthesia

Jeannette A. Vizuete, Siveshigan Pillay, Kamran Diba, Kristina M. Ropella, Anthony G. Hudetz
2012 Frontiers in Integrative Neuroscience  
The balance between excitation and inhibition is considered to be of significant importance for neural computation and cognitive function.  ...  Excitatory and inhibitory functional connectivity in intact cortical neuronal networks in wakefulness and graded levels of anesthesia has not been systematically investigated.  ...  Kamran Diba would like to thank Asohan Amarasingham for valuable discussions. Anthony G. Hudetz would like to thank Gyorgy Buzsaki for his valuable suggestions.  ... 
doi:10.3389/fnint.2012.00090 pmid:23091451 pmcid:PMC3469825 fatcat:vy3xaaqkgzecnfehviuiioo3pe

Thalamic synchrony and the adaptive gating of information flow to cortex

Qi Wang, Roxanna M Webber, Garrett B Stanley
2010 Nature Neuroscience  
An integrate-and-fire model using experimentally measured thalamic input reproduced the observed transformations.  ...  Using an ideal observer of cortical activity, we found that performance in detecting vibrissal deflections degraded with adaptation while performance in discriminating among vibrissal deflections of different  ...  The time scale of firing activity across upstream neural populations is transferred to downstream neural activity by the dynamics of synaptic integration across the brain regions, and thus the range of  ... 
doi:10.1038/nn.2670 pmid:21102447 pmcid:PMC3082843 fatcat:cb7tpioaqnho7ppqs7p2bxau3y

On how correlations between excitatory and inhibitory synaptic inputs maximize the information rate of neuronal firing

Pavel A. Puzerey, Roberto F. Galán
2014 Frontiers in Computational Neuroscience  
Conversely, inhibition that is too delayed broadens neuronal integration times, thereby diminishing spike-time precision and increasing the firing frequency.  ...  Cortical neurons receive barrages of excitatory and inhibitory inputs which are not independent, as network structure and synaptic kinetics impose statistical correlations.  ...  long lags will likely decrease the precision of neuronal firing by prolonging the window of integration of presynaptic inputs.  ... 
doi:10.3389/fncom.2014.00059 pmid:24936182 pmcid:PMC4047963 fatcat:o6j4d3wykbf2hhvllz2l6p7n2y

Analysis of reflex modulation with a biologically realistic neural network

Arno H. A. Stienen, Alfred C. Schouten, Jasper Schuurmans, Frans C. T. van der Helm
2007 Journal of Computational Neuroscience  
The model is an integration of a biologically realistic neural network consisting of motoneurons and interneurons, modeling 12 populations of spinal neurons, and a one degree-of-freedom musculoskeletal  ...  Applications lay in the fields of human motor control and neurological disorders, where hypotheses on motor dysfunction can be tested, like spasticity, clonus, and tremor.  ...  The authors would like to thank D.P. Bashor for proof reading a draft version of this article.  ... 
doi:10.1007/s10827-007-0037-7 pmid:17503169 pmcid:PMC2799624 fatcat:znfa3pz7y5csxchb7gdffzxplu

Frequency-dependent signal transmission and modulation by neuromodulators

Hiroshi T Ito
2008 Frontiers in Neuroscience  
Oscillatory brain activity is a prominent feature of neural transmission.  ...  Here, we review the significance of frequency-dependent signal modulation in brain function and how a neuronal network can possess such properties.  ...  Most animal behaviors require the coordinated activity of sensory, integrative and motor brain areas.  ... 
doi:10.3389/neuro.01.027.2008 pmid:19225586 pmcid:PMC2622745 fatcat:yzidyuq6wzfhfa4zlt3x5cis3a

Diversity of Neural Responses in the Brainstem during Smooth Pursuit Eye Movements Constrains the Circuit Mechanisms of Neural Integration

M. Joshua, J. F. Medina, S. G. Lisberger
2013 Journal of Neuroscience  
Neural integration converts transient events into sustained neural activity.  ...  We recorded the expression of integration in the time-varying firing rates of cerebellar and brainstem neurons in the monkey during pursuit of step-ramp target motion.  ...  So far, the data on saccades has not been integrated into a computational neural model like ours.  ... 
doi:10.1523/jneurosci.3732-12.2013 pmid:23575860 pmcid:PMC3705570 fatcat:ibisdbnpd5ephcvtzxalgsegse

Awake dynamics and brain-wide direct inputs of hypothalamic MCH and orexin networks

