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Inflammation, demyelination, and degeneration — Recent insights from MS pathology

Christine Stadelmann, Christiane Wegner, Wolfgang Brück
2011 Biochimica et Biophysica Acta - Molecular Basis of Disease  
In conclusion, direct and indirect mechanisms seem to play a role in neuronal damage in multiple sclerosis and EAE.  ...  Introduction Multiple sclerosis (MS) is an inflammatory demyelinating CNS disease frequently starting in young adulthood.  ... 
doi:10.1016/j.bbadis.2010.07.007 pmid:20637864 fatcat:qzbsdxaakrgzjcxezfhgge3jve

Neuropathologic Correlates of Magnetic Resonance Imaging in Multiple Sclerosis

G. R. Wayne Moore, Cornelia Laule
2012 Journal of Neuropathology and Experimental Neurology  
The advent of magnetic resonance imaging (MRI) has revolutionized concepts of the pathogenesis of multiple sclerosis (MS).  ...  neuropathologic findings in MS patients.  ...  FIGURE 2 . 2 Typical in-vivo clinical magnetic resonance imaging scans from a patient with relapsing-remitting multiple sclerosis.  ... 
doi:10.1097/nen.0b013e3182676388 pmid:22892523 fatcat:karmszlarrf6tild7nqa6gybd4

Multiple sclerosis and Alzheimer disease through the looking glass of MR imaging

Giovanni B Frisoni, Massimo Filippi
2005 American Journal of Neuroradiology  
Indirect evidence for early widespread gray matter involvement in relapsing remitting multi- ple sclerosis. NeuroImage 2004;21:1825-1829 17. Coles AJ, Wing MG, Molyneux P, et al.  ...  Evidence for widespread axonal damage at the earliest clinical stage of multiple sclerosis. Brain 2003;126:433-437 16. Inglese M, Ge Y, Filippi M, et al.  ... 
pmid:16286389 pmcid:PMC7976192 fatcat:u2ie4mm5r5fmrayxyaufdgmt2i

Neuroimaging Correlates of Cognitive Dysfunction in Adults with Multiple Sclerosis

Maria Petracca, Giuseppe Pontillo, Marcello Moccia, Antonio Carotenuto, Sirio Cocozza, Roberta Lanzillo, Arturo Brunetti, Vincenzo Brescia Morra
2021 Brain Sciences  
Cognitive impairment is a frequent and meaningful symptom in multiple sclerosis (MS), caused by the accrual of brain structural damage only partially counteracted by effective functional reorganization  ...  investigated through the application of advanced neuroimaging, here, we offer an up-to-date overview of the latest findings on structural, functional and metabolic correlates of cognitive impairment in  ...  A schematic representation of the main targets of PET imaging in multiple sclerosis (gray boxes), along with Figure 4 . 4 Figure 4. Cerebellar functional connectivity in multiple sclerosis.  ... 
doi:10.3390/brainsci11030346 pmid:33803287 fatcat:4jfvrxiabvcitifwvhosdkdggm

Mitochondrial Dysfunction and Multiple Sclerosis

Isabella Peixoto de Barcelos, Regina M. Troxell, Jennifer S. Graves
2019 Biology  
In recent years, several studies have examined the potential associations between mitochondrial dysfunction and neurodegenerative diseases such as multiple sclerosis (MS), Parkinson's disease and Alzheimer's  ...  An overview of mitochondrial diseases that may overlap with MS are also discussed, as well as possible therapeutic targets for the treatment of MS and other neurodegenerative conditions.  ...  Table 1 . 1 Evidence of mitochondrial involvement in Progressive Forms of Multiple Sclerosis compared to Controls or RRMS.  ... 
doi:10.3390/biology8020037 pmid:31083577 pmcid:PMC6627385 fatcat:x3kkljluhbeixdwen7gsijzag4

