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Improving HIV Early Infant Diagnosis Supply Chains in Sub-Saharan Africa: Models and Application to Mozambique

Jónas Oddur Jónasson, Sarang Deo, Jérémie Gallien
2017 Operations Research  
Yet most countries in sub-Saharan Africa experience significant delays in diagnosis due to operational inefficiencies in early infant diagnosis (EID) networks.  ...  Early diagnosis of HIV among infants born to HIV infected mothers is critical because roughly 50% of untreated infected infants die before the age of two years.  ...  Acknowledgments We thank the National Institute of Health in Mozambique and the Clinton Health Access Initiative for providing data and information regarding the problem setting, in particular Dr.  ... 
doi:10.1287/opre.2017.1646 fatcat:o3mtjrxt6vek7bqyaqo53imwlq

Improving HIV Early Infant Diagnosis Supply Chains in Sub-Saharan Africa: Models and Application to Mozambique

Sarang Deo, JJrrmie Gallien, Jonas Oddur Jonasson
2014 Social Science Research Network  
(EC.4) e-companion to Deo, Gallien, and Jónasson: Improving HIV infant diagnosis supply chains ec3 (Details) (i) Denote the random number of samples for a given shipment from clinic i by X i .  ...  Deo, Gallien, and Jónasson: Improving HIV infant diagnosis supply chains . (a) the approximate waiting time function. (b) the linear segments after 5 iterations.  ... 
doi:10.2139/ssrn.2511549 fatcat:xvsc7yzuo5bfbk3l2r5hic5vgy

HIV point-of-care diagnostics: meeting the special needs of sub-Saharan Africa

Godwin Abazho Aleku, Moses P Adoga, Simon M Agwale
2014 Journal of Infection in Developing Countries  
Sub-Saharan Africa, accounting for 70% of the 35 million people living with HIV worldwide, obviously carries the heaviest burden of the HIV epidemic.  ...  Therefore, quality diagnostics that are easy to use, inexpensive, and amenable for use at point of care (POC) are a dire necessity.  ...  Technologies for early infant diagnosis (EID) Early infant diagnosis (EID) of HIV infection confers substantial benefits to HIV-infected and HIVexposed infants, to their families, and to programs providing  ... 
doi:10.3855/jidc.4664 pmid:25313598 fatcat:3tckqizpejekzlypnxfuqejcwe

Elimination of Mother-To-Child Transmission of HIV Infection: The Drug Resource Enhancement against AIDS and Malnutrition Model

Giuseppe Liotta, Maria Marazzi, Khethimipilo Mothibi, Ines Zimba, Evelyne Amangoua, Esther Bonje, Bernard Bossiky, Precious Robinson, Paola Scarcella, Kebby Musokotwane, Leonardo Palombi, Paola Germano (+11 others)
2015 International Journal of Environmental Research and Public Health  
and solutions for the elimination of HIV vertical transmission in sub-Saharan Africa.  ...  transmission to less than 5% at 24 months of age, as well as maternal mortality and infant mortality in both HIV infected and exposed populations to levels similar to those of uninfected individuals.  ...  Acknowledgements The authors would like to thank all the patients followed in the DREAM program across Africa, the Ministry of Health of Mozambique as well as the multiple volunteers and the Community  ... 
doi:10.3390/ijerph121013224 pmid:26506365 pmcid:PMC4627027 fatcat:xyhr3q7uunhyrh22qgxw3rh2w4

Global Disparities in Hepatitis B Elimination—A Focus on Africa

Mark W. Sonderup, C. Wendy Spearman
2022 Viruses  
Innovations and simplified tools exist in order to achieve elimination, but what is desperately required is the will to implement these strategies through the support of appropriate investment and funding  ...  The strategy, while achievable, has exposed existing global disparities in healthcare systems and their ability to implement such policies.  ...  To contextualize this disparity, there are 52 Fibroscan R machines available in sub-Saharan Africa and several hundred in North Africa.  ... 
doi:10.3390/v14010082 pmid:35062286 pmcid:PMC8777803 fatcat:7etowvzzkzhafmgrfrfniihvre

Medication adherence in pregnant women with human immunodeficiency virus receiving antiretroviral therapy in sub-Saharan Africa: a systematic review

Olumuyiwa Omonaiye, Snezana Kusljic, Pat Nicholson, Elizabeth Manias
2018 BMC Public Health  
This systematic review aimed to examine the enablers and barriers of medication adherence among HIV positive pregnant women in sub-Saharan Africa.  ...  The use of antiretroviral therapy (ART) is a core strategy proposed by the World Health Organization in preventing mother to child transmission (MTCT) of HIV.  ...  The corresponding author had full access to all data in the study and had final responsibility for the decision to submit for publication.  ... 
doi:10.1186/s12889-018-5651-y pmid:29945601 pmcid:PMC6020364 fatcat:xkohdv5honc33i3rbo4mc36dzy

