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In vivo neuropathology of the hippocampal formation in AD: A radial mapping MR-based study

G.B. Frisoni, F. Sabattoli, A.D. Lee, R.A. Dutton, A.W. Toga, P.M. Thompson
2006 NeuroImage  
The aim of the study was to locate in vivo the structural changes within the hippocampal formation in AD patients of mild to moderate severity.  ...  This study supports the possibility of carrying out in vivo macroscopic neuropathology of the hippocampus with MR imaging in the neurodegenerative dementias. D  ...  Acknowledgments Funding support for this work was provided in part by grants from the National Institute of Aging, National Institute for Biomedical Imaging and Bioengineering, and the National Center  ... 
doi:10.1016/j.neuroimage.2006.03.015 pmid:16631382 fatcat:4o65oigidffllkfvweh62nl6sy

Medial temporal atrophy in early and late-onset Alzheimer's disease

Enrica Cavedo, Michela Pievani, Marina Boccardi, Samantha Galluzzi, Martina Bocchetta, Matteo Bonetti, Paul M. Thompson, Giovanni B. Frisoni
2014 Neurobiology of Aging  
the Radial Atrophy Mapping technique, hippocampal volume was measured using a manual method.  ...  These findings support the notion that limbic involvement is a prominent feature of LOAD but not EOAD.  ...  According to the hypothesis of a greater MTL system neuropathology in LOAD, we expected to find a specific amygdalar tissue loss in those nuclei connected to the hippocampal formation in LOAD but not in  ... 
doi:10.1016/j.neurobiolaging.2014.03.009 pmid:24721821 pmcid:PMC4053814 fatcat:nemwisjur5ax7isotdtczkvoim

White matter changes in the perforant path area in patients with amyotrophic lateral sclerosis

J. Mollink, M. Hiemstra, K.L. Miller, I.N. Huszar, M. Jenkinson, J. Raaphorst, M. Wiesmann, O. Ansorge, M. Pallebage‐Gamarallage, A.M. van Cappellen van Walsum
2019 Neuropathology and Applied Neurobiology  
The aim of this study was to test the hypothesis that white matter degeneration of the perforant path - as part of the Papez circuit - is a key feature of amyotrophic lateral sclerosis (ALS), even in the  ...  absence of frontotemporal dementia (FTD) or deposition of pTDP-43 inclusions in hippocampal granule cells.  ...  Dederen for instructing in the cutting of the sections for PLI. Also, thanks to C. Grabitz and J. de Ruyter van Steveninck for their laboratory work.  ... 
doi:10.1111/nan.12555 pmid:31002412 pmcid:PMC6852107 fatcat:gq5tc5n4jrfgdndzeubqe4ixca

Automatic Morphological Analysis of Medial Temporal Lobe

Andrea Chincarini, Mirko Corosu, Gianluca Gemme, Piero Calvini, Roberta Monge, Maria Antonietta Penco, Luca Rei, Sandro Squarcia, Patrizia Boccacci, Guido Rodriguez
2010 The Open Nuclear Medicine Journal  
Our main focus is the relevance of the morphological analysis of MTL, and in particular of the hippocampal formation, in making the diagnosis of AD and in distinguishing it from other dementias.  ...  Research in Alzheimer's disease (AD) has seen a tremendous growth of candidate biomarkers in the last decade.  ...  The aim of [24] was to locate in vivo the structural changes within the hippocampal formation in AD patients of mild to moderate severity.  ... 
doi:10.2174/1876388x01002010031 fatcat:qix37g6d4ngoper5be7kzlwuky

The fornix provides multiple biomarkers to characterize circuit disruption in a mouse model of Alzheimer's disease

Alexandra Badea, Lauren Kane, Robert J. Anderson, Yi Qi, Mark Foster, Gary P. Cofer, Neil Medvitz, Anne F. Buckley, Andreas K. Badea, William C. Wetsel, Carol A. Colton
2016 NeuroImage  
In vivo and ex vivo magnetic resonance imaging (MRI) revealed that CVN-AD mice replicate the hippocampal atrophy (6%), characteristic of humans with AD, and also present changes in subcortical areas.  ...  Graphical Abstract One line summary White matter changes in the fimbria/fornix play a role in the progression of AD, and can be used as a biomarker of disease, and as a target for therapy Keywords Alzheimer's  ...  The Center for In Vivo Microscopy is supported through NIH awards P41 EB015897 and 1S10OD010683-01 (to Dr. G Allan Johnson).  ... 
doi:10.1016/j.neuroimage.2016.08.014 pmid:27521741 pmcid:PMC5159324 fatcat:n3tleh6cczcalkhj5qwfz463ga

