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Neuronal dysfunction and disconnection of cortical hubs in nondemented subjects with elevated amyloid-burden

Alex Drzezga, Alex Becker, Koene van Dijk, Aish Sreenivasan, Tanveer Talukdar, Caroline Sullivan, Aaron Schultz, Jorge Sepulcre, Deepti Putcha, Douglas Greve, Keith Johnson, Reisa Sperling
2011 Alzheimer's & Dementia  
Published Version Disruption of functional connectivity between brain regions may represent an early functional consequence of b-amyloid pathology prior to clinical Alzheimer's disease.  ...  These results indicate that disruption of functional connectivity and hypometabolism may represent early functional consequences of emerging molecular Alzheimer's disease pathology, evolving prior to clinical  ...  Pittsburgh for advice on PiB imaging and analysis, the Massaschusetts Alzheimer's Disease Research Center (ADRC) and Dr Liang Yap for assistance with subject recruitment, Dr Dorene Rentz, Meghan Frey,  ... 
doi:10.1016/j.jalz.2011.05.176 fatcat:swdtbxgf7vatxezjhmdyh6tfkq

Neuronal dysfunction and disconnection of cortical hubs in non-demented subjects with elevated amyloid burden

Alexander Drzezga, J. Alex Becker, Koene R. A. Van Dijk, Aishwarya Sreenivasan, Tanveer Talukdar, Caroline Sullivan, Aaron P. Schultz, Jorge Sepulcre, Deepti Putcha, Doug Greve, Keith A. Johnson, Reisa A. Sperling
2011 Brain  
Published Version Disruption of functional connectivity between brain regions may represent an early functional consequence of b-amyloid pathology prior to clinical Alzheimer's disease.  ...  These results indicate that disruption of functional connectivity and hypometabolism may represent early functional consequences of emerging molecular Alzheimer's disease pathology, evolving prior to clinical  ...  Pittsburgh for advice on PiB imaging and analysis, the Massaschusetts Alzheimer's Disease Research Center (ADRC) and Dr Liang Yap for assistance with subject recruitment, Dr Dorene Rentz, Meghan Frey,  ... 
doi:10.1093/brain/awr066 pmid:21490054 pmcid:PMC3102239 fatcat:cr4thtqw7zbjxdfazbkmn6g3ym

Imaging Clinical Subtypes and Associated Brain Networks in Alzheimer's Disease

Karl Herholz
2022 Brain Sciences  
Alzheimer's disease (AD) does not present uniform symptoms or a uniform rate of progression in all cases.  ...  The classification of subtypes can be based on clinical symptoms or patterns of pathological brain alterations.  ...  Conflicts of Interest: The author declare no conflict of interest. Brain Sci. 2022, 12, 146  ... 
doi:10.3390/brainsci12020146 pmid:35203910 pmcid:PMC8869882 fatcat:c7yypbbjybd3pixelwm4ddb3p4

Is amyloid-β harmful to the brain? Insights from human imaging studies

William Jagust
2015 Brain  
Although the amyloid-b protein associated with the Alzheimer's disease plaque has been detectable in living people for over a decade, its importance in the pathogenesis of Alzheimer's disease is still  ...  If amyloid-b is crucial to the development of Alzheimer's disease, it should be associated with other Alzheimer's disease-like neurological changes.  ...  Funding This work was supported in part by NIH grant AG034570.  ... 
doi:10.1093/brain/awv326 pmid:26614753 pmcid:PMC4990654 fatcat:gks652s4szbipco5x2yh56c75i

Region-Specific Hierarchy between Atrophy, Hypometabolism, and -Amyloid (A ) Load in Alzheimer's Disease Dementia

R. La Joie, A. Perrotin, L. Barre, C. Hommet, F. Mezenge, M. Ibazizene, V. Camus, A. Abbas, B. Landeau, D. Guilloteau, V. de La Sayette, F. Eustache (+2 others)
2012 Journal of Neuroscience  
Gray matter atrophy, glucose hypometabolism, and β-amyloid Aβ deposition are well-described hallmarks of Alzheimer's disease, but their relationships are poorly understood.  ...  Significant differences in the levels of atrophy, hypometabolism, and Aβ deposition were found in most brain areas, but the hierarchy differed across regions.  ...  Moreover, there may also be differences in the sequence of events according to brain regions, as suggested by discrepancies in the regional pattern of atrophy, hypometabolism, and A␤ deposition.  ... 
doi:10.1523/jneurosci.2170-12.2012 pmid:23152610 pmcid:PMC6794030 fatcat:aemh44m5lrgajglzezgp25w2ju