A Multi-Disciplinary Approach to Implementation Science

Rachel Sturke, Christine Harmston, R. J. Simonds, Lynne M. Mofenson, George K. Siberry, D. Heather Watts, James McIntyre, Nalini Anand, Laura Guay, Delivette Castor, Pim Brouwers, Joan D. Nagel
2014 Journal of Acquired Immune Deficiency Syndromes  
In resource-limited countries, interventions to prevent mother-to-child HIV transmission (PMTCT) have not yet realized their full potential health impact, illustrating the common gap between the scientific  ...  Elimination of mother-to-child HIV transmission can only be achieved through understanding of key implementation barriers and successful adaptation of scientifically proven interventions to the local environment  ...  NICHD, NIMH South Africa Mary-Ann Davies Closing the gaps in PMTCT program coverage, early infant diagnosis and treatment NICHD Kenya Carey Farquhar HIV Testing and Educating Male Partners  ... 
doi:10.1097/qai.0000000000000323 pmid:25310124 fatcat:t2uea6yebfg6bfw42bjbr7fdqq

The interesting cross-paths of HIV/AIDS and water in Southern Africa with special reference to South Africa

CL Obi, B Onabolu, MNB Momba, JO Igumbor, J Ramalivahna, PO Bessong, EJ Van Rensburg, M Lukoto, E Green, TB Mulaudzi
2007 Water S.A  
Estimates of the HIV/AIDS epidemic in South Africa vary but attest to a mature and generalised epidemic.  ...  Improving water quality will lead to a decline in child and adult mortality as well as diarrhoeal diseases in people living with HIV/AIDS.  ...  The WHO (2004) noted that in sub-Saharan Africa, sanitation coverage was a mere 36% with only 31% of the rural inhabitants in developing countries having access to improved sanitation as opposed to 73%  ... 
doi:10.4314/wsa.v32i3.5277 fatcat:djtfsoxc6nbrpcjeqf3sacwnqy

Schistosomiasis with a Focus on Africa

Oyime Poise Aula, Donald P. McManus, Malcolm K. Jones, Catherine A. Gordon
2021 Tropical Medicine and Infectious Disease  
Substantial progress has been made in controlling schistosomiasis in some African countries, but the disease still prevails in most parts of sub-Saharan Africa with an estimated 800 million people at risk  ...  Schistosomiasis is a common neglected tropical disease of impoverished people and livestock in many developing countries in tropical Africa, the Middle East, Asia, and Latin America.  ...  Acknowledgments: The authors would like to thank Madeleine Flynn from the Communications and Marketing Department at the QIMR Berghofer Medical Research Institute for her assistance in producing the figures  ... 
doi:10.3390/tropicalmed6030109 pmid:34206495 fatcat:qll535i3sbd6zpsl2pdfk7eiyq

Role of public-private partnerships in achieving UNAIDS HIV treatment targets

Ritu Shrivastava, Peter N. Fonjungo, Yenew Kebede, Rajendra Bhimaraj, Shabnam Zavahir, Christina Mwangi, Renuka Gadde, Heather Alexander, Patricia L. Riley, Andrea Kim, John N. Nkengasong
2019 BMC Health Services Research  
Despite progress towards achieving UNAIDS 90-90-90 goals, barriers persist in laboratory systems in sub-Saharan Africa (SSA) restricting scale up of early infant diagnosis (EID) and viral load (VL) test  ...  PPP contributions to laboratory systems strengthening are a model and present opportunities that can be leveraged to strengthen systems to achieve the UNAIDS 90-90-90 treatment targets for HIV/AIDS.  ...  Acknowledgements The authors would like to thank Joanna M. Taliano, librarian at Center for Disease Control and Prevention, Atlanta, USA for helping in the literature search.  ... 
doi:10.1186/s12913-018-3744-z fatcat:mz646yj5grb5np4g5qbcg3jiti

Integrated maternal and child health services in Mozambique: structural health system limitations overshadow its effect on follow-up of HIV-exposed infants

