Filters








238 Hits in 15.3 sec

Increased Cerebral Blood Flow after single dose of antipsychotics in healthy volunteers depends on dopamine D2 receptor density profiles [article]

Pierluigi Selvaggi, Peter CT Hawkins, Ottavia Dipasquale, Gaia Rizzo, Alessandro Bertolino, Juergen Dukart, Fabio Sambataro, Giulio Pergola, Steven CR Williams, Federico E Turkheimer, Fernando Zelaya, Mattia Veronese (+1 others)
<span title="2018-06-02">2018</span> <i title="Cold Spring Harbor Laboratory"> bioRxiv </i> &nbsp; <span class="release-stage" >pre-print</span>
Here, we analysed MRI-based rCBF data from a placebo-controlled study in healthy volunteers, who received a single dose of three different D2 receptor antagonists and tested the association of the main  ...  Cerebral Blood Flow (rCBF).  ...  We also thank Gil Brown (London College of Communication, UAL London, UK) for her help on illustrations. Finally, we thank all the volunteers who took part in the study.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1101/336933">doi:10.1101/336933</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/4xfvamyr25fr5hzwb55orvc6he">fatcat:4xfvamyr25fr5hzwb55orvc6he</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190501105909/https://www.biorxiv.org/content/biorxiv/early/2018/06/02/336933.full.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/bf/58/bf58320a2beb89fef03b30534c62581b1606dc37.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1101/336933"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> biorxiv.org </button> </a>

Dose dependent occupancy of central dopamine D2 receptors by the novel neuroleptic CP-88,059-01: a study using positron emission tomography and11C-raclopride

C. J. Bench, A. A. Lammertsma, R. J. Dolan, P. M. Grasby, S. J. Warrington, K. Gunn, M. Cuddigan, D. J. Turton, S. Osman, R. S. J. Frackowiak
<span title="">1993</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/476xkwimnredro3yrtvqfs2ujq" style="color: black;">Psychopharmacology</a> </i> &nbsp;
Binding of 11C-raclopride decreased in a dose dependent manner, and 85 % dopamine D 2 receptor occupancy was achieved with the highest dose of CP-88,059-1.  ...  Positron emission tomography (PET) and 11C. raclopride were used to measure the occupancy of central dopamine D2 receptors by a new neuroleptic, CP-88,059-1.  ...  The expert assistance of the staff of the MRC Cyclotron Unit and in particular Claire Taylor, Andreanna Williams, Ian Watson and Dr. Steve Waters is gratefully acknowledged.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/bf02244926">doi:10.1007/bf02244926</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/7871035">pmid:7871035</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/lcld7y55obggziflaahkvhhcxm">fatcat:lcld7y55obggziflaahkvhhcxm</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20170830044131/http://library.mpib-berlin.mpg.de/ft/ext/rd/RD_Dose_1993.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/33/27/33277b9591adc5989ad1cf56a643acb631dec73d.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/bf02244926"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> springer.com </button> </a>

Striatal and extra-striatal D2/D3 dopamine receptor occupancy by quetiapine in vivo [123I]-epidepride single photon emission tomography (SPET) study

C. M. E. Stephenson, V. Bigliani, H. M. Jones, R. S. Mulligan, P. D. Acton, D. Visvikis, P. J. Ell, R. W. Kerwin, L. S. Pilowsky
<span title="">2000</span> <i title="Royal College of Psychiatrists"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/r2ls53ulyfeynk6h7jbxyybana" style="color: black;">British Journal of Psychiatry</a> </i> &nbsp;
Selective action at limbic cortical dopamine D2-like receptors could mediate atypical antipsychotic efficacy with few extrapyramidal side-effects.  ...  Method The high-affinity D2/D3 ligand [123I]-epidepride and single photon emission tomography were used to estimate D2/D3 specific binding and an index of relative percentage D2/D3 occupancy in striatal  ...  If limbic selectivity cerebral blood flow.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1192/bjp.177.5.408">doi:10.1192/bjp.177.5.408</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/11059993">pmid:11059993</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/zrnytlg6nveyhnjmocfp5wlzz4">fatcat:zrnytlg6nveyhnjmocfp5wlzz4</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190501060556/https://www.cambridge.org/core/services/aop-cambridge-core/content/view/A3CBC6930F5A54B6B2FE7886861BB95B/S0007125000227323a.pdf/div-class-title-striatal-and-extra-striatal-d-span-class-sub-2-span-d-span-class-sub-3-span-dopamine-receptor-occupancy-by-quetiapine-span-class-italic-in-vivo-span-div.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/d4/89/d48992de617b40a2018d83ce8f4ad9ba33149cc0.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1192/bjp.177.5.408"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a>

