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Incorporation of SPECT bone marrow imaging into intensity modulated whole-pelvic radiation therapy treatment planning for gynecologic malignancies

John C. Roeske, Anthony Lujan, Richard C. Reba, Bill C. Penney, S. Diane Yamada, Arno J. Mundt
2005 Radiotherapy and Oncology  
and purpose: To incorporate single-photon emission computed tomography (SPECT) bone marrow (BM) imaging into the treatment planning process to reduce the volume of BM irradiated in gynecologic patients  ...  receiving intensity-modulated whole-pelvic radiation therapy (IM-WPRT).  ...  Intensity modulated radiation therapy (IMRT) is receiving increasing attention in the treatment of gynecologic malignancies.  ... 
doi:10.1016/j.radonc.2005.06.017 pmid:16024116 fatcat:i5q3gsa6srajhfuycr6yypfdim

Intensity-modulated radiotherapy as a means of reducing dose to bone marrow in gynecologic patients receiving whole pelvic radiotherapy

Anthony E Lujan, Arno J Mundt, S.Diane Yamada, Jacob Rotmensch, John C Roeske
2003 International Journal of Radiation Oncology, Biology, Physics  
Purpose: To evaluate intensity-modulated whole pelvis radiotherapy (IM-WPRT) (with bone marrow [BM] as a planning constraint) as a means to reduce the volume of pelvic BM irradiated.  ...  Conclusion: BMS IM-WPRT significantly reduces the volume of pelvic BM irradiated compared with conventional WPRT.  ...  In addition to the small bowel and rectum, a large volume of the pelvic bone marrow (BM) is also irradiated.  ... 
doi:10.1016/s0360-3016(03)00521-2 pmid:12957265 fatcat:srpzzozhvracfgukhdqv4lfoii

Feasibility of dose escalating [18F]fluciclovine positron emission tomography positive pelvic lymph nodes during moderately hypofractionated radiation therapy for high-risk prostate cancer

Andrew M. McDonald, Samuel J. Galgano, Jonathan E. McConathy, Eddy S. Yang, Michael C. Dobelbower, Rojymon Jacob, Soroush Rais-Bahrami, Jeffrey W. Nix, Richard A. Popple, John B. Fiveash
2019 Advances in Radiation Oncology  
tomography (PET)/magnetic resonance imaging (MRI).  ...  For each case, a radiation treatment plan was generated to deliver 70 Gy to the prostate and proximal seminal vesicles, 60.2 Gy to the PET-positive LNs, and 50.4 Gy to the elective nodal regions, simultaneously  ...  Radiation delivery techniques (eg, intensity modulated radiation therapy [IMRT] or volumetric modulated arc therapy) were identical to what was used for the original treatment plan.  ... 
doi:10.1016/j.adro.2019.05.008 pmid:31673658 pmcid:PMC6817530 fatcat:ykhmhiiu55aenicjkug2mqp6t4

Hematologic toxicity in anal cancer patients during combined chemo-radiation: a radiation oncologist perspective

Pierfrancesco Franco, Francesca Arcadipane, Riccardo Ragona, Massimiliano Mistrangelo, Paola Cassoni, Patrizia Racca, Mario Morino, Gianmauro Numico, Umberto Ricardi
2017 Expert Review of Anticancer Therapy  
Areas covered: Since more than a half of bone marrow is comprised within the pelvic region, the radiation dose received by this functional compartment is crucial.  ...  In general, accounting for bone marrow during the treatment planning process may be important to decrease the acute hematologic toxicity profile during concurrent chemo-radiation in anal cancer patients  ...  The relative proportion of this two compartments is a strong influence on the magnetic resonance signal intensity during dedicated imaging procedures.  ... 
doi:10.1080/14737140.2017.1288104 pmid:28277103 fatcat:nvyburfbqvf4xbnwz4ceyarjly

Feasibility study on dosimetry verification of volumetric-modulated arc therapy-based total marrow irradiation

Yun Liang, Gwe-Ya Kim, Todd Pawlicki, Arno J. Mundt, Loren K. Mell
2013 Journal of Applied Clinical Medical Physics  
The purpose of this study was to develop dosimetry verification procedures for volumetric-modulated arc therapy (VMAT)-based total marrow irradiation (TMI).  ...  The plan strategy similar to published studies was adopted. The PTV was divided into head and neck, chest, and pelvic regions, with separate plans each of which is composed of 2-3 arcs/fields.  ...  (4) Intensity-modulated radiation therapy (IMRT)-based total marrow irradiation (TMI) is one solution to optimize treatment and permit dose escalation.  ... 
doi:10.1120/jacmp.v14i2.3852 pmid:23470926 pmcid:PMC5714362 fatcat:hlkbpzhoufclfpx64pkc476gau

