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Insights of the brain damage response using antibodies identifying surface antigens on neural stem cells and neuroblasts

JoseA Garcia-Sanz, Silvia Santamaria
2015 Neural Regeneration Research  
These antibodies were coupled to magnetic nanoglicoparticles to in vivo identify by magnetic resonance imaging (MRI) neuroblasts or NSCs in their niches, and track their migration in response to brain  ...  In this regard, the presence of CSC was first demonstrated in vivo in glioblastomas, intestinal tumors, and skin cancer, using genetic tracing of the cells (Baker, 2012).  ... 
doi:10.4103/1673-5374.165266 pmid:26692845 pmcid:PMC4660741 fatcat:pmhrwgokzzhbjno4i657xmihz4

Stem cells in drug discovery, regenerative medicine and cancer

C Bart Rountree
2011 Genome Medicine  
Acknowledgements CBR acknowledges funding from the American Cancer Society Research Scholar Award MGO-116519 and the National Institute of Health K08 Award K08DK080928.  ...  Daadi showed that in vivo molecular imaging using functional magnetic resonance imaging (MRI) allows tracking of hES-cell-derived neural progenitors to the source of a brain injury.  ...  Abbreviations hES, human embryonic stem; iPS, induced pluripotent stem; MRI, magnetic resonance imaging, MSCs, mesenchymal stem cells.  ... 
doi:10.1186/gm229 pmid:21418554 pmcid:PMC3092100 fatcat:b3f4dpqvzfguhgygktkvnfp3ue

Chemokine CXC receptor 4-mediated glioma tumor tracking by bone marrow-derived neural progenitor/stem cells

Q. Xu, X. Yuan, M. Xu, F. McLafferty, J. Hu, B. S. Lee, G. Liu, Z. Zeng, K. L. Black, J. S. Yu
2009 Molecular Cancer Therapeutics  
The recognized brain tumor-tracking property of neural progenitor/stem cells opened the possibility of targeting malignant brain tumors using neural progenitor/stem cells.  ...  Elucidating the molecular mechanism of brain tumor tracking by adult source stem cells may provide basis for the development of future targeted therapy for malignant brain tumors.  ...  Acknowledgments We thank Iman Abdulkadir for the technical help in tissue culture and Akop Seksenyan for critically reading this manuscript.  ... 
doi:10.1158/1535-7163.mct-09-0273 pmid:19723878 pmcid:PMC2760002 fatcat:zsts5xdvx5fzvfyn32cmwcjzm4

Magnetic Tagging of Therapeutic Cells for MRI

M. D. Budde, J. A. Frank
2009 Journal of Nuclear Medicine  
Monitoring magnetically labeled cells with MRI has furthered our understanding of cellular migration and the pathophysiology of diseases in experimental models.  ...  Transplantation of stem cells or immune cells has shown promise for the treatment of several diseases.  ...  Magnetically labeled neural stem cells (NSCs) or neural jnm053546-pm n 1/16/09 progenitor cells have been implanted in the normal brains of neonatal or adult animals, in stroke (5, 22) , traumatic brain  ... 
doi:10.2967/jnumed.108.053546 pmid:19164242 pmcid:PMC2633027 fatcat:fz2vqagww5fofbd5qm2p2zihua

Multimodality Molecular Imaging of Stem Cells Therapy for Stroke

Fangfang Chao, Yehua Shen, Hong Zhang, Mei Tian
2013 BioMed Research International  
In this review, we describe existing methods of tracking transplanted stem cells in vivo, including magnetic resonance imaging (MRI), nuclear medicine imaging, and optical imaging (OI).  ...  Because of tissue depth and the blood-brain barrier (BBB), in vivo imaging of stem cells therapy for stroke has unique challenges.  ...  Current imaging modalities have been proposed for in vivo tracking of stem cells transplantation for stroke, including magnetic resonance imaging (MRI), nuclear medicine imaging and optical imaging (OI  ... 
doi:10.1155/2013/849819 pmid:24222920 pmcid:PMC3816035 fatcat:vog7fa3qwrbwdl5ar4xp7ssnlq

Tracking Neural Progenitor Cell Migration in the Rodent Brain Using Magnetic Resonance Imaging