An investigation of regional cerebral blood flow and tissue structure changes after acute administration of antipsychotics in healthy male volunteers

Peter C.T. Hawkins, Tobias C. Wood, Anthony C. Vernon, Alessandro Bertolino, Fabio Sambataro, Juergen Dukart, Emilio Merlo-Pich, Celine Risterucci, Hanna Silber-Baumann, Eamonn Walsh, Ndabezinhle Mazibuko, Fernando O. Zelaya (+1 others)
<span title="2017-10-23">2017</span> <i title="Wiley"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/wtsn7qcbmrhjppax2iuhu4xj2m" style="color: black;">Human Brain Mapping</a> </i> &nbsp;
This illustrates that a single clinically relevant oral dose of an antipsychotic has no detectable acute effect on T1 in healthy volunteers.  ...  To address this, we examined the effects of a single, clinical dose of three commonly prescribed antipsychotics on quantitative measures of T1 and regional blood flow of the healthy human brain.  ...  This illustrates that a single clinically relevant oral dose of an antipsychotic has no detectable acute effect on T1 in healthy volunteers.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1002/hbm.23844">doi:10.1002/hbm.23844</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/29058358">pmid:29058358</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/c3x326q45fboxohk7mpbk56tei">fatcat:c3x326q45fboxohk7mpbk56tei</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200321192535/https://kclpure.kcl.ac.uk/portal/files/84281890/An_investigation_of_regional_HAWKINS_Publishedonline23October2017_GREEN_AAM.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/53/3c/533c3966eb388dba3de1dd1ac0ae7020f329010a.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1002/hbm.23844"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> wiley.com </button> </a>

Baseline Perfusion Alterations Due to Acute Application of Quetiapine and Pramipexole in Healthy Adults

Lars Michels, Sigrid Scherpiet, Philipp Stämpfli, Uwe Herwig, Annette B. Brühl
<span title="2016-07-27">2016</span> <i title="Oxford University Press (OUP)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/t7zhumcn45gvdefswsettbaxjm" style="color: black;">International Journal of Neuropsychopharmacology</a> </i> &nbsp;
Methods: In this randomized crossover, placebo-controlled, and rater-blinded study, 25 healthy adults received an acute dose placebo substance (starch), quetiapine (dopamine receptor antagonist), or pramipexole  ...  Pramipexole increased cerebral blood flow compared with placebo in the caudate nucleus, putamen, middle frontal, supplementary motor area, and brainstem (substantia nigra), but reduced cerebral blood flow  ...  Statement of Interest None.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1093/ijnp/pyw067">doi:10.1093/ijnp/pyw067</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/27466220">pmid:27466220</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC5137281/">pmcid:PMC5137281</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/ml2hdxoe5ffzxmmqeivtaktdfi">fatcat:ml2hdxoe5ffzxmmqeivtaktdfi</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190227184636/http://pdfs.semanticscholar.org/8501/5378785eb400591b5e64e8591f61e3892f3b.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/85/01/85015378785eb400591b5e64e8591f61e3892f3b.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1093/ijnp/pyw067"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> oup.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137281" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

The time course of binding to striatal dopamine D2 receptors by the neuroleptic ziprasidone (CP-88,059-01) determined by positron emission tomography

C. J. Bench, A. A. Lammerstma, P. M. Grasby, R. J. Dolan, R. S. J. Frackowiak, S. J. Warrington, M. Boyce, K. P. Gunn, L. Y. Brannick
<span title="">1996</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/476xkwimnredro3yrtvqfs2ujq" style="color: black;">Psychopharmacology</a> </i> &nbsp;
With increasing time between dosing and PET scanning there was a curvitinear increase in BR so that all studies performed at or after 18 h post-dose gave BPs in the normal range (mean_+2 SD).  ...  In a third party blind study, six healthy male control subjects received a predose of 40 mg ziprasidone and were scanned at an interval of between 4 and 36 h post-dose.  ...  Acknowledgements The expert assistance of the staff of the MRC Cyclotron Unit and in particular Claire Taylor, Andreanna Williams, Ian Watson and Steve Waters is gratefully acknowledged.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/bf02245614">doi:10.1007/bf02245614</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/8935809">pmid:8935809</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/r4jj2u24kbd7za4ihtun6fbwpu">fatcat:r4jj2u24kbd7za4ihtun6fbwpu</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200312230258/https://pure.mpg.de/rest/items/item_2615295_2/component/file_2623872/content" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/c1/29/c1290f5d3f28cad8e6d016e2c570386e4a9281e6.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/bf02245614"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> springer.com </button> </a>

