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Bioactive compounds and their libraries: An insight into prospective phytotherapeutics approach for oral mucocutaneous cancers

Henry A. Adeola, Afsareen Bano, Ravina Vats, Amit Vashishtha, Deepika Verma, Deepak Kaushik, Vineet Mittal, Md. Habibur Rahman, Agnieszka Najda, Ghadeer M. Albadrani, Amany A. Sayed, Sameh M. Farouk (+5 others)
2021 Biomedicine and Pharmacotherapy  
Hence, we discuss herein, the potential benefits, opportunities and challenges of using bioactive compound libraries in the management of OMCs.  ...  Hence, there is a pressing demand for the use of cost-effective in silico approaches to identify diagnostic tools and treatment targets for diseases with high burdens in these regions.  ...  Acknowledgements This research work was funded by the Deanship of Scientific Research at Princess Nourah bint Abdulrahman University, through the Fast-track Research Funding Program.  ... 
doi:10.1016/j.biopha.2021.111809 pmid:34144454 fatcat:io5eoytox5b4xfo5753tww27p4

Click Chemistry in Natural Product Modification

Xiang Zhang, Shuning Zhang, Songfeng Zhao, Xuan Wang, Bo Liu, Hongtao Xu
2021 Frontiers in Chemistry  
This paper showcases the state-of-the-art development of click chemistry in natural product modification and summarizes the pharmacological activities of the active derivatives as well as the mechanism  ...  It enables the ready synthesis of diverse sets of natural product derivatives either for the optimization of their drawbacks or for the construction of natural product-like drug screening libraries.  ...  These efforts have led to the discovery of various important clinical drugs, such as anticancer agents (e.g., taxol and doxorubicin), immunosuppressants (e.g., cyclosporine and doxorubicin), antimalarial  ... 
doi:10.3389/fchem.2021.774977 pmid:34869223 pmcid:PMC8635925 fatcat:trkkqm2tyzd2de4325s6fy37oe

Drug Discovery of Plausible Lead Natural Compounds That Target the Insulin Signaling Pathway: Bioinformatics Approaches

Siba Shanak, Najlaa Bassalat, Ahmad Barghash, Sleman Kadan, Mahmoud Ardah, Hilal Zaid, Wen-Bin Shang
2022 Evidence-Based Complementary and Alternative Medicine  
We invite interested researchers to test these compounds as potential novel type II DM drugs and explore their therapeutic mechanisms.  ...  Dozens of antidiabetic natural compounds were reported and tested in vivo, in silico, and in vitro.  ...  of science (HZ and SS).  ... 
doi:10.1155/2022/2832889 pmid:35356248 pmcid:PMC8958086 fatcat:jocmyhk2vjbqdi6qbgjjgrusby

The Role of Epigenetic Modifications in Human Cancers and the Use of Natural Compounds as Epidrugs: Mechanistic Pathways and Pharmacodynamic Actions

Abdelhakim Bouyahya, Hamza Mechchate, Loubna Oumeslakht, Ikrame Zeouk, Sara Aboulaghras, Abdelaali Balahbib, Gokhan Zengin, Mohammad Amjad Kamal, Monica Gallo, Domenico Montesano, Nasreddine El Omari
2022 Biomolecules  
The mechanisms of these substances are specific and pleiotropic and can sometimes be stochastic, and their use as anticancer epidrugs is currently a remarkable avenue in the fight against human cancers  ...  In this work, we aimed to explain the mechanistic involvement of epigenetic pathways in the cancer process, as well as the abilities of natural bioactive compounds isolated from medicinal plants (flavonoids  ...  The lead-like fraction was characterized in terms of chemical space coverage and scaffold composition before docking.  ... 
doi:10.3390/biom12030367 pmid:35327559 pmcid:PMC8945214 fatcat:iwstj7qg7nbzpaojhly7eubmki