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Association of Insulin Resistance with Sodium Valproate Therapy among Epileptic Patient

Md Azizul Haque, Md Rafiqul Islam, Sheikh Mahbub Alam, Muhammad Nazmul Haque, Md Aynul Haque, Niloy Ranjan Roy, Imran Sarker, Md Habibur Rahman
2017 Bangladesh Journal of Neuroscience  
Epilepsy is a common neurological disorder. Sodium valproate is one of the commonest broad spectrum antiepileptic drugs and it is used worldwide. Weight gain is the common side effect which is known to be associated with insulin resistance. The aim of this study was to see the association of sodium valproate therapy with insulin resistance among epileptic patients. Methods: It was a cross-sectional analytical study. Total 102 patients (51 epileptic patients with valproate monotherapy for at
more » ... t one year and another 51 age and sex matched newly diagnosed epileptic patients without any anti-epileptic drugs) were selected in this study. The study was carried out from March 2016 to April 2017 for one year in the epilepsy clinic and outpatient Department of Neurology at Bangabandhu Sheikh Mujib Medical University, Dhaka. Participants underwent anthropometric evaluations and biochemical tests including fasting blood sugar and fasting insulin level. Insulin resistance (IR) index was calculated. Result: In this study mean duration of valproate treatment was 3.12±1.26 years and mean sodium valproate dose was 1133±440.5 mg/day (17.7±6.65 mg/kg/day). This study revealed serum fasting insulin level in valproate group and non-valproate group was 11.05±4.86 (ìU/ml) and 7.39±2.01 (ìU/ml) respectively. Fasting blood glucose was 4.71±0.79 (mmol/L) in valproate group and 4.41±0.62 (mmol/L) in non- valproate group. Calculated IR index in valproate group and non-valproate group was 2.17±0.55 and 1.46±0.39 respectively. IR index, fasting insulin and blood glucose all were significantly higher in valproate group than non- valproate group. This study also revealed mild positive correlation of IR index with dose and duration of valproate treatment. Conclusion: Sodium valproate treated patient had significantly higher IR index than control group. Bangladesh Journal of Neuroscience 2017; Vol. 33 (2): 63-69
doi:10.3329/bjn.v33i2.57519 fatcat:m6lpvmql4bce3g5nzrrj45znra

Challenges in Using ctDNA to Achieve Early Detection of Cancer [article]

Imran S Haque, Olivier Elemento
2017 bioRxiv   pre-print
Early detection of cancer is a significant unmet clinical need. Improved technical ability to detect circulating tumor-derived DNA (ctDNA) in the cell-free DNA (cfDNA) component of blood plasma via next-generation sequencing and established correlations between ctDNA load and tumor burden in cancer patients have spurred excitement about the possibilities of detecting cancer early by performing ctDNA mutation detection. We reanalyze published data on the expected ctDNA allele fraction in
more » ... age cancer and the population statistics of cfDNA concentration to show that under conservative technical assumptions, high-sensitivity cancer detection by ctDNA mutation detection will require either more blood volume (150-300mL) than practical for a routine screen or variant filtering that may be impossible given our knowledge of cancer evolution, and will likely remain out of economic reach for routine population screening without multiple-order-of-magnitude decreases in sequencing cost. Instead, new approaches that integrate ctDNA mutations with multiple other blood-based analytes (such as exosomes, circulating tumor cells, ctDNA epigenetics, metabolites) as well as integration of these signals over time for each individual may be needed.
doi:10.1101/237578 fatcat:aoyk4tikbvgl3moesmbemz62li

Large-Scale Chemical Informatics on GPUs [chapter]

Imran S. Haque, Vijay S. Pande
2011 GPU Computing Gems Emerald Edition  
In this chapter we present the design and optimization of GPU implementations of two popular chemical similarity techniques: Gaussian shape overlay (GSO) and LINGO. GSO involves a data-parallel, arithmetically intensive iterative numerical optimization; we use it to examine issues of thread parallelism, arithmetic optimization, and CPU-GPU transfer overhead minimization. LINGO is a string similarity algorithm that, in its canonical CPU implementation, is bandwidth intensive and branch heavy,
more » ... h limited data parallelism. We present an algorithmic redesign allowing GPU implementation of such a low arithmetic-intensity kernel and discuss techniques for memory optimization that enable large speedup. Source code for the programs described here is available online: PAPER (for Gaussian shape overlay) can be downloaded at under the GPL, and single-instruction, multiple LINGO (SIML) (for LINGO) at under a BSD license. GPU Computing Gems.
doi:10.1016/b978-0-12-384988-5.00002-4 fatcat:hesijgxyjbhc7gswp7nnocpgga