Molecular imaging of schizophrenia: neurochemical findings in a heterogeneous and evolving disorder

Paul Cumming, Anissa Abi-Dargham, Gerhard Gründer
<span title="2020-11-13">2020</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/ewewbkkyvfat3ngsktdrzbzog4" style="color: black;">Behavioural Brain Research</a> </i> &nbsp;
Occupancy studies have established the relevant target engagement by antipsychotic medications at dopamine D2/3 receptors in living brain.  ...  Similarly, competition SPECT studies show greater basal and amphetamine-evoked dopamine occupancy at post-synaptic dopamine D2/3 receptors in patients with schizophrenia, but the difference is likewise  ...  Indeed, something similar occurs among healthy volunteers treated with a low dose of an antipsychotic medication, which acutely results in disinhibition of dopamine synthesis via autoreceptor blockade,  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.bbr.2020.113004">doi:10.1016/j.bbr.2020.113004</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/33197459">pmid:33197459</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/jqyyyyat7zhwrldtt5xwndupcu">fatcat:jqyyyyat7zhwrldtt5xwndupcu</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210427185912/https://boris.unibe.ch/148569/1/Cumming_Molecular%20imaging%20of%20schizophrenia%20Neurochemical%20findings%20in%20a%20heterogeneous%20and%20evolving%20disorder.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/4f/ca/4fca0d666dc0fa3fd66c744963f4e879f1326727.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.bbr.2020.113004"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> elsevier.com </button> </a>

Contribution of SPECT Measurements of D2 and 5-HT2A Occupancy to the Clinical Development of the Antipsychotic SB-773812

A. M. Catafau, S. Bullich, G. Nucci, C. Burgess, F. Gray, E. Merlo-Pich
<span title="2011-03-18">2011</span> <i title="Society of Nuclear Medicine"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/es34xtfdxrgybg2kmdq2n5xqry" style="color: black;">Journal of Nuclear Medicine</a> </i> &nbsp;
Study A consisted of SB-773812 single doses in healthy volunteers-D 2 occupancy measured at 48 (n 5 9) and 56 mg (n 5 9) and 5-HT 2A occupancy at 56 mg (n 5 9); study B consisted of D 2 and 5-HT 2A occupancy  ...  measured in 12 stabilizedschizophrenia patients on stable doses (16-18 d of 56 mg/d) after washout of previous medication; and study C included D 2 occupancy measured in a double-blind study of patients  ...  ; and all the subjects participating in the studies.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.2967/jnumed.110.081885">doi:10.2967/jnumed.110.081885</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/21421726">pmid:21421726</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/faqgjokx5bcyjp4wkwfgyrt5um">fatcat:faqgjokx5bcyjp4wkwfgyrt5um</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190223213740/http://pdfs.semanticscholar.org/5707/92d33e3474a8039f0a9caa05f2ae2dadce72.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/57/07/570792d33e3474a8039f0a9caa05f2ae2dadce72.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.2967/jnumed.110.081885"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a>

