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In vivo strain and stress estimation of the heart left and right ventricles from MRI images

Zhenhua Hu, Dimitris Metaxas, Leon Axel
2003 Medical Image Analysis  
We composite material model for the stress estimation of the in applied the residual stress at the end of diastole to make vivo left and right ventricles.  ...  However, the stress and strain The geometrical model chosen is the same as given in estimation of the in vivo heart is much more complicated (Haber et al., 2000; Haber, 2000) .  ... 
doi:10.1016/s1361-8415(03)00032-x pmid:14561549 fatcat:qnqzurh5yjfmjmr7wll3ui3kzy

In-vivo Strain and Stress Estimation of the Left Ventricle from MRI Images [chapter]

Zhenhua Hu, Dimitris Metaxas, Leon Axel
2002 Lecture Notes in Computer Science  
In this paper, we present a novel statistical model to estimate the invivo material properties and strain and stress distribution in the left ventricle.  ...  Little information is known about in-vivo heart strain and stress distribution.  ...  Acknowledgements This research has been funded by grants from the NIH.  ... 
doi:10.1007/3-540-45786-0_87 fatcat:7yuvbvb6fncgzafffaiikqngoq

A Framework for Evaluating Myocardial Stiffness Using 3D-Printed Hearts [article]

Fikunwa Kolawole, Mathias Peirlinck, Tyler E. Cork, Vicky Y. Wang, Seraina A. Dual, Marc E. Levenston, Ellen Kuhl, Daniel B. Ennis
2021 bioRxiv   pre-print
However, in vivo validation of these estimates is exceedingly difficult due to the lack of a known ground-truth in vivo myocardial stiffness.  ...  We have developed 3D-printed heart phantoms of known myocardium-mimicking stiffness and MRI relaxation properties and incorporated the heart phantoms within a highly controlled MRI-compatible setup to  ...  Measuring in vivo passive myocardial stiffness requires a comprehensive evaluation of the mechanical behavior (stress-strain) in diastole.  ... 
doi:10.1101/2021.02.21.432169 fatcat:zzk2ubhhxrcohp6gji5vtbcq2e

Cardiac Strain Analysis Using Cine Magnetic Resonance Imaging and Computed Tomography

Michinobu Nagao, Yuzo Yamasaki
2018 Cardiovascular Imaging Asia  
Previous studies using tagged MRI demonstrated that a contraction delay between the right and left ventricles correlated with right ventricular dysfunction in adults with congenital heart disease and pulmonary  ...  Cardiac MRI lacks the disadvantages of acoustic windows and a narrow field of view, with the advantage of measuring right ventricular strain and the geometric difference in left ventricular contraction  ...  Acknowledgments This work was supported by the Japan Society for the Promotion of Science (JSPS) KAKENHI (16K10321). We would like to thank Mr. Yuichiro Sano and Mrs.  ... 
doi:10.22468/cvia.2018.00052 fatcat:oc5xxakgszerrli3vw4lmus2ve

Left Ventricular Diastolic and Systolic Material Property Estimation from Image Data [chapter]

Adarsh Krishnamurthy, Christopher Villongco, Amanda Beck, Jeffrey Omens, Andrew McCulloch
2015 Lecture Notes in Computer Science  
However, to replicate the regional mechanics of the heart accurately, both the nonlinear passive and active material properties must be estimated reliably.  ...  The resulting end-diastolic and end-systolic geometry from the simulation were compared with measured image data.  ...  Acknowledgments The methods and simulations in this paper were performed using Continuity 6.4b (r8149). We would like to thank Jeff Van Dorn for providing us with technical support for the software.  ... 
doi:10.1007/978-3-319-14678-2_7 pmid:25729778 pmcid:PMC4339056 fatcat:hec7v7kxmzeqhkdcfp23s2xzaq

Effects of using the unloaded configuration in predicting the in vivo diastolic properties of the heart

Amir Nikou, Shauna M. Dorsey, Jeremy R. McGarvey, Joseph H. Gorman, Jason A. Burdick, James J. Pilla, Robert C. Gorman, Jonathan F. Wenk
2016 Computer Methods in Biomechanics and Biomedical Engineering  
In the current study, in-vivo measurements were acquired using magnetic resonance images (MRI) and synchronous pressure catheterization in the LV (N=5).  ...  While much insight has been gained from these studies, one important limitation associated with computational modeling arises when using in-vivo images of the heart to generate the reference state of the  ...  Gorman), and by a grant from the National Science Foundation CMMI-1538754 (J. Wenk).  ... 
doi:10.1080/10255842.2016.1183122 pmid:27153460 pmcid:PMC5278778 fatcat:k6n3mper4jfqxonlrnbfmfzg24

