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Validation of High-Resolution Tractography AgainstIn VivoTracing in the Macaque Visual Cortex

Hojjatollah Azadbakht, Laura M. Parkes, Hamied A. Haroon, Mark Augath, Nikos K. Logothetis, Alex de Crespigny, Helen E. D'Arceuil, Geoffrey J. M. Parker
2015 Cerebral Cortex  
We performed probabilistic tractography on high angular resolution diffusion imaging data of 2 ex vivo, in vitro macaque brains.  ...  Diffusion magnetic resonance imaging (MRI) allows for the noninvasive in vivo examination of anatomical connections in the human brain, which has an important role in understanding brain function.  ...  Parker et al. (2002) provided the first diffusion-weighted imaging comparison of the macaque and the human brains using fast marching tractography, based on diffusion tensor information.  ... 
doi:10.1093/cercor/bhu326 pmid:25787833 pmcid:PMC4816782 fatcat:mjwsnxio55d6rdtm7h74l3zjsu

Validation of structural brain connectivity networks: The impact of scanning parameters

Karen S. Ambrosen, Simon F. Eskildsen, Max Hinne, Kristine Krug, Henrik Lundell, Mikkel N. Schmidt, Marcel A.J. van Gerven, Morten Mørup, Tim B. Dyrby
2019 NeuroImage  
Evaluation of the structural connectivity (SC) of the brain based on tractography has mainly focused on the choice of diffusion model, tractography algorithm, and their respective parameter settings.  ...  As performance metric, we use cross entropy as a measure that enables comparison of the relative tracer labeled neuron counts to the streamline counts from tractography.  ...  Acknowledgement We wish to thank Thomas Kn€ osche, MPI in Leipzig for good discussions in relation to SNR and image resolution.  ... 
doi:10.1016/j.neuroimage.2019.116207 pmid:31539592 fatcat:fplus64mfbczbob6q7zulw6vta

Magnetic resonance and the human brain: anatomy, function and metabolism

I. -F. Talos, A. Z. Mian, K. H. Zou, L. Hsu, D. Goldberg-Zimring, S. Haker, J. G. Bhagwat, R. V. Mulkern
2006 Cellular and Molecular Life Sciences (CMLS)  
A. et al. (2002) Initial demonstration of in vivo tracing of axonal projections in the macaque brain and comparison with the human brain using diffusion tensor imaging and fast marching tractography.  ...  J. (2002) Estimating distributed anatomical connectivity using fast marching methods and diffusion tensor imaging. IEEE Trans. Med. Imaging 21: 505-512 Parker G. J., Stephan K. E., Barker G.  ... 
doi:10.1007/s00018-005-5522-4 pmid:16568243 fatcat:pjshqjophjhz5crmeqmkzjiv5m

Characterization of U-shape streamline fibers: Methods and applications

Tuo Zhang, Hanbo Chen, Lei Guo, Kaiming Li, Longchuan Li, Shu Zhang, Dinggang Shen, Xiaoping Hu, Tianming Liu
2014 Medical Image Analysis  
Diffusion tensor imaging (DTI), high angular resolution diffusion imaging (HARDI), and Diffusion Spectrum Imaging (DSI) have been widely used in the neuroimaging field to examine the macro-scale fiber  ...  cortical sulci based on DTI, HARDI, and DSI datasets of human, chimpanzee and macaque brains.  ...  The authors would like to thank the Human Connectome Project (http:// for sharing the DSI dataset.  ... 
doi:10.1016/ pmid:24835185 pmcid:PMC4122429 fatcat:xkllcu5fqzc3flmepgmi3a6lte

Functional Mechanisms of Recovery after Chronic Stroke: Modeling with the Virtual Brain

M. I. Falcon, J. D. Riley, V. Jirsa, A. R. McIntosh, E. Elinor Chen, A. Solodkin
2016 eNeuro  
In 20 individuals with stroke and 11 controls, we obtained rest fMRI, T1w, and diffusion tensor imaging (DTI) data.  ...  We present such an approach using The Virtual Brain (TVB), a neuroinformatics platform that uses empirical neuroimaging data to create dynamic models of an individual's human brain; specifically, we simulate  ...  from the b0 image and application of the mask to all diffusion images using the Brain Extraction Tool from FSL (Smith, 2002) , (3) fitting of a diffusion tensor at each voxel using FSL's dtifit function  ... 
doi:10.1523/eneuro.0158-15.2016 pmid:27088127 pmcid:PMC4819288 fatcat:v5lwqkhwm5gg7esop657gyfx6e