Spinal Cord Involvement in MS and Other Demyelinating Diseases

Mariano Marrodan, María I. Gaitán, Jorge Correale
2020 Biomedicines  
Diagnostic accuracy is poor in demyelinating myelopathies, and therefore a challenge for neurologists in daily practice, mainly because of the multiple underlying pathophysiologic mechanisms involved in  ...  disorders including: multiple sclerosis (MS), neuromyelitis optica spectrum disorder, acute disseminated encephalomyelitis, anti-myelin oligodendrocyte glycoprotein antibody-associated disease, and glial  ...  The funders had no role in the design of the study; in the collection, analysis, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.  ... 
doi:10.3390/biomedicines8050130 pmid:32455910 fatcat:foyt4pnjhvabdp74qemxuu6avy

The Role of Advanced Magnetic Resonance Imaging Techniques in Multiple Sclerosis Clinical Trials

Kedar R. Mahajan, Daniel Ontaneda
2017 Neurotherapeutics  
The current landscape of multiple sclerosis clinical trials is currently expanding to include testing not only of anti-inflammatory agents, but also neuroprotective, remyelinating, neuromodulating, and  ...  Advanced magnetic resonance imaging techniques hold significant promise for accelerating the development of different treatment modalities targeting a variety of pathways in MS.  ...  Juxtacortical lesions in multiple sclerosis: assessment of gray matter involvement using phase difference-enhanced imaging (PADRE). Magn Reson Med Sci 2016;15(4):349-354. 25.  ... 
doi:10.1007/s13311-017-0561-8 pmid:28770481 fatcat:nwefozrjtjafngwma3aibamu3a

Thalamic–hippocampal–prefrontal disruption in relapsing–remitting multiple sclerosis

Kyle C. Kern, Stefan M. Gold, Brian Lee, Michael Montag, Jessica Horsfall, Mary-Frances O'Connor, Nancy L. Sicotte
2015 NeuroImage: Clinical  
Cortical, thalamic and hippocampal gray matter atrophy in relapsing-remitting MS (RRMS) is associated cognitive deficits.  ...  Conclusions: Hippocampal-thalamic-prefrontal disruption affects cognitive performance in early RRMS with mild to minimal cognitive impairment, confirming both white and gray matter involvement in MS and  ...  Conclusions Hippocampal-thalamic-prefrontal disruption affects cognitive function in RRMS before significant functional impairment is evident, confirming both white and gray matter involvement in MS and  ... 
doi:10.1016/j.nicl.2014.12.015 pmid:26106524 pmcid:PMC4473119 fatcat:62sxtbdm5ncyfdx7lk4o2taid4

Unraveling the MRI-Based Microstructural Signatures Behind Primary Progressive and Relapsing-Remitting Multiple Sclerosis Phenotypes

Ilaria Boscolo Galazzo, Lorenza Brusini, Muge Akinci, Federica Cruciani, Marco Pitteri, Stefano Ziccardi, Albulena Bajrami, Marco Castellaro, Ahmed M A Salih, Francesca B Pizzini, Jorge Jovicich, Massimiliano Calabrese (+1 others)
2021 Journal of Magnetic Resonance Imaging  
The mechanisms driving primary progressive and relapsing-remitting multiple sclerosis (PPMS/RRMS) phenotypes are unknown.  ...  Magnetic resonance imaging (MRI) studies support the involvement of gray matter (GM) in the degeneration, highlighting its damage as an early feature of both phenotypes.  ...  Acknowledgments We thank Alberto De Luca and Agnese Tamanti for the helpful discussions on dMRI pre-processing, and all the technicians and clinicians that helped with MRI and clinical data collection.  ... 
doi:10.1002/jmri.27806 pmid:34189804 pmcid:PMC9290631 fatcat:44puaafxsrbu7ev67gsjx3eshy

Magnetic Resonance Imaging in Multiple Sclerosis

Christopher C. Hemond, Rohit Bakshi
2018 Cold Spring Harbor Perspectives in Medicine  
Bakshi's laboratory for preparing Fig-  ...  (B) White matter lesions in a patient with relapsing-remitting multiple sclerosis, showing deep white matter and periventricular lesions with central veins (red arrows).  ...  Typical multiple sclerosis (MS) white matter and gray matter lesions in the brain as shown by cerebral 3T magnetic resonance imaging (MRI).  ... 
doi:10.1101/cshperspect.a028969 pmid:29358319 fatcat:ytdy4yzrsbabnejyqbwof4nefe

