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Dopaminergic medication reduces striatal sensitivity to negative outcomes in Parkinson's disease [article]

Brónagh McCoy, Sara Jahfari, Gwenda Engels, Tomas Knapen, Jan Theeuwes
2018 bioRxiv   pre-print
During learning, medication in PD reduced an overemphasis on negative outcomes.  ...  Reduced levels of dopamine in Parkinson's disease (PD) contribute to changes in learning, resulting from the loss of midbrain dopamine neurons that transmit a teaching signal to the striatum.  ...  The motor part of the Unified Parkinson's Disease Rating Scale (UPDRS III) was carried out before 1033 each fMRI session. An overview of several test scores is provided in the table below.  ... 
doi:10.1101/445528 fatcat:p2i4yasknverboimmcv5qvmrje

Parkinson's disease and dopaminergic therapy—differential effects on movement, reward and cognition

J. B. Rowe, L. Hughes, B. C. P. Ghosh, D. Eckstein, C. H. Williams-Gray, S. Fallon, R. A. Barker, A. M. Owen
2008 Brain  
Nineteen patients were studied in relative 'on' and 'off' states, induced by dopaminergic medication withdrawal (Hoehn and Yahr stages 1^4).  ...  We used a bimodality continuous performance task during fMRI to examine how patients with Parkinson's disease represent the prospect of reward and switch between competing task rules accordingly.  ...  Acknowledgements We are grateful to all our participants, especially the patients who voluntarily withdrew from their medication in order to participate.  ... 
doi:10.1093/brain/awn112 pmid:18577547 pmcid:PMC2494617 fatcat:qfdjgzgyefc4jjn6izltv2iomq

Temporal dynamics of basal ganglia under-recruitment in Parkinson's disease: transient caudate abnormalities during updating of working memory

P. Marklund, A. Larsson, E. Elgh, J. Linder, K. A. Riklund, L. Forsgren, L. Nyberg
2008 Brain  
foci in caudate nuclei, putamen and globus pallidus in Parkinson's disease patients, which indicates suboptimal phasic implementation of striatal D 2 -dependent gating mechanisms during updating.  ...  Parkinson's disease.  ...  This research was supported by grants from The Swedish Medical Research Council, The Parkinson Foundation in Sweden, The Swedish Association of Persons with Neurological Disabilities, The University of  ... 
doi:10.1093/brain/awn309 pmid:19036762 fatcat:lvdnvk4aojhp7jb2muz4jc5nzm

The role of dopamine in the brain - lessons learned from Parkinson's disease

David Meder, Damian Marc Herz, James Benedict Rowe, Stéphane Lehéricy, Hartwig Roman Siebner
2018 NeuroImage  
The core impairment of dopaminergic neurotransmission has motivated the use of functional magnetic resonance imaging (fMRI) in patients with Parkinson's disease to elucidate the role of dopamine in motor  ...  Despite these ambiguities, fMRI studies in Parkinson's disease demonstrated a central role of dopamine in the generation of movement vigour (bradykinesia) and the control of excessive movements (dyskinesia  ...  HRS holds a full professorship in precision medicine at the Faculty of Health and Medical Sciences, University of Copenhagen, sponsored by the Lundbeck Foundation.  ... 
doi:10.1016/j.neuroimage.2018.11.021 pmid:30465864 fatcat:p6uqi3krb5cx3h6avkka67zrxy

Linking brain activity during sequential gambling to impulse control in Parkinson's disease

Brian N. Haagensen, Damian M. Herz, David Meder, Kristoffer H. Madsen, Annemette Løkkegaard, Hartwig R. Siebner
2020 NeuroImage: Clinical  
Dopaminergic treatment may impair the ability to suppress impulsive behaviours in patients with Parkinson's disease, triggering impulse control disorders.  ...  Patients performed a sequential gambling task while being ON and OFF their regular dopaminergic treatment.  ...  These funding sources were not involved in the design, data collection or interpretation of the study. Appendix A.  ... 
doi:10.1016/j.nicl.2020.102330 pmid:32688307 pmcid:PMC7369593 fatcat:dh2bg5rl7nfgnovfkmdxxm3xci

