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Imaging of Perfusion, Angiogenesis, and Tissue Elasticity after Stroke

Abraham Martín, Emilie Macé, Raphael Boisgard, Gabriel Montaldo, Benoit Thézé, Mickael Tanter, Bertrand Tavitian
2012 Journal of Cerebral Blood Flow and Metabolism  
Blood flow interruption in a cerebral artery causes brain ischemia and induces dramatic changes of perfusion and metabolism in the corresponding territory.  ...  The SWI is a promising novel imaging method for monitoring the evolution of cerebral ischemia over time in animals.  ...  Acknowledgements The authors are grateful to Drs Catherine Vuillemard, PharmD, Nicolas Tournier, PharmD, and Philippe Gervais, PharmD for help in formulation of the radiopharmaceuticals.  ... 
doi:10.1038/jcbfm.2012.49 pmid:22491156 pmcid:PMC3421095 fatcat:nx25wppsr5czrmb6r5sojrkkqy

Photoacoustic imaging for monitoring of stroke diseases: A review

Xi Yang, Yun-Hsuan Chen, Fen Xia, Mohamad Sawan
2021 Photoacoustics  
In this manuscript, we review the achievements and progress of this technology and its applications in stroke and related diseases in small animal models as well as for human brain imaging.  ...  The photoacoustic imaging approach reconstructs images of an object based on the energy excitation by optical absorption and its conversion to acoustic waves, due to corresponding thermoelastic expansion  ...  Apart from the middle cerebral artery of the brain, venous sinus of small animal has also been detected using PAI [74] . Besides, all works use small animal models for preclinical research.  ... 
doi:10.1016/j.pacs.2021.100287 fatcat:rxxyz36w2nfelbz6zjesziaili

Imaging of Small Animal Peripheral Artery Disease Models: Recent Advancements and Translational Potential

Jenny Lin, Evan Phillips, Ti'Air Riggins, Gurneet Sangha, Sreyashi Chakraborty, Janice Lee, Roy Lycke, Clarissa Hernandez, Arvin Soepriatna, Bradford Thorne, Alexa Yrineo, Craig Goergen
2015 International Journal of Molecular Sciences  
While rodents are being used to investigate PAD pathophysiology, imaging of these animal models has been underutilized.  ...  This review focuses on structural and molecular information and disease progression revealed by recent imaging efforts of aortic, cerebral, and peripheral vascular disease models in mice, rats, and rabbits  ...  Acknowledgments We acknowledge Bruno Roseguini, Corey Neu, Corey Berlant, and Jim McMasters for their editing assistance and general comments in our manuscript preparation.  ... 
doi:10.3390/ijms160511131 pmid:25993289 pmcid:PMC4463694 fatcat:o7cqh66t7rfm7ltwrxt77bxsim

Sonosensitive capsules for brain thrombolysis increase ischemic damage in a stroke model

Clara Correa-Paz, María F. Navarro Poupard, Ester Polo, Manuel Rodríguez-Pérez, Martina Migliavacca, Ramón Iglesias-Rey, Alberto Ouro, Elena Maqueda, Pablo Hervella, Tomás Sobrino, José Castillo, Pablo del Pino (+2 others)
2022 Journal of Nanobiotechnology  
In this study, we evaluated the rtPA release of ultrasound (US)-responsive SCs in healthy mice and the therapeutic effect in a thromboembolic stroke model.  ...  To overcome the limitations of rtPA and improve its effectiveness, we recently designed sonosensitive sub-micrometric capsules (SCs) loaded with rtPA with a size of approximately 600 nm, synthesized using  ...  In vivo release of the rtPA from SCs with and without gelatine by US application The in vivo triggering of rtPA release from SCs was initially evaluated in healthy animals.  ... 
doi:10.1186/s12951-022-01252-9 pmid:35062954 pmcid:PMC8780814 fatcat:ztgv4at5cnfubaxoynom566hmi

Spectral Doppler optical coherence tomography imaging of localized ischemic stroke in a mouse model

