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Altered relationship between cortisol response to social stress and mediotemporal function during fear processing in people at clinical high risk for psychosis: a preliminary report

Cathy Davies, Elizabeth Appiah-Kusi, Robin Wilson, Grace Blest-Hopley, Matthijs G. Bossong, Lucia Valmaggia, Michael Brammer, Jesus Perez, Paul Allen, Robin M. Murray, Philip McGuire, Sagnik Bhattacharyya
2021 European Archives of Psychiatry and Clinical Neuroscience  
We examined the relationship between cortisol response to social stress and mediotemporal function during fear processing in healthy people and in CHR patients.  ...  This relationship differed significantly between the control and placebo groups (p = 0.033), but not between the placebo and cannabidiol groups (p = 0.67).  ...  In siblings of patients with psychosis, smaller hippocampal volumes are associated with increased emotional and cortisol responses to daily life stress [89] .  ... 
doi:10.1007/s00406-021-01318-z pmid:34480630 pmcid:PMC8938358 fatcat:fv6acpn63vaiblhpljbckxw5we

Panel and Study Groups

2013 Neuropsychopharmacology  
In addition there are 30-76 patients with schizophrenia (depending on the brain region and assay) and 63 patients with affective disorders.  ...  prefrontal cortex (DLPFC) in a large cohort of normals and patients with schizophrenia, bipolar illness and major depression.  ...  ability of eCBs to not only strengthen responses leading to the procurement of reward but also those leading to the reduction of harm.  ... 
doi:10.1038/npp.2013.278 fatcat:expu2u3f3reypazj7tt7jhybfa

Panel, Mini-panel and Study Group

2014 Neuropsychopharmacology  
Methods: In a series of studies in healthy individuals and unaffected first-degree relatives of schizophrenia patients we have established and confirmed the link of these phenotypes to the genetic liability  ...  For ventral striatal activation during reward processing our data provide the first evidence for a systems-level intermediate phenotype signaling increased genetic risk for schizophrenia, which demonstrates  ...  Results: Data from healthy controls demonstrate that concentrations of AEA are rapidly increased in the serum of males following exposure to the Trier social stress test.  ... 
doi:10.1038/npp.2014.279 pmid:25466712 pmcid:PMC4261146 fatcat:v6fgkukh6zgtdmswrjpk46dvhi

Time to re-engage psychiatric drug discovery by strengthening confidence in preclinical psychopharmacology

Mark David Tricklebank, Trevor W. Robbins, Camilla Simmons, Erik H. F. Wong
2021 Psychopharmacology  
We propose the following 8 principles that could be used, in various combinations, to enhance CNS drug discovery: (1) consider incorporating the NIMH Research Domain Criteria (RDoC) approach; (2) engage  ...  Mental illness is expected to become the leading cause of disability worldwide by 2030.  ...  Funding Work leading to this review received funding from the Innovative Medicines Initiative Joint Undertaking under grant agreement no.115008.  ... 
doi:10.1007/s00213-021-05787-x pmid:33694032 fatcat:gh4m3mmjlzhirfh3ekenxpddvi

Poster Session I

2013 Neuropsychopharmacology  
Compared to vehicle, acute KYN (both 25 and 100 mg/kg) produced a four-fold increase (from B9 to B40) in sample phase omissions during the first 15 min of the task.  ...  We investigated three issues: (1) whether the impairing effects of acute KYNA elevations can be generalized to another PFC-mediated task, the Delay Non-Match to Position (DNMTP) working memory task; (2  ...  This hyperconnectivity is unique to this group of patients and is not seen in patients who endorse AH in the absence of VH, in schizophrenia patients who endorse neither, or in healthy controls.  ... 
doi:10.1038/npp.2013.279 fatcat:54ipecxjarcvljrvn5fgtgif5u

Poster Session I

2010 Neuropsychopharmacology  
in males 2.23-fold relative to controls, but was without effect in treated females (Condition X Sex interaction: 1,18 ¼ 5.04, po0.05).  ...  Li was also shown to down-regulate the expression of sodium myo-inositol co-transporter (SMIT)1, responsible for the uptake of myo-inositol from extracellular fluid.  ...  This association was significant in the women subgroup (po0.001), but not in the men subgroup (p ¼ 0.73).  ... 
doi:10.1038/npp.2010.216 fatcat:v3q2xjxc45b2hckv33pzz7mtee

Poster Session III

2010 Neuropsychopharmacology  
We then employed an omission session in which the rat was rewarded for not pressing the lever (omitted responses) followed by an extinction probe test session to measure responsiveness towards the lever  ...  Expression of additional genes potentially relevant to schizophrenia, but not directly related to neurotransmitter systems also were found to be influenced.  ...  Identification of the D2 DAR required its immunoprecipitation revealing it to be approximately equally distributed amongst fractions 4-11.  ... 
doi:10.1038/npp.2010.218 fatcat:i5knteqsgveybffza7g6b4iqei

Cognition-Emotion Dysinteraction in Schizophrenia

Alan Anticevic, Philip R. Corlett
2012 Frontiers in Psychology  
We review emerging evidence suggesting deficits in some, but not other, specific emotional processes in schizophrenia -namely an intact ability to perceive emotion "in-the-moment" but poor prospective  ...  We conclude with a brief treatment of the neurobiology of schizophrenia and the need to close our explanatory gap between cellular-level hypotheses and complex behavioral symptoms observed in this illness  ...  Its contents are solely the responsibility of the authors and do not necessarily represent the official view of NIH.  ... 
doi:10.3389/fpsyg.2012.00392 pmid:23091464 pmcid:PMC3470461 fatcat:mf5ciwlbebctzgiax2xkajjfbu

