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Page 14330 of The Journal of Neuroscience Vol. 29, Issue 52 [page]

2008 The Journal of Neuroscience  
‘ald X, Vendrell P, Bartrés-Faz D, Clemente I, Bargallo N, Jurado MA, (2007) Impact of the COMT Val108/158 Met and DAT genotypes on prefrontal function in healthy subjects.  ...  Egan MF, Goldberg TE, Kolachana BS, Callicott JH, Mazzanti CM, Straub RE, Goldman D, Weinberger DR (2001) Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia.  ... 

Genetic influence on the working memory circuitry: Behavior, structure, function and extensions to illness

Katherine H. Karlsgodt, Peter Bachman, Anderson M. Winkler, Carrie E. Bearden, David C. Glahn
2011 Behavioural Brain Research  
This has implications for our understanding of the transmission of working memory deficits in both healthy and disordered populations.  ...  In this review we explore different functional and structural components of the working memory circuitry, and the degree to which each of them is contributed to by genetic factors.  ...  Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia. Proc Natl Acad Sci USA. 2001; 98:6917-22. [PubMed: 11381111] 46.  ... 
doi:10.1016/j.bbr.2011.08.016 pmid:21878355 pmcid:PMC3545474 fatcat:6hfegvxglvahvh7xjyxk4otlpy

Genetic Addiction Risk Score (GARS): Molecular Neurogenetic Evidence for Predisposition to Reward Deficiency Syndrome (RDS)

Kenneth Blum, Marlene Oscar-Berman, Zsolt Demetrovics, Debmalya Barh, Mark S. Gold
2014 Molecular Neurobiology  
We have published extensively on the neurogenetics of brain reward systems with reference to the genes related to dopaminergic function in particular.  ...  The primary driver of RDS is a hypodopaminergic trait (genes) as well as epigenetic states (methylation and deacetylation on chromatin structure).  ...  Val108/158 Met might be used as an independent biomarker of suicidal behavior across different psychopathologies COMT Val(15) Met variation Both controls and opiate users with Met/Met genotypes  ... 
doi:10.1007/s12035-014-8726-5 pmid:24878765 pmcid:PMC4225054 fatcat:5qaum5mxazdphod7fxsacqegui

Genes of the serotonergic and dopaminergic pathways and their interaction affect the expression of Behavioural and Psychological Symptoms in Dementia (BPSD)

Petroula Proitsi, Michelle Lupton, Suzanne Reeves, Gillian Hamilton, Nicola Archer, Belinda Martin, Paul hollingworth, Brian Lawlord, Michael Gill, Michael Owen, Julie Williams, Simon Lovestone (+1 others)
2009 Nature Precedings  
Although there is evidence for the involvement of genes of serotonergic and dopaminergic systems in the manifestation of the Behavioural and Psychological Symptoms in Dementia (BPSD), genetic association  ...  We used 1008 probable AD patients from the UK and applied a Multiple Indicators Multiple Causes (MIMIC) approach to investigate the effect of 11 polymorphisms in the serotonergic and dopaminergic systems  ...  Impact of the COMT Val108/158 Met and DAT genotypes on prefrontal function in healthy subjects.  ... 
doi:10.1038/npre.2009.3896.1 fatcat:qr54rhxs6jdvhctqx7ox5gxyvi

DNA Methylation, Substance Use and Addiction: a Systematic Review of Recent Animal and Human Research from a Developmental Perspective

Charlotte A. M. Cecil, Esther Walton, Essi Viding
2015 Current Addiction Report  
Growing evidence points to the role of epigenetic mechanisms, including DNA methylation, in substance use and addiction.  ...  The majority of extant studies (i) focused on exposure during adulthood, (ii) examined the effects of alcohol use, (iii) employed a candidate gene approach, and (iv) were cross-sectional.  ...  No association between membrane-bound COMT promoter methylation and alcohol or cannabis use; significant interaction with COMT Val108/158 Met genotype in predicting high-frequent cannabis use. 28  ... 
doi:10.1007/s40429-015-0072-9 fatcat:k2gt4zfcjrdy3lvbi6ijx275km

Genetic Variations in the Dopamine Reward System Influence Exercise Reinforcement and Tolerance for Exercise Intensity

Kyle Flack, Christopher Pankey, Kelsey Ufholz, LuAnn Johnson, James N. Roemmich
2019 Behavioural Brain Research  
Genotypes related to dopamine metabolism moderate the reinforcing value of behaviors, but genetic moderators of exercise reinforcement have not been established.  ...  Exercise is a reinforcing behavior and finding exercise highly reinforcing is characteristic of habitual exercisers.  ...  Acknowledgements 297 The authors would like to thank Doreen Rolshoven, Jackie Nelson and student interns for 298 their assistance with implementation of the protocol, data collection and data entry.  ... 
doi:10.1016/j.bbr.2019.112148 pmid:31404557 fatcat:suyptg2e2bcahld66ujgcyn4tm

Poster Session I

2004 Neuropsychopharmacology  
Subjects with CC genotype (high DBH; N=78) were compared with carriers of the T allele (low DBH: N=50).  ...  Addicted subjects were compared to age-matched healthy controls (n=6).  ...  One source of individual variation is the COMT gene, which contains a common functional polymorphism (Val108/158/Met) that produces a significant change in enzyme activity.  ... 
doi:10.1038/sj.npp.1300646 fatcat:ee4zdyczlzc2pgxomn5ucq6cm4

Poster Session III

2006 Neuropsychopharmacology  
Specifically, when the seed point was in the amygdala, significant reductions in functional connectivity was found in a large area of the medial prefrontal cortices (MPFC), anterior and posterior cingulate  ...  Subjects had no other substance abuse, and averaged >5 drinks/day on at least 70% of the days in the 90 days prior to screening.  ...  Results: Using the mixed model to assess the impact of total Fazekas score on MADRS score as a function of time, with age, race and education as covariates there was a strong trend for a statistically  ... 
doi:10.1038/sj.npp.1301268 fatcat:rl22v3qzwfh4hcr2c4z3b2daoi

Final Program, The 2012 International Neuropsychological Society Mid-Year Meeting/11th Nordic Meeting in Neuropsychology June 27–30, 2012 Oslo, Norway

2012 Journal of the International Neuropsychological Society  
The problems of inattentiveness, over-activity and impulsivity are the defining features in current diagnostic manuals but a clear understanding of the core symptoms or their origin is still lacking.  ...  The symposium will include four talks that describe some of the current approaches to understanding and alleviating ADHD in adult life, combining research techniques and paradigms both from cognitive neuroscience  ...  When each patient was compared with healthy individuals significant elevations of theta were found in 25.8% of the patients and in only one healthy control subject (2.6%).  ... 
doi:10.1017/s1355617712001063 fatcat:hvqdxc6a5jb6rfbhapoem4q72i

A review of molecular genetic studies of neurocognitive deficits in schizophrenia

Gwyneth Zai, Trevor Robbins, Barbara Sahakian, James L Kennedy, Apollo-University Of Cambridge Repository, Apollo-University Of Cambridge Repository
2019
Extensive literature has demonstrated impaired cognition including executive function, attention, and memory in schizophrenia patients when compared to healthy subjects.  ...  This review 1) provides an overview of recent studies and 2) develops an up-to-date conceptualization of genetic variations influencing neurocognitive functions in schizophrenia