J. Antonio González, Panagiota Iordanidou, Molly Strom, Antoine Adamantidis, Denis Burdakov
2016 Nature Communications  
This MCH cell activity correlates with novelty exploration, is inhibited by stress and is inversely predicted by OH cell activity.  ...  These data reveal cell-type-specific LH dynamics during sensory integration, and identify direct neural controllers of MCH neurons.  ...  Acknowledgements We thank Mateo Vélez-Fort and Troy Margrie for advice on retrograde tracing, and Rui Costa, Cornelia Schöne and Christin Kosse for advice or assistance with photometry.  ... 
doi:10.1038/ncomms11395 pmid:27102565 pmcid:PMC4844703 fatcat:y5k2ym2grvawdo5vbkzkb23f4y

A tale of two species: Neural integration in zebrafish and monkeys

M. Joshua, S.G. Lisberger
2015 Neuroscience  
Here, we review experiments and computational studies on a circuit function called "neural integration" that occurs in the brainstems of larval zebrafish, primates, and species "in between".  ...  Yet, the non-human primate remains the gold-standard for the analysis of the neural basis of behavior, and as a bridge to the operation of the human brain.  ...  Acknowledgments-Research supported by the Howard Hughes Medical Institute, NIH grant EY017210, and the Human Frontiers Science Program.  ... 
doi:10.1016/j.neuroscience.2014.04.048 pmid:24797331 pmcid:PMC4216779 fatcat:2yysh3y6pzegxjj5qxzbg3t6mm

Nonrandom Local Circuits in the Dentate Gyrus

P. Larimer, B. W. Strowbridge
2008 Journal of Neuroscience  
Using triple and quadruple simultaneous intracellular recordings in rat hippocampal slices, we find that mossy cells evoke EPSPs with high failure rates onto hilar neurons.  ...  Intralamellar hilar synapses appear to function primarily by integrating synchronous inputs and presynaptic burst discharges, allowing hilar cells to respond over a large dynamic range of input strengths  ...  neural activity.  ... 
doi:10.1523/jneurosci.3612-08.2008 pmid:19020015 pmcid:PMC5546755 fatcat:s5u2swo7tndvfb6l7inbc6b6mi

From Structure to Behavior in Basolateral Amygdala-Hippocampus Circuits

Ying Yang, Jian-Zhi Wang
2017 Frontiers in Neural Circuits  
With recent technological advances, the causal investigations of specific neural circuit between amygdala and hippocampus will help us understand the brain mechanisms of emotion-regulated memories and  ...  Here, we briefly introduce the anatomy and functions of amygdala and hippocampus, and then present behavioral, electrophysiological, optogenetic and biochemical evidence from recent studies to illustrate  ...  ACKNOWLEDGMENTS This work was supported in parts by grants from National Natural Science Foundation of China (NSFC) (91632305, 91632111), and by the Ministry of Science and Technology of China (2016YFC1305800  ... 
doi:10.3389/fncir.2017.00086 pmid:29163066 pmcid:PMC5671506 fatcat:7bfz6xwmivhohdcvczmd7evnn4

The role of spike timing for thalamocortical processing

W Usrey
2002 Current Opinion in Neurobiology  
WM Usrey is supported by the National Institutes of Health (grants EY13588 and EY12576), the Esther A and Joseph Klingenstein Fund, and the Alfred P Sloan Foundation.  ...  Acknowledgements Thanks to A Kimberley McAllister, Jose-Manuel Alonso and Henry Alitto for comments on earlier versions of this manuscript.  ...  Gray lines indicate shuffle correlations or confidence levels for stimulus-driven correlations. Modified with permission from [29 • ,33 • ,35 •• ]. •• ,35 •• ] (Figure 3).  ... 
doi:10.1016/s0959-4388(02)00339-2 pmid:12139989 fatcat:rqpu2igjozdu3a7yc4yf2o6bru

SWIMMY: Free Software for Teaching Neurophysiology of Neuronal Circuits

William Grisham, Natalie A Schottler, Franklin B Krasne
2008 Journal of Undergraduate Neuroscience Education  
finally (6) use an animation that corresponds to the activity of the motoneurons to discover the behavioral effects produced by various lesions and explain them in terms of their neural underpinnings.  ...  SWIMMY is now available for free online complete with student and instructor manuals at http://mdcune.psych.ucla.edu.  ...  Hines), a version of NEURON is distributed and downloaded along with SWIMMY. Supported by NSF DUE-0717306 to Dr. William Grisham.  ... 
pmid:23492869 pmcid:PMC3592681 fatcat:oogklcvwqnggvloovnwsgeqisa
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