Estimation of mechanical properties from gated SPECT and cine MRI data using a finite-element mechanical model of the left ventricle

B. Feng, A.I. Veress, A. Sitek, G.T. Gullberg, D.G. Roy
2001 IEEE Transactions on Nuclear Science  
An ellipsoidal and a cylindrical model of the left ventricle were developed under both passive loading and active contraction.  ...  Parameters that describe the material properties of the myocardium were estimated for the cylindrical model by fitting the radial motion described by the model to gated SPECT and cine MRI data.  ...  ACKNOWLEDGMENT The authors would like to thank S. Webb for proofreading the manuscript.  ... 
doi:10.1109/23.940154 fatcat:alidzlzf7zct7jfcktvwhskbti

Progress Toward using MRI and a Heart Model to Estimate Patient-Specific Indices of Cardiac Function

M. Sermesant, P. Moireau, R. Andriantsimiavona, J. Sainte-Marie, O. Camara, R. Cimrman, D. L.G. Hill, D. Chapelle, R. Razavi, Eric Cancès, Jean-Frédéric Gerbeau
2005 ESAIM: Proceedings and Surveys  
In this article, we present a framework to estimate cardiac function parameters like local myocardium contractility using clinical MRI, a heart model and data assimilation.  ...  An electromechanical model of the heart can be simulated on this mesh. Data assimilation makes it possible to estimate local contractility from given displacements.  ...  Acknowledgements The authors would like to thank for their collaboration the Cardiac MR Research Group in Guy's Hospital, London and the co-workers of the ICEMA collaborative research actions  ... 
doi:10.1051/proc:2005017 fatcat:vimeveyszbggxhh4iwfdtptrcy

Elevated ventricular wall stress disrupts cardiomyocyte t-tubule structure and calcium homeostasis

Michael Frisk, Marianne Ruud, Emil K. S. Espe, Jan Magnus Aronsen, Åsmund T. Røe, Lili Zhang, Per Andreas Norseng, Ole M. Sejersted, Geir A. Christensen, Ivar Sjaastad, William E. Louch
2016 Cardiovascular Research  
Methods and results MRI and blood pressure measurements were employed to examine regional wall stress across the left ventricle of sham-operated and failing, post-infarction rat hearts.  ...  In failing hearts, elevated left ventricular diastolic pressure and ventricular dilation resulted in markedly increased wall stress, particularly in the thin-walled region proximal to the infarct.  ...  Acknowledgements The authors thank the Section of Comparative Medicine, Oslo University Hospital Ullevål (Oslo, Norway) for animal care. We thank  ... 
doi:10.1093/cvr/cvw111 pmid:27226008 pmcid:PMC5031949 fatcat:sqsua6qbgzgc5jkzgadnfa4yde

Magnetic resonance imaging assessment of myocardial elastic modulus and viscosity using displacement imaging and phase-contrast velocity mapping

Han Wen, Eric Bennett, Neal Epstein, Jonathan Plehn
2005 Magnetic Resonance in Medicine  
MRI-determined VDTCs were similar in the three regions (VDTC = −1.15 ± 12.37 versus 3.04 ± 7.25 versus 4.17 ± 5.76 ms, P = ns) and did not differ from lateral and septal wall strain gauge assessment (VDTC  ...  in agreement with direct strain gauge measurements (3.78 ± 0.93 and 2.96 ± 0.88 kPa for the lateral wall and the septum, P = ns for both versus MRI).  ...  Hiroshi Ashikaga and Elliot McVeigh of NHLBI/NIH for allowing us to scan their ischemic dog model and providing the Gd-DTPA contrast images.  ... 
doi:10.1002/mrm.20589 pmid:16086299 pmcid:PMC2886520 fatcat:7v5hrh2kv5aujh5aalpno33mhe

Construction and Validation of Subject-Specific Biventricular Finite-Element Models of Healthy and Failing Swine Hearts From High-Resolution DT-MRI