Early Stage Alterations in White Matter and Decreased Functional Interhemispheric Hippocampal Connectivity in the 3xTg Mouse Model of Alzheimer's Disease

Francis A. M. Manno, Arturo G. Isla, Sinai H. C. Manno, Irfan Ahmed, Shuk Han Cheng, Fernando A. Barrios, Condon Lau
2019 Frontiers in Aging Neuroscience  
The results obtained in this study characterize the early stage changes in interhemispheric hippocampal connectivity in the 3xTg-AD mouse that could represent a translational biomarker to human models  ...  in preclinical stages of the AD.  ...  FM is a doctoral student of the ''Programa de Doctorado en Ciencias Biomédicas, Universidad Nacional Autonoma de México'' (UNAM) and received a fellowship (578458) from ''Consejo Nacional de Ciencia y  ... 
doi:10.3389/fnagi.2019.00039 pmid:30967770 pmcid:PMC6440287 fatcat:56ix4rczt5h2jdwzo5apkwomri

Detection of aberrant hippocampal mossy fiber connections: Ex vivo mesoscale diffusion MRI and microtractography with histological validation in a patient with uncontrolled temporal lobe epilepsy

Michel Modo, T. Kevin Hitchens, Jessie R. Liu, R. Mark Richardson
2015 Human Brain Mapping  
Mesoscopic ex vivo MR imaging hence provides an exciting new avenue to study hippocampi from treatment-resistant patients and allows exploration of existing hypotheses, as well as the development of new  ...  At the macroscale, in vivo MRI often reveals hippocampal atrophy and decreased fractional anisotropy, whereas at the microscopic scale, there frequently is evidence of neuronal loss and gliosis.  ...  In contrast, in shorter delta AD maps subtle signal distortions could occur that lead to a blurring of signal boundaries.  ... 
doi:10.1002/hbm.23066 pmid:26611565 pmcid:PMC4718824 fatcat:wg577ebcw5byzmtuwlywhusrgi

Neuroimaging of Mouse Models of Alzheimer's Disease

Amandine Jullienne, Michelle V. Trinh, Andre Obenaus
2022 Biomedicines  
The goal of this review is to provide the reader with broad framework to guide future studies in existing and future mouse models of AD.  ...  A broad range of mouse models recapitulate certain aspects of the human AD, but no single model simulates the human disease spectrum.  ...  Methods for the generation of MR-derived parametric maps also differ.  ... 
doi:10.3390/biomedicines10020305 pmid:35203515 pmcid:PMC8869427 fatcat:ns6vr5fd7ncdnotye5rmenp63a

Associative memory deficits in mild cognitive impairment: The role of hippocampal formation

M. Atienza, K.C. Atalaia-Silva, G. Gonzalez-Escamilla, E. Gil-Neciga, A. Suarez-Gonzalez, J.L. Cantero
2011 NeuroImage  
Neuropathological events featuring early stages of Alzheimer's disease (AD) appear in the entorhinal cortex (EC), subiculum (SB) and cornu ammonis 1 (CA1) of hippocampus, which may account for associative  ...  Volume changes in EC and hippocampal subfields were determined by using deformation-based morphometry techniques applied to probabilistic cytoarchitectonic maps derived from post mortem human brains.  ...  Acknowledgments We are grateful to all participants for their collaboration in this study.  ... 
doi:10.1016/j.neuroimage.2011.05.047 pmid:21640840 fatcat:cft3qwpt2vag7lko6ykfdcamky

White matter changes in the perforant path in patients with amyotrophic lateral sclerosis [article]

Jeroen Mollink, Marlies Hiemstra, Karla L Miller, Istvan N Huszar, Mark Jenkinson, Joost Raaphorst, Maximilian Wiesmann, Olaf Ansorge, Menuka Pallebage-Gamarallage, Anne-Marie van Cappellen van Walsum
2019 bioRxiv   pre-print
of pTDP-43 inclusions in hippocampal granule cells.  ...  The dMRI results show a significant decrease in fractional anisotropy (p=0.01) and an increase in mean diffusivity (p=0.01), axial diffusivity (p=0.03) and radial diffusivity (p=0.03) in the perforant  ...  Circuit of Papez with a schematic representation of the hippocampal formation.  ... 
doi:10.1101/547588 fatcat:2ncny53sqnbr7iqvfxgmsyovaa

