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Individual differences in amygdala reactivity following nicotinic receptor stimulation in abstinent smokers

Matthew T. Sutherland, Allison J. Carroll, Betty Jo Salmeron, Thomas J. Ross, L. Elliot Hong, Elliot A. Stein
2013 NeuroImage  
During the amygdala reactivity paradigm, nicotinic acetylcholine receptor (nAChR) stimulation by nicotine and varenicline decreased reaction time (RT) in abstinent smokers but not in nonsmokers.  ...  Specifically, in the SI-smoker cohort abstinence-induced elevated amygdala reactivity was down-regulated by nAChR stimulation.  ...  Not all abstinent smokers displayed consistent RT reductions following nAChR stimulation.  ... 
doi:10.1016/j.neuroimage.2012.10.043 pmid:23110878 pmcid:PMC3636184 fatcat:re5mmzlnjvbhha3y7ocbfp6fta

Targeting the Noradrenergic System for Gender-Sensitive Medication Development for Tobacco Dependence

T. L. Verplaetse, A. H. Weinberger, P. H. Smith, K. P. Cosgrove, Y. S. Mineur, M. R. Picciotto, C. M. Mazure, S. A. McKee
2015 Nicotine & Tobacco Research  
outcomes in women and (b) smoking for nicotine reinforcement in men.  ...  Results: We hypothesize that noradrenergic agents that normalize noradrenergic activity may differentially attenuate stress reactivity in women and nicotine-related reinforcement in men, indicating that  ...  They found significantly higher numbers of nicotinic receptors in male smokers but not in female smokers when compared to same-sex nonsmokers.  ... 
doi:10.1093/ntr/ntu280 pmid:25762760 pmcid:PMC4432402 fatcat:z4vot2jqjjeg3esasqbmd6pjly

Neuroimaging, genetics and the treatment of nicotine addiction

Riju Ray, James Loughead, Ze Wang, John Detre, Edward Yang, Ruben Gur, Caryn Lerman
2008 Behavioural Brain Research  
Neuroimaging studies have begun to elucidate the functional neuroanatomy and neurochemistry underlying effects of nicotine and nicotine abstinence.  ...  To date, only a few neuroimaging studies have explored effects of nicotine or abstinence on brain activity as a function of genotype.  ...  Neurochemical effects-Two recent SPECT imaging studies utilizing specific ligands to the nicotinic receptors (nAChRs) scanned smokers after differing intervals of nicotine abstinence.  ... 
doi:10.1016/j.bbr.2008.05.021 pmid:18599130 pmcid:PMC2600518 fatcat:fgkl36pnfvcopjkfqre524hmci

Altered amygdala function in nicotine addiction: Insights from human neuroimaging studies

Yoan Mihov, René Hurlemann
2012 Neuropsychologia  
Consequently, we here review brain imaging studies reporting altered neural responses of the amygdala in nicotine addiction.  ...  In light of this empirical evidence, we propose that impaired amygdala-guided harm avoidance and executive functions may be instrumental in maintaining nicotine addiction despite serious health consequences  ...  With one exception all PET studies described in the following have generally followed a similar design: chronic cigarette smokers were asked to remain abstinent overnight; abstinence was verified by a  ... 
doi:10.1016/j.neuropsychologia.2012.04.028 pmid:22575084 fatcat:hcjzavew5veznm6bttkgzdtcka

Neural mechanisms underlying nicotine addiction: acute positive reinforcement and withdrawal

Shelly S. Watkins, George F. Koob, Athina
2000 Nicotine & Tobacco Research  
that are hypothesized to contribute to the negative affective state associated with nicotine abstinence.  ...  chronic administration are examined followed by a discussion of potential neuroadaptations within these neurochemical systems that may lead to the development of nicotine dependence.  ...  Watkins was supported by a NIDA Individual National Research Service Award (DA05898).  ... 
doi:10.1080/14622200050011277 pmid:11072438 fatcat:6frdlcxhsrcs3krzwtzlg4j6mm

Neuroimaging of Nicotine Dependence: Key Findings and Application to the Study of Smoking–Mental Illness Co-morbidity