Cortical white matter: beyond the pale remarks, main conclusions and discussion

2010 Frontiers in Neuroanatomy  
signal in diffusion-weighted imaging of the human fetal brain. 18.  ...  Diffusion tensor imaging revealed disturbances of myelin function and distribution, alterations of connectivity and integrity of fi ber tracts such as the cingulate bundle and uncinate fasciculus.  ...  A commentary on Linking white and grey matter in schizophrenia: Oligodendrocyte and neuron pathology in the prefrontal cortex by Höistad, M., Segal, D., Takahashi, N., Sakurai, T., Buxbaum, J.  ... 
doi:10.3389/neuro.05.004.2010 pmid:20428509 pmcid:PMC2859874 fatcat:vpuvvsmpvbbgtprjulwh6muqty


2019 Stereotactic and Functional Neurosurgery  
Also, we did not experience any serious side effects of BBBD which can be associated with the bleeding or other brain tissue damage in the immediate and delayed MR imaging after BBBD.  ...  The purpose of this study is to evaluate the safety of the MR guided focused ultrasound (MRgFUS) using ExAblate ® Model 4000 Type 2.0 used as a tool to disrupt the blood brain barrier (BBBD) in patients  ...  Methods: We used diffusion weighted imaging-based tractography acquired from 30 healthy subjects from the Human Connectome Project.  ... 
doi:10.1159/000501568 fatcat:pv2k5hzuindpdmffhvqlkl25ji

International Society for Therapeutic Ultrasound Conference 2016

Brian Fowlkes, Pejman Ghanouni, Narendra Sanghvi, Constantin Coussios, Paul C. Lyon, Michael Gray, Christophoros Mannaris, Marie de Saint Victor, Eleanor Stride, Robin Cleveland, Robert Carlisle, Feng Wu (+723 others)
2017 Journal of Therapeutic Ultrasound  
Acknowledgements Acknowledgement Parts of the work were supported by EMRT HLT03 DUTy project. The EMRP is jointly funded by the EMRP participating countries within EURAMET and the European Union.  ...  This may pose a challenge when treating an organ which comprises of several tissue types. Another challenge stems from the need for a high rate of image acquisition.  ...  Objectives Diffusion tensor imaging (DTI) is a valuable tool for localizing white matter fibres and measure metrics of diffusivity.  ... 
doi:10.1186/s40349-016-0079-2 fatcat:wjrvxyhd5bappjipymenn5swwq

2016 Biennial Meeting of the American Society for Stereotactic and Functional Neurosurgery, Chicago, IL, USA, June 18-21, 2016: Abstracts

2016 Stereotactic and Functional Neurosurgery  
In a group of patients with extreme levels of treatment-resistance to conventional treatments, using a within-subject analysis, DBS was associated with a decrease in the rate of suicide attempts and hospitalizations  ...  Conclusion This represents the largest single-centre experience of SCC DBS for psychiatric illness in the world.  ...  Since SM is not readily identifiable on conventional MRI, we evaluated whether diffusion tensor imaging and MR tractography can be used to identify the SM for DBS targeting.  ... 
doi:10.1159/000455386 pmid:28092908 fatcat:dfobre7vdfcqvekxhbc4aekwgy

5th International Symposium on Focused Ultrasound

Menashe Zaaroor, Alon Sinai, Dorit Goldsher, Ayelet Eran, Maria Nassar, Ilana Schlesinger, Jonathon Parker, Vinod Ravikumar, Pejman Ghanouni, Sherman Stein, Casey Halpern, Vibhor Krishna (+1008 others)
2016 Journal of Therapeutic Ultrasound  
A3 Tractography-based VIM identification for Focused Ultrasound thalamotomy: initial results which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate  ...  BPN rapidly penetrate brain tissue due to a dense coat of polyethylene glycol, and this approach mediates efficient and localized transgene expression in the brain of healthy rats.  ...  In this study, we used in vivo diffusion kurtosis imaging (DKI) to measure brain water diffusion changes in vivo in rats at varying FUS exposure levels at the focal spot and away from the focal spot.  ... 
doi:10.1186/s40349-016-0076-5 fatcat:4vm7i5mt6vheni3hflxd3pwl2i

