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In Silico Trial to test COVID-19 candidate vaccines: a case study with UISS platform [article]

Giulia Russo, Marzio Pennisi, Marco Viceconti, Francesco Pappalardo
2020 arXiv   pre-print
UISS is then potentially ready to be used as an in silico trial platform to predict the outcome of vaccination strategy against SARS-CoV-2.  ...  To promptly and rapidly respond to pandemic events, the application of in silico trials can be used for designing and testing medicines against SARS-CoV-2 and speed-up the vaccine discovery pipeline, predicting  ...  ACKNOWLEDGEMENT The authors would like to thank all the researchers that are involved in finding potentially effective vaccines candidates against SARS-CoV-2 virus.  ... 
arXiv:2005.02289v1 fatcat:iswr3tvcwracrhywxlmdsdcxgu

In Silico Trial to test COVID-19 candidate vaccines: a case study with UISS platform [article]

Giulia Russo, Marzio Pennisi, Marco Viceconti, Francesco Pappalardo
2020 bioRxiv   pre-print
Universal Immune System Simulator (UISS) in silico platform is potentially ready to be used as an in silico trial platform to predict the outcome of vaccination strategy against SARS-CoV-2.  ...  To promptly and rapidly respond to pandemic events, the application of in silico trials can be used for designing and testing medicines against SARS-CoV-2 and speed-up the vaccine discovery pipeline, predicting  ...  ACKNOWLEDGEMENT The authors would like to thank all the researchers that are involved in finding potentially effective vaccines candidates against SARS-CoV-2 virus.  ... 
doi:10.1101/2020.05.06.080630 fatcat:q34emx465bf27jgpvbk6rzq2wi

In silico trial to test COVID-19 candidate vaccines: a case study with UISS platform

Giulia Russo, Marzio Pennisi, Epifanio Fichera, Santo Motta, Giuseppina Raciti, Marco Viceconti, Francesco Pappalardo
2020 BMC Bioinformatics  
Universal Immune System Simulator (UISS) in silico platform is potentially ready to be used as an in silico trial platform to predict the outcome of vaccination strategy against SARS-CoV-2.  ...  Here, UISS has been extended to be used as an in silico trial platform to speed-up and drive the discovery pipeline of vaccine against SARS-CoV-2.  ...  As a case study, here we report a first application of UISS in silico platform to provide predictions of the efficacy of a potential therapy against COVID-19 based on a mAb strategy intervention like the  ... 
doi:10.1186/s12859-020-03872-0 pmid:33308153 fatcat:mzimcxouwvavblx2btbrdark2y

A multi-step and multi-scale bioinformatic protocol to investigate potential SARS-CoV-2 vaccine targets

Giulia Russo, Valentina Di Salvatore, Giuseppe Sgroi, Giuseppe Alessandro Parasiliti Palumbo, Pedro A Reche, Francesco Pappalardo
2021 Briefings in Bioinformatics  
The COVID-19 pandemic has highlighted the need to come out with quick interventional solutions that can now be obtained through the application of different bioinformatics software to actively improve  ...  As a working example, we applied this problem solving protocol to predict the cross-reactivity of pre-existing vaccination interventions against SARS-CoV-2.  ...  Funding Horizon 2020 Framework Programme, H2020-EU-3.1.5, In Silico Trial for Vaccine Development, acronym "STriTuVaD" project, grant id number: 777123.  ... 
doi:10.1093/bib/bbab403 pmid:34607353 pmcid:PMC8500048 fatcat:2hgst7w32vepfl2xcqobfhaihe

Exploring the Power and Promise of In Silico Clinical Trials with Application in COVID-19 Infection

Abdelrahman H. Abdelmoneim, Safinaz I. Khalil, Hiba Awadelkareem Osman Fadl, Ayesan Rewane, Sahar G. Elbager
2021 Sudan Journal of Medical Sciences  
Keywords: in silico, clinical trials, COVID-19, SARS-CoV-2, vaccine How  ...  Results: Successful use of in silico trials was observed in many of the reviewed evidence. Conclusion: In silico clinical trials can be used in refining clinical trials for COVID-19 infection.  ...  Acknowledgements The authors would like to thank Israa Isam for helping in designing Figure 1 . Ethical Considerations Not required.  ... 
doi:10.18502/sjms.v16i3.9697 fatcat:qmaw3blnqrfcti2o3mwmbmujru

Toward computational modelling on immune system function

Francesco Pappalardo, Giulia Russo, Pedro A. Reche
2020 BMC Bioinformatics  
The workshop has continued its growing tendency, with a total of 18 accepted papers that have been presented in a full day workshop.  ...  The covered topics range from computer-aided identification of T cell epitopes to the prediction of heart rate variability to prevent brain injuries, from In Silico modeling of Tuberculosis and generation  ...  Acknowledgements The Co-Chairs wish to thank all the program committee members who rapidly managed the review process and contributed to advertise the workshop with their efforts and time.  ... 
doi:10.1186/s12859-020-03897-5 pmid:33308137 fatcat:nkcsqmolsjholihix7ajahg2ry

SIMCor. Deliverable 10.1: In-silico trial impact assessment framework (ECRIN, M12)

Burç Aydin, Christian Ohmann
2021 Zenodo  
Examples and use cases of published in-silico trials are presented as well as existing tools to support in-silico trials described.  ...  In the introductory part a status view on this area is given. The document starts with basic terminology and definitions related to in-silico approaches.  ...  AAPS J. 2017; 19: 1002 44 Russo G, Pennisi, M, Fichera, E et al. In silico trial to test COVID-19 candidate vaccines: a case study with UISS platform.  ... 
doi:10.5281/zenodo.6353627 fatcat:5llrvkyytjbbrfgfw36gumqecu

Immune-checkpoint inhibitors from cancer to COVID‑19: A promising avenue for the treatment of patients with COVID‑19 (Review)

Silvia Vivarelli, Luca Falzone, Francesco Torino, Giuseppa Scandurra, Giulia Russo, Roberto Bordonaro, Francesco Pappalardo, Demetrios Spandidos, Giuseppina Raciti, Massimo Libra
2020 International Journal of Oncology  
treatment of COVID19, in association with the supportive standard care.  ...  This has led to a boom in biomedical research studies at all stages of the pipeline, from the in vitro to the clinical phase.  ...  The authors would like to specially thank Dr Golnar Kolahgar, University of Cambridge, for her support with the English language revision and editing of this manuscript.  ... 
doi:10.3892/ijo.2020.5159 pmid:33491759 pmcid:PMC7864014 fatcat:dnrcctqjwffl5jbguf6uqh2abe