Christiane L. Mallett, Dorela D. Shuboni-Mulligan, Erik M. Shapiro
2019 Frontiers in Neuroscience  
The study of neurogenesis and neural progenitor cells (NPCs) is important across the biomedical spectrum, from learning about normal brain development and studying disease to engineering new strategies  ...  In adult mammals, NPCs proliferate in two main areas of the brain, the subventricular zone (SVZ) and the subgranular zone, and continue to migrate even after neurogenesis has ceased within the rest of  ...  FUNDING Funds for open access publication fees originated from the Department of Radiology, Michigan State University.  ... 
doi:10.3389/fnins.2018.00995 pmid:30686969 pmcid:PMC6337062 fatcat:jani2npy5jcezp3ihswqb4zyya

Live Imaging of Mouse Endogenous Neural Progenitors Migrating in Response to an Induced Tumor

Gema Elvira, Isabel García, Marina Benito, Juan Gallo, Manuel Desco, Soledad Penadés, Jose A. Garcia-Sanz, Augusto Silva, Joseph Najbauer
2012 PLoS ONE  
The Nilo2-mGNP complexes allowed, by magnetic resonance imaging in living animals, the in vivo identification of endogenous neural precursors at their niche, as well as their migration to a lesion site  ...  Aiming to in vivo identify endogenous neural precursor cells migrating towards a brain damage site, the monoclonal antibody Nilo2 recognizing cell surface antigens on neuroblasts, was coupled to magnetic  ...  Martínez for CT-2A cells. We are grateful to the CIB animal facility, confocal microscopy and flow cytometry services at CIB-CSIC. Author Contributions  ... 
doi:10.1371/journal.pone.0044466 pmid:22957072 pmcid:PMC3434138 fatcat:prsmd7rgebfntnyfnh5xpxddtq

Intranasal Delivery of Neural Stem/Progenitor Cells: A Noninvasive Passage to Target Intracerebral Glioma

Matthias Reitz, Maria Demestre, Jan Sedlacik, Hildegard Meissner, Jens Fiehler, Seung U. Kim, Manfred Westphal, Nils Ole Schmidt
2012 Stem Cells Translational Medicine  
Tumor-targeting and migratory pathways of murine and human NSPCs were investigated by intravital magnetic resonance imaging and in histological time course analyses in the intracerebral U87, NCE-G55T2,  ...  We investigated the feasibility of intranasal administration of neural stem/progenitor cells (NSPCs) as an alternative, noninvasive, and direct passage for the delivery of stem cells to target malignant  ...  ACKNOWLEDGMENTS This work was supported by grants of the Deutsche Forschungsgemeinschaft (Schm 1631/3-1, SE 2052/1-1), Hamburger Krebshilfe e.V., and the Stiftung zur Bekämpfung neuroviraler Erkrankungen  ... 
doi:10.5966/sctm.2012-0045 pmid:23283548 pmcid:PMC3659670 fatcat:lnsbbbjnargn5gadzpqnjlcgkm

Stem cells: Implications in the development of brain tumors

I.A. Matos Rojas, D. Bertholdo, M. Castillo
2012 Radiología (English Edition)  
This article reviews the characteristics of non-tumor and tumor stem cells, emphasizing the importance of brain tumor stem cells in the pathogenesis of common brain tumors.  ...  Stem cells in brain tumors also proliferate, undergo self-renewal, and give rise to other poorly differentiated cells.  ...  Magnetic resonance tracking of magnetically labeled autologous bone marrow CD34+ cells transplanted into the spinal cord via lumbar puncture technique in patients with chronic spinal cord injury: CD34+  ... 
doi:10.1016/j.rxeng.2012.07.003 fatcat:gzpv2tv4vrcfzbfrpwhlxwps64

Molecular Imaging in Tracking Tumor Stem-Like Cells

Tian Xia, Han Jiang, Chenrui Li, Mei Tian, Hong Zhang
2012 Journal of Biomedicine and Biotechnology  
of molecular imaging of cancer stem-like cells biomarkers.  ...  The technologies of molecular imaging will reveal mechanisms of cancer progression and provide visual targets for novel therapeutics.  ...  (micro-PET) imaging [42] , cell tracking with magnetic resonance imaging (MRI) after the hepatic progenitor cells labeled with EpCAM microbeads [43] , CD133-specific monoclonal [44] , and so on.  ... 
doi:10.1155/2012/420364 pmid:22570529 pmcid:PMC3335324 fatcat:sfoy27w3mnc4bh6p3jwuj4koga

