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Improved segmentation of deep brain grey matter structures using magnetization transfer (MT) parameter maps
2009
NeuroImage
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We demonstrate improved automated segmentation of putamen, pallidum, pulvinar and substantia nigra using MT images. ...
Currently available structural T1-weighted (T1w) magnetic resonance images do not provide sufficient contrast for reliable automated segmentation of various subcortical grey matter structures. ...
To this end, we used parameter maps based on magnetization transfer (MT) contrast. ...
doi:10.1016/j.neuroimage.2009.03.053
pmid:19344771
pmcid:PMC2694257
fatcat:odlwvq4ajffj3eo3qqrgv76h3u
Voxel-Based quantitative MRI reveals spatial patterns of grey matter alteration in multiple sclerosis
2020
Human Brain Mapping
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(qMRI) parameters-magnetization transfer (MT) saturation, longitudinal (R1), and effective transverse (R2*) relaxation rates, derived from data acquired during a single scanning session. ...
The qMRI maps were computed and segmented in different tissue classes. ...
Voxel-based analysis of grey matter magnetization transfer ratio maps in early relapsing remitting multiple sclerosis. ...
doi:10.1002/hbm.25274
pmid:33155763
pmcid:PMC7856642
fatcat:eshdgoc7rngrpg6uxyjspzzifq
Expanding the clinical phenotypes of MT-ATP6 mutations
2014
Human Molecular Genetics
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To correct this bias, we have performed a screening of the MT-ATP6 gene in a large collection of patients suspected of suffering different mitochondrial DNA (mtDNA) disorders. ...
Two of them in patients showing phenotypes that have not been commonly associated to mutations in the MT-ATP6 gene. ...
Computerized tomography scan and magnetic resonance imaging (MRI) showed cerebellum and brainstem atrophy and diffuse increased signal on cerebellar white matter. ...
doi:10.1093/hmg/ddu339
pmid:24986921
fatcat:jfg3xhfanbcehetf325i6zxe54
Technical Note: Simultaneous Segmentation and Relaxometry for MRI through Multitask Learning
2019
Medical Physics (Lancaster)
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2019 pre-print arXiv:1911.12389v1 fatcat:zrjtnbizgzclvoevch6f6g34oy
The proposed multitask learning method can directly generate brain apparent T1 and T2 maps, as well as synthetic T1- and T2-weighted images, in conjunction with segmentation of gray matter, white matter ...
This study demonstrated a magnetic resonance (MR) signal multitask learning method for three-dimensional (3D) simultaneous segmentation and relaxometry of human brain tissues. ...
results in general, with slightly improved gray matter separation in the cortex (arrows in Fig. 6 ); while FAST is better at some deep brain structures, i.e., putamen and the head of caudate. ...
doi:10.1002/mp.13756
pmid:31396973
pmcid:PMC6800607
fatcat:eyvagxub4fby7m2xq2rrjxledi
Synthetic quantitative MRI through relaxometry modelling
2016
NMR in Biomedicine
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The synthetic MT map is shown to provide improved segmentation of deep grey matter structures, relative to segmentation using T 1 -weighted images or R 1 maps. ...
In the second application, a map of magnetization transfer (MT) saturation is synthesized without the need to acquire an MT-weighted volume, which directly leads to a reduction in the specific absorption ...
improved segmentation of deep grey matter (GM) structures. 12 These segmentation benefits are of great clinical importance because changes in regions such as the basal ganglia are associated with a ...
doi:10.1002/nbm.3658
pmid:27753154
pmcid:PMC5132086
fatcat:gdeqyoesdbgh5ib77hn7yfpldm
Regional specificity of MRI contrast parameter changes in normal ageing revealed by voxel-based quantification (VBQ)
2011
NeuroImage
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Using a whole-brain approach in a cohort of 26 adults, aged 18-85 years, we performed voxel-based morphometric (VBM) analysis and voxel-based quantification (VBQ) of diffusion tensor, magnetization transfer ...
(MT), R1, and R2* relaxation parameters. ...
We took advantage of a more reliable characterisation of subcortical structures based on automated tissue classification using MT maps with exquisite contrast between GM and WM in deep brain regions . ...
doi:10.1016/j.neuroimage.2011.01.052
pmid:21277375
pmcid:PMC3093621
fatcat:ff53tqdqdbhp7a4vuozx77gr3e
Mt Everest trek causes impaired cardiac high energy phosphate metabolism and diastolic impairment
2009
Journal of Cardiovascular Magnetic Resonance
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The use of ICDs in this large patient population is still limited by high costs and possible adverse events including inappropriate discharges and progression of heart failure. ...
Journal of Cardiovascular Magnetic Resonance 2009, 11(Suppl 1):O1 Introduction: Prophylactic implantation of a cardioverter/ defibrillator (ICD) has been shown to reduce mortality in patients with chronic ...
Conclusion: We presented a robust, accurate and efficient method for the fully automatic delineation of the myocardium contours in LA + SA cine CMR images, which can be used for accurate LV functional ...
doi:10.1186/1532-429x-11-s1-o6
fatcat:d7ji776ko5ahvewxejrzp5uew4
Whole brain and deep gray matter structure segmentation: Quantitative comparison between MPRAGE and MP2RAGE sequences
2021
PLoS ONE
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Objective T1-weighted MRI images are commonly used for volumetric assessment of brain structures. ...