Advances in External Beam Radiation Therapy and Brachytherapy for Cervical Cancer

C.W. Williamson, H.C. Liu, J. Mayadev, L.K. Mell
2021 Clinical Oncology  
Further technological advances have established intensity-modulated radiation therapy (IMRT) as a standard treatment modality, given the ability to maintain tumoricidal doses to target volumes while reducing  ...  In the realm of brachytherapy, a shift from point-based dose planning to image-guided brachytherapy has been associated with improved local control and reduced toxicity, with additional refinement ongoing  ...  The proton plans showed reduced volumes of pelvic bone marrow, bladder and bowel receiving 10e30 Gy.  ... 
doi:10.1016/j.clon.2021.06.012 pmid:34266728 fatcat:nwodwibpb5bdziovo3k5vwbjnm

Long Term Clinical Outcome and Late Toxicity of Intensity Modulated Versus Conventional Pelvic Radiation Therapy for Locally Advanced Cervix Carcinoma

Ajeet Kumar Gandhi, Daya Nand Sharma, Goura Kishor Rath, Pramod Kumar Julka, Vellaiyan Subramani, Seema Sharma, Durai Manigandan, Sunesh Kumar
2019 Journal of Clinical and Diagnostic Research  
EBRT dose was 50.4 Gray in 28 fractions over 5.5 weeks in both the treatment arms. Cisplatin 40 mg/m 2 intravenous weekly during the course of CCRT was given  ...  Original Article Study Design Patients were randomized to either WP-IMRT or WP-CRT arms by computer aided random numbers.  ...  Pelvic control rates in the recent series with incorporation of magnetic resonance imaging-based image guided brachytherapy have improved to 85-90% [19] .  ... 
doi:10.7860/jcdr/2019/40260.12741 fatcat:jkgxz3rnwfg3xbcvay4nambjdm

Image-guided brachytherapy (IGBT) combined with whole pelvic intensity-modulated radiotherapy (WP-IMRT) for locally advanced cervical cancer: a prospective study from Chiang Mai University Hospital, Thailand

Ekkasit Tharavichitkul, Somsak Wanwilairat, Somvilai Chakrabandhu, Pitchayaponne Klunklin, Wimrak Onchan, Damrongsak Tippanya, Wannapa Nopnop, Razvan Galalae, Imjai Chitapanarux
2013 Journal of Contemporary Brachytherapy  
Purpose: A report of preliminary results and toxicity profiles using image-guided brachytherapy (IGBT) combined with whole pelvic intensity-modulated radiation therapy (WP-IMRT) for locally advanced cervical  ...  Conclusion: The combination of image-guided brachytherapy and intensity-modulated radiotherapy improved the dose distribution to tumor volumes and avoided overdose in OARs which could be converted in excellent  ...  Acknowledgements The author offers many thanks to the staff of the NRU-CMU in the Gynecologic Oncology Cluster and the Division of Therapeutic Radiology and Oncology, Faculty of Medicine, Chiang Mai University  ... 
doi:10.5114/jcb.2013.34338 pmid:23634150 pmcid:PMC3635045 fatcat:mbq57p7qlrhvzdlnslnighrguq

Multi-modality organ-based approach to expected imaging findings, complications and recurrent tumour in the genitourinary tract after radiotherapy

Nicola Schieda, Shawn Christopher Malone, Omran Al Dandan, Parvati Ramchandani, Evan S. Siegelman
2013 Insights into Imaging  
Expected imaging findings, RT-related complications and the diagnosis of recurrent tumour following RT in the GU tract often necessitate a multi-modality imaging approach, the incorporation of functional  ...  Imaging follow-up in patients who have received RT is performed to assess for treatment response, evaluate for tumour recurrence and to diagnose complications related to treatment.  ...  Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and  ... 
doi:10.1007/s13244-013-0295-z pmid:24277341 pmcid:PMC3948910 fatcat:mouzszp7yvfkraxm6ioqvtd3kq

EP-1316: Clinical experience with intensity modulated radiation total marrow irradiation (IMTMI)

B. Aydogan, M. Koshy, D. Rondelli, M. Surucu, K. Ahn, G. Kavak, S. Brett, P. Patel, N. Ozturk, R. Weichselbaum
2013 Radiotherapy and Oncology  
This approach probably allows to reduce the treatment time respect to the use of a isocenter for each lesion.  ...  Purpose/Objective: We are currently investigating the feasibility of adding total marrow irradiation with a conventional myeloablative regimen of Fludarabine and IV Busalfan prior to allogeneic stem cell  ...  We concluded that a 3 mm bone to PTV expansion was adequate to accurately target bone marrow in IM-TMI treatments and the kV imaging improved delivery accuracy while reducing the setup time considerably  ... 
doi:10.1016/s0167-8140(15)33622-7 fatcat:s2mgrmywmzbc3jk73mivt4quz4