Localized Acral Hypertrophy

Saifullah Khalid, Mohd Faizan, Imran Ahmad, Sabarish Narayanasamy, Ansarul Haque, Ibne Ahmad
2015 Oman Medical Journal  
doi:10.5001/omj.2015.14 pmid:25830006 pmcid:PMC4371455 fatcat:r5lbaoltinhszemkabbjnoyexi

Crystal structure of 4,4′-dinitro-[1,1′-biphenyl]-2-amine

Md. Serajul Haque Faizi, Ashanul Haque, Necmi Dege, Syed Imran Hasan, Mustafa Dege, Valentina A. Kalibabchuk
2017 Acta Crystallographica Section E: Crystallographic Communications  
Serajul Haque Faizi, Ashanul Haque, Necmi Dege, Syed Imran Hasan, Mustafa Dege and Valentina A.  ... 
doi:10.1107/s205698901700408x pmid:28435718 pmcid:PMC5382619 fatcat:y3bipaalmvc3ndkv6ci2wfx6g4

PAPER—Accelerating parallel evaluations of ROCS

Imran S. Haque, Vijay S. Pande
2010 Journal of Computational Chemistry  
Molecule Runtime PAPER-Accelerating Parallel Evaluations of ROCS Haque and Pande • Vol. 00, No. 00 • Journal of Computational Chemistry  ... 
doi:10.1002/jcc.21307 pmid:19421991 fatcat:q4ish6x5dva5nmyoa2rdvc7kwq

SCISSORS: Practical Considerations

Steven M. Kearnes, Imran S. Haque, Vijay S. Pande
2013 Journal of Chemical Information and Modeling  
The SCISSORS method described by Haque and Pande 14, 15 uses similarity relative to a fixed basis set to generate vector representations for molecules that can be used for rapid pairwise comparisons.  ...  Haque 24 noted that small values are more difficult to approximate at low rank due to vector space considerations, which suggests an explanation for the observation that optimal color Tanimoto predictions  ... 
doi:10.1021/ci400264f pmid:24289274 pmcid:PMC4207653 fatcat:mgq5q6encfh6dkangfkbog7s2e

Response to Stoll and Resta

Gabriel A. Lazarin, Imran S. Haque, Shivani Nazareth, Eric A. Evans
2013 Genetics in Medicine  
Lazarin, MS 1 , Imran S. Haque, PhD 1 , Shivani Nazareth, MS 1 and Eric A. Evans, PhD 1 1 Counsyl, South San Francisco, California, USA. Correspondence: Eric A.  ... 
doi:10.1038/gim.2013.19 pmid:23552454 pmcid:PMC3835141 fatcat:hhev7ojwqbfsbjiyuncgjt7ity

Determinants of Firm's Export Performance in China's Automobile Industry

Muhammad Imran, Zhaoquan Jian, Adnan Haque, Mariusz Urbański, Sree Nair
2018 Sustainability  
The automobile industry has significantly contributed towards China's economy. After producing approximately 24.5 million vehicles in 2015, China's automobile industry has achieved its greatest height by emerging worldwide as the top automobile producer. However, China's automobile industry could not sustain this achievement and it witnessed a sudden growth rate decrease in 2016–2017, reflecting their poor export performance. To address this problem, the prime objective of this research is to
more » ... plore the roles of total quality management (TQM), entrepreneurial orientation (EO), export market orientation (EMO), brand orientation (BO) and cleaner production (CP) in firm export performance (FEP). For this reason, a quantitative research approach with cross-sectional research design was adopted by gathering the data from 347 respondents working as export managers at Chinese automobile companies via simple random technique. Partial least square structural equation modeling (PLS-SEM) through software smartPLS-3.2.7 employed to analyze data. Results revealed that the TQM, EO, EMO, BO, and CP has a significant association with FEP. Additionally, findings confirmed CP as a moderating variable that contributes positively to FEP. The research has eminently contributed to the export performance of the automobile industry, specifically in China. It is very beneficial to practitioners in the Chinese automobile industry as it will assist them in regaining and exceeding their record export performance while also contributes to resource-based-view theory.
doi:10.3390/su10114078 fatcat:q5kre57fb5hllh34bmigul3dai