Lingfeng Yu, Elaine Nguyen, Gangjun Liu, Bernard Choi, Zhongping Chen
2010 Journal of Biomedical Optics  
imaging well suited for small animal studies.  ...  Our in vivo experiments shows that SDOCTI can provide complementary quantified flow information that is an alternative to blood volume measurement, and can be used as a means for cortical microvasculature  ...  Acknowledgments This work is supported by the National Institutes of Health (EB-00293, EB-010090, RR-01192), and the Air Force Office of Science Research (FA9550-04-1-0101) .  ... 
doi:10.1117/1.3505016 pmid:21198180 pmcid:PMC3013149 fatcat:nbjsvpe4bjgn3bzmqdqqfwi3fe

Pressure Drop in Tortuosity/Kinking of the Internal Carotid Artery: Simulation and Clinical Investigation

Lijun Wang, Feng Zhao, Daming Wang, Shen Hu, Jiachun Liu, Zhilun Zhou, Jun Lu, Peng Qi, Shiying Song
2016 BioMed Research International  
Carotid kinking leads to blood pressure reduction. In certain conditions, kinking may affect the cerebral blood supply and be associated with cerebral ischemia.  ...  Whether carotid tortuosity/kinking of the internal carotid artery leads to cerebral ischemia remains unclear.  ...  A decline in MAP may lead to a decrease in the cerebral blood flow.  ... 
doi:10.1155/2016/2428970 pmid:27195283 pmcid:PMC4852326 fatcat:qoogwo27b5b3lhiwex4dc7otku


2008 Cerebrovascular Diseases  
After calibration of the image of ultrasound and MRI using skin marker and probe, BVS system can display an arbitrary cross-section of MRI image corresponding to ultrasound image track-  ...  The patients were performed brain MRI with skin marker attached to the different three points of head, and their MRI volume data were installed in BVS software.  ...  In stroke applications, it would be desirable to avoid the serious side effects of tPA, and it may also be useful to not employ contrast agents.  ... 
doi:10.1159/000143522 fatcat:fs5jcqgkeralbkg35cs6rlvdxu

Transcranial photoacoustic characterization of neurovascular physiology during early-stage photothrombotic stroke in neonatal piglets in vivo [article]

Jeeun Kang, Xiuyun Liu, Suyi Cao, Steven R Zeiler, Ernest M Graham, Emad M Boctor, Raymond C Koehler
2021 bioRxiv   pre-print
In particular, we conclude that the HbO2 saturation metric can be used alone to identify regional stroke lesions.  ...  Perinatal ischemic stroke is estimated to occur in 1/2300-1/5000 live births, but early differential diagnosis from global hypoxia-ischemia is often difficult.  ...  for clinical translation is still limited by the use of the rodents with impractical imaging scale and small signal attenuation with its very thin skull layer.  ... 
doi:10.1101/2021.07.08.451613 fatcat:mopoydgsxng3xluuy75uoxthse

Studies in Rheoencephalography (REG)

Michael Bodo
2010 Journal of Electrical Bioimpedance  
In animal studies, REG was used to monitor the lower limit of cerebral blood flow (CBF) autoregulation (AR) using a newly developed algorithm.  ...  In these studies, REG was compared to known stroke risk factors and to results obtained using carotid ultrasound measurements.  ...  Two milestone contributors of this overview have to mention by names: Emil Pasztor, who initiated REG use for neuro-monitoring, and Frederick Pearce, who made it possible.  ... 
doi:10.5617/jeb.109 fatcat:y74b2bz7o5dbfj4eimcr2i7tzq

Impact of anesthetic agents on cerebrovascular physiology in children

2009 Pediatric Anaesthesia  
The role of the pediatric neuroanesthetist is to provide comprehensive care to children with neurologic pathologies. The cerebral physiology is influenced by the developmental stage of the child.  ...  The understanding of the effects of anesthetic agents on the physiology of cerebral vasculature in the pediatric population has significantly increased in the past decade allowing a more rationale decision  ...  Sodium thiopental is capable of reducing the extent of cerebral damage in focal cerebral ischemia (102, 103) , and in cerebral edema induced by cortical freeze injury in animal studies (104) .  ... 
doi:10.1111/j.1460-9592.2008.02826.x pmid:19040505 fatcat:35au53vqojgv5hxipdjisbcrsy