Reward sensitivity and action in parkinson's disease patients with and without apathy

Kinan Muhammed, Michael Ben Yehuda, Daniel Drew, Sanjay Manohar, Masud Husain
2021 Brain Communications  
disease tested ON and OFF dopaminergic medication.  ...  An oculomotor task that measures pupillary and saccadic response to monetary incentives was used to assess reward sensitivity, first in 23 young and 18 elderly controls, and then in 22 patients with Parkinson's  ...  Parkinson's disease patients were tested ON and OFF their normal dopaminergic medication.  ... 
doi:10.1093/braincomms/fcab022 pmid:33855297 pmcid:PMC8024004 fatcat:krf5zr7vtrbzpiv6mjkxozvbiu

Identifying the neural correlates of doorway freezing in Parkinson's disease

Elie Matar, James M. Shine, Moran Gilat, Kaylena A. Ehgoetz Martens, Philip B. Ward, Michael J. Frank, Ahmed A. Moustafa, Sharon L. Naismith, Simon J. G. Lewis
2019 Human Brain Mapping  
Patients underwent testing randomised between both their "ON" and "OFF" medication states.  ...  Freezing of gait (FOG) in Parkinson's disease (PD) is frequently triggered upon passing through narrow spaces such as doorways.  ...  The patients underwent neurological examination using section III of the Unified Parkinson's Disease Rating Scale (UPDRS; (Goetz et al., 2007) in their ON and OFF states just prior to entering the scanner  ... 
doi:10.1002/hbm.24506 pmid:30637883 fatcat:5p2yugsaf5bgtgwru7c4inejsy

Reward learning deficits in Parkinson's disease depend on depression [article]

Monique HM Timmer, Guillaume Sescousse, Marieke E van der Schaaf, Rianne AJ Esselink, Roshan Cools
2016 bioRxiv   pre-print
Depression is one of the most common and debilitating non-motor symptoms of Parkinson's disease (PD).  ...  (fMRI) in 22 non-depressed PD patients and 19 PD patients with past or present PD-related depression.  ...  Acknowledgements We would like to thank all participants for their cooperation in the study. Furthermore, we are grateful to Dr.  ... 
doi:10.1101/069062 fatcat:ch2mkp4tsnbzrbnn2azhiat62q

Attention to action in Parkinson's disease

James Rowe, Klaas Enno Stephan, Karl Friston, Richard Frackowiak, Andrew Lees, Richard Passingham
2002 Brain  
disconnection between the prefrontal cortex and the supplementary and premotor cortex in Parkinson's disease.  ...  = statistical parametric mapping; UPDRS = Uni®ed Parkinson's Disease Rating Scale.  ...  Neuropsychometric testing of patients has suggested impairments on tests sensitive to frontal lobe damage (Lange et al., 1993; Stam et al., 1993; Owen et al., 1997) , proportional to the reduction in  ... 
doi:10.1093/brain/awf036 pmid:11844728 fatcat:aaifa4bpxzdf3pmoc43c7n2ru4

Reward learning deficits in Parkinson's disease depend on depression

M. H. M. Timmer, G. Sescousse, M. E. van der Schaaf, R. A. J. Esselink, R. Cools
2017 Psychological Medicine  
Depression is one of the most common and debilitating non-motor symptoms of Parkinson's disease (PD).  ...  Conclusions The present findings demonstrate that impairments in reversal learning from reward v. punishment and associated striatal signalling depend on the presence of (a history of) depression in PD  ...  However, the behavioural pattern (across both patient groups) observed in the current study was more akin to that seen in previous studies when patients were in an OFF rather than an ON state, suggesting  ... 
doi:10.1017/s0033291717000769 pmid:28374660 fatcat:yprebuk4kzbqboafiatgsqk4fu

The cognitive functions of the caudate nucleus

Jessica A. Grahn, John A. Parkinson, Adrian M. Owen
2008 Progress in Neurobiology  
Performance of patients with Parkinson's disease on the Tower of London test of planning when 'on' and 'off' L-Dopa medication (right).  ...  Performance of patients with mild Parkinson's disease on the Tower of London test of planning (left).  ... 
doi:10.1016/j.pneurobio.2008.09.004 pmid:18824075 fatcat:fbpqz62o5rge7b4rpbjeclk7le