Adult neurogenesis, human after all (again): classic, optimized, and future approaches

Paul J. Lucassen, Carlos P. Fitzsimons, Evgenia Salta, Mirjana Maletic-Savatic
2019 Behavioural Brain Research  
In this perspective article, we reflect on the recent debate about the existence of human neurogenesis and discuss direct, and also indirect, support for the ongoing formation, and functional relevance  ...  , of new neurons in the adult and aged human hippocampus.  ...  Based on this, and given the continued presence of adult neurogenesis in other species, the authors raised questions about the functional relevance of neurogenesis in adult humans [27] .  ... 
doi:10.1016/j.bbr.2019.112458 pmid:31899214 fatcat:tdr7icowbzhcjcakhmnf7f3keq

Influence of APOE Genotype on Hippocampal Atrophy over Time - An N=1925 Surface-Based ADNI Study

Bolun Li, Jie Shi, Boris A. Gutman, Leslie C. Baxter, Paul M. Thompson, Richard J. Caselli, Yalin Wang, Ornit Chiba-Falek
2016 PLoS ONE  
The apolipoprotein E (APOE) e4 genotype is a powerful risk factor for late-onset Alzheimer's disease (AD).  ...  tensor-based morphometry (mTBM) and radial distance.  ...  Data used in preparation of this article were obtained from the  ... 
doi:10.1371/journal.pone.0152901 pmid:27065111 pmcid:PMC4827849 fatcat:kixuu3x6qrc73fdxbc67d355b4

Electroclinical, MRI and neuropathological study of 10 patients with nodular heterotopia, with surgical outcomes

L. Tassi
2004 Brain  
Abbreviations: AD = architectural dysplasia; CB = calbindin; CD = cytoarchitectural dysplasia; CR = calretinin; EEG = electroencephalogram; FLAIR = fluid-attenuated inversion recovery; GFAP = glial fibrillary  ...  acidic protein; IR = inversion recovery; MAP2 = microtubule-associated protein 2; MCD = malformations of cortical development; PV = parvalbumin; SEEG stereo-electroencephalogram; SCH = subcortical heterotopia  ...  RBNE01NR34-008 from the Italian Ministry of Health, and by a grant from the Fondazione Banca del Monte di Lombardia.  ... 
doi:10.1093/brain/awh357 pmid:15618282 fatcat:bq3xcjybgvebncdwe65tpw6le4

In vivo imaging of tau pathology using multi-parametric quantitative MRI

J.A. Wells, J.M. O'Callaghan, H.E. Holmes, N.M. Powell, R.A. Johnson, B. Siow, F. Torrealdea, O. Ismail, S. Walker-Samuel, X. Golay, M. Rega, S. Richardson (+10 others)
2015 NeuroImage  
Here we employ a multi-parametric array of five translatable MRI techniques to characterise the in vivo pathophysiological phenotype of the rTg4510 mouse model of tauopathy (structural imaging, diffusion  ...  We demonstrate that the above markers unambiguously discriminate between the transgenic group and age-matched controls and provide a comprehensive profile of the multifaceted neuropathological processes  ...  The authors also acknowledge the help from Deanna Koeger and Gerald Bricker for co-ordinating the blood pressure studies  ... 
doi:10.1016/j.neuroimage.2015.02.023 pmid:25700953 pmcid:PMC4626540 fatcat:enc5s3mngzhfndudeqlvezeexm

Hippocampal and Amygdalar Local Structural Differences in Elderly Patients with Schizophrenia

Annapaola Prestia, Enrica Cavedo, Marina Boccardi, Cristina Muscio, Andrea Adorni, Cristina Geroldi, Matteo Bonetti, Paul M. Thompson, Giovanni B. Frisoni
2015 The American journal of geriatric psychiatry  
The Radial Atrophy Mapping technique was used to reconstruct the 3D shape of the amygdala and the hippocampus.  ...  The hippocampus showed significant tissue loss in the medio-caudal and antero-lateral aspects of CA1, and in medial section of its left head (pre-and parasubiculum;).  ...  Paul Thompson is supported, in part, by NIH Grants R01EB008281, EB008432, EB007813, AG036535 and AG020098, and by the NIBIB, NCRR, NIA, and NICHD, agencies of the U.S. National Institutes of Health.  ... 
doi:10.1016/j.jagp.2014.01.006 pmid:24534522 pmcid:PMC4382088 fatcat:ni7muh6hgfhdbkjb2vundemevm
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