Advances in functional neuroimaging in dementias and potential pitfalls

Katherine Standley, Charles Brock, Michael Hoffmann
2012 Neurology International  
Neuroimaging is continuously advancing at a rapid rate and has progressed from excluding relatively uncommon secondary causes (stroke, tumor) to assisting with early diagnosis and subtype of dementia.  ...  Structural imaging has given way to functional, metabolic and receptor imaging.  ...  Acknowledgments: presented in part at the 2011 Annual Meeting of the Florida Society of Neurology Lake Buena Vista, Florida September  ... 
doi:10.4081/ni.2012.e7 pmid:22593811 pmcid:PMC3349962 fatcat:adid33psabfbrkit6omtbhhi5q

Diagnosis of Alzheimer's disease with [18F]PET in mild and asymptomatic stages

Alexander Drzezga
2009 Behavioural Neurology  
Particularly, [18F]FDG PET as a marker of regional neuronal function has been demonstrated to represent a most sensitive and specific method for early identification of AD-pathology and thus for prediction  ...  Consequently, clinical measures of cognitive impairment, as used for definition of dementia, will not allow early diagnosis of AD-pathology in the mild or asymptomatic stages.  ...  The author thanks Nicola Karina for the careful review of the manuscript.  ... 
doi:10.3233/ben-2009-0228 pmid:19847049 pmcid:PMC5444274 fatcat:ap6qxw6lufbrdo6h75nfehq7ce

Diagnosis of Alzheimer's Disease with [18F]PET in Mild and Asymptomatic Stages

Alexander Drzezga
2009 Behavioural Neurology  
Particularly, [18F]FDG PET as a marker of regional neuronal function has been demonstrated to represent a most sensitive and specific method for early identification of AD-pathology and thus for prediction  ...  Consequently, clinical measures of cognitive impairment, as used for definition of dementia, will not allow early diagnosis of AD-pathology in the mild or asymptomatic stages.  ...  The author thanks Nicola Karina for the careful review of the manuscript.  ... 
doi:10.1155/2009/276026 fatcat:2rutwjtjgrcwjatgazbm6pbdiu

The link between cardiovascular risk, Alzheimer's disease, and mild cognitive impairment: support from recent functional neuroimaging studies

Luiz K. Ferreira, Jaqueline H. Tamashiro-Duran, Paula Squarzoni, Fabio L. Duran, Tania C. Alves, Carlos A. Buchpiguel, Geraldo F. Busatto
2014 Revista Brasileira de Psiquiatria  
Conclusion: There is a large body of evidence from functional neuroimaging studies supporting the hypothesis that CVRFs may play a causal role in the pathophysiology of AD.  ...  In vivo assessment of AD-related pathology with amyloid imaging techniques provided further evidence linking CVRFs and AD, but there is still limited information resulting from this new technology.  ...  Acknowledgements This work was supported by grants number 2012/11898-5 (LKF) and 2012/50329-6 (GFB) from Fundac ¸a ˜o de Amparo a `Pesquisa do Estado de Sa ˜o Paulo (FAPESP).  ... 
doi:10.1590/1516-4446-2013-1275 pmid:24918525 fatcat:hqqgrldcm5g3lm2dit5nmvrwiq

Measuring Cortical Connectivity in Alzheimer's Disease as a Brain Neural Network Pathology: Toward Clinical Applications