F. Joseph McClernon
2009 Journal of dual diagnosis  
Studies comparing smokers and nonsmokers have shown that smokers have less grey matter density in frontal brain regions and greater concentrations of nicotinic receptors.  ...  Studies of smoking abstinence have identified functional brain correlates of increased reactivity to smoking-related cues, and worsening of concentration.  ...  Among nicotine-naïve individuals, the α4β2 nicotine receptor has high densities in thalamus, followed by midbrain, pons, cerebellum and cortex (Kimes et al., 2003) .  ... 
doi:10.1080/15504260902869204 pmid:19756221 pmcid:PMC2743422 fatcat:kravede3ejavxiyqaurijnqzha

Effects of Nicotine Deprivation and Replacement on BOLD-fMRI Response to Smoking Cues as a Function of DRD4 VNTR Genotype

Xiaomeng Xu, Uraina S. Clark, Sean P. David, Richard C. Mulligan, Valerie S. Knopik, John McGeary, James MacKillop, Jeanne McCaffery, Raymond S. Niaura, Lawrence H. Sweet
2014 Nicotine & Tobacco Research  
introduction: Reactivity to smoking cues is an important factor in the motivation to smoke and has been associated with the dopamine receptor 4 variable number tandem repeat (DRD4 exon III VNTR) polymorphism  ...  In contrast, the DRD4 L individuals exhibited no significant response in the left amygdala under nicotine replacement or deprivation, and their response did not differ as a function of nicotine.  ...  However, few studies have examined cue reactivity of nicotine-deprived smokers in the context of nicotine administration.  ... 
doi:10.1093/ntr/ntu010 pmid:24659022 pmcid:PMC4072897 fatcat:h3vhyugmqvd2dm5r2ke53hgrje

Overnight deprivation from smoking disrupts amygdala responses to fear

Oezguer A. Onur, Alexandra Patin, Yoan Mihov, Boris Buecher, Birgit Stoffel-Wagner, Thomas E. Schlaepfer, Henrik Walter, Wolfgang Maier, René Hurlemann
2011 Human Brain Mapping  
Our results show no difference in amygdala responses to faces between nonsmokers and satiated smokers.  ...  We suggest that aberrant amygdala reactivity in overnight-deprived smokers may reflect a pre-existing vulnerability to smoking and/or increase the risk of smoking relapse after a cessation attempt.  ...  b r Aberrant Amygdala Reactivity in Deprived Smokers r r 1409 r TABLE II .  ... 
doi:10.1002/hbm.21293 pmid:21618661 fatcat:dqbryqf2kngczifngnfno6ofye

Brain Reactivity to Smoking Cues Prior to Smoking Cessation Predicts Ability to Maintain Tobacco Abstinence

Amy C. Janes, Diego A. Pizzagalli, Sarah Richardt, Blaise deB. Frederick, Sarah Chuzi, Gladys Pachas, Melissa A. Culhane, Avram J. Holmes, Maurizio Fava, A. Eden Evins, Marc J. Kaufman
2010 Biological Psychiatry  
Smokers then made a quit attempt and were grouped based on outcomes (abstinence vs. slip: smoking Ն 1 cigarette after attaining abstinence).  ...  Results: Slip subjects had heightened fMRI reactivity to smoking-related images in brain regions implicated in emotion, interoceptive awareness, and motor planning and execution.  ...  This research was supported in part by  ... 
doi:10.1016/j.biopsych.2009.12.034 pmid:20172508 pmcid:PMC2954596 fatcat:nmm5jzon45gnffzhize7ad5dna

Neural Signatures of Cognitive Flexibility and Reward Sensitivity Following Nicotinic Receptor Stimulation in Dependent Smokers

Elise Lesage, Sarah E. Aronson, Matthew T. Sutherland, Thomas J. Ross, Betty Jo Salmeron, Elliot A. Stein
2017 JAMA psychiatry  
OBJECTIVE To independently assess the effects of nicotine dependence and stimulation of the nicotinic acetylcholine receptor on the ability to interpret valence information (reward sensitivity) and subsequently  ...  DESIGN, SETTING, AND PARTICIPANTS Nicotine-dependent smokers and nonsmokers completed a probabilistic reversal learning task during acquisition of functional magnetic resonance imaging (fMRI) in a 2-drug  ...  differences in cue reactivity or reward anticipation, while our contrast focused on reward receipt.  ... 
doi:10.1001/jamapsychiatry.2017.0400 pmid:28403383 pmcid:PMC5539833 fatcat:3inuf5kqifhpfei7yay62y4yx4