Poster Session II

2012 Neuropsychopharmacology  
circuitry responsive to the anticipation of rewards.  ...  We sought to examine the MOR response to social rejection in MDD patients compared to healthy controls.  ...  As predicted, the evocative (but not the neutral) cues activated limbic motivational circuitry -offering a window onto the brain processes that can undermine cognitive control in patients and non-patients  ... 
doi:10.1038/npp.2012.220 fatcat:coblfrtlujc6hdycjbnrdwzslm

Self-beneficial belief updating as a coping mechanism for stress-induced negative affect [article]

Nora Czekalla, Janine Baumann, David S Stolz, Annalina V Mayer, Johanna F Voges, Lena Rademacher, Frieder Michel Paulus, Sören Krach, Laura Müller-Pinzler
2020 bioRxiv   pre-print
The aim of the current study was to investigate the affect-regulating potential of self-related belief updating after exposure to social-evaluative stress, in comparison to non-social physical stress or  ...  We found that social-evaluative stress was accompanied by an increase in cortisol and negative affect which was related to a shift in self-related belief updating towards the positive direction.  ...  Increased responses of the reward circuitry to positive task 572 feedback following acute stress in healthy controls but not in siblings of schizophrenia 573 patients.  ... 
doi:10.1101/2020.12.02.408096 fatcat:w2ymdtuxhfhpretfqkqt4xln74

Poster Session I

2014 Neuropsychopharmacology  
In tradeoffs between reward size and response requirement, the cached value robustly incorporated the benefit, but not the cost of the option and thus, did not account for all of the economic parameters  ...  Following reward devaluation, rats' choices reflected the devalued reward immediately but the cached values did not initially and updated following experiential pairing of the cue with the reward at its  ...  Methods: Sixty two healthy controls were compared to 101 first break patients in the Preparing to Overcome Prepotency (POP) task, a cued stimulus-response reversal task.  ... 
doi:10.1038/npp.2014.280 fatcat:xunw4pdn75hlnmhvvksgp2lsse

Poster Session II

2010 Neuropsychopharmacology  
Further, increased activations in the temporo-parietal junction during the false belief vs. false photograph condition were observed in healthy controls, but not in schizophrenia patients.  ...  Following extinction, anxiety ratings to the CS + decreased in the healthy adults [po0.009] but not the healthy adolescents [p40.3] .  ...  Results: The results showed that METH, but not ACSF, produced positive place reinforcement learning post conditioning in each brain area in the bottom-up order, however, in the top-down order METH, but  ... 
doi:10.1038/npp.2010.217 fatcat:gbcgyi35jbdndlwhlgwio7ts7y

Neurobiology of bipolar disorders: a review of genetic components, signaling pathways, biochemical changes, and neuroimaging findings

Giselli Scaini, Samira S. Valvassori, Alexandre P. Diaz, Camila N. Lima, Deborah Benevenuto, Gabriel R. Fries, Joao Quevedo
2020 Revista Brasileira de Psiquiatria  
The advance in the understanding of the neurobiology underlying BD could help in the identification of new therapeutic targets as well as biomarkers for early detection, prognosis, and response to treatment  ...  Despite the advances in the pathophysiological knowledge of BD, the diagnosis and management of the disease are still essentially clinical.  ...  Disclosure The authors report no conflicts of interest.  ... 
doi:10.1590/1516-4446-2019-0732 pmid:32267339 fatcat:sno6jsj2engozlpkgbpjrpicvu

Developmental Trajectories to Reduced Activation of Positive Valence Systems: A Review of Biological and Environmental Contributions

Autumn Kujawa, Daniel N. Klein, Samantha Pegg, Anna Weinberg
2020 Developmental Cognitive Neuroscience  
Reduced activation of positive valence systems (PVS), including blunted neural and physiological responses to pleasant stimuli and rewards, has been shown to prospectively predict the development of psychopathology  ...  We propose that there may be multiple, dynamic developmental trajectories to reduced PVS activation in which combinations of genes, temperament, and exposure to severe, prolonged, or uncontrollable stress  ...  Acknowledgements The Stony Brook Temperament Study is funded by NIMH R01 MH069942 to DNK.  ... 
doi:10.1016/j.dcn.2020.100791 pmid:32510349 pmcid:PMC7225621 fatcat:cbwdo2qhf5bm7ptdegu4tjdm34

ACNP 59th Annual Meeting: Poster Session I

2020 Neuropsychopharmacology  
Predator stress tended to increase PTSD-like phenotype in WT, but not KO, mice.  ...  Recently, we paired acute restraint stress with a novel odor and found that stressed rats showed increased reactivity when exposed to a stress-conditioned stimulus (stress-CS) in a defensive burying task  ...  Greater arousal-related activity in the bilateral prefrontal cortex (BA 9) was related to better performance in healthy controls, but not FEP patients.  ... 
doi:10.1038/s41386-020-00890-7 pmid:33279934 pmcid:PMC7735198 fatcat:mqfz5f66vfbuvdbnrj7b2jt334
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