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Informed Switching Strongly Decreases the Prevalence of Antibiotic Resistance in Hospital Wards

Roger D. Kouyos, Pia Abel zur Wiesch, Sebastian Bonhoeffer, Christophe Fraser
2011 PLoS Computational Biology  
We use an epidemiological model for a single hospital ward in order to assess the performance of cycling strategies which take into account the frequency of antibiotic resistance in the hospital ward.  ...  Antibiotic resistant nosocomial infections are an important cause of mortality and morbidity in hospitals.  ...  Conceived and designed the experiments: RDK PAzW SB. Performed the experiments: RDK PAzW. Analyzed the data: RDK PAzW. Wrote the paper: RDK PAzW SB.  ... 
doi:10.1371/journal.pcbi.1001094 pmid:21390265 pmcid:PMC3048378 fatcat:el2lykuiuvhozkaagvbg7uknaa

Trends in paediatric inpatient antibiotic therapy in a secondary care setting

C. H. Quaak, E. Cové, G. J. Driessen, G. A. Tramper-Stranders
2018 European Journal of Pediatrics  
This could be explained by awareness and interventions in the context of antimicrobial stewardship. A decrease in antibiotic use is also feasible and important in non-tertiary paediatric wards.  ...  These findings were confirmed for the specific diseases: third-generation cephalosporin use decreased for both UTI (93% vs. 45%; p = 0.002) and LRTI (14% vs. 6%; p = 0.18); the duration of intravenous  ...  Acknowledgements Authors want to thank Monique Walenbergh-van Veen, hospital pharmacist, and Bernadette Kamerbeek, data manager, for assistance with data collection.  ... 
doi:10.1007/s00431-018-3185-z pmid:29948254 pmcid:PMC6061058 fatcat:u26ofq4vybctxhacbefpwyu5km

Cycling Empirical Antibiotic Therapy in Hospitals: Meta-Analysis and Models

Pia Abel zur Wiesch, Roger Kouyos, Sören Abel, Wolfgang Viechtbauer, Sebastian Bonhoeffer, Claus O. Wilke
2014 PLoS Pathogens  
Theoretical studies suggest that coordinating empirical usage of antibiotics in a hospital ward can contain the spread of resistance.  ...  The rise of resistance together with the shortage of new broad-spectrum antibiotics underlines the urgency of optimizing the use of available drugs to minimize disease burden.  ...  In our general metaanalysis we found that the baseline prevalence of resistance strongly affects the success of cycling.  ... 
doi:10.1371/journal.ppat.1004225 pmid:24968123 pmcid:PMC4072793 fatcat:zzbjhnywnzgcdnt2xovs7etxji

Antimicrobial stewardship initiatives throughout Europe: proven value for money

Edwin J.M. Oberjé, Marit A.C. Tanke, Patrick P.T. Jeurissen
2017 Infectious Disease Reports  
Prevention of antimicrobial resistance needs rigorous actions at ward level, institution level, national level and at supra-national levels.  ...  Antimicrobial stewardship is recognized as a key component to stop the current European spread of antimicrobial resistance.  ...  Acknowledgements: the authors would like to thank the researchers who conducted the studies described in this paper for their collaboration and contribution to this paper: Jan Kluytmans (Amphia Hospital  ... 
doi:10.4081/idr.2017.6800 pmid:28458794 pmcid:PMC5391535 fatcat:2ii7pnqudreznduijqsew34hba

Strategies to enhance rational use of antibiotics in hospital: a guideline by the German Society for Infectious Diseases

K. de With, F. Allerberger, S. Amann, P. Apfalter, H.-R. Brodt, T. Eckmanns, M. Fellhauer, H. K. Geiss, O. Janata, R. Krause, S. Lemmen, E. Meyer (+9 others)
2016 Infection - Journal for the clinical study and treatment of infections  
Strategies to enhance rational use of antibiotics in hospital de With, K.; Allerberger, F.; Amann, S.; Apfalter, P.; Brodt, H. -R.; Eckmanns, T.; Fellhauer, M.; Geiss, H. K.; Janata, O.; Krause, R.  ...  A point prevalence survey provides information on the choice of substance, dose, dosing interval and route of administration.  ...  The amount of days of vancomycin therapy decreased by 36 %. However, no information was provided on clinical outcome [418] .  ... 
doi:10.1007/s15010-016-0885-z pmid:27066980 pmcid:PMC4889644 fatcat:eqsoyic2dngsfhuge4ij72qmpy

Point Prevalence Survey of Antimicrobial Prescription and Infection in Pediatric and Neonatal wards of Two Iranian Teaching Hospitals