Dementia-Related Psychosis and the Potential Role for Pimavanserin

Jeffery L. Cummings, D. P. Devanand, Stephen M. Stahl
<span title="2020-08-19">2020</span> <i title="Cambridge University Press (CUP)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/mse7gshn6veaviozh3n5meteaq" style="color: black;">CNS Spectrums</a> </i> &nbsp;
Pimavanserin, an atypical antipsychotic, is a selective serotonin inverse agonist/antagonist at 5-HT2A receptors.  ...  Modulation of the 5-HT2A receptor may mitigate hyperactivity at both psychosis-associated pathways.  ...  The authors received editorial assistance in the preparation of this manuscript from Arbor Scientia, Inc., which was supported by Acadia Pharmaceuticals Inc., San Diego, CA. Dr.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1017/s1092852920001765">doi:10.1017/s1092852920001765</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/32811586">pmid:32811586</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC8318559/">pmcid:PMC8318559</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/yhekbgxivjgf5opwg5fyisxcmu">fatcat:yhekbgxivjgf5opwg5fyisxcmu</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210428212517/https://www.cambridge.org/core/services/aop-cambridge-core/content/view/7F3A8422F6FFEA8C5261FD694D0CCB11/S1092852920001765a.pdf/div-class-title-dementia-related-psychosis-and-the-potential-role-for-pimavanserin-div.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/88/c1/88c1f3b5d642ef61c6e7e6ad24c058583e638500.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1017/s1092852920001765"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> cambridge.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8318559" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Functional Significance of Central D1 Receptors in Cognition: Beyond Working Memory

Hidehiko Takahashi, Makiko Yamada, Tetsuya Suhara
<span title="2012-01-11">2012</span> <i title="SAGE Publications"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/zh7dem5jnfbevczyfq7zr6yhme" style="color: black;">Journal of Cerebral Blood Flow and Metabolism</a> </i> &nbsp;
We measured both D1 and D2 receptors in the brain using positron emission tomography in healthy subjects, with the aim of elucidating how regional D1 and D2 receptors are differentially involved in cognitive  ...  The role of dopamine D1 receptors in prefrontal cortex function, including working memory, is well acknowledged.  ...  , Culture, Sports, Science, and Technology of Japan (MEXT), a Grant-in-aid for scientific research on innovative areas: Prediction and Decision Making (23120009), a Grant by Takeda Science Foundation and  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1038/jcbfm.2011.194">doi:10.1038/jcbfm.2011.194</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/22234338">pmid:22234338</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3390810/">pmcid:PMC3390810</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/cf4zto3d35ezxk52xsu4ly5odi">fatcat:cf4zto3d35ezxk52xsu4ly5odi</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190309172917/http://pdfs.semanticscholar.org/fd10/f76f73d0db7bce51de52898d2d0ebbcbec84.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/fd/10/fd10f76f73d0db7bce51de52898d2d0ebbcbec84.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1038/jcbfm.2011.194"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390810" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

JuSpace: A tool for spatial correlation analyses of magnetic resonance imaging data with positron emission tomography derived neurotransmitter maps [article]

Juergen Dukart, Stefan Holiga, Michael Rullmann, Rupert Lanzenberger, Peter C.T. Hawkins, Mitul A. Mehta, Swen Hesse, Henryk Barthel, Osama Sabri, Robert Jech, Simon B. Eickhoff
<span title="2020-04-18">2020</span> <i title="Cold Spring Harbor Laboratory"> bioRxiv </i> &nbsp; <span class="release-stage" >pre-print</span>
We apply JuSpace to two datasets covering Parkinson's disease patients (PD) on and off levodopa and risperidone-induced changes in rsfMRI and cerebral blood flow (CBF).  ...  Based on this approach, we introduce a Matlab-based toolbox (JuSpace) allowing for cross-modal correlation of MRI-based measures with positron emission tomography (PET) and single photon emission computed  ...  Increased cerebral blood flow after single dose of antipsychotics in healthy volunteers depends on https://doi.org/10.1016/j.neuroimage.2018.12.028 Smith, G.S., Price, J.C., Lopresti, B.J., Huang, Y.,  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1101/2020.04.17.046300">doi:10.1101/2020.04.17.046300</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/3dotyjxfn5brzbh5g53nco6blm">fatcat:3dotyjxfn5brzbh5g53nco6blm</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200419235530/https://www.biorxiv.org/content/biorxiv/early/2020/04/18/2020.04.17.046300.full.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/30/59/3059f2e004afb4d92a4ddb1e6a2675e2cff6b09b.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1101/2020.04.17.046300"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> biorxiv.org </button> </a>

Neurochemical imaging in schizophrenia

Nina Urban, Anissa Abi-Dargham
<span title="">2010</span> <i title="Springer-Verlag"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/a5xry3enonaefkfsj5virpdclq" style="color: black;">Current topics in behavioral neurosciences</a> </i> &nbsp;
of action of antipsychotic medications.  ...  This chapter reviews the studies using neurochemical brain imaging methods for (1) detection of abnormalities in indices of dopamine and serotonin transmission in patients with schizophrenia compared to  ...  Additionally, peripheral clearance, regional cerebral blood flow, and transport of the radiotracer across the BBB influence the radioactivity profile over time and can vary significantly from subject to  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/21312402">pmid:21312402</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/tjzta237sbcblahot3ubamnasy">fatcat:tjzta237sbcblahot3ubamnasy</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200709112148/https://tauruspet.med.yale.edu/staff/edm42/courses/ENAS_880_2012/papers/Urban-Abi-Dargham_Imaging-Schizophrenia-2010.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/43/1b/431b89f807354f7272c2131ed34739f0fd35ae35.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a>

