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IntAct: an open source molecular interaction database
2004
Nucleic Acids Research
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IntAct provides an open source database and toolkit for the storage, presentation and analysis of protein interactions. ...
All IntAct software, data and controlled vocabularies are available at http://www.ebi.ac.uk/intact. ...
IntAct provides a comprehensive, open source database and analysis system for protein interactions which can be locally installed and adapted to the needs of the local organization, thereby reducing development ...
doi:10.1093/nar/gkh052
pmid:14681455
pmcid:PMC308786
fatcat:w2yaa3blanhh7ffh63qbungt5y
The IntAct molecular interaction database in 2012
2011
Nucleic Acids Research
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IntAct is an open-source, open data molecular interaction database and toolkit. ...
Specialized views then allows 'zooming in' on the full annotation of interactions, interactors and their properties. IntAct source code and data are freely available at ...
ACKNOWLEDGEMENTS The authors thank Paula de Matos and the EBI ChEBI team for the development of the chemical search module in IntAct. ...
doi:10.1093/nar/gkr1088
pmid:22121220
pmcid:PMC3245075
fatcat:5grh3dougnbuxkosirzc5wkizi
The IntAct molecular interaction database in 2010
2009
Nucleic Acids Research
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IntAct is an open-source, open data molecular interaction database and toolkit. ...
Specialized views then allows 'zooming in' on the full annotation of interactions, interactors and their properties. IntAct source code and data are freely available at ...
ACKNOWLEDGEMENTS The authors thank Paula de Matos and the EBI ChEBI team for the development of the chemical search module in IntAct. ...
doi:10.1093/nar/gkp878
pmid:19850723
pmcid:PMC2808934
fatcat:rvotbwzdvnbxlctix6wui6znii
IntAct--open source resource for molecular interaction data
2007
Nucleic Acids Research
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IntAct is an open source database and software suite for modeling, storing and analyzing molecular interaction data. ...
IntAct supports and encourages local installations as well as direct data submission and curation collaborations. IntAct source code and data are freely available from http://www.ebi.ac.uk/intact. ...
Funding to pay the Open Access publication charges for this article was provided by Felics. Conflict of interest statement. There are no conflict of interest. ...
doi:10.1093/nar/gkl958
pmid:17145710
pmcid:PMC1751531
fatcat:nuzqfjvlwvdq3dwcdvs3nxicei
The Relationship between the UniProt Knowledgebase (UniProtKB) and the IntAct Molecular Interaction Databases
2009
Nature Precedings
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European Bioinformatics Institute References: Features within a UniProtKB/SwissProt entry leading to connection with the IntAct database: ...
IntAct is funded by the European Commission under FELICS, contract number 021902 (RII3) within the Research Infrastructure Action of the FP6 "Structuring the European Research Area" Programme. ...
Statistics: Release 57.0 (of 24-Mar-09) of UniProtKB/Swiss-Prot contains 428650 sequence entries.IntAct provides a freely available, open source database system and analysis tools for protein-protein interaction ...
doi:10.1038/npre.2009.3936.1
fatcat:tokgm2ax4ng7nboy6o756bg5ju
The Relationship between the UniProt Knowledgebase (UniProtKB) and the IntAct Molecular Interaction Databases
2009
Nature Precedings
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European Bioinformatics Institute References: Features within a UniProtKB/SwissProt entry leading to connection with the IntAct database: ...
IntAct is funded by the European Commission under FELICS, contract number 021902 (RII3) within the Research Infrastructure Action of the FP6 "Structuring the European Research Area" Programme. ...
Statistics: Release 57.0 (of 24-Mar-09) of UniProtKB/Swiss-Prot contains 428650 sequence entries.IntAct provides a freely available, open source database system and analysis tools for protein-protein interaction ...
doi:10.1038/npre.2009.3936
fatcat:ubn53pnwvfgijeyw4wdklqenx4
IntAct App: a Cytoscape application for molecular interaction network visualisation and analysis
2021
Bioinformatics
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IntAct App is a Cytoscape 3 application that grants in-depth access to IntAct's molecular interaction data. ...
Implementation available at https://apps.cytoscape.org/apps/intactapp, while the source code is available at https://github.com/EBI-IntAct/IntactApp. ...
Introduction IntAct is an open-source molecular interaction database which captures experimental evidence from the literature in high detail (Orchard et al., 2014) , following the deep curation model ...
doi:10.1093/bioinformatics/btab319
pmid:33961020
pmcid:PMC8545338
fatcat:owd2ky2yxnekzb7y35juh7u24q
The MIntAct project—IntAct as a common curation platform for 11 molecular interaction databases
2013
Nucleic Acids Research
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IntAct (freely available at http://www.ebi.ac.uk/ intact) is an open-source, open data molecular interaction database populated by data either curated from the literature or from direct data depositions ...