Jafar Soltani, Department of Pediatrics, Kurdistan University of Medical Sciences Faculty of Medicine, Sanandaj, Iran, Gholamreza Pouladfar, Ann Versporten, Mike Sharland, Herman Goossen, Zahra Jafarpour, Naseh Soleimani, Professor Alborzi Clinical Microbiology Research Center, Nemazee Teaching Hospital, Shiraz University of Medical Sciences, Shiraz, Iran, Laboratory of Medical Microbiology, Vaccine & Infectious Disease Institute (VAXINFECTIO), University of Antwerp Faculty of Medicine and Health Science, Antwerp, Belgium, Paediatric Infectious Diseases Research Group, Institute for Infection and Immunity, St. Georges University of London, London, UK, Laboratory of Medical Microbiology, Vaccine & Infectious Disease Institute (VAXINFECTIO), University of Antwerp Faculty of Medicine and Health Science, Antwerp, Belgium (+2 others)
2018 Erciyes Tıp Dergisi/Erciyes Medical Journal  
Objective: Point Prevalence Surveys (PPSs) provide useful data on the patterns of in-hospital antimicrobial prescription.  ...  We used a validated and standardized method based on the Antibiotic Resistance and Prescribing in European Children project.  ...  Conflict of Interest: The authors have no conflict of interest to declare. Financial Disclosure: The authors declared that this study has received no financial support.  ... 
doi:10.5152/etd.2018.18191 fatcat:p54jwgrcvzbe3gznbhiyz7s6xu

Hospital-Based Strategies for Combating Resistance

Robert C. Owens, Louis Rice
2006 Clinical Infectious Diseases  
Selective pressures generated by the indiscriminate use of b-lactam antibiotics have resulted in increased bacterial resistance across all b-lactams classes.  ...  organisms in hospital settings.  ...  L.R. has served as a consultant to Wyeth, Elan, Merck, Cubist, Theravancet, Pinnacle, Cumbre, and Pfizer; has served on the speakers' bureaus of Wyeth, Elan, Merck, and Cubist; and has received grant support  ... 
doi:10.1086/500664 pmid:16544268 fatcat:2qvrs5dtgfbebf24dlgasi63da

An assessment of antibiotics prescribed at the secondary health-care level in the Kyrgyz Republic

Kambaralieva Baktygul, Bozgunchiev Marat, Zurdinov Ashirali, Md Harun-Or-rashid, Junichi Sakamoto
2011 Nagoya journal of medical science  
A retrospective analysis was performed of antibiotic prescriptions in 251 inpatient records of patients admitted to the Sokuluk Territorial Hospital.  ...  There was a significantly higher inappropriate choice of antibiotics in gynecology (OR = 2.70, 95% CI = 1.02-7.69) when compared with that in other wards.  ...  ACKNOWLEDGMENTS We wish to express our gratitude to the physicians of Sokuluk Territorial Hospital, and to A. Mamasheva for her assistance in collecting data. We are also indebted to Rev.  ... 
pmid:21928697 pmcid:PMC4831224 fatcat:ffrvbb3xb5bzvpxqln5bdtvk3i

Covering more territory to fight resistance: considering nurses' role in antimicrobial stewardship

R. Edwards, LN Drumright, M. Kiernan, A. Holmes
2011 Journal of Infection Prevention  
The potential contribution nurses can make to the management of antimicrobials within an inpatient setting could impact on the development of antimicrobial resistance (AMR) and healthcare associated infections  ...  As nurses have the most consistent presence as patient carer, they are in the ideal position to provide this level of service.  ...  Acknowledgments The authors acknowledge the support from the National Institute for Health Research (NIHR) Biomedical Research Centre Funding Scheme at Imperial College and the support from the National  ... 
doi:10.1177/1757177410389627 pmid:21532974 pmcid:PMC3083718 fatcat:tde553wsfvhrdadgdn7x5nzuue

Mathematical basis for the assessment of antibiotic resistance and administrative counter-strategies

Hans H. Diebner, Anna Kather, Ingo Roeder, Katja de With, Ricardo Martinez-Garcia
2020 PLoS ONE  
control strategy in hospitals to reduce the prevalence of antibiotic-resistant pathogens in nosocomial or community-acquired infections.  ...  As a showcase, which serves as a proof-of-principle, we apply the derived methods to records of antibiotic consumption and prevalence of antibiotic-resistant germs from University Hospital Dresden (cf.  ...  In practice, i.e. in the absence of a properly defined study protocol, an allocation of both antibiotic consumption as well as the prevalence of resistant pathogens to precisely defined wards or groups  ... 
doi:10.1371/journal.pone.0238692 pmid:32881947 fatcat:kyycxptjn5cmzcoxqvl6msxbga

Opportunities and barriers to implementing antibiotic stewardship in low and middle-income countries: Lessons from a mixed-methods study in a tertiary care hospital in Ethiopia

