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Inferring ADR causality by predicting the Naranjo Score from Clinical Notes

Bhanu Pratap Singh Rawat, Abhyuday Jagannatha, Feifan Liu, Hong Yu
2021 AMIA Annual Symposium Proceedings  
predict the Naranjo score and the causal relation between the medication and an ADR.  ...  In this paper, we propose a methodology to automatically infer causal relations from patients' discharge summaries by combining the capabilities of deep learning and statistical learning models.  ...  Nadya Frid for annotating the discharge summaries regarding Naranjo Questionnaire and William Temps for also extracting the raw EHR data for experiments.  ... 
pmid:33936480 pmcid:PMC8075501 fatcat:uilctrr7nzhcrmrkskjmncvzou

Naranjo Question Answering using End-to-End Multi-task Learning Model

Bhanu Pratap Singh Rawat, Fei Li, Hong Yu
2019 Proceedings of the 25th ACM SIGKDD International Conference on Knowledge Discovery & Data Mining - KDD '19  
In this study, we present the first attempt to automatically infer the causality between a drug and an ADR from electronic health records (EHRs) by answering the Naranjo questionnaire, the validated clinical  ...  Clinical judgement studies help judge the causal relation between a medication and its ADRs.  ...  Nadya Frid for annotating the discharge summaries regarding Naranjo Questionnaire. This work was supported by the grant HL125089 from the National Institutes of Health (NIH).  ... 
doi:10.1145/3292500.3330770 pmid:31799022 pmcid:PMC6887102 fatcat:nf2c33dhzndpnn5q3ojpy3efyu

Incidence, risk factors and risk prediction of hospital-acquired suspected adverse drug reactions: a prospective cohort of Ugandan inpatients

Ronald Kiguba, Charles Karamagi, Sheila M Bird
2017 BMJ Open  
Risk scores were generated from coefficients of ADR risk-factor logistic regression models.  ...  We also constructed risk scores to predict and qualitatively assess for peculiarities between low-risk and high-risk ADR patients.  ...  In each research team, clinical data related to suspected ADRs were captured from clinical notes in the patient's file, from clinical examination of the patient by each team's medical officer and by patient  ... 
doi:10.1136/bmjopen-2015-010568 pmid:28110281 pmcid:PMC5253535 fatcat:xiy3g5s2qzbu7drn5dmotxvyfa

American Geriatrics Society-Beers Criteria and adverse drug reactions: a comparative cross-sectional study of Nigerian and South African older inpatients

Sule Ajibola Saka, Manimbulu Nlooto, Frasia Oosthuizen
2018 Clinical Interventions in Aging  
The medical records of older persons aged ≥60 years who were hospitalized in teaching hospitals in Nigeria and South Africa were randomly selected, and retrospectively evaluated for ADRs by two clinical  ...  pharmacists using the Naranjo algorithm.  ...  The total score for each suspected ADR encounter was calculated and the causal relationship determined.  ... 
doi:10.2147/cia.s176899 pmid:30538434 pmcid:PMC6251468 fatcat:5tj6ps6suvbdfduqbjhy7dhudu

Factors associated with adverse drug reaction occurrence and prognosis, and their economic impacts in older inpatients in Taiwan: a nested case–control study

Pei-Ju Liao, Chien-Tai Mao, Tun-Liang Chen, Shin-Tarng Deng, Kuang-Hung Hsu
2019 BMJ Open  
reported ADR cases from a patient cohort containing 108 548 older inpatients were collected from 2006 to 2012.  ...  There were 1854 non-ADR matched controls; a maximum of 1:5 matched by age, sex and principal diagnosis were collected.ExposurePolypharmacy, the number of drugs prescribed, comorbidities and the admission  ...  Regarding the ADR characteristics, the Naranjo score, as rated by senior pharmacists, was recorded to reflect the causality of the reported ADR cases.  ... 
doi:10.1136/bmjopen-2018-026771 pmid:31079084 pmcid:PMC6530431 fatcat:k3cfxz7m7zbvxmqscifourauoq

Impact of gender, depression severity and type of depressive episode on efficacy and safety of escitalopram: an observational study on major depressive disorder patients in southern India

Tatiyana Mandal, Laxminarayana Kurady Bairy, Podila Satya Venkata Narasimha Sharma, Vijaya Lakshmi Valaparla
2021 The Egyptian Journal of Neurology Psychiatry and Neurosurgery  
The efficacy was influenced by baseline depression severity whereas more ADRs were reported by male patients.  ...  The decline in HDRS-17 and MADRS scores from baseline was significant (p value < 0.05) at all follow-up visits and a similar pattern was seen with CGI.  ...  Acknowledgements We sincerely acknowledge the assistance provided by Dr. Amritavarshini R and Dr. Linda Thomas from the Department of Psychiatry, KMC, Manipal, during data collection.  ... 
doi:10.1186/s41983-021-00302-7 fatcat:7tzmkli74jdzlmdkheukpetiz4

New Insights in Computational Methods for Pharmacovigilance: E-Synthesis, a Bayesian Framework for Causal Assessment

Francesco De Pretis, Barbara Osimani
2019 International Journal of Environmental Research and Public Health  
A state of the art on evidence synthesis is presented, followed by the illustration of E-Synthesis, a Bayesian framework for causal assessment.  ...  Today's surge of big data coming from multiple sources is raising the stakes that pharmacovigilance has to win, making evidence synthesis a more and more robust approach in the field.  ...  The causal indicators are parents of report nodes which mediate causal inference from the concrete data (the reports) towards the causal hypothesis.  ... 
doi:10.3390/ijerph16122221 pmid:31238543 pmcid:PMC6617215 fatcat:npeayycfafa3rhegosnvz2k4hm