Chronic Progressive Multiple Sclerosis – Pathogenesis of Neurodegeneration and Therapeutic Strategies

Dirk Fitzner, Mikael Simons
2010 Current Neuropharmacology  
Multiple sclerosis (MS) is an inflammatory, autoimmune, demyelinating disease of the central nervous system (CNS) that usually starts as a relapsing-remitting disease.  ...  While treatment of relapsing-remitting MS (RRMS) has improved dramatically over the last decade, the therapeutic options for chronic progressive MS, both primary and secondary, are still limited.  ...  the Multiple Sclerosis Functional Composite score and for T1 and T2 lesion volume [89] .  ... 
doi:10.2174/157015910792246218 pmid:21358979 pmcid:PMC3001222 fatcat:qaegnlmutjc6nncznxdnrznfsi

Longitudinal cortical network reorganization in early relapsing–remitting multiple sclerosis

Vinzenz Fleischer, Nabin Koirala, Amgad Droby, René-Maxime Gracien, Ralf Deichmann, Ulf Ziemann, Sven G. Meuth, Muthuraman Muthuraman, Frauke Zipp, Sergiu Groppa
2019 Therapeutic Advances in Neurological Disorders  
In conclusion, our findings provide evidence for gray matter network reorganization subsequent to clinical disease manifestation in patients with early RRMS.  ...  The aim of this study was to investigate longitudinal evolution of gray matter networks in early relapsing-remitting MS (RRMS) compared with healthy controls (HCs) and contrast network dynamics with conventional  ...  Acknowledgements The authors thank all the patients who consented to be enrolled in the research.  ... 
doi:10.1177/1756286419838673 pmid:31040880 pmcid:PMC6482642 fatcat:2mbwrcnhl5dsfdvhrvjoudl44u

Inflammatory demyelinating diseases of the central nervous system [chapter]

Romana Höftberger, Hans Lassmann
2018 Handbook of Clinical Neurology  
Demyelinated plaques are present in the white as well as gray matter, such as the cerebral or cerebellar cortex and brainstem nuclei.  ...  The MS pathology is qualitatively similar in different disease stages, such as relapsing remitting MS or secondary or primary progressive MS, but the prevalence of different lesion types differs quantitatively  ...  relapsing remitting MS (Polman et al., 2006) .  ... 
doi:10.1016/b978-0-12-802395-2.00019-5 pmid:28987175 pmcid:PMC7149979 fatcat:ae3nah5g6zgoxjc3vqhnv2dmm4

Thalamic Injury and Cognition in Multiple Sclerosis

Moein Amin, Daniel Ontaneda
2021 Frontiers in Neurology  
Multiple sclerosis (MS) produces demyelination and degeneration in both gray and white matter. Both cortical and deep gray matter injury is observed during the course of MS.  ...  Among deep gray matter structures, the thalamus has received special attention, as it undergoes volume loss in different MS subtypes and is involved in the earliest form of the disease, radiologically  ...  Imaging of the Thalamus in Multiple Sclerosis T1-and T2-weighted images are less sensitive to detect lesions in gray matter regions due to inherent structural differences between gray matter and white  ... 
doi:10.3389/fneur.2020.623914 pmid:33613423 pmcid:PMC7892763 fatcat:dgrykmyohfbw5o2beqqlabxhhq

Neuroimaging in Multiple Sclerosis [chapter]

Elisabeth Andreadou
2012 Neuroimaging - Clinical Applications  
The 2001 McDonald diagnostic criteria for multiple sclerosis included MRI evidence of dissemination in space (DIS) and dissemination in time (DIT), which allowed a diagnosis of multiple sclerosis to be  ...  MS lesions are primarily found in white matter but also in gray matter and usually affect the periventricular regions, corpus callosum, juxtacortical gray-white matter junction in the white matter, and  ...  Neuroimaging in Multiple Sclerosis, Neuroimaging -Clinical Applications, Prof.  ... 
doi:10.5772/24069 fatcat:dk3zwfkz6jhctdrgmrhj2hwhaq
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