Female Pelvis: Genital Organs [chapter]

Rosemarie Forstner, Teresa Margarida Cunha
2015 Medical Radiology  
Medical Radiology -Radiation Oncology is a unique series that aims to document the most innovative technologies in all fi elds within radiology, thereby informing the physician in practice of the latest  ...  of radiation eff ects, with the emphasis on maximizing cure and minimizing complications.  ...  Imaging of Gastrointestinal Complications and Toxicity Following Tumor Therapy  ... 
doi:10.1007/174_2015_1054 fatcat:3pptfpaakjcdjiz225n4lewejm

Radiation Therapy‐Associated Toxicity: Etiology, Management, and Prevention

Kyle Wang, Joel E. Tepper
2021 Ca  
There is usually a direct relationship between the radiation dose and volume to normal tissues and the risk of toxicity, which has led to guidelines and recommended dose limits for most tissues.  ...  Radiation therapy (RT) is a curative treatment for many malignancies and provides effective palliation in patients with tumor-related symptoms.  ...  radiosurgery [SRS] and stereotactic body RT [SBRT]), image-guided (eg, magnetic resonance imaging [MRI]-guided or computed tomography [CT]-guided) brachytherapy, and particle therapy (eg, protons), allow  ... 
doi:10.3322/caac.21689 pmid:34255347 fatcat:f2oh5brfgzh3hhk3hnehcsmnpi

Ewing Sarcoma—Diagnosis, Treatment, Clinical Challenges and Future Perspectives

Stefan K. Zöllner, James F. Amatruda, Sebastian Bauer, Stéphane Collaud, Enrique de Álava, Steven G. DuBois, Jendrik Hardes, Wolfgang Hartmann, Heinrich Kovar, Markus Metzler, David S. Shulman, Arne Streitbürger (+6 others)
2021 Journal of Clinical Medicine  
In this review, we focus on the current standard of diagnosis and treatment while attempting to answer some of the most pressing questions in clinical practice.  ...  In addition, this review provides scientific answers to clinical phenomena and occasionally defines the resulting translational studies needed to overcome the hurdle of treatment-associated morbidities  ...  Nowadays, the primary diagnostic work-up of bone pain, especially in children, requires magnetic resonance imaging (MRI) which exceeds a high negative predictive value for malignant bone tumors [20] .  ... 
doi:10.3390/jcm10081685 pmid:33919988 pmcid:PMC8071040 fatcat:plkmlsd3a5gppbfwntqm3nvshy

Phase 1 study of concurrent sunitinib and image-guided radiotherapy followed by maintenance sunitinib for patients with oligometastases

Johnny Kao, Stuart Packer, Ha Linh Vu, Myron E. Schwartz, Max W. Sung, Richard G. Stock, Yeh-Chi Lo, Delphine Huang, Shu-Hsia Chen, Jamie A. Cesaretti
2009 Cancer  
METHODS: Eligible patients had 1 to 5 sites of metastatic cancer measuring ≤6 cm. The most common treatment sites were bone, liver, and lung.  ...  BACKGROUND To determine the safety and maximum-tolerated dose of concurrent sunitinib and image-guided radiotherapy (IGRT) followed by maintenance sunitinib in oligometastastic patients.  ...  Acknowledgments Supported in part by the Mount Sinai School of Medicine Department of Radiation Oncology and Pfizer.  ... 
doi:10.1002/cncr.24412 pmid:19536893 pmcid:PMC4370266 fatcat:z7vw5jzeejcvflfmhxs2ejbive

Proton Radiotherapy for Solid Tumors of Childhood

Shane E. Cotter, Sean M. McBride, Torunn I. Yock
2012 Technology in Cancer Research and Treatment  
Radiation therapy is responsible for a significant proportion of these late effects, but a relatively new and emerging modality, proton radiotherapy hold great promise to drastically reduce these treatment  ...  The increasing efficacy of pediatric cancer therapy over the past four decades has produced many long-term survivors that now struggle with serious treatment related morbidities affecting their quality  ...  Acknowledgements We would like to thank Dr. Jay Loeffler, MD for helpful discussion of the manuscript and Judith Adams, CMD for assistance with the generation of figures.  ... 
doi:10.7785/tcrt.2012.500295 pmid:22417062 pmcid:PMC4527470 fatcat:o4xksxueifasfekc4zgh44rjvm
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