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Neuronal dysfunction and disconnection of cortical hubs in nondemented subjects with elevated amyloid-burden
2011
Alzheimer's & Dementia
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Published Version Disruption of functional connectivity between brain regions may represent an early functional consequence of b-amyloid pathology prior to clinical Alzheimer's disease. ...
These results indicate that disruption of functional connectivity and hypometabolism may represent early functional consequences of emerging molecular Alzheimer's disease pathology, evolving prior to clinical ...
Pittsburgh for advice on PiB imaging and analysis, the Massaschusetts Alzheimer's Disease Research Center (ADRC) and Dr Liang Yap for assistance with subject recruitment, Dr Dorene Rentz, Meghan Frey, ...
doi:10.1016/j.jalz.2011.05.176
fatcat:swdtbxgf7vatxezjhmdyh6tfkq
Neuronal dysfunction and disconnection of cortical hubs in non-demented subjects with elevated amyloid burden
2011
Brain
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Published Version Disruption of functional connectivity between brain regions may represent an early functional consequence of b-amyloid pathology prior to clinical Alzheimer's disease. ...
These results indicate that disruption of functional connectivity and hypometabolism may represent early functional consequences of emerging molecular Alzheimer's disease pathology, evolving prior to clinical ...
Pittsburgh for advice on PiB imaging and analysis, the Massaschusetts Alzheimer's Disease Research Center (ADRC) and Dr Liang Yap for assistance with subject recruitment, Dr Dorene Rentz, Meghan Frey, ...
doi:10.1093/brain/awr066
pmid:21490054
pmcid:PMC3102239
fatcat:cr4thtqw7zbjxdfazbkmn6g3ym
Imaging Clinical Subtypes and Associated Brain Networks in Alzheimer's Disease
2022
Brain Sciences
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Alzheimer's disease (AD) does not present uniform symptoms or a uniform rate of progression in all cases. ...
The classification of subtypes can be based on clinical symptoms or patterns of pathological brain alterations. ...
Conflicts of Interest: The author declare no conflict of interest. Brain Sci. 2022, 12, 146 ...
doi:10.3390/brainsci12020146
pmid:35203910
pmcid:PMC8869882
fatcat:c7yypbbjybd3pixelwm4ddb3p4
Is amyloid-β harmful to the brain? Insights from human imaging studies
2015
Brain
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Although the amyloid-b protein associated with the Alzheimer's disease plaque has been detectable in living people for over a decade, its importance in the pathogenesis of Alzheimer's disease is still ...
If amyloid-b is crucial to the development of Alzheimer's disease, it should be associated with other Alzheimer's disease-like neurological changes. ...
Funding This work was supported in part by NIH grant AG034570. ...
doi:10.1093/brain/awv326
pmid:26614753
pmcid:PMC4990654
fatcat:gks652s4szbipco5x2yh56c75i
Region-Specific Hierarchy between Atrophy, Hypometabolism, and -Amyloid (A ) Load in Alzheimer's Disease Dementia
2012
Journal of Neuroscience
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Gray matter atrophy, glucose hypometabolism, and β-amyloid Aβ deposition are well-described hallmarks of Alzheimer's disease, but their relationships are poorly understood. ...
Significant differences in the levels of atrophy, hypometabolism, and Aβ deposition were found in most brain areas, but the hierarchy differed across regions. ...
Moreover, there may also be differences in the sequence of events according to brain regions, as suggested by discrepancies in the regional pattern of atrophy, hypometabolism, and A deposition. ...
doi:10.1523/jneurosci.2170-12.2012
pmid:23152610
pmcid:PMC6794030
fatcat:aemh44m5lrgajglzezgp25w2ju
Advances in functional neuroimaging in dementias and potential pitfalls
2012
Neurology International
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Neuroimaging is continuously advancing at a rapid rate and has progressed from excluding relatively uncommon secondary causes (stroke, tumor) to assisting with early diagnosis and subtype of dementia. ...
Structural imaging has given way to functional, metabolic and receptor imaging. ...
Acknowledgments: presented in part at the 2011 Annual Meeting of the Florida Society of Neurology Lake Buena Vista, Florida September ...
doi:10.4081/ni.2012.e7
pmid:22593811
pmcid:PMC3349962
fatcat:adid33psabfbrkit6omtbhhi5q
Diagnosis of Alzheimer's disease with [18F]PET in mild and asymptomatic stages
2009
Behavioural Neurology
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Particularly, [18F]FDG PET as a marker of regional neuronal function has been demonstrated to represent a most sensitive and specific method for early identification of AD-pathology and thus for prediction ...
Consequently, clinical measures of cognitive impairment, as used for definition of dementia, will not allow early diagnosis of AD-pathology in the mild or asymptomatic stages. ...
The author thanks Nicola Karina for the careful review of the manuscript. ...
doi:10.3233/ben-2009-0228
pmid:19847049
pmcid:PMC5444274
fatcat:ap6qxw6lufbrdo6h75nfehq7ce
Diagnosis of Alzheimer's Disease with [18F]PET in Mild and Asymptomatic Stages
2009
Behavioural Neurology
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Particularly, [18F]FDG PET as a marker of regional neuronal function has been demonstrated to represent a most sensitive and specific method for early identification of AD-pathology and thus for prediction ...