Basolateral amygdala and stress-induced hyperexcitability affect motivated behaviors and addiction

B M Sharp
2017 Translational Psychiatry  
In summary, BLA is required to promote responding for natural reward and respond to second-order drug-conditioned cues; reinstate cue-dependent drug seeking; express stress-enhanced reacquisition of nicotine  ...  In this Review, we discuss molecular mechanisms and neural circuits that regulate physiological and stress-induced dysfunction of BLA/amygdala and its principal output neurons.  ...  individual differences in brain reactivity to cues, reflecting the complex patterns and individual variation in human addiction.  ... 
doi:10.1038/tp.2017.161 pmid:28786979 pmcid:PMC5611728 fatcat:76uatdxjwrbo7l6frrddtndesa

Sex Differences in Substance Use Disorders: A Neurobiological Perspective

Jennifer L. Cornish, Asheeta A. Prasad
2021 Frontiers in Global Women's Health  
Recent clinical studies in SUD analyzing sex differences reveal neurobiological changes that are differentially impacted in common reward processing regions such as the striatum, hippocampus, amygdala,  ...  We reflect on the contribution of sex hormones, period of drug use and abstinence, and the potential impact of these factors on the interpretation of the reported findings.  ...  For example, receptor level differences exist between the sexes in SUD, with the function of β2-nicotinic acetylcholine receptors altered between male and female abstinent smokers (57) .  ... 
doi:10.3389/fgwh.2021.778514 pmid:34957467 pmcid:PMC8692274 fatcat:xfynagswh5ctzj3ghxajjw6hhu

Pharmacological intervention and abstinence in smokers undergoing cessation treatment: A psychophysiological study

Yong Cui, Jeffrey M. Engelmann, Jonathan Xian, Jennifer A. Minnix, Cho Y. Lam, Maher Karam-Hage, Paul M. Cinciripini, Jason D. Robinson
2018 International Journal of Psychophysiology  
Prior research has indicated an important role of nicotinic mechanisms in negative affect processing.  ...  The most effective smoking cessation medication, varenicline, targets nicotinic acetylcholine receptors (nAChRs) as a partial agonist, while another first-line cessation medication, bupropion, has shown  ...  However, Pfizer had no roles in designing or conducting the parent clinical trial or the current study.  ... 
doi:10.1016/j.ijpsycho.2017.12.001 pmid:29223599 pmcid:PMC5759327 fatcat:aohz2eilwjgtdmdjzbmxinuwju

Neural substrates of cue reactivity: association with treatment outcomes and relapse

Kelly E. Courtney, Joseph P. Schacht, Kent Hutchison, Daniel J. O. Roche, Lara A. Ray
2015 Addiction Biology  
within four primary categories of substances: alcohol, nicotine, cocaine and opioids.  ...  . fMRI cue-reactivity paradigms represent an ideal platform to probe the involvement of neurobiological pathways subserving the reward/motivation system in addiction and potentially offer a translational  ...  Acute NRT administration following overnight abstinence was associated with greater smoking cue-elicited striatal and amygdalar activation in a sample of non-treatment-seeking smokers (Xu et al. 2014  ... 
doi:10.1111/adb.12314 pmid:26435524 pmcid:PMC4986996 fatcat:nt2ogkw4irdetnjnujdfo7oulu

The Insula: A Brain Stimulation Target for the Treatment of Addiction

Christine Ibrahim, Dafna S. Rubin-Kahana, Abhiram Pushparaj, Martin Musiol, Daniel M. Blumberger, Zafiris J. Daskalakis, Abraham Zangen, Bernard Le Foll
2019 Frontiers in Pharmacology  
There are three main brain stimulation techniques that are outlined in this review: transcranial magnetic stimulation (TMS), transcranial direct current stimulation (tDCS), and deep brain stimulation (  ...  This review focuses on both the preclinical and clinical evidence demonstrating the role of the insula in addiction, thereby demonstrating its promise as a target for brain stimulation.  ...  In addition, studies approached different phases of addiction (i.e., abstinent vs non-abstinent users).  ... 
doi:10.3389/fphar.2019.00720 pmid:31312138 pmcid:PMC6614510 fatcat:pl7zuvi6fbcdrjtfkfy2t4fgve
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