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Blood flow in intracranial aneurysms treated with Pipeline embolization devices: computational simulation and verification with Doppler ultrasonography on phantom models

Anderson Chun On Tsang, Simon Sui Man Lai, Wai Choi Chung, Abraham Yik Sau Tang, Gilberto Ka Kit Leung, Alexander Kai Kei Poon, Alfred Cheuk Hang Yu, Kwok Wing Chow
2015 Ultrasonography  
Conclusion: The CFD estimation of flow reduction in aneurysms treated with a flow-diverting stent was verified by Doppler ultrasonography in patient-specific phantom models of bifurcation and side-wall  ...  Purpose: The aim of this study was to validate a computational fluid dynamics (CFD) simulation of flow-diverter treatment through Doppler ultrasonography measurements in patient-specific models of intracranial  ...  We wish to thank Synapse Therapeutic Limited (Hong Kong) for donating the Pipeline embolization device used in this study.  ... 
doi:10.14366/usg.14063 pmid:25754367 pmcid:PMC4372715 fatcat:diqiiz26nzhnjcyiakmfp4hsxq

Hemodynamic Effects of Stent Struts versus Straightening of Vessels in Stent-Assisted Coil Embolization for Sidewall Cerebral Aneurysms

Kenichi Kono, Aki Shintani, Tomoaki Terada, Roi Gurka
2014 PLoS ONE  
Citation: Kono K, Shintani A, Terada T (2014) Hemodynamic Effects of Stent Struts versus Straightening of Vessels in Stent-Assisted Coil Embolization for Sidewall Cerebral Aneurysms.  ...  Placement of stent struts in the initial vessel geometries reduced flow velocity in aneurysms by 23.1%66.3%. Straightening of vessels without stent struts reduced flow velocity by 9.6%612.6%.  ...  A smaller time step, 0.001 s, showed ,0.2% difference in mean flow velocity in aneurysms, assuring verification of a time step of 0.005 s.  ... 
doi:10.1371/journal.pone.0108033 pmid:25247794 pmcid:PMC4172595 fatcat:fwgpqc6rd5arldvsf2u2a63qqu

Towards Predicting Patient-Specific Flow-Diverter Treatment Outcomes for Bifurcation Aneurysms: From Implantation Rehearsal to Virtual Angiograms

T. W. Peach, K. Spranger, Y. Ventikos
2015 Annals of Biomedical Engineering  
This study examines the treatment of bifurcation aneurysms endovascularly with flow-diverting stents and presents an integrative computational modeling suite allowing for rehearsing all aspects of the  ...  Virtual angiograms and contrast residence curves are created, which offer unique clinical relevance and the potential for future in vivo verification of simulated results.  ...  Megahed of the ESI Group for allowing the use of the CFD-ACE suite.  ... 
doi:10.1007/s10439-015-1395-3 pmid:26240061 pmcid:PMC4690836 fatcat:zxubzl4ib5hipdh7hgau4fqady

Computational Hemodynamic Modeling of Arterial Aneurysms: A Mini-Review

Sarah N. Lipp, Elizabeth E. Niedert, Hannah L. Cebull, Tyler C. Diorio, Jessica L. Ma, Sean M. Rothenberger, Kimberly A. Stevens Boster, Craig J. Goergen
2020 Frontiers in Physiology  
For aneurysms in locations where thrombosis is the primary concern, diameter is also used to determine the level of therapeutic anticoagulation, a treatment that increases the possibility of internal bleeding  ...  In this review, we highlight recent work that investigates aneurysm geometry, model parameter assumptions, and other specific considerations that influence computational aneurysm simulations.  ...  OUTLOOK Although there is tremendous hope for the use of CFD modeling of aneurysms to aid in clinical decision making, there are only a few instances of CFD in surgical planning or large clinical cohort  ... 
doi:10.3389/fphys.2020.00454 pmid:32477163 pmcid:PMC7235429 fatcat:ek4ycgu5f5b6xdocxtzdozc6sy

Modelling the interaction of haemodynamics and the artery wall: Current status and future prospects