Treating Addiction [chapter]

L.F. Tófoli, D.B. de Araujo
<span title="">2016</span> <i title="Elsevier"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/zpggjvvgzzhxpmlz6bxewht76u" style="color: black;">International review of neurobiology</a> </i> &nbsp;
This chapter outlines relevant EEG and brain imaging studies evaluating the effects of psychedelics on the brain.  ...  Covert examination of psychedelics persisted through the 1990s; the turn of the century and especially the past 10 years, however, has seen a resurgent interest in psychedelic substances (eg, LSD, ayahuasca  ...  Such findings led to development of risperidone, an antipsychotic that in addition to blocking dopamine receptors, inhibits 5HT 2A receptors (Colpaert, 2003) .  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/bs.irn.2016.06.005">doi:10.1016/bs.irn.2016.06.005</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/27503452">pmid:27503452</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/tebj6wujpvhb7pt3kwstbqerti">fatcat:tebj6wujpvhb7pt3kwstbqerti</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20170830003210/http://www.ouramazingworld.org/uploads/4/3/8/6/43860587/2016_to%CC%81foli_de_arau%CC%81jo_-_treating_addiction-_perspectives_from_eeg_and_imaging_studies_on_psychedelics_%5Bauthors%5D.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/28/a0/28a079554b9bdb3a30b2004a0d5c36b811cbf0c2.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/bs.irn.2016.06.005"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> elsevier.com </button> </a>

Neuroreceptor Mapping 2000

<span title="">2000</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/sa477uo7lveh7hchpikpixop5u" style="color: black;">NeuroImage</a> </i> &nbsp;
The A 2A receptors are mainly expressed in the striatum where they are functionally linked to D 2 dopamine receptors.  ...  However, its cerebral distribution does not completely overlap with the distribution of A 2A receptors.  ...  Previous human and animal studies yielded evidence of both decreases and increases in cerebral blood flow (CBF) after AMPH (0.25-5 mg/kg) (1-3).  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1006/nimg.2000.0622">doi:10.1006/nimg.2000.0622</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/z7wjtrzb6jacva4vohw447zx2e">fatcat:z7wjtrzb6jacva4vohw447zx2e</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20050509163852/http://www.ps.uci.edu:80/~markm/tracer_kinetics/neuroimage_11_S1-S84_neuroreceptor_mapping_2000.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/81/a3/81a3d4bb3134bef0c562a2f0b151c3438bffb80c.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1006/nimg.2000.0622"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> Publisher / doi.org </button> </a>

The endocannabinoid system as a target for modelling psychosis

Dagmar Koethe, Carolin Hoyer, F. Markus Leweke
<span title="2009-06-16">2009</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/476xkwimnredro3yrtvqfs2ujq" style="color: black;">Psychopharmacology</a> </i> &nbsp;
Based on the data available, we examine the contribution of these studies to an improved neurobiological assessment of endocannabinoid functioning in psychosis and schizophrenia.  ...  evidence for a deleterious influence of cannabis use on both manifestation and course of the disease.  ...  Single-photon emission computed tomography (SPECT) studies demonstrated increased global cerebral blood flow (CBF) in participants smoking marijuana, with increased regional CBF (rCBF) in the bilateral  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s00213-009-1591-7">doi:10.1007/s00213-009-1591-7</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/19529920">pmid:19529920</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/535udwmq3jauxagr7al27bsz3q">fatcat:535udwmq3jauxagr7al27bsz3q</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200320184911/http://www.biblioteca.cij.gob.mx/Archivos/Materiales_de_consulta/Drogas_de_Abuso/Articulos/44389390.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/15/e1/15e1011fb3dfad285d57b4e54ba20252751274bb.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s00213-009-1591-7"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> springer.com </button> </a>
&laquo; Previous Showing results 1 &mdash; 15 out of 238 results