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In vivo imaging of tau pathology using multi-parametric quantitative MRI

J.A. Wells, J.M. O'Callaghan, H.E. Holmes, N.M. Powell, R.A. Johnson, B. Siow, F. Torrealdea, O. Ismail, S. Walker-Samuel, X. Golay, M. Rega, S. Richardson (+10 others)
2015 NeuroImage  
Here we employ a multi-parametric array of five translatable MRI techniques to characterise the in vivo pathophysiological phenotype of the rTg4510 mouse model of tauopathy (structural imaging, diffusion  ...  Tau-induced pathological changes included grey matter atrophy, increased radial diffusivity in the white matter, decreased amide proton transfer and hyperperfusion.  ...  of a multi-parametric imaging biomarker for early detection of tau pathology in the clinic.  ... 
doi:10.1016/j.neuroimage.2015.02.023 pmid:25700953 pmcid:PMC4626540 fatcat:enc5s3mngzhfndudeqlvezeexm

3D Mapping of Neurofibrillary Tangle Burden in the Human Medial Temporal Lobe [article]

Paul A Yushkevich, Mónica Muñoz López, Maria Mercedes Iñiguez de Onzoño Martin, Ranjit Ittyerah, Sydney Lim, Sadhana Ravikumar, Madigan L. Bedard, Stephen Pickup, Weixia Liu, Jiancong Wang, Ling Yu Hung, Jade Lasserve (+28 others)
2021 bioRxiv   pre-print
To address this limitation, ex vivo MRI and dense serial histological imaging in 18 human medial temporal lobe (MTL) specimens were used to construct 3D quantitative maps of NFT burden in the MTL at individual  ...  Our knowledge of the pattern of NFT progression in the human brain, critical to the development of imaging biomarkers and interpretation of in vivo imaging studies in AD, is based on conventional 2D histology  ...  Recent advances in positron emission tomography (PET) imaging enabled in vivo detection and mapping of tau pathology in three dimensions (3D).  ... 
doi:10.1101/2021.01.15.421909 fatcat:s3nobgjpxreancsjqx7hc7nzwy

Tissue magnetic susceptibility mapping as a marker of tau pathology in Alzheimer's disease

J. O'Callaghan, H. Holmes, N. Powell, J.A. Wells, O. Ismail, I.F. Harrison, B. Siow, R. Johnson, Z. Ahmed, A. Fisher, S. Meftah, M.J. O'Neill (+4 others)
2017 NeuroImage  
In this study, we perform Quantitative Susceptibility Mapping (QSM) and T2* mapping in the rTg4510, a mouse model of tauopathy, both in vivo and ex vivo.  ...  The concentration of neurofibrillary tangles was found to be low to intermediate in these brain regions indicating that QSM may be a useful biomarker for early stage detection of tau pathology in neurodegenerative  ...  Scan time could be further reduced using an Echo Planar readout for inclusion in an in-vivo multi-parametric AD imaging protocol (Mesrob et al., 2012; Walhovd et al., 2009; Cherubini et al., 2010; Yang  ... 
doi:10.1016/j.neuroimage.2017.08.003 pmid:28797738 pmcid:PMC5678288 fatcat:gowljys7mvhv3asqcwh5cgzupq

Locus coeruleus imaging as a biomarker for noradrenergic dysfunction in neurodegenerative diseases

2019 Brain  
In combination with neuropathological biomarkers, in vivo locus coeruleus imaging could help to understand the contribution of locus coeruleus neurodegeneration to clinical and pathological manifestations  ...  Novel MRI approaches now provide an opportunity to quantify structural features of the locus coeruleus in vivo during disease progression.  ...  To this end, quantitative (parametric) MRI (Weiskopf et al., 2013) has shown promise by quantifying specific tissue properties in terms of physical units and may now be used for quantitative LC imaging  ... 
doi:10.1093/brain/awz193 pmid:31327002 pmcid:PMC6736046 fatcat:yxdzlopav5aefguycccazxz34a

Quantitative in vivo measurement of early axonal transport deficits in a triple transgenic mouse model of Alzheimer's disease using manganese-enhanced MRI

Jieun Kim, In-Young Choi, Mary L. Michaelis, Phil Lee
2011 NeuroImage  
The data show that impairment in axonal transport is a very early event in AD pathology in these mice, preceding both deposition of Aβ plaques and formation of Tau fibrils.  ...  In this study, we investigated age-dependent alterations in the axonal transport rate in a longitudinal assessment of the triple transgenic mouse olfactory system, using fast multi-sliced T 1 mapping with  ...  Acknowledgments This study was supported in part by the Alzheimer's Association (NIRG-07-60405 to Dr. Lee), the National Institutes of Health (5R21AG027419 to Dr.  ... 
doi:10.1016/j.neuroimage.2011.02.039 pmid:21338698 pmcid:PMC3098472 fatcat:apc3etj4dnarlb3f6g26uhvjry