25th Annual Computational Neuroscience Meeting: CNS-2016

Tatyana O. Sharpee, Alain Destexhe, Mitsuo Kawato, Vladislav Sekulić, Frances K. Skinner, Daniel K. Wójcik, Chaitanya Chintaluri, Dorottya Cserpán, Zoltán Somogyvári, Jae Kyoung Kim, Zachary P. Kilpatrick, Matthew R. Bennett (+597 others)
2016 BMC Neuroscience  
I will discuss theoretical results that point to functional advantages of splitting neural populations into subtypes, both in feedforward and recurrent networks.  ...  Part of this complexity is related to the number of different cell types that work together to encode stimuli.  ...  Acknowledgements: The work of JB, RG, and SMC was supported in part by R01MH1006674 from the National Institutes of Health.  ... 
doi:10.1186/s12868-016-0283-6 pmid:27534393 pmcid:PMC5001212 fatcat:bt45etzj2bbolfcxlxo7hlv6ju

Proceedings of the World Molecular Imaging Congress 2021, October 5-8, 2021: General Abstracts

2022 Molecular Imaging and Biology  
Body : Purpose: To demonstrate an application of fast iterative method to enhance contrast and image resolution in clinical MRI imaging.  ...  Improvements in image resolution after the application of the method have also been demonstrated.  ...  The nanocluster system with a high selectivity showed the potential for fluorescence imaging and the integrating of gold and MMAE demonstrated excellent concurrent chemotherapy-radiotherapy efficacy, which  ... 
doi:10.1007/s11307-021-01693-y pmid:34982365 pmcid:PMC8725635 fatcat:4sfb3isoyfdhfbiwxfr55gvqym

XXIst Congress of the European Society for Stereotactic and Functional Neurosurgery. Implementing Research in Clinical Applications. Maastricht, The Netherlands, September 17-20, 2014: Abstracts

2014 Stereotactic and Functional Neurosurgery  
There are few reports about similar cases in the literature.  ...  This presentation is to initiate the discussion to share experience from different departments, because there is a lack of published data on this phenomenon.  ...  Now it is our purpose to perform a characterization of the Acc in vivo, using high-field MRI and Diffusion-Tensor-Imaging/Tractography.  ... 
doi:10.1159/000367644 pmid:25247733 fatcat:i6v7nsnacvfv3mjvpvrxmtlkxu

Poster Session I

2014 Neuropsychopharmacology  
Conclusions: Importantly for human studies, many of the IFN-induced transcripts in the brain are also influenced in the peripheral blood.  ...  Comparing these results with transcriptional changes in humans may help elucidate why most people don't develop depression in the setting of inflammation and why some do.  ...  In contrast to diffusion tensor imaging, an advantage of diffusion spectrum imaging is that it provides information regarding the constituent fibers and enables resolution of crossing fibers for tractography  ... 
doi:10.1038/npp.2014.280 fatcat:xunw4pdn75hlnmhvvksgp2lsse

ACNP 58th Annual Meeting: Panels, Mini-Panels and Study Groups

2019 Neuropsychopharmacology  
The kinetics of dynorphin signal activation, duration and spread were characterized in striatum using a combination of photorelease, sensor imaging and electrophysiology.  ...  Most neurons synthesize and release neuropeptides in addition to fast transmitters such as glutamate and GABA, yet our understanding of neuropeptide signaling is cursory and many fundamental questions  ...  The diffusion images were preprocessed and fit with a tensor model with FSL (DTIFIT) and registered to the ENIGMA skeleton template, then whole skeleton values of Fractional Anisotropy (FA), Mean Diffusivity  ... 
doi:10.1038/s41386-019-0544-z pmid:31801977 pmcid:PMC6957922 fatcat:hjyvf7fcpbf2fhxit6rlhsvg2y
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