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Centiloid scaling for quantification of brain amyloid with [18F]flutemetamol using multiple processing methods

Mark R. Battle, Lovena Chedumbarum Pillay, Val J. Lowe, David Knopman, Bradley Kemp, Christopher C. Rowe, Vincent Doré, Victor L. Villemagne, Christopher J. Buckley
2018 EJNMMI Research  
A standardised method for quantifying β-amyloid PET tracers would allow comparison across different tracers and different sites.  ...  Here, we apply the Centiloid method to [18F]flutemetamol and [11C]PiB (PiB, Pittsburgh compound B) PET images and derive the scaling factor to express their binding in Centiloids.  ...  ., for his discussions and review of the manuscript. 3 Austin Health, Melbourne, Australia.  ... 
doi:10.1186/s13550-018-0456-7 pmid:30519791 pmcid:PMC6281542 fatcat:yfogcgwj2rabza7ay3r3lucwbq

Higher Coffee Consumption Is Associated With Slower Cognitive Decline and Less Cerebral Aβ-Amyloid Accumulation Over 126 Months: Data From the Australian Imaging, Biomarkers, and Lifestyle Study

Samantha L. Gardener, Stephanie R. Rainey-Smith, Victor L. Villemagne, Jurgen Fripp, Vincent Doré, Pierrick Bourgeat, Kevin Taddei, Christopher Fowler, Colin L. Masters, Paul Maruff, Christopher C. Rowe, David Ames (+2 others)
2021 Frontiers in Aging Neuroscience  
Aβ-amyloid-mediated oxidative stress and inflammatory processes.  ...  Higher baseline coffee consumption was also associated with slower Aβ-amyloid accumulation over 126 months, and lower risk of progressing to "moderate," "high," or "very high" Aβ-amyloid burden status  ...  Imaging with PET was conducted using 11C-PiB, 18F-NAV4694, or 18F-flutemetamol at the Western Australia PET and Cyclotron Service, Sir Charles Gairdner Hospital, and Oceanic Medical Imaging, Perth.  ... 
doi:10.3389/fnagi.2021.744872 pmid:34867277 pmcid:PMC8641656 fatcat:nw2l7uivsjcjpj5xpbzm7zlpm4

Understanding emerging biomarkers and lifestyle factors in aging and Alzheimer disease

Stephanie Schultz
This model was also used for generating the rate of change for cortical thickness,18F-FDG PET, and PiB-PET, for each individual (for plotting purposes).  ...  Amyloid-β-PET imaging was done using a bolus injection of ¹¹C-PiB. Acquisition consisted of a 70-min scan starting at injection or a 30-min scan beginning 40 min after injection.  ...  Furthermore, when we re-examined the relationship between neuroticism and tau-PET SUVRs, accounting for Aβ levels, results remained the same for select regions, including the amygdala, with a trend towards  ... 
doi:10.7936/2y01-5674 fatcat:3iazsq77krhe5awbbzgyo42kkm