Consequently, clinical measures of cognitive impairment, as used for definition of dementia, will not allow early diagnosis of AD-pathology in the mild or asymptomatic stages. ...
The author thanks Nicola Karina for the careful review of the manuscript. ...
doi:10.1155/2009/276026
fatcat:2rutwjtjgrcwjatgazbm6pbdiu
The link between cardiovascular risk, Alzheimer's disease, and mild cognitive impairment: support from recent functional neuroimaging studies
2014
Revista Brasileira de Psiquiatria
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Conclusion: There is a large body of evidence from functional neuroimaging studies supporting the hypothesis that CVRFs may play a causal role in the pathophysiology of AD. ...
In vivo assessment of AD-related pathology with amyloid imaging techniques provided further evidence linking CVRFs and AD, but there is still limited information resulting from this new technology. ...
Acknowledgements This work was supported by grants number 2012/11898-5 (LKF) and 2012/50329-6 (GFB) from Fundac ¸a ˜o de Amparo a `Pesquisa do Estado de Sa ˜o Paulo (FAPESP). ...
doi:10.1590/1516-4446-2013-1275
pmid:24918525
fatcat:hqqgrldcm5g3lm2dit5nmvrwiq
Measuring Cortical Connectivity in Alzheimer's Disease as a Brain Neural Network Pathology: Toward Clinical Applications
2016
Journal of the International Neuropsychological Society
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and neurophysiological substrates of Alzheimer's disease (AD) as a brain neural network pathology affecting structural and functional cortical connectivity underlying human cognition.Methods:We reviewed ...
Clinical applications of these measures are still limited.Conclusions:Structural and functional (in vivo) cortical connectivity measures represent a reliable marker of cerebral reserve capacity and should ...
Seed-based analysis uses correlations of rs-fMRI spontaneous low-frequency fluctuations between a seed region and the rest of the brain (Figure 1-I) Cortical connectivity in Alzheimer's disease 139 ...
doi:10.1017/s1355617715000995
pmid:26888613
fatcat:ugywcnr6grbbvfmme5l6tzuwqi
Regional disconnection in Alzheimer dementia and amyloid positive MCI: Association of EEG functional connectivity and brain glucose metabolism
2020
Brain Connectivity
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The disconnection hypothesis of Alzheimer's disease (AD) is supported by growing neuroimaging and neurophysiological evidence of altered brain functional connectivity in cognitively impaired individuals ...
Topographical EEG measures of functional connectivity detect regional dysfunction of AD-vulnerable brain areas as evidenced by association and spatial overlap with the cortical glucose hypometabolism in ...
Introduction T he disconnection hypothesis of Alzheimer's disease (AD) has emerged as a result of the growing neuroimaging and neurophysiological evidence of altered brain functional connectivity in cognitively ...
doi:10.1089/brain.2020.0785
pmid:33073602
pmcid:PMC7757561
fatcat:6bcckkjsxng57ohqmxyso4xml4
Resting State Functional Connectivity in Preclinical Alzheimer's Disease
2013
Biological Psychiatry
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a distinctive pattern of amyloid plaque deposition in default mode network regions. ...
as Alzheimer's disease (AD). ...
This would be a particularly valuable tool in the case of Lewy body dementia, which commonly is associated with pathological deposition of brain amyloid. ...
doi:10.1016/j.biopsych.2012.11.028
pmid:23290495
pmcid:PMC3537262
fatcat:msh6yrrburcjbiuosuzungl7bi
Hypermetabolic Cerebellar Connectome in Alzheimer's Disease
2021
Brain Connectivity
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We hypothesize that the hypermetabolic regions are also important in disease pathology in AD. ...
The brain regions with higher BC in AD network showed a progressive increase in FDG uptake over 2 years in prodromal AD patients (n=39). ...
We observed significant decrease in hubness of a few hypometabolic regions in AD network which may be a direct consequence of corticocortical dysconnectivity. ...
doi:10.1089/brain.2020.0937
pmid:34155909
fatcat:6ui2sxstejh4ljw2xlfymbewfu
Dissection of prodromal Alzheimer rsquo s disease
2018
Frontiers in Bioscience
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and low cost has intrigued a wide range of interests. ...
Prodromal stage of AD, a great opportunity for effective treatment and postponing the disease onset, has drawn extensive attention. ...
Consequently, functional MRI has the potential to elucidate the characteristics of prodromal AD and Aβ pathology may be linked to changes of brain functional activity. ...
doi:10.2741/4643
pmid:28930599
fatcat:5yzeruxgl5evpi2buq4qxmezru
Neuroimaging Biomarkers for Alzheimer's Disease
2019
Molecular Neurodegeneration
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Currently, over five million Americans suffer with Alzheimer's disease (AD). In the absence of a cure, this number could increase to 13.8 million by 2050. ...
(e.g. fMRI activity, network correlations), connectivity decline (e.g. diffusion anisotropy), and pathological aggregates (e.g. amyloid and tau PET). ...
MAY is supported by NIA P50AG05146, R21AG049220 and R01AG053555. ...
doi:10.1186/s13024-019-0325-5
pmid:31174557
pmcid:PMC6555939
fatcat:xr6dap7dqvg4fhnnyujvkfor4y
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