This study aimed to quantitatively assess the agreement of whole brain tissue and deep GM (DGM) volumes obtained from MP2RAGE compared to the widely used MP-RAGE sequence. ...
This can be achieved mainly by segmenting the brain structures based on T1-weighted, T2-weighted, proton density (PD), magnetic transfer (MT), or multi-contrasts [3, 4] . ...
doi:10.1371/journal.pone.0254597
pmid:34358242
pmcid:PMC8345829
fatcat:cfihzqdrwrekrnvthdy6shydby
Brain and Spinal Cord MRI in Multiple Sclerosis: an Update
2017
Neurology International Open
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Quantitative MRI methods and ultra-high-field MRI offer the opportunity for the quantitative assessment of damage in normal-appearing brain tissue. ...
However, the standardization of these techniques with the goal of implementation in clinical routine will be one of the major challenges in the near future. ...
Conflict of interest M. P. Wattjes received consultancy and speaking fees from Biogen, Genzyme, IXICO, Novartis, Roche. P. Raab has nothing to disclose. ...
doi:10.1055/s-0043-118111
fatcat:4db5qma5gnakdidzen24wa7oou
Studying cyto and myeloarchitecture of the human cortex at ultra-high field with quantitative imaging: R 1 , R 2 * and magnetic susceptibility
2017
NeuroImage
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While both R 1 and R 2 * maps decrease monotonically from the white matter to the pial surface due to the decrease of myelin and iron between these regions, magnetic susceptibility maps have a more complex ...
regions, suggesting these features could be used for individual cortical brain parcellation. ...
The authors would like to thank Daniel Gallichan for sequence development support, Tim van Mourik for providing the software to calculate equi-volume depth segmentation of the cortical maps, Jonathan Polimeni ...
doi:10.1016/j.neuroimage.2016.12.009
pmid:27939794
fatcat:st7wxajt6rf7ffecu5c2wfco5y
Flexible proton density (PD) mapping using multi-contrast variable flip angle (VFA) data
2019
NeuroImage
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The multi-contrast PD values homogeneity and accuracy within the cerebrospinal fluid (CSF) and deep brain structures are increased beyond that obtained using PD* maps. ...
within tissue class of the final map. ...
Aiming to utilise all available data, we employed all the contrasts for the PD map estimation including the magnetization transfer (MT) weighted scan in the MPM protocol. ...
doi:10.1016/j.neuroimage.2018.11.023
pmid:30465865
pmcid:PMC7611405
fatcat:t3vdexztkfhujmrp6akieqrneq
Childhood socio‐economic disadvantage predicts reduced myelin growth across adolescence and young adulthood
2020
Human Brain Mapping
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This association was observed for magnetization transfer in cortical, subcortical and core white matter regions, and also in key subcortical nuclei. ...
(MT), a myelin-sensitive marker, in 288 participants (149 female) between 14 and 25 years of age at baseline. ...
For this purpose, we used nonlinear registration to obtain normalised (grey and white matter) tissue segment maps using both within-and between-subjects modulation. ...
doi:10.1002/hbm.25024
pmid:32432383
pmcid:PMC7375075
fatcat:x6vpq7t7fbgbhppwy44rsskcim
hMRI – A toolbox for quantitative MRI in neuroscience and clinical research
2019
NeuroImage
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) that can be used for quantitative parameter analysis and accurate delineation of subcortical brain structures. ...
This toolbox allows the estimation of high-quality multi-parameter qMRI maps (longitudinal and effective transverse relaxation rates R1 and R2⋆, proton density PD and magnetisation transfer MT saturation ...
(2009)
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MT
49 C
Improved segmentation of deep brain grey matter structures using magnetisation
transfer saturation (MT) parameter maps. ...
doi:10.1016/j.neuroimage.2019.01.029
pmid:30677501
pmcid:PMC6547054
fatcat:6m7s4t2vajhshgybudevhuh3bi
Monitoring Progressive Multiple Sclerosis with Novel Imaging Techniques
2018
Neurology and Therapy
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Advanced imaging techniques that have the advantage of metrics with increased sensitivity to short-term tissue changes and increased specificity to the structural abnormalities characteristic of PMS have ...
magnetic resonance imaging techniques and (3) discuss recent advancements and future perspectives in monitoring PMS with imaging techniques. ...
Advanced MRI Techniques Magnetization Transfer imaging Magnetization transfer (MT) MRI provides an index, called the MT ratio (MTR), whose values reflect the efficiency of the magnetization exchange between ...
doi:10.1007/s40120-018-0103-2
pmid:29956263
fatcat:5atggmvtjredddx237lqlkwejq
Neuroimaging Correlates of Cognitive Dysfunction in Adults with Multiple Sclerosis
2021
Brain Sciences
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Cognitive impairment is a frequent and meaningful symptom in multiple sclerosis (MS), caused by the accrual of brain structural damage only partially counteracted by effective functional reorganization ...
correlates of cognitive impairment in adults with MS, focusing on the mechanisms sustaining damage accrual and on the identification of useful imaging markers of cognitive decline. ...
Conflicts of Interest: The authors declare no conflict of interest. ...
doi:10.3390/brainsci11030346
pmid:33803287
fatcat:4jfvrxiabvcitifwvhosdkdggm
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