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In vivo imaging of tau pathology using multi-parametric quantitative MRI
2015
NeuroImage
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Here we employ a multi-parametric array of five translatable MRI techniques to characterise the in vivo pathophysiological phenotype of the rTg4510 mouse model of tauopathy (structural imaging, diffusion ...
Tau-induced pathological changes included grey matter atrophy, increased radial diffusivity in the white matter, decreased amide proton transfer and hyperperfusion. ...
of a multi-parametric imaging biomarker for early detection of tau pathology in the clinic. ...
doi:10.1016/j.neuroimage.2015.02.023
pmid:25700953
pmcid:PMC4626540
fatcat:enc5s3mngzhfndudeqlvezeexm
3D Mapping of Neurofibrillary Tangle Burden in the Human Medial Temporal Lobe
[article]
2021
bioRxiv
pre-print
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To address this limitation, ex vivo MRI and dense serial histological imaging in 18 human medial temporal lobe (MTL) specimens were used to construct 3D quantitative maps of NFT burden in the MTL at individual ...
Our knowledge of the pattern of NFT progression in the human brain, critical to the development of imaging biomarkers and interpretation of in vivo imaging studies in AD, is based on conventional 2D histology ...
Recent advances in positron emission tomography (PET) imaging enabled in vivo detection and mapping of tau pathology in three dimensions (3D). ...
doi:10.1101/2021.01.15.421909
fatcat:s3nobgjpxreancsjqx7hc7nzwy
Tissue magnetic susceptibility mapping as a marker of tau pathology in Alzheimer's disease
2017
NeuroImage
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In this study, we perform Quantitative Susceptibility Mapping (QSM) and T2* mapping in the rTg4510, a mouse model of tauopathy, both in vivo and ex vivo. ...
The concentration of neurofibrillary tangles was found to be low to intermediate in these brain regions indicating that QSM may be a useful biomarker for early stage detection of tau pathology in neurodegenerative ...
Scan time could be further reduced using an Echo Planar readout for inclusion in an in-vivo multi-parametric AD imaging protocol (Mesrob et al., 2012; Walhovd et al., 2009; Cherubini et al., 2010; Yang ...
doi:10.1016/j.neuroimage.2017.08.003
pmid:28797738
pmcid:PMC5678288
fatcat:gowljys7mvhv3asqcwh5cgzupq
Locus coeruleus imaging as a biomarker for noradrenergic dysfunction in neurodegenerative diseases
2019
Brain
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In combination with neuropathological biomarkers, in vivo locus coeruleus imaging could help to understand the contribution of locus coeruleus neurodegeneration to clinical and pathological manifestations ...
Novel MRI approaches now provide an opportunity to quantify structural features of the locus coeruleus in vivo during disease progression. ...
To this end, quantitative (parametric) MRI (Weiskopf et al., 2013) has shown promise by quantifying specific tissue properties in terms of physical units and may now be used for quantitative LC imaging ...
doi:10.1093/brain/awz193
pmid:31327002
pmcid:PMC6736046
fatcat:yxdzlopav5aefguycccazxz34a
Quantitative in vivo measurement of early axonal transport deficits in a triple transgenic mouse model of Alzheimer's disease using manganese-enhanced MRI
2011
NeuroImage
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The data show that impairment in axonal transport is a very early event in AD pathology in these mice, preceding both deposition of Aβ plaques and formation of Tau fibrils. ...
In this study, we investigated age-dependent alterations in the axonal transport rate in a longitudinal assessment of the triple transgenic mouse olfactory system, using fast multi-sliced T 1 mapping with ...
Acknowledgments This study was supported in part by the Alzheimer's Association (NIRG-07-60405 to Dr. Lee), the National Institutes of Health (5R21AG027419 to Dr. ...
doi:10.1016/j.neuroimage.2011.02.039
pmid:21338698
pmcid:PMC3098472
fatcat:apc3etj4dnarlb3f6g26uhvjry
In vivo characterization and quantification of neurofibrillary tau PET radioligand [18F]MK-6240 in humans from Alzheimer's disease dementia to young controls
2018
Journal of Nuclear Medicine
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Parametric SUVR images were used to identify regions of potential off-target binding and to compare binding patterns with neurofibrillary tau staging established in neuropathology literature. ...
This work investigates in vivo kinetics, quantification strategies and imaging characteristics of a novel tau PET radioligand 18 F-MK-6240 in humans. ...
Recently, cross-sectional analyses of Aβ and tau PET imaging have indicated these biomarkers follow hierarchical patterns that may be useful for in vivo disease staging (7, 8) . ...
doi:10.2967/jnumed.118.209650
pmid:29777006
fatcat:uvjzowoc2bcirnkhp7sixzplc4
Pathological correlates of white matter hyperintensities in a case of progranulin mutation associated frontotemporal dementia
2018
Neurocase
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We first performed segmentation and localization analyses of WMH present on cadaveric MRI FLAIR images, then selected five different brain regions directly matched to differing severities of WMH for histological ...
In vivo and cadaveric MRI showed progressive, asymmetric frontotemporal and parietal atrophy, and asymmetrical WMH predominantly affecting frontal mid-zones. ...
Acknowledgments The authors acknowledge the support of the ...
doi:10.1080/13554794.2018.1506039
pmid:30112957
fatcat:wpespguvhbcrxpnmj4ohgtjjdi
A review of β-amyloid neuroimaging in Alzheimer's disease
2014
Frontiers in Neuroscience
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Neuroimaging has enabled in vivo visualization of pathological changes in the brain associated with the disease, providing a greater understanding of its pathophysiological development and progression. ...