In vivo characterization and quantification of neurofibrillary tau PET radioligand [18F]MK-6240 in humans from Alzheimer's disease dementia to young controls

Tobey J Betthauser, Karly A Cody, Matthew D Zammit, Dhanabalan Murali, Alexander K Converse, Todd E Barnhart, Charles K Stone, Howard A Rowley, Sterling C Johnson, Bradley T Christian
2018 Journal of Nuclear Medicine  
Parametric SUVR images were used to identify regions of potential off-target binding and to compare binding patterns with neurofibrillary tau staging established in neuropathology literature.  ...  This work investigates in vivo kinetics, quantification strategies and imaging characteristics of a novel tau PET radioligand 18 F-MK-6240 in humans.  ...  Recently, cross-sectional analyses of Aβ and tau PET imaging have indicated these biomarkers follow hierarchical patterns that may be useful for in vivo disease staging (7, 8) .  ... 
doi:10.2967/jnumed.118.209650 pmid:29777006 fatcat:uvjzowoc2bcirnkhp7sixzplc4

Pathological correlates of white matter hyperintensities in a case of progranulin mutation associated frontotemporal dementia

Ione O.C. Woollacott, Martina Bocchetta, Carole H. Sudre, Basil H. Ridha, Catherine Strand, Robert Courtney, Sebastien Ourselin, M. Jorge Cardoso, Jason D. Warren, Martin N. Rossor, Tamas Revesz, Nick C. Fox (+3 others)
2018 Neurocase  
We first performed segmentation and localization analyses of WMH present on cadaveric MRI FLAIR images, then selected five different brain regions directly matched to differing severities of WMH for histological  ...  In vivo and cadaveric MRI showed progressive, asymmetric frontotemporal and parietal atrophy, and asymmetrical WMH predominantly affecting frontal mid-zones.  ...  Acknowledgments The authors acknowledge the support of the  ... 
doi:10.1080/13554794.2018.1506039 pmid:30112957 fatcat:wpespguvhbcrxpnmj4ohgtjjdi

A review of β-amyloid neuroimaging in Alzheimer's disease

Paul A. Adlard, Bob A. Tran, David I. Finkelstein, Patricia M. Desmond, Leigh A. Johnston, Ashley I. Bush, Gary F. Egan
2014 Frontiers in Neuroscience  
Neuroimaging has enabled in vivo visualization of pathological changes in the brain associated with the disease, providing a greater understanding of its pathophysiological development and progression.  ...  Nonetheless, current insights from neuroimaging combined with the elucidation of biochemical and molecular processes in AD are informing the ongoing development of new imaging techniques and their application  ...  Ex vivo MRI scans of matched sections imaged using either a (A) T 2 SE or (D) T * 2 GE pulse sequence.  ... 
doi:10.3389/fnins.2014.00327 pmid:25400539 pmcid:PMC4215612 fatcat:265nreraargevcyzu4cvjaikvq

Usefulness of Multi-Parametric MRI for the Investigation of Posterior Cortical Atrophy

Andrea Arighi, Mario Rango, Marco Bozzali, Anna M. Pietroboni, Giorgio Fumagalli, Laura Ghezzi, Chiara Fenoglio, Pietro R. Biondetti, Nereo Bresolin, Daniela Galimberti, Elio Scarpini, Francisco J. Esteban
2015 PLoS ONE  
In conclusion, this study indicates the potential usefulness of a multi-parametric MRI approach for an early diagnosis and staging of patients with PCA.  ...  The aim of this study was to assess, using quantitative Magnetic Resonance Imaging techniques, the pattern of regional grey matter loss and metabolism in individuals with PCA to improve pathophysiological  ...  In conclusion, within the limitation of a small sample size, this study indicates the potential usefulness of a multi-parametric MRI approach, in combination with CSF biomarkers, for the differential diagnosis  ... 
doi:10.1371/journal.pone.0140639 pmid:26480294 pmcid:PMC4610670 fatcat:hwps6g6tv5cmtph4sysc44gpyq

In vivo tau PET imaging in dementia: Pathophysiology, radiotracer quantification, and a systematic review of clinical findings

Benjamin Hall, Elijah Mak, Simon Cervenka, Franklin I. Aigbirhio, James B. Rowe, John T. O'Brien
2017 Ageing Research Reviews  
Finally, we propose novel directions for future tau research, including (a) longitudinal imaging in preclinical dementia, (b) multi-modal mapping of tau pathology onto other pathological processes such  ...  Recently, it has become possible to assess the regional distribution and severity of tau burden in vivo with the development of novel radiotracers for positron emission tomography (PET) imaging.  ...  MRI, diffusion imaging, FLAIR, functional MRI).  ... 
doi:10.1016/j.arr.2017.03.002 pmid:28315409 fatcat:smfaty5kajflvhl3yadnlwnji4