P.V. Lawford, Y. Ventikos, A.W. Khir, M. Atherton, D. Evans, D.R. Hose, C.M. Care, P.N. Watton, I. Halliday, D.C. Walker, A.P. Hollis, M.W. Collins
2008 Biomedicine and Pharmacotherapy  
Clinical research has historically focused on the two main strategies of in vivo and in vitro experimentation.  ...  The haemodynamic environment can give rise to deleterious remodeling, for example, atherosclerosis or aneurysms.  ...  The authors wish to acknowledge the support of the EU Sixth Framework programme (AneurIST, COAST) and BRET (The Bardhan Research and Education Trust) for aspects of this work.  ... 
doi:10.1016/j.biopha.2008.07.054 pmid:18768288 fatcat:daaprdzgd5cttapjccvg3tmdgy

Utilizing Computational Fluid Dynamics in Cardiovascular Engineering and Medicine-What You Need to Know. Its Translation to the Clinic/Bedside

Danny Bluestein
2017 Artificial Organs  
While there is a growing recognition within the clinical community and regulatory agencies of the tremendous benefits in employing CFD for such purposes, with CFD steadily gaining traction in the clinic  ...  The advent of computational fluid dynamics (CFD) made the simulation of complex transport phenomena in medicine and biology feasible.  ...  For quantifying the thrombogenic potential of VADs the CFD simulation should be solved as a two-phase flow problem, for example, where a large population of platelets is represented in the particulate  ... 
doi:10.1111/aor.12914 pmid:28181302 pmcid:PMC5720151 fatcat:fnovdcjkpncybn6ng5osqyht34

Patient-Specific Modeling of Cardiovascular Mechanics

C.A. Taylor, C.A. Figueroa
2009 Annual Review of Biomedical Engineering  
Finally, the patient-specific modeling has enabled an entirely new application of cardiovascular mechanics, namely predicting outcomes of alternate therapeutic interventions for individual patients.  ...  Applications of patient-specific models of cardiovascular mechanics are presented, followed by a discussion of the challenges and opportunities that lie ahead.  ...  ACKNOWLEDGMENTS This review was supported, in part, by grants from the National Science Foundation (ITR-0205741) and the National Institutes of Health (U54 GM072970). We also acknowledge expert  ... 
doi:10.1146/annurev.bioeng.10.061807.160521 pmid:19400706 pmcid:PMC4581431 fatcat:hyc2p2gvwffx5m2egsvausrsla

Flow Imaging and Computing: Large Artery Hemodynamics

David A. Steinman, Charles A. Taylor
2005 Annals of Biomedical Engineering  
future directions for, imaging and computational modeling of blood flow in the large arteries and the microcirculation.  ...  ; and the latter in a separate paper by Cristini.  ...  boundary conditions of detailed CFD models. 35 Compared to a decade ago, it is now relatively easy to carry out CFD simulations, which is both a blessing and a curse.  ... 
doi:10.1007/s10439-005-8772-2 pmid:16389516 fatcat:d36mvrigobddre2tfdmqtpuswq

The Role of Biofluid Mechanics in the Assessment of Clinical and Pathological Observations

Maria Siebes, Yiannis Ventikos
2010 Annals of Biomedical Engineering  
When combined with underlying physiological models, a powerful set of tools becomes available to address unmet clinical needs, predominantly in the direction of enhanced diagnosis, as well as assessment  ...  Biofluid mechanics is increasingly applied in support of diagnosis and decision-making for treatment of clinical pathologies.  ...  into large-scale studies that hold great promise of a robust and predictive categorization of lesions, without the need for costly computational hemodynamics simulations, for aneurysms but also for a more  ... 
doi:10.1007/s10439-010-9903-y pmid:20087774 pmcid:PMC2841261 fatcat:snaw4qa22vhiloatikwafdvmsi

The Role of Computational Modeling and Simulation in the Total Product Life Cycle of Peripheral Vascular Devices

Tina M. Morrison, Maureen L. Dreher, Srinidhi Nagaraja, Leonardo M. Angelone, Wolfgang Kainz
2017 Journal of Medical Devices  
Manufacturers of medical devices intended for use in the peripheral vasculature, such as stents, inferior vena cava (IVC) filters, and stent-grafts, mainly use computational modeling and simulation (CM  ...  The Center for Devices and Radiological Health (CDRH) wants to advance the use of CM&S for medical devices and supports the development of virtual physiological patients, clinical trial simulations, and  ...  Kenneth Cavanaugh from the FDA for his thorough review of the materials to ensure their accuracy. This material is declared a work of the U.S.  ... 
doi:10.1115/1.4035866 pmid:29479395 pmcid:PMC5823268 fatcat:eoj5cpbhsvdctkndggww5ks5lq