Focused Ultrasound in Neuroscience. State of the Art and Future Perspectives

Giuseppe Roberto Giammalva, Cesare Gagliardo, Salvatore Marrone, Federica Paolini, Rosa Maria Gerardi, Giuseppe Emmanuele Umana, Kaan Yağmurlu, Bipin Chaurasia, Gianluca Scalia, Federico Midiri, Ludovico La Grutta, Luigi Basile (+7 others)
2021 Brain Sciences  
Moreover, using low-frequencies tcMRgFUS systems temporarily disrupts the blood–brain barrier, making this procedure suitable in neuro-oncology and neurodegenerative disease for controlled drug delivery  ...  Since it is an emerging technology, tcMRgFUS is still the subject of countless disparate studies, even if its effectiveness has been already proven in many experimental and therapeutic fields.  ...  Acknowledgments: We thank the reviewer and the editor for revising this paper and making it successful. Conflicts of Interest: The authors declare no conflict of interest.  ... 
doi:10.3390/brainsci11010084 pmid:33435152 fatcat:dqo2frpfbffifneog2f5c7vxay

Oral Presentations

2007 Cerebrovascular Diseases  
As we know, most substances and drugs that would be potentially useful for treatment of a variety of brain disorders cannot be applied due to their inability to penetrate the blood-brain barrier (BBB).  ...  With the ever expanding diversity of therapeutic ultrasound applications ranging from cell ablation to sonothrombolysis, sonoporation and enhancement of angiogenesis, it is becoming increasingly important  ...  Microvascular perfusion maps provide complementary imaging information on brain ischemia.  ... 
doi:10.1159/000104179 pmid:17708021 fatcat:5eg2g6kklzhmfcyhrnljuhfeze

Advances in Doppler optical coherence tomography and angiography

Yan Li, Jason Chen, Zhongping Chen
2019 Translational Biophotonics  
These functional techniques have been widely used in research and clinical applications, particularly in ophthalmology.  ...  Here, we review the principles, representative methods, and applications of different Doppler OCT techniques, followed by discussion on the innovations, limitations, and future directions of each of these  ...  ACKNOWLEDGMENTS This work is supported by the National Institutes of Health (R01HL-125084, R01HL-127271, R01EY-026091, R01EY-028662), American Heart Association (18PRE34050021), and the National Science  ... 
doi:10.1002/tbio.201900005 pmid:33005888 pmcid:PMC7523705 fatcat:okhwzb4ht5hdnlbypgiy4h5loq

Visualization, imaging and new preclinical diagnostics in radiation oncology

Clemens C Cyran, Philipp M Paprottka, Michel Eisenblätter, Dirk A Clevert, Carsten Rist, Konstantin Nikolaou, Kirsten Lauber, Frederik Wenz, Daniel Hausmann, Maximilian F Reiser, Claus Belka, Maximilian Niyazi
2014 Radiation Oncology  
Functional and molecular imaging techniques allow for the non-invasive characterization of tissues in vivo, using different modalities, including computed tomography (CT), magnetic resonance imaging (MRI  ...  Characterizing the tumor microenvironment prior to and in response to irradiation will help to optimize the outcome of radiotherapy.  ...  soft tissue contrast imaging of tumors in small animal models.  ... 
doi:10.1186/1748-717x-9-3 pmid:24387195 pmcid:PMC3903445 fatcat:4wwmweh6efgwdp6vwysfh3nuba

Portable Near-Infrared Technologies and Devices for Noninvasive Assessment of Tissue Hemodynamics

Lin Hou, Yinqiu Liu, Lixia Qian, Yucong Zheng, Jinnan Gao, Wenxing Cao, Yu Shang
2019 Journal of Healthcare Engineering  
Then, we elaborate on the NIRS instrumentation, either commercially available or custom-made, as well as their applications to physiological studies and clinic.  ...  As one of the portable optical technologies to explore human physiology and assist in healthcare, near-infrared diffuse optical spectroscopy (NIRS) for tissue oxygenation measurement has been developed  ...  For these purposes, animal models were often used to create the relevant diseases, including the cerebral ischemia on rat and mouse [3, 42] , hindlimb ischemia on the mouse [52] , and melanoma tumor  ... 
doi:10.1155/2019/3750495 pmid:30891170 pmcid:PMC6390246 fatcat:kgg6mclmzjgjzb2wmi2y7i5lym
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