Kevin L. Sack, Eric Aliotta, Daniel B. Ennis, Jenny S. Choy, Ghassan S. Kassab, Julius M. Guccione, Thomas Franz
2018 Frontiers in Physiology  
of subject-specificity included in the models represents a milestone for modeling efforts that captures realism of the whole heart.  ...  ACKNOWLEDGMENTS The authors thank Pamela Derish in the Department of Surgery, University of California San Francisco for proofreading the manuscript.  ...  LV, left ventricle; RV, right ventricle.  ... 
doi:10.3389/fphys.2018.00539 pmid:29896107 pmcid:PMC5986944 fatcat:yj65uj5ayrd2rktaidgkubbaxu

A Novel Method for Quantifying Smooth Regional Variations in Myocardial Contractility Within an Infarcted Human Left Ventricle Based on Delay-Enhanced Magnetic Resonance Imaging

Martin Genet, Lik Chuan Lee, Liang Ge, Gabriel Acevedo-Bolton, Nick Jeung, Alastair Martin, Neil Cambronero, Andrew Boyle, Yerem Yeghiazarians, Sebastian Kozerke, Julius M. Guccione
2015 Journal of Biomechanical Engineering  
We demonstrate the utility of our method for quantifying smooth regional variations in myocardial contractility using cardiac DE-MR and CSPAMM-MR images acquired from a 78-yr-old woman who experienced  ...  One of the main driving forces for adverse LV remodeling is assumed to be an abnormally high level of ventricular wall stress, and many existing and new treatments for heart failure fundamentally attempt  ...  Acknowledgment The authors thank Pamela Derish in the Department of Surgery, UCSF, for proofreading the manuscript. Nomenclature  ... 
doi:10.1115/1.4030667 pmid:25994000 pmcid:PMC4476031 fatcat:rsf7r43v5vhcfbweerh6obracy

A numerical study of a heart phantom model

Y. Zhu, X.Y. Luo, H. Gao, C. McComb, C. Berry
2014 International Journal of Computer Mathematics  
The phantom is made of a hydrogel material which mimics the elasticity of human soft tissue, and is composed of anatomically correct left and right ventricle structures.  ...  In this paper, we develop a computational heart phantom model based on magnetic resonance imaging (MRI) of a dynamic multi-modality heart phantom.  ...  Elizabeth Tanner in University of Glasgow for material testing. All simulations were performed on the Linux workstations at the School of Mathematics and Statistics, University of Glasgow.  ... 
doi:10.1080/00207160.2013.854337 fatcat:2eehk6hh5rf3bj3zp7j7in3apa

Patient-specific models of cardiac biomechanics

Adarsh Krishnamurthy, Christopher T. Villongco, Joyce Chuang, Lawrence R. Frank, Vishal Nigam, Ernest Belezzuoli, Paul Stark, David E. Krummen, Sanjiv Narayan, Jeffrey H. Omens, Andrew D. McCulloch, Roy C.P. Kerckhoffs
2013 Journal of Computational Physics  
Semi-automated methods were developed for optimizing the passive material properties while simultaneously computing the unloaded reference geometry of the ventricles for stress analysis.  ...  Human myofiber and sheet architecture is modeled using eigenvectors computed from diffusion tensor MR images from an isolated, fixed human organ-donor heart and transformed to the patientspecific geometric  ...  Acknowledgments The study has been supported by NIH grant R01 HL96544 and the National Biomedical Computation Resource (NIH grant P41 RR08605).  ... 
doi:10.1016/j.jcp.2012.09.015 pmid:23729839 pmcid:PMC3667962 fatcat:ctwegokuczgvhdco7isrgpfdhm

Estimating passive mechanical properties in a myocardial infarction using MRI and finite element simulations

Dimitri Mojsejenko, Jeremy R. McGarvey, Shauna M. Dorsey, Joseph H. Gorman, Jason A. Burdick, James J. Pilla, Robert C. Gorman, Jonathan F. Wenk
2014 Biomechanics and Modeling in Mechanobiology  
Specifically, properties will be determined by minimizing the difference between in-vivo strains and volume calculated from MRI and finite element model predicted strains and volume.  ...  Myocardial infarction (MI) triggers a series of maladaptive events that lead to structural and functional changes in the left ventricle.  ...  Acknowledgments This study was supported by National Institutes of Health grants R01 HL063954 (Gorman), R01 HL111090 (Burdick), and T32 HL007954 (Burdick), and by a grant from the American Heart Association  ... 
doi:10.1007/s10237-014-0627-z pmid:25315521 pmcid:PMC4398581 fatcat:qiyppnasoreqhmg7nslygbpqse
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