Stefan Teipel, Michel J. Grothe, Juan Zhou, Jorge Sepulcre, Martin Dyrba, Christian Sorg, Claudio Babiloni
2016 Journal of the International Neuropsychological Society  
and neurophysiological substrates of Alzheimer's disease (AD) as a brain neural network pathology affecting structural and functional cortical connectivity underlying human cognition.Methods:We reviewed  ...  Clinical applications of these measures are still limited.Conclusions:Structural and functional (in vivo) cortical connectivity measures represent a reliable marker of cerebral reserve capacity and should  ...  Seed-based analysis uses correlations of rs-fMRI spontaneous low-frequency fluctuations between a seed region and the rest of the brain (Figure 1-I) Cortical connectivity in Alzheimer's disease 139  ... 
doi:10.1017/s1355617715000995 pmid:26888613 fatcat:ugywcnr6grbbvfmme5l6tzuwqi

Regional disconnection in Alzheimer dementia and amyloid positive MCI: Association of EEG functional connectivity and brain glucose metabolism

Una Smailovic, Thomas Koenig, Irina Savitcheva, Konstantinos Chiotis, Agneta Nordberg, Kaj Blennow, Bengt Winblad, Vesna Jelic
2020 Brain Connectivity  
The disconnection hypothesis of Alzheimer's disease (AD) is supported by growing neuroimaging and neurophysiological evidence of altered brain functional connectivity in cognitively impaired individuals  ...  Topographical EEG measures of functional connectivity detect regional dysfunction of AD-vulnerable brain areas as evidenced by association and spatial overlap with the cortical glucose hypometabolism in  ...  Introduction T he disconnection hypothesis of Alzheimer's disease (AD) has emerged as a result of the growing neuroimaging and neurophysiological evidence of altered brain functional connectivity in cognitively  ... 
doi:10.1089/brain.2020.0785 pmid:33073602 pmcid:PMC7757561 fatcat:6bcckkjsxng57ohqmxyso4xml4

Resting State Functional Connectivity in Preclinical Alzheimer's Disease

Yvette I. Sheline, Marcus E. Raichle
2013 Biological Psychiatry  
a distinctive pattern of amyloid plaque deposition in default mode network regions.  ...  as Alzheimer's disease (AD).  ...  This would be a particularly valuable tool in the case of Lewy body dementia, which commonly is associated with pathological deposition of brain amyloid.  ... 
doi:10.1016/j.biopsych.2012.11.028 pmid:23290495 pmcid:PMC3537262 fatcat:msh6yrrburcjbiuosuzungl7bi

Hypermetabolic Cerebellar Connectome in Alzheimer's Disease

Vinay Gupta, Samuel Booth, Ji Hyun Ko
2021 Brain Connectivity  
We hypothesize that the hypermetabolic regions are also important in disease pathology in AD.  ...  The brain regions with higher BC in AD network showed a progressive increase in FDG uptake over 2 years in prodromal AD patients (n=39).  ...  We observed significant decrease in hubness of a few hypometabolic regions in AD network which may be a direct consequence of corticocortical dysconnectivity.  ... 
doi:10.1089/brain.2020.0937 pmid:34155909 fatcat:6ui2sxstejh4ljw2xlfymbewfu

Dissection of prodromal Alzheimer rsquo s disease

Ying Han
2018 Frontiers in Bioscience  
and low cost has intrigued a wide range of interests.  ...  Prodromal stage of AD, a great opportunity for effective treatment and postponing the disease onset, has drawn extensive attention.  ...  Consequently, functional MRI has the potential to elucidate the characteristics of prodromal AD and Aβ pathology may be linked to changes of brain functional activity.  ... 
doi:10.2741/4643 pmid:28930599 fatcat:5yzeruxgl5evpi2buq4qxmezru

Neuroimaging Biomarkers for Alzheimer's Disease

Freddie Márquez, Michael A. Yassa
2019 Molecular Neurodegeneration  
Currently, over five million Americans suffer with Alzheimer's disease (AD). In the absence of a cure, this number could increase to 13.8 million by 2050.  ...  (e.g. fMRI activity, network correlations), connectivity decline (e.g. diffusion anisotropy), and pathological aggregates (e.g. amyloid and tau PET).  ...  MAY is supported by NIA P50AG05146, R21AG049220 and R01AG053555.  ... 
doi:10.1186/s13024-019-0325-5 pmid:31174557 pmcid:PMC6555939 fatcat:xr6dap7dqvg4fhnnyujvkfor4y
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