Sanal Flow Choking: A Paradigm Shift in Computational Fluid Dynamics Code Verification and Diagnosing Detonation and Hemorrhage in Real‐World Fluid‐Flow Systems

Valsalayam Raghavapanicker Sanal Kumar, Vigneshwaran Sankar, Nichith Chandrasekaran, Ajith Sukumaran, Sulthan Ariff Rahman Mohamed Rafic, Rajaghatta Sundararam Bharath, Roshan Vignesh Baskaran, Charlie Oommen, Pradeep Kumar Radhakrishnan, Shiv Kumar Choudhary
2020 Global Challenges  
for computational fluid dynamics (CFD) code verification.  ...  The blockage factor predicted at the Sanal flow choking condition can be taken as an infallible data for various in silico model verification, validation, and calibration.  ...  The Equation (8) is a cogent mathematical model for predicting the average friction coefficient, which the CFD community was waiting for decades for in silico experiments and also for the model verification  ... 
doi:10.1002/gch2.202000012 pmid:32837737 pmcid:PMC7267099 fatcat:owlbqf627bdrtayoxawe5xcfhi

Flow characteristics in a canine aneurysm model: A comparison of 4D accelerated phase-contrast MR measurements and computational fluid dynamics simulations

Jingfeng Jiang, Kevin Johnson, Kristian Valen-Sendstad, Kent-Andre Mardal, Oliver Wieben, Charles Strother
2011 Medical Physics (Lancaster)  
Qualitative visual assessments and quantitative comparisons of the time-resolved velocity fields obtained from the PC-MRA measurements and the CFD simulations were performed using a defined similarity  ...  animal-specific CFD simulations.  ...  In Eqs. (1) and (2), blood was modeled as an incompressible laminar fluid with a density of 1050 kg=m 3 . Both non-Newtonian and Newtonian viscosity models were used for CFD simulations.  ... 
doi:10.1118/1.3652917 pmid:22047395 pmcid:PMC3223510 fatcat:5dyzuskfejf4zppzxvlsucpuke

Modeling Stented Coronary Arteries: Where We are, Where to Go

Stefano Morlacchi, Francesco Migliavacca
2012 Annals of Biomedical Engineering  
Interesting progresses have been made in the numerical modeling of stenting procedures both from a structural and a fluid dynamics points of view.  ...  Nowadays, increased computational power allows for numerical models to meet clinical needs and include more complex cases such as the implantation of multiple stents in bifurcations or curved vessels.  ...  et al. 29 This strategy allows the reconstruction of a reliable fluid domain of an in vitro bench test of stenting procedures able to be used for CFD studies.  ... 
doi:10.1007/s10439-012-0681-6 pmid:23090621 fatcat:ncoy4ppagrdlrc3vcczoa3grqu

Computational Study of Haemodynamic Effects of Entry- and Exit-Tear Coverage in a DeBakey Type III Aortic Dissection: Technical Report

C. Karmonik, J. Bismuth, D.J. Shah, M.G. Davies, D. Purdy, A.B. Lumsden
2011 European Journal of Vascular and Endovascular Surgery  
Conclusions: CFD results from computational models of a DeBakey type III AD representing separate coverage of entrance and exit tears correlated with clinical experience.  ...  Here, we investigate if computational fluid dynamics (CFD) can provide an initial understanding of pressure changes in an AD computational model when covering entry and exit tears and removing the intra-arterial  ...  Conflict of Interest/Funding None. Appendix Supporting information Supplementary data associated with this article can be found, in the on-line version, at doi:10.1016/j.ejvs.2011. 04.008.  ... 
doi:10.1016/j.ejvs.2011.04.008 pmid:21549622 fatcat:2nw5x3g3hnbwnhivysugv2cd7e

Post-processing techniques of 4D flow MRI: velocity and wall shear stress [article]

Qi Gao, Xingli Liu, Hongping Wang, Fei Li, Peng Wu, Zhaozhuo Niu, Mansu Jin, RunJie Wei
2019 arXiv   pre-print
However, the traditional DFS does not have the ability to deal with the flow in the near wall region of vessel, especially for satisfying the no-slip boundary condition.  ...  As a result, a special wall function is required for accurately computing wall shear stress (WSS).  ...  As for streamlines in the upper segment of descending aorta in CFD, a twisted flow is shown because of the rigid wall boundary condition during simulation.  ... 
arXiv:1912.03621v1 fatcat:uc5jehfpljcv3oxwv3dqih3afy
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