Effect of increasing dietary metabolizable protein on nitrogen efficiency in Holstein dairy cows

Muhammad Imran, Talat Naseer Pasha, Muhammad Qamer Shahid, Imran Babar, Muhammad Naveed ul Haque
2016 Asian-Australasian Journal of Animal Sciences  
Objective: The objective of the study was to determine the effects of increasing levels of meta bolizable protein (MP) on lactation performance and nitrogen (N) efficiencies in lactating dairy cows. Methods : Nine multiparous cows in mid lactation [113±25 days in milk] received three treat ments in a 3×3 Latin square design with a period length of 21 days. The treatments were three diets, designed to provide similar energy and increasing supply of MP (g/d) (2,371 [low], 2,561 [medium], and
more » ... [high] with corresponding crude protein levels [%]) 15.2, 18.4, and 20.9, respectively. Results: Increasing MP supplies did not modify dry matter intake, however, it increased milk protein, fat, and lactose yield linearly. Similarly, fat corrected milk increased linearly (9.3%) due to an increase in both milk yield (5.2%) and milk fat content (7.8%). No effects were observed on milk protein and lactose contents across the treatments. Milk nitrogen efficiency (MNE) decreased from 0.26 to 0.20; whereas, the metabolic efficiency of MP decreased from 0.70 to 0.60 in low to high MP supplies, respectively. The concentration of blood urea nitrogen (BUN) increased linearly in response to increasing MP supplies. Conclusion: Increasing MP supplies resulted in increased milk protein yield; however, a higher BUN and low MNE indicated an efficient utilization of dietary protein at low MP supplies.
doi:10.5713/ajas.16.0564 pmid:28002937 pmcid:PMC5411825 fatcat:n5rczfwi3nfpbh4f6labjndc74

Uncertain Environment and Organizational Performance: The Mediating Role of Organizational Innovation

Misbah Haque, Imran Ali
2016 Asian Social Science  
<p><strong>Purpose: </strong>How to survive<strong> </strong>in dynamic and uncertain business environment?, is one of the biggest<strong> </strong>challenge for corporations today. To answer this question, current study<strong> </strong>examines the role of organizational innovation for improving performance in today's competitive, dynamic and uncertain business environment.<strong></strong></p><p><strong>Design:</strong> The study used structured closed-ended survey questionnaire and data is
more » ... ollected through self-administered technique to increase the response rate. The unit of analysis is the employees working in cellular industry in Pakistan. The analysis techniques includes, validity analysis through confirmatory factor analysis (CFA) reliability analysis through Cronbach alpha, correlation analysis, hypotheses testing utilizing structure equation modeling (SEM) in AMOS software whereas, mediation through method of Baron and Kenny (1986).</p><p><strong>Findings:</strong> Results show that organizational innovation plays the mediating role between uncertain environment and organizational performance. <strong></strong></p><p><strong>Practical implications: </strong>The study proposes<strong> </strong>that organizational innovation is inevitable<strong> </strong>for maintaining organizational performance in uncertain business environment particularly in dynamic industries.</p><p><strong>Originality:</strong> The current study proposed and tested an important conceptual model that explains the mediating role of organizational innovation to enhance the organizational performance in uncertain business environment.</p>
doi:10.5539/ass.v12n9p124 fatcat:gr7djhbqavfclhlw3njicgbgiq

A Fast 3 x N Matrix Multiply Routine for Calculation of Protein RMSD [article]

Imran S Haque, Kyle A Beauchamp, Vijay S Pande
2014 bioRxiv   pre-print
The bottleneck for the rapid calculation of the root-mean-square deviation in atomic coordinates (RMSD) between pairs of protein structures for large numbers of conformations is the evaluation of a (3xN) x (Nx3) matrix product over conformation pairs. Here we describe two matrix multiply routines specialized for the 3xN case that are able to significantly outperform (by up to 3X) off- the-shelf high-performance linear algebra libraries for this computation, reaching machine limits on
more » ... . The routines are implemented in C and Python libraries, and are available at
doi:10.1101/008631 fatcat:ihxoepv6fnbevi4ofmvhcsq4fq