Amyloid-β, p-tau and reactive microglia are pathological correlates of MRI cortical atrophy in Alzheimer's disease

Irene Frigerio, Baayla D C Boon, Chen-Pei Lin, Yvon Galis-de Graaf, John Bol, Paolo Preziosa, Jos Twisk, Frederik Barkhof, Jeroen J M Hoozemans, Femke H Bouwman, Annemieke J M Rozemuller, Wilma D J van de Berg (+1 others)
2021 Brain Communications  
Moreover, we show that post-mortem in-situ MRI can be used as proxy for ante-mortem in-vivo MRI.  ...  of the pathological underpinnings of MRI atrophic patterns in Alzheimer's disease.  ...  teams, Tjado HJ Morrema and Danae de Gooijer for cutting sections and Martijn Steenwijk for the lesion filling MRI script.  ... 
doi:10.1093/braincomms/fcab281 pmid:34927073 pmcid:PMC8677327 fatcat:zqzs5tu6yjb25k7gv3ttkqg3xa

Biological, Neuroimaging, and Neurophysiological Markers in Frontotemporal Dementia: Three Faces of the Same Coin

Barbara Borroni, Alberto Benussi, Enrico Premi, Antonella Alberici, Elena Marcello, Fabrizio Gardoni, Monica Di Luca, Alessandro Padovani, George Perry, Jesus Avila, Massimo Tabaton, Xiongwei Zhu
2018 Journal of Alzheimer's Disease  
The aim of the present review is to unravel the progress in biomarker discovery, discussing the potential applications of available biological, imaging, and neurophysiological markers.  ...  In the same view, identifying the neuropathological hallmarks of the disease is key in light of future disease-modifying treatments.  ...  Considering FTD, magnetic resonance imaging (MRI) has been widely used for in vivo visualization of brain atrophy in the different clinical phenotypes of FTD, clearly reporting abnormalities in frontal  ... 
doi:10.3233/jad-170584 pmid:29171998 pmcid:PMC5870000 fatcat:dbpqyqpvwrfuzhfpgfmorfgbma

Detecting Microglial Density With Quantitative Multi-Compartment Diffusion MRI

Sue Y. Yi, Brian R. Barnett, Maribel Torres-Velázquez, Yuxin Zhang, Samuel A. Hurley, Paul A. Rowley, Diego Hernando, John-Paul J. Yu
2019 Frontiers in Neuroscience  
We explored the sensitivity of quantitative multi-compartment diffusion MRI, and specifically neurite orientation dispersion and density imaging (NODDI), to detect changes in microglial density in the  ...  Monte Carlo simulations of water diffusion using a NODDI acquisition scheme were performed to measure changes in a virtual MRI signal following modeled cellular changes within the extra-neurite space.  ...  We explored the sensitivity of quantitative multi-compartment diffusion MRI, and specifically neurite orientation dispersion and density imaging (NODDI), to detect changes in microglial density in the  ... 
doi:10.3389/fnins.2019.00081 pmid:30837826 pmcid:PMC6389825 fatcat:bqgcgir6ozhybaixn3iaecgatu

Neuroimaging of Mouse Models of Alzheimer's Disease

Amandine Jullienne, Michelle V. Trinh, Andre Obenaus
2022 Biomedicines  
Here, we provide an overview of the human MRI and PET imaging landscape as a prelude to an in-depth review of preclinical imaging in mice.  ...  We also highlight aspects of MRI and PET imaging that could be improved to increase rigor and reproducibility in future imaging studies.  ...  In summary, the use of T1 and T2 relaxometry imaging could be useful for the rapid assessment of underlying pathology.  ... 
doi:10.3390/biomedicines10020305 pmid:35203515 pmcid:PMC8869427 fatcat:ns6vr5fd7ncdnotye5rmenp63a

In vivo characterization and quantification of neurofibrillary tau PET radioligand [18F]MK-6240 in humans from Alzheimer's disease dementia to young controls [article]

Tobey J Betthauser, Karly A Cody, Matthew D Zammit, Dhanabalan Murali, Alexander K Converse, Todd E Barnhart, Charles K Stone, Howard A Rowley, Sterling C. Johnson, Bradley T Christian
2018 bioRxiv   pre-print
Parametric SUVR images were used to identify regions of potential off-target binding and to compare binding patterns with neurofibrillary tau staging established in neuropathology literature.ResultsStandard  ...  This work investigates in vivo kinetics, quantification strategies and imaging characteristics of a novel tau PET radioligand [18F]MK-6240 in humans.MethodsFifty-one individuals ranging from cognitively  ...  Recently, cross-sectional analyses of Aβ and tau PET imaging have indicated these biomarkers follow hierarchical patterns that may be useful for in vivo disease staging (7, 8) .  ... 
doi:10.1101/290064 fatcat:dzxbgup3hfhojmapx24l2v4yh4
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