Placebo response in Parkinson's disease: Comparisons among 11 trials covering medical and surgical interventions

Christopher G. Goetz, Joanne Wuu, Michael P. McDermott, Charles H. Adler, Stanley Fahn, Curt R. Freed, Robert A. Hauser, Warren C. Olanow, Ira Shoulson, P.K. Tandon, Sue Leurgans
2008 Movement Disorders  
我々はこれまでの PD 試験に,妥当性の 確立している転帰評価尺度として Unified Parkinson's Disease Rating Scale(UPDRS)Part Ⅰ Ⅰ Ⅰ (運動)スコアを用 いたプラセボ効果の厳密な定義を適用した。  ...  ポジティブな期待感,意欲,目新しいこ とへの反応を司る神経経路にはドパミン作動性の活性化 が関与しているため 2,3 ,パーキンソン病(Parkinson's disease; PD)患者に認められる高いポジティブ・プラセ ボ反応率には特別な関心が寄せられている 4,5 。プラセボ 介入時のポジティブ反応率には,患者関連ならびに試験 関連の様々な因子が影響する可能性がある。  ...  Acknowledgments: This study was supported by NIH Grant (1 R21AT001440-91A2). Acknowledgments: This study was supported by NIH Grant (1 R21AT001440-91A2).  ... 
doi:10.1002/mds.21894 pmid:18228568 fatcat:tjffymj43jeohbjsrkl24qkzem

Living with Parkinson's and the Emerging Role of Occupational Therapy

Jelka Jansa, Ana Aragon
2015 Parkinson's Disease  
to the complex pathology and personal, domestic, and social impacts, affecting the functioning of Parkinson's disease patients on a daily basis.  ...  The purpose of this work is to outline the role of occupational therapy clinical practice in the management of people living with Parkinson's disease and its emergent evidence base, combined with details  ...  Acknowledgments This paper was inspired by CPPF and the authors would like to thank Mary Law for useful advice on the initial draft.  ... 
doi:10.1155/2015/196303 pmid:26495151 pmcid:PMC4606403 fatcat:jum7eh5gazalxgfqqmivbp6ju4

Turning markers into targets – scoping neural circuits for motor neurofeedback training in Parkinson's disease

David M.A. Mehler
2022 Brain-Apparatus Communication: A Journal of Bacomics  
Purpose: Motor symptoms of patients suffering from Parkinson's disease (PD) are currently mainly treated with dopaminergic pharmacology, and where indicated, with deep brain stimulation.  ...  Recommendations for best practice in study design and reporting are provided, highlighting the importance of adequate control conditions and statistical power.  ...  Franziska Klein for helpful comments on an earlier version of this manuscript.  ... 
doi:10.1080/27706710.2022.2061300 fatcat:kcub7pstqfep3cois755fqifoy

Therapeutic Subthalamic Nucleus Deep Brain Stimulation Reverses Cortico-Thalamic Coupling during Voluntary Movements in Parkinson's Disease

Josh Kahan, Laura Mancini, Maren Urner, Karl Friston, Marwan Hariz, Etienne Holl, Mark White, Diane Ruge, Marjan Jahanshahi, Tessel Boertien, Tarek Yousry, John S. Thornton (+4 others)
2012 PLoS ONE  
Deep brain stimulation of the subthalamic nucleus (STN DBS) has become an accepted treatment for patients experiencing the motor complications of Parkinson's disease (PD).  ...  Despite the technical demands associated with the safe acquisition of fMRI data from patients with implanted hardware, robust activation changes were identified in the insula cortex and thalamus in response  ...  Inclusion in this study was restricted to those patients who (1) could tolerate lying flat while being both off medication and off stimulation, (2) exhibited minimal head tremor, and (3) demonstrated an  ... 
doi:10.1371/journal.pone.0050270 pmid:23300524 pmcid:PMC3530565 fatcat:wec4gmxaardbnaeu5c2dpfsqpi
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