SSCM: A method to analyze and predict the pathogenicity of sequence variants [article]

Sharad Vikram, Matthew D Rasmussen, Eric A Evans, Imran S Haque
2015 bioRxiv   pre-print
The advent of cost-effective DNA sequencing has provided clinics with high-resolution information about patients' genetic variants, which has resulted in the need for efficient interpretation of this genomic data. Traditionally, variant interpretation has been dominated by many manual, time-consuming processes due to the disparate forms of relevant information in clinical databases and literature. Computational techniques promise to automate much of this, and while they currently play only a
more » ... porting role, their continued improvement for variant interpretation is necessary to tackle the problem of scaling genetic sequencing to ever larger populations. Here, we present SSCM-Pathogenic, a genome-wide, allele-specific score for predicting variant pathogenicity. The score, generated by a semi-supervised clustering algorithm, shows predictive power on clinically relevant mutations, while also displaying predictive ability in noncoding regions of the genome.
doi:10.1101/021527 fatcat:lbdroo5q6fb2tgl7sbiy7haj6y

Hepatoprotective Effect of Calotropis procera in Isoniazid and Rifampicin Induced Hepatotoxicity

Noor Kamil, Hafiz Syed Imran-ul-Haque
2014 Pharmacognosy Journal  
Objective: In this study anti-tubercular (Anti-TB) drugs (isoniazid [INH] and rifampicin [RMP]) induced liver toxicity has been studied for the hepatoprotective effect of hydroethanolic extract of Calotropis procera (CP) fl owers in rats. Materials and Methods: Animals were divided into four groups, group A was given normal saline (1 ml/kg), group B received INH (50 mg/kg) and RMP (100 mg/kg) group C received INH (50 mg/kg), RMP (100 mg/kg) and CP (150 mg/kg) orally for 14 days. Results:
more » ... ical markers of liver toxicity such as aspartate aminotransferase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), and bilirubin and tissue histology were done inall groups. Anti-TB drugs (INH 50 mg/kg and RMP 100 mg/kg) have enhanced the ALT, AST, ALP, bilirubin and histological changes in liver, whereas co-administration of anti-TB drugs with CP has reduced these levels within the normal range. Conclusion: Findings of this study showed the hepatoprotective effect of CP against INH and RMP administration to reduce the liver damage for chronic treatment.
doi:10.5530/pj.2014.5.3 fatcat:g3yn57g26raq5d7fdk7c22zubi

Smith-Lemli-Opitz syndrome carrier frequency and estimates of in utero mortality rates [article]

Gabriel A. Lazarin, Imran S Haque, Eric A Evans, James D. Goldberg
2016 bioRxiv   pre-print
Objective: To tabulate individual allele frequencies and total carrier frequency for Smith-Lemli-Opitz syndrome (SLOS) and compare expected versus observed birth incidences. Design: Retrospective analysis of patients from the general population who have undergone carrier screening for SLOS. Setting: Individuals were offered and elected carrier screening in their respective physician's offices. Patients: 262,399 individuals with no indication of family or personal history of Smith-Lemli-Opitz
more » ... drome, primarily US-based, screened for Smith-Lemli-Opitz syndrome mutations as part of an expanded carrier screening panel. Intervention(s): Data on mutations in the DHCR7 gene causing SLOS were analyzed to estimate carrier frequencies in multiple ethnic groups. SLOS birth incidences obtained from existing literature are then compared to our data to estimate the effect of SLOS on fetal survival. Main Outcome Measure(s): Individual and cumulative allele frequencies stratified by self-reported patient ethnicity. Results: SLOS carrier frequency is highest in individuals of Ashkenazi Jewish ancestry (1 in 43) and Northern Europeans (1 in 54). Comparing predicted birth incidence to that observed in published literature suggests that approximately 42% to 88% of affected conceptuses experience fetal demise. Conclusion: SLOS is relatively frequent in certain populations and, due to its impact on fetal survival, merits preconception screening.
doi:10.1101/085084 fatcat:qfrt5heasvehjcdlszr76lyyhq
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