Diederike Geelhoed, Yves Lafort, Élder Chissale, Baltazar Candrinho, Olivier Degomme
2013 BMC Health Services Research  
The follow-up of HIV-exposed infants remains a public health challenge in many Sub-Saharan countries.  ...  Regular technical support and adequate basic working conditions are essential for improved performance in the follow-up of HIV-exposed infants in peripheral public healthcare facilities in Mozambique.  ...  Acknowledgements We thank the Flemish International Cooperation Agency (FICA) for funding this study within the project 'Integrated Network for the Fight against HIV/SIDA/STI in Tete Province, Mozambique  ... 
doi:10.1186/1472-6963-13-207 pmid:23758816 pmcid:PMC3679935 fatcat:z6k7gp5snvgafgtvlz6u53fcge

Pandemics and Burden of Stroke and Epilepsy in Sub-Saharan Africa: Experience from a Longstanding Health Programme

Massimo Leone, Fausto Ciccacci, Stefano Orlando, Sandro Petrolati, Giovanni Guidotti, Noorjehan Abdul Majid, Victor Tamba Tolno, JeanBaptiste Sagno, Darlington Thole, Fabio Massimo Corsi, Michelangelo Bartolo, Maria Cristina Marazzi
2021 International Journal of Environmental Research and Public Health  
Eighty percent of people with stroke live in low- to middle-income nations, particularly in sub-Saharan Africa (SSA) where stroke has increased by more than 100% in the last decades.  ...  Disease Relief through Excellent and Advanced Means (DREAM) is a health programme active since 2002 to prevent and treat HIV/AIDS and related disorders in 10 SSA countries.  ...  Acknowledgments: We wish to thank Giuseppe Liotta for his valuable suggestions and Silvia Bordoni for assistance with the English.  ... 
doi:10.3390/ijerph18052766 pmid:33803352 fatcat:ntjn5ltjjrhadcvkokd5o3d344

Sustainable HIV treatment in Africa through viral-load-informed differentiated care

Andrew Phillips, Amir Shroufi, Lara Vojnov, Jennifer Cohn, Teri Roberts, Tom Ellman, Kimberly Bonner, Christine Rousseau, Geoff Garnett, Valentina Cambiano, Fumiyo Nakagawa, Deborah Ford (+37 others)
2015 Nature  
In most countries in sub-Saharan Africa, measurement of viral load is not widely available.  ...  Currently, the most feasible approach to begin to measure viral load in many There are inefficiencies in current approaches to monitoring patients on antiretroviral therapy in sub-Saharan Africa.  ...  ACKNOWLEDGEMENTS Funding for the study was received from the HIV Modelling Consortium, the Bill and Melinda Gates Foundation, the World Health Organization and the HIV Diagnostics Modelling Consortium.  ... 
doi:10.1038/nature16046 pmid:26633768 pmcid:PMC4932825 fatcat:nch7nlcervapbn7blytwdcrzoq

POC CD4 Testing Improves Linkage to HIV Care and Timeliness of ART Initiation in a Public Health Approach: A Systematic Review and Meta-Analysis

Lara Vojnov, Jessica Markby, Caroline Boeke, Lindsay Harris, Nathan Ford, Trevor Peter, Pierre Roques
2016 PLoS ONE  
We conducted a systematic review and meta-analysis to identify the extent to which POC improves linkages to HIV care and timeliness of ART initiation.  ...  Random effects models were used to estimate pooled risk ratios, pooled proportions, and 95% confidence intervals. Results We identified 30 eligible studies, most of which were completed in Africa.  ...  The included studies spanned eight countries, most within sub-Saharan Africa. All studies were conducted between 2009 and 2015.  ... 
doi:10.1371/journal.pone.0155256 pmid:27175484 pmcid:PMC4866695 fatcat:2knewjwi25cepalqsuk626ubzu

Preparing national tiered laboratory systems and networks to advance diagnostics in Africa and meet the continent's health agenda: Insights into priority areas for improvement

Pascale Ondoa, Nqobile Ndlovu, Mah-Sere Keita, Marguerite Massinga-Loembe, Yenew Kebede, Collins Odhiambo, Teferi Mekonen, Aytenew Ashenafi, Amha Kebede, John Nkengasong
2020 African Journal of Laboratory Medicine  
input in data collection and analysis.  ...  Acknowledgements The authors thank the African Society for Laboratory Medicine and the Africa Centres for Disease Control and Prevention team members Samba Diallo, Edwin Shumba and Anafi Mataka for their  ...  assessed, only 40% had the capacity to conduct culture or polymerase chain reaction-based tuberculosis diagnosis, 11% and 34% could perform HIV drug resistance genotyping and early infant diagnosis, and  ... 
doi:10.4102/ajlm.v9i2.1103 pmid:33102173 pmcid:PMC7565058 fatcat:ne5oqclnz5adpmlj5bvboronnq
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