Tumor initiating cells in malignant gliomas: biology and implications for therapy

Costas G. Hadjipanayis, Erwin G. Van Meir
2009 Journal of Molecular Medicine  
A rare subpopulation of cells within malignant gliomas, which shares canonical properties with neural stem cells (NSCs), may be integral to glial tumor development and perpetuation.  ...  These cells, also known as tumor initiating cells (TICs), have the ability to self-renew, develop into any cell in the overall tumor population (multipotency), and proliferate.  ...  Daniel Brat who kindly provided the microscopic sections of the brain and the immunohistochemistry staining present in Fig. 1 .  ... 
doi:10.1007/s00109-009-0440-9 pmid:19189072 pmcid:PMC2693383 fatcat:ssbrcbcbezhv5dqucd7co6osue

Application of Nanotechnology in Stem-Cell-Based Therapy of Neurodegenerative Diseases

Shima Masoudi Asil, Jyoti Ahlawat, Gileydis Guillama Barroso, Mahesh Narayan
2020 Applied Sciences  
Nanodelivery of functional compounds can enhance the efficiency of neuron therapy by stem cells and development of nanobased techniques for real-time, accurate and long-lasting imaging of stem-cell cycle  ...  Application of nanomaterial in stem-cell culture will be also beneficial to modulation of stem-cell differentiation using nanomedicines.  ...  The magnetic properties of metallic NPs make them useful for magnetic resonance imaging. Loading stem cells with AuNPs can facilitate tracking of transplanted cells in stem-cell therapy procedures.  ... 
doi:10.3390/app10144852 fatcat:lqsyr2onkrhplj6xyoowsgopze

Molecular Imaging in Stem Cell Therapy for Spinal Cord Injury

Fahuan Song, Mei Tian, Hong Zhang
2014 BioMed Research International  
Molecular imaging technology including positron emission tomography (PET), magnetic resonance imaging (MRI), optical imaging (i.e., bioluminescence imaging (BLI)) gives the hope to complete the knowledge  ...  In this paper, we mainly review the molecular imaging technology in stem cell therapy for SCI.  ...  Magnetic Resonance Optical Imaging.  ... 
doi:10.1155/2014/759514 pmid:24701583 pmcid:PMC3950476 fatcat:qbjsq7nhz5h3dgp5di6g63cgvq

Chimeric Animal Models in Human Stem Cell Biology

J. C. Glover, J.-L. Boulland, G. Halasi, N. Kasumacic
2010 ILAR journal  
factors, fusion of host and donor cells, and in vivo imaging and tracking.  ...  It is likely that increasingly sophisticated uses of human/animal chimeric models will be developed through advances in genetic manipulation, cell delivery, and in vivo imaging.  ...  Acknowledgments The authors' work is supported by the Norwegian Research Council through funding of the Norwegian Center for Stem Cell Research and SFI-CAST.  ... 
doi:10.1093/ilar.51.1.62 fatcat:edn6u4srqjf3nk3lexkunechtu

Neural stem cells as novel therapeutic vehicles for genetic therapy in gliomas

Tobias Alécio Mattei, Renata Dal-Prá Ducci, Ricardo Ramina, Paulo Henrique Pires De Aguiar
Recent studies have demonstrated the existence of a small fraction of glioma cells (specially in high-grade tumors) endowed with features of primitive neural progenitor cells and tumor-initiating function  ...  role as novel vehicles for delivery of targeted genetic therapy approaches.  ...  STEM CELL IMAGING TRACKING Superparamagnetic iron oxide (SPIO) nanoparticles are being used for intracellular magnetic labeling of stem cells and other cells in order to monitor cell trafficking by magnetic  ... 
doi:10.22290/jbnc.v19i1.655 fatcat:k5a2z2ehgfbcxc5efvubli2q4u
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