Nonetheless, current insights from neuroimaging combined with the elucidation of biochemical and molecular processes in AD are informing the ongoing development of new imaging techniques and their application ...
Ex vivo MRI scans of matched sections imaged using either a (A) T 2 SE or (D) T * 2 GE pulse sequence. ...
doi:10.3389/fnins.2014.00327
pmid:25400539
pmcid:PMC4215612
fatcat:265nreraargevcyzu4cvjaikvq
Usefulness of Multi-Parametric MRI for the Investigation of Posterior Cortical Atrophy
2015
PLoS ONE
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In conclusion, this study indicates the potential usefulness of a multi-parametric MRI approach for an early diagnosis and staging of patients with PCA. ...
The aim of this study was to assess, using quantitative Magnetic Resonance Imaging techniques, the pattern of regional grey matter loss and metabolism in individuals with PCA to improve pathophysiological ...
In conclusion, within the limitation of a small sample size, this study indicates the potential usefulness of a multi-parametric MRI approach, in combination with CSF biomarkers, for the differential diagnosis ...
doi:10.1371/journal.pone.0140639
pmid:26480294
pmcid:PMC4610670
fatcat:hwps6g6tv5cmtph4sysc44gpyq
In vivo tau PET imaging in dementia: Pathophysiology, radiotracer quantification, and a systematic review of clinical findings
2017
Ageing Research Reviews
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Finally, we propose novel directions for future tau research, including (a) longitudinal imaging in preclinical dementia, (b) multi-modal mapping of tau pathology onto other pathological processes such ...
Recently, it has become possible to assess the regional distribution and severity of tau burden in vivo with the development of novel radiotracers for positron emission tomography (PET) imaging. ...
MRI, diffusion imaging, FLAIR, functional MRI). ...
doi:10.1016/j.arr.2017.03.002
pmid:28315409
fatcat:smfaty5kajflvhl3yadnlwnji4
Amyloid-β, p-tau and reactive microglia are pathological correlates of MRI cortical atrophy in Alzheimer's disease
2021
Brain Communications
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Moreover, we show that post-mortem in-situ MRI can be used as proxy for ante-mortem in-vivo MRI. ...
of the pathological underpinnings of MRI atrophic patterns in Alzheimer's disease. ...
teams, Tjado HJ Morrema and Danae de Gooijer for cutting sections and Martijn Steenwijk for the lesion filling MRI script. ...
doi:10.1093/braincomms/fcab281
pmid:34927073
pmcid:PMC8677327
fatcat:zqzs5tu6yjb25k7gv3ttkqg3xa
Biological, Neuroimaging, and Neurophysiological Markers in Frontotemporal Dementia: Three Faces of the Same Coin
2018
Journal of Alzheimer's Disease
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The aim of the present review is to unravel the progress in biomarker discovery, discussing the potential applications of available biological, imaging, and neurophysiological markers. ...
In the same view, identifying the neuropathological hallmarks of the disease is key in light of future disease-modifying treatments. ...
Considering FTD, magnetic resonance imaging (MRI) has been widely used for in vivo visualization of brain atrophy in the different clinical phenotypes of FTD, clearly reporting abnormalities in frontal ...
doi:10.3233/jad-170584
pmid:29171998
pmcid:PMC5870000
fatcat:dbpqyqpvwrfuzhfpgfmorfgbma
Detecting Microglial Density With Quantitative Multi-Compartment Diffusion MRI
2019
Frontiers in Neuroscience
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We explored the sensitivity of quantitative multi-compartment diffusion MRI, and specifically neurite orientation dispersion and density imaging (NODDI), to detect changes in microglial density in the ...
Monte Carlo simulations of water diffusion using a NODDI acquisition scheme were performed to measure changes in a virtual MRI signal following modeled cellular changes within the extra-neurite space. ...
We explored the sensitivity of quantitative multi-compartment diffusion MRI, and specifically neurite orientation dispersion and density imaging (NODDI), to detect changes in microglial density in the ...
doi:10.3389/fnins.2019.00081
pmid:30837826
pmcid:PMC6389825
fatcat:bqgcgir6ozhybaixn3iaecgatu
Neuroimaging of Mouse Models of Alzheimer's Disease
2022
Biomedicines
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Here, we provide an overview of the human MRI and PET imaging landscape as a prelude to an in-depth review of preclinical imaging in mice. ...
We also highlight aspects of MRI and PET imaging that could be improved to increase rigor and reproducibility in future imaging studies. ...
In summary, the use of T1 and T2 relaxometry imaging could be useful for the rapid assessment of underlying pathology. ...
doi:10.3390/biomedicines10020305
pmid:35203515
pmcid:PMC8869427
fatcat:ns6vr5fd7ncdnotye5rmenp63a
In vivo characterization and quantification of neurofibrillary tau PET radioligand [18F]MK-6240 in humans from Alzheimer's disease dementia to young controls
[article]
2018
bioRxiv
pre-print
Preserved Fulltext
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Parametric SUVR images were used to identify regions of potential off-target binding and to compare binding patterns with neurofibrillary tau staging established in neuropathology literature.ResultsStandard ...
This work investigates in vivo kinetics, quantification strategies and imaging characteristics of a novel tau PET radioligand [18F]MK-6240 in humans.MethodsFifty-one individuals ranging from cognitively ...
Recently, cross-sectional analyses of Aβ and tau PET imaging have indicated these biomarkers follow hierarchical patterns that may be useful for in vivo disease staging (7, 8) . ...
doi:10.1101/290064
fatcat:dzxbgup3hfhojmapx24l2v4yh4
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