All data manually curated by the MINT curators have been moved into the IntAct database at EMBL-EBI and are merged with the existing IntAct dataset. ...
Part of the motivation for providing the entire IntAct code base as open source was to reduce redundant development of interaction database platforms. ...
doi:10.1093/nar/gkt1115
pmid:24234451
pmcid:PMC3965093
fatcat:5qemzevwgzdjln3y4pxvgfz7aa
VisioProt-MS: interactive 2D maps from intact protein mass spectrometry
2018
Bioinformatics
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To our knowledge, this is the only open source standalone application that allows the dynamic comparison of several MS files, a prerequisite for comparative analysis of different biological conditions. ...
VisioProt-MS is designed to summarize and analyze intact protein and top-down proteomics data. ...
VisioProt-MS is a user-friendly and highly compatible open source web application that plots and overlays interactive 2 D maps from deconvoluted LC-MS run(s). ...
doi:10.1093/bioinformatics/bty680
pmid:30084957
fatcat:ouwswu6nyjakrlzmciukl332g4
Investigating Viral Proteins and Intact Viruses with Mass Spectrometry
[chapter]
2003
Topics in current chemistry
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Mass spectrometry has become a fundamental technology for virology and an important tool in probing the structure and function of viruses. ...
More recently, new mass spectrometry approaches have been used to detect intact viruses. ...
These identifications were made using the molecular weight range of 0-100 kDa and the database searches were constrained to mammals for BSA and viruses for HK97. ...
doi:10.1007/3-540-36113-8_8
fatcat:3r2f4fwmarashhralqdwsnzkz4
Dual Role of Functionally Intact Dyadic Junctions in Cardiac Excitation-Contraction Coupling
2015
Biophysical Journal
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Altogether, the results shed new light on molecular determinants important for CaV1.2 functional targeting in cardiomyocytes, and suggest a new unconventional role for functionally intact dyads-as being ...
Since cAMP activates the kinase PKA, which in turn increases Ca 2þ release through sarcoplasmic reticulum RyR channels, CaSF was measured as an index of RyR open probability. ...
doi:10.1016/j.bpj.2014.11.1467
fatcat:khd5roo35zagjf6jy6ruc3cr4a
Combining Chemical Cross-linking and Mass Spectrometry of Intact Protein Complexes to Study the Architecture of Multi-subunit Protein Assemblies
2017
Journal of Visualized Experiments
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Mass spectrometry of intact protein complexes (sometimes called 'native' mass spectrometry), on the other hand, involves the analysis of intact proteins and protein complexes without hydrolysis into peptides ...
It reveals protein stoichiometries as well as protein and ligand interactions. ...
The results from BS3 cross-linking are visualized in an interaction network ( Figure 3D) showing intra-molecular interactions as well as interactions between different subunits. ...
doi:10.3791/56747
pmid:29286378
pmcid:PMC5755487
fatcat:wg2vkc5gy5ecbia2elye3oozm4
Large-scale intact glycopeptide identification by Mascot database search
2018
Scientific Reports
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We present an approach for automated annotation of intact glycopeptide mass spectra. ...
glycoprotein databases. ...
against protein databases to generate molecular networks for intact large scale glycopeptide identification. ...
doi:10.1038/s41598-018-20331-2
pmid:29391424
pmcid:PMC5795011
fatcat:cx5d5iq45jfg3l2kcqbrog2g4e
Different Stationary Phase Selectivities and Morphologies for Intact Protein Separations
2016
Chromatographia
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, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. ...
Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution ...
In order to achieve efficiencies comparable to those of good packed columns, porous layer open tubular (PLOT) columns must have an inner diameter of the order of 15 μm or less. ...
doi:10.1007/s10337-016-3168-z
pmid:28529348
pmcid:PMC5413533
fatcat:yqnb7cr52bdafhelms6ou4g2ym
The indoor environment - a potent source for intact human-associated anaerobes
[article]
2020
bioRxiv
pre-print
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Less than 25% of the prokaryotic signatures originate from intact - and thus potentially living - cells with an apparent survival advantage for aerobic and stress resistant taxa. ...
As interaction and exchange of microbes between the human body and its environment is crucial for a healthy human microbiome, the built environment (BE) might represent a potent source for commensal microbes ...
Whether obligately anaerobic human commensals can be transmitted between individuals via the BE is still an open question. ...
doi:10.1101/2020.12.02.406132
fatcat:e3nbrece4rcefmbjintpyjetya
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