Gebremedhin Beedemariam Gebretekle, Damen Haile Mariam, Workeabeba Abebe, Wondwossen Amogne, Admasu Tenna, Teferi Gedif Fenta, Michael Libman, Cedric P. Yansouni, Makeda Semret, Albert Figueras
2018 PLoS ONE  
Our aim was to explore healthcare providers' knowledge and perceptions on AMR, and barriers/facilitators to successful implementation of a pharmacist-led AMS intervention in a referral hospital in Ethiopia  ...  Global action plans to tackle antimicrobial resistance (AMR) include implementation of antimicrobial stewardship (AMS), but few studies have directly addressed the challenges faced by low and middle-income  ...  Acknowledgments The authors would like to thank Dr Tinsae Alemayehu Tekle and Sasen Efrem for conducting a point prevalence survey of antibiotic use in the institution prior to the start of this study.  ... 
doi:10.1371/journal.pone.0208447 pmid:30571688 pmcid:PMC6301706 fatcat:pymgncpcufblxg4aj7af2nqxly

Environmental Contamination Due to Methicillin-Resistant Staphylococcus aureus: Possible Infection Control Implications

John M. Boyce, Gail Potter-Bynoe, Claire Chenevert, Thomas King
1997 Infection control and hospital epidemiology  
Objective: To study the possible role of contaminated environmental surfaces as a reservoir of methicillin-resistant Staphylococcus aureus (MRSA) in hospitals.  ...  Design: A prospective culture survey of inanimate objects in the rooms of patients with MRSA. Setting: A 200-bed university-affiliated teaching hospital.  ...  The Role of Information Management A hospital computer system can be used to store information regarding long-term isolation indicators for patients known to be colonized with antibiotic-resistant pathogens  ... 
doi:10.1086/502213 pmid:12785411 fatcat:37oa5dsjhjejrbjoqu62nutpqq

Broad spectrum antibiotic use among in-patients at a hospital in Nairobi, Kenya

Kizito M. Mariita, Harriet A. Chirima, Carol K. Maina
2018 International Journal of Basic & Clinical Pharmacology  
This study aimed to describe the use of nine broad spectrum antibiotics among in-patients of The Nairobi Hospital (TNH) so as to identify opportunities for quality improvement.Methods: This was a retrospective  ...  Antimicrobial resistance is an increasingly serious threat to global public health. While the use of antibiotics is an important contributing factor, there are gaps regarding this in our region.  ...  Nebert Mchidi of TNH School of Nursing and Mr. Conrad Wanyama of Kenya Medical Research Institute for their technical assistance in data analysis and manuscript proof reading.  ... 
doi:10.18203/2319-2003.ijbcp20185154 fatcat:7eigierdcnd4fjwcitfi6wbsvq

First Characterization of a Cluster of VanA-Type Glycopeptide-ResistantEnterococcus faecium,Colombia

Diana Panesso, Sigifredo Ospina, Jaime Robledo, María Claudia Vela, Julieta Peña, Orville Hernández, Jinnethe Reyes, César A. Arias
2002 Emerging Infectious Diseases  
glycopeptide-resistant enterococci (GRE) were isolated from 23 infected patients at a teaching hospital in Medellín, Colombia.  ...  This study is the first molecular characterization of GRE in Colombia.  ...  Her research interests include the molecular mechanisms of resistance to glycopeptides in enterococci and the clinical impact of bacterial resistance to antibiotics.  ... 
doi:10.3201/eid0809.010435 pmid:12194774 pmcid:PMC2732560 fatcat:ink2bieagbfd5pmtifk2nsgj2e

In-Hospital Macro-, Meso-, and Micro-Drivers and Interventions for Antibiotic Use and Resistance: A Rapid Evidence Synthesis of Data from Canada and Other OECD Countries

Rosa Stalteri Mastrangelo, Anisa Hajizadeh, Thomas Piggott, Mark Loeb, Michael Wilson, Luis Enrique Colunga Lozano, Yetiani Roldan, Hussein El-Khechen, Anna Miroshnychenko, Priya Thomas, Holger J. Schünemann, Robby Nieuwlaat (+1 others)
2022 Canadian Journal of Infectious Diseases and Medical Microbiology  
Hospitals continue to face challenges in reducing incorrect antibiotic use due to social and cultural factors at the level of the health system, the care facility, the provider, and the patient.  ...  The amount and type of antibiotics used may affect resistance rates.  ...  Acknowledgments e authors would like to acknowledge the 2019 Spotlight Report Team for their collaboration.  ... 
doi:10.1155/2022/5630361 pmid:35509517 pmcid:PMC9061047 fatcat:rwiwhfglpzhz5flg2id3gdqj6q
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