Clinical Pharmacist Driven Impact towards Intensive Monitoring and Reporting of Adverse Drug Events in Psychiatric Patients

Disha A Khoda, Madiwalayya S Ganachari
2016 Journal of Pharmacovigilance  
This incidence rate could be minimized by the presence of a clinical Pharmacist for better treatment and creating awareness of the medicines to the patients.  ...  , and analysis of ADEs (causality, severity and preventability).  ...  appears no conflict of interest by any of the contributing authors.  ... 
doi:10.4172/2329-6887.1000128 fatcat:zxpdn3a36be7llywsqy3rp2ahe

Assessment tool for hospital admissions related to medications: development and validation in older patients

Thomas G. H. Kempen, Mariann Hedström, Hanna Olsson, Amanda Johansson, Sara Ottosson, Yousif Al-Sammak, Ulrika Gillespie
2018 International Journal of Clinical Pharmacy  
Assessment of the same 100 admissions by two experienced clinicians acted as gold standard.  ...  The sensitivity and specificity values were 70/86% and 74/70%, positive and negative predictive values were 73/74% and 71/83% respectively.  ...  We would also like to thank all the participating final-year pharmacy students at Uppsala University and the clinical pharmacists at Uppsala University Hospital for their time and valuable input in the  ... 
doi:10.1007/s11096-018-0768-8 fatcat:yp3oe2j7tbfohkhb2zdgtdgaye

Frameworks for Evaluating Qualitative and Quantitative Information on Adverse Drug Events throughout Development through to Marketing [chapter]

Kaori Nomura, Brian David Edwards
2018 Molecular Insight of Drug Design  
Significant public health issues caused by adverse drug reactions in the post-marketing phase, such as birth defects by thalidomide, have been well described.  ...  Underpinned by understanding of the traditional methods of evaluating adverse drug reactions, new developments in IT and computing might well help us to detect drug safety signals earlier, enabling prompt  ...  As a more specific evaluation criterion, nine criteria by Hill [24] and a number of scoring algorithms such as that devised by Naranjo et al.  ... 
doi:10.5772/intechopen.76331 fatcat:ueh2y6djizhjzfitg762gj4dqa

Incidence and cost of medication harm in older adults following hospital discharge: a multicentre prospective study in the UK

Nikesh Parekh, Khalid Ali, Jennifer M. Stevenson, J. Graham Davies, Rebekah Schiff, Tischa Van der Cammen, Jatinder Harchowal, James Raftery, Chakravarthi Rajkumar
2018 British Journal of Clinical Pharmacology  
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Polypharmacy is increasingly common in older adults in the UK. • Older adults are vulnerable to medication-related problems during transitions of care from hospital  ...  Participants were followed up for 8 weeks by senior pharmacists, using three data sources (hospital readmission review, participant telephone interview and primary care records), to identify MRH and associated  ...  If an ADR was suspected, the validated Naranjo algorithm [24] was used to assess causality, in conjunction with the British National Formulary and Summary of Product Characteristics.  ... 
doi:10.1111/bcp.13613 pmid:29790202 pmcid:PMC6046489 fatcat:7sxeebtngbhuxlkmltbhrctg5i

Clinical Judgement Study using Question Answering from Electronic Health Records

Bhanu Pratap Singh Rawat, Fei Li, Hong Yu
Our proposed model identifies the causal relation by answering a subset of Naranjo questionnaire Naranjo et al. (1981) from electronic health records.  ...  Clinical judgement studies are essential for recognising the causal relation of a medication with adverse drug reactions (ADRs).  ...  Also, clinical pharmacologists frequently disagree when analyzing the causality of ADRs Naranjo et al. (1981) .  ... 
pmid:31897452 pmcid:PMC6939641 fatcat:matumeqoardojgn3xl2v7u3kla

OAE: The Ontology of Adverse Events

Yongqun He, Sirarat Sarntivijai, Yu Lin, Zuoshuang Xiang, Abra Guo, Shelley Zhang, Desikan Jagannathan, Luca Toldo, Cui Tao, Barry Smith
2014 Journal of Biomedical Semantics  
The representation and analysis of AEs are critical to the improvement of public health.  ...  After a medical intervention, adverse events (AEs) may occur which lie outside the intended consequences of the intervention.  ...  Smith's work on this paper was supported by NIAID grant R01AI77706 on Immune System Biological Networks. The article-processing charge for this article was paid by a discretionary fund from Dr.  ... 
doi:10.1186/2041-1480-5-29 pmid:25093068 pmcid:PMC4120740 fatcat:fjkxotcponejphoy6u5s26xsmi


2008 British Journal of Clinical Pharmacology  
After applying of the Naranjo criteria, the causality between the reaction and the drug was interpreted as doubtful (1 ADR), probable (56 ADR’s) and possible (21 ADR's).  ...  The expert panel assessed clinically significant ADR’s and drug interactions. A probability level of the ADR’s was evaluated by means of Naranjo criteria.  ... 
doi:10.1111/j.1365-2125.2007.03059.x fatcat:yfgjp2fsejfyvix6myrfteiz2y

A study on adverse drug reactions in a tertiary care hospital in Bangalore

Basavaraj Bhandare, Shabeer, P Student
Indian Journal of Pharmacy and Pharmacology   unpublished
Standard procedure was followed in reporting the ADRs by all healthcare personnel. Naranjo and Hartwig scales were used to assess the causality and severity of ADRs reported.  ...  The assessment by Naranjo scale showed that relationship of ADR and the suspected drug was definite in 12 cases, probable in 45 cases, possible in 88 cases and doubtful in 15 cases.  ...  Causality assessment was done by using Naranjo scale.  ... 
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