7,382 Hits in 8.4 sec

In vivo assessment of myelination by phase imaging at high magnetic field

Gregory A. Lodygensky, José P. Marques, Rajika Maddage, Elodie Perroud, Stéphane V. Sizonenko, Petra S. Hüppi, Rolf Gruetter
2012 NeuroImage  
We conclude that highresolution phase images, acquired at high field, allow assessment of myelination and dysmyelination.  ...  The present study evaluated the potential of using the phase of T 2 * weighted MR images to characterize myelination during brain development and pathology in rodents at 9.4 T.  ...  Acknowledgments This study was supported by Swiss National Fund 33CM30-124101 and 132821, by CIBM of the UNIL, UNIGE, HUG, CHUV, EPFL and the Boninchi, De Reuter, Leenaards and Jeantet Foundations.  ... 
doi:10.1016/j.neuroimage.2011.09.057 pmid:21985911 fatcat:2m5tzuu7vjcrlkazcicjfj5sfm

Research Highlights: Highlights from the latest articles in imaging

R Marc Lebel
2012 Imaging in Medicine  
Evaluation of: Gregory A, Lodygensky GA, Marques JP et al. In vivo assessment of myelination by phase imaging at high magnetic field. Neuroimage 59(and susceptibility maps.  ...  In summary, this work provides important in vivo and ex vivo confirmation of the role of myelin in phase imaging.  ... 
doi:10.2217/iim.12.8 fatcat:ix2it43yn5glrcifknkonk66xq

Chronic Multiple Sclerosis Lesions: Characterization with High-Field-Strength MR Imaging

Bing Yao, Francesca Bagnato, Eiji Matsuura, Hellmut Merkle, Peter van Gelderen, Fredric K. Cantor, Jeff H. Duyn
2012 Radiology  
Purpose: To elucidate the mechanism of magnetic resonance (MR) imaging contrast in multiple sclerosis (MS) lesion appearance by using susceptibility-weighted imaging and to assess with histologic correlation  ...  the role of iron and myelin in generating this MR imaging contrast.  ...  Acknowledgments: We thank Drs Xin Yu and Steve Dodd for their assistances with the imaging at 11.7 T.  ... 
doi:10.1148/radiol.11110601 pmid:22084205 pmcid:PMC3244667 fatcat:iwc574javbe7rc2nr63zdwbzg4

Comparison of Magnetic Susceptibility Tensor and Diffusion Tensor of the Brain

Wei Li, Chunlei Liu
2013 Journal of Neuroscience and Neuroengineering  
Susceptibility tensor imaging (STI) provides a novel approach for noninvasive assessment of the white matter pathways of the brain.  ...  Using mouse brain ex vivo, we compared STI with diffusion tensor imaging (DTI), in terms of tensor values, principal tensor values, anisotropy values, and tensor orientations.  ...  Acknowledgments The study was supported in part by the National Institutes of Health (NIH) through grant R01 MH096979 to C. L and NIBIB P41 EB015897 to Duke Center for In Vivo Microscopy.  ... 
doi:10.1166/jnsne.2013.1075 pmid:25401058 pmcid:PMC4230339 fatcat:urdgbn4rzffu7aglwkzpfmfbhq

Susceptibility tensor imaging (STI) of the brain

Wei Li, Chunlei Liu, Timothy Q. Duong, Peter C. M. van Zijl, Xu Li
2016 NMR in Biomedicine  
echo signal phase on the orientation of biological tissues with respect to the main magnetic field.  ...  STI provides a consistent interpretation of the dependence of phase and susceptibility on orientation at multiple scales.  ...  Acknowledgement This work was supported in part by the National Institutes of Health (NIH) through grants R01 MH096979 and R01NS079653 to CL and P41 EB015909 to PvZ, a Research Grant from the William &  ... 
doi:10.1002/nbm.3540 pmid:27120169 pmcid:PMC5083244 fatcat:oaye4p5ekrcl3dyww7ljlllcv4

Susceptibility induced gray–white matter MRI contrast in the human brain

Christian Langkammer, Nikolaus Krebs, Walter Goessler, Eva Scheurer, Kathrin Yen, Franz Fazekas, Stefan Ropele
2012 NeuroImage  
Contributions of myelin and iron to local variations of the susceptibility were assessed by univariate and multivariate linear regression analysis.  ...  the individual contribution of these factors is limited in vivo.  ...  Acknowledgments This work was supported by the Austrian Science Fund (projects P20103 and P23576).  ... 
doi:10.1016/j.neuroimage.2011.08.045 pmid:21893208 pmcid:PMC3236994 fatcat:orcimzqftfbo3pegih55gznteu

Advances in noninvasive myelin imaging

Florence Heath, Samuel A. Hurley, Heidi Johansen-Berg, Cassandra Sampaio-Baptista
2017 Developmental Neurobiology  
Here, we offer a nontechnical review of MRI techniques developed to specifically monitor myelin such as magnetization transfer (MT) and myelin water imaging (MWI).  ...  This allows for specific monitoring of myelination longitudinally and noninvasively in the healthy brain as well as assessment of treatment and intervention efficacy.  ...  This work was supported by Wellcome Principal Research Fellowship to HJB (WT110027/Z/15/Z).  ... 
doi:10.1002/dneu.22552 pmid:29082667 pmcid:PMC5813152 fatcat:twua2vnmnbfkdlkbvim7kcxbgu

Ultrashort echo time (UTE) magnetic resonance imaging of myelin: technical developments and challenges

Ya-Jun Ma, Hyungseok Jang, Eric Y. Chang, Annie Hiniker, Brian P. Head, Roland R. Lee, Jody Corey-Bloom, Graeme M. Bydder, Jiang Du
2020 Quantitative Imaging in Medicine and Surgery  
Acknowledgments Funding: This study was supported by the National Institutes of Health (R01NS092650).  ...  subtraction by removing the phase error caused by the initial phase offset and phase evolution due to field inhomogeneity (37) .  ...  (38) , and a second step to correct for the phase error induced by B 0 field inhomogeneity.  ... 
doi:10.21037/qims-20-541 pmid:32550129 pmcid:PMC7276362 fatcat:zyqzhrwwzbb2vc4x524npyy73m

In vivo quantification of T2⁎ anisotropy in white matter fibers in marmoset monkeys

Pascal Sati, Afonso C. Silva, Peter van Gelderen, Maria I. Gaitan, Jillian E. Wohler, Steven Jacobson, Jeff H. Duyn, Daniel S. Reich
2012 NeuroImage  
In the present work, we analyzed high-resolution, multi-gradient-echo images of in vivo marmoset brains at 7T, and compared them with ex vivo diffusion tensor images, to show that R 2 * relaxation in white  ...  T 2 * -weighted MRI at high field is a promising approach for studying noninvasively the tissue structure and composition of the brain.  ...  We also thank the Intramural Research Program of NINDS for support.  ... 
doi:10.1016/j.neuroimage.2011.08.064 pmid:21906687 pmcid:PMC3230780 fatcat:mp2ep44pzbfsxkuc3z6rtzt56a

Magnetic susceptibility anisotropy of human brain in vivo and its molecular underpinnings

Wei Li, Bing Wu, Alexandru V. Avram, Chunlei Liu
2012 NeuroImage  
This model provides a consistent interpretation of the orientation dependence of macroscopic magnetic susceptibility in normal mouse brain ex vivo and human brain in vivo and the microscopic origin of  ...  The source of susceptibility anisotropy in white matter is likely to be myelin as evidenced by the loss of anisotropy in the dysmyelinating shiverer mouse brain.  ...  The imaging of mouse brains was carried out at the Center of In Vivo Microscopy of Duke University. In vivo human imaging was conducted at the Brain Imaging and Analysis Center of Duke University.  ... 
doi:10.1016/j.neuroimage.2011.10.038 pmid:22036681 pmcid:PMC3254777 fatcat:ga6ittd2pzhgfo26imjpythvxa

High-Resolution MR Imaging of the Human Brainstem In vivo at 7 Tesla

Andreas Deistung, Andreas Schäfer, Ferdinand Schweser, Uta Biedermann, Daniel Güllmar, Robert Trampel, Robert Turner, Jürgen R. Reichenbach
2013 Frontiers in Human Neuroscience  
We explored the potential of high-resolution magnetic resonance imaging (MRI) at 7 T for depicting the intricate anatomy of the human brainstem in vivo by acquiring and generating images with multiple  ...  In conclusion, high-resolution, multi-contrast MR imaging at 7T is a versatile tool to non-invasively assess the individual anatomy and tissue composition of the human brainstem.  ...  ACKNOWLEDGMENTS We would like to thank Andrew Webb (Gorter Center for High Field MRI, Department of Radiology, Leiden University Medical Center) for providing the dielectric pads as well as Penny  ... 
doi:10.3389/fnhum.2013.00710 pmid:24194710 pmcid:PMC3810670 fatcat:vi55pw3f2ndi7jlbvgtgyigxzm

The contribution of myelin to magnetic susceptibility-weighted contrasts in high-field MRI of the brain

Jongho Lee, Karin Shmueli, Byeong-Teck Kang, Bing Yao, Masaki Fukunaga, Peter van Gelderen, Sara Palumbo, Francesca Bosetti, Afonso C. Silva, Jeff H. Duyn
2012 NeuroImage  
T 2 *-weighted gradient-echo MRI images at high field (≥ 7 Tesla) have shown rich image contrast within and between brain regions.  ...  Comparison of in-vivo and in-vitro data showed that, although tissue T 2 * values were reduced by formalin fixation, gray-white matter frequency contrast was relatively unaffected and fixation had a negligible  ...  Acknowledgments This research was supported (in part) by the Intramural Research Program of the NIH, NINDS. The authors appreciate useful comments from Dr. Hang Joon Jo at NIH.  ... 
doi:10.1016/j.neuroimage.2011.10.076 pmid:22056461 pmcid:PMC3288572 fatcat:bvunqeu4lvfytkth6e33pdny4y

Ex vivo susceptibility-weighted imaging anatomy of canine brain–comparison of imaging and histological sections

Germain Arribarat, Benjamin Cartiaux, Samuel Boucher, Charles Montel, Hélène Gros-Dagnac, Yoann Fave, Patrice Péran, Giovanni Mogicato, Alexandra Deviers
2022 Frontiers in Neuroanatomy  
The imaging protocol was validated by visual inspection of the SWI images that provided a high anatomical detail, as demonstrated by their comparison with corresponding microscopic sections.  ...  Now that access of large domestic mammals to high-field MRI becomes more common, techniques initially implemented for human patients can be used for the structural and functional study of the brain of  ...  Ex vivo susceptibility-weighted imaging The MRI examination was performed at the Toulouse Institute for Brain Sciences, using a high-field 3.0 T MRI scanner (Intera Achieva; Philips, Best, The Netherlands  ... 
doi:10.3389/fnana.2022.948159 pmid:36124091 pmcid:PMC9481421 fatcat:iega72ouqzbtppouz3xlqe3aja

Direct magnitude and phase imaging of myelin using ultrashort echo time (UTE) pulse sequences: A feasibility study

Qun He, Yajun Ma, Shujuan Fan, Hongda Shao, Vipul Sheth, Graeme M. Bydder, Jiang Du
2017 Magnetic Resonance Imaging  
The preliminary results suggest that the IR-UTEsequence allows simultaneous magnitude and phase imaging of myelin in vitro and in vivo.  ...  Both magnitude and phase images were generated for myelin and rubber phantoms as well white matter in vivo using the IR-UTE sequence.  ...  Acknowledgments This study was supported by the National Institutes of Health (R01NS092650).  ... 
doi:10.1016/j.mri.2017.02.009 pmid:28219648 pmcid:PMC5503674 fatcat:2dwp6ykhcbelfbdwi5scskv56e

Monitoring demyelination and remyelination by magnetization transfer imaging in the mouse brain at 9.4 T

Wafaa Zaaraoui, Mathilde Deloire, Michel Merle, Céline Girard, Gérard Raffard, Marc Biran, Matilde Inglese, Klaus G. Petry, Oded Gonen, Bruno Brochet, Jean-Michel Franconi, Vincent Dousset
2008 Magnetic Resonance Materials in Physics, Biology and Medicine  
Objective-The aim of this study was to assess quantitatively structural changes in myelin content occurring during demyelination and remyelination by magnetization transfer imaging (MTI).  ...  Materials and methods-In a reversible model of demyelination with no axonal loss, mice intoxicated by cuprizone were studied by MTI in vivo at 9.4 T.  ...  Acknowledgments This study was supported by ARSEP, ARMA, CNRS, programme Imagerie du Petit Animal and Région Aquitaine.  ... 
doi:10.1007/s10334-008-0141-3 pmid:18779984 pmcid:PMC2598411 fatcat:orbh5eiobrgi3fxrzl7d6tcoty
« Previous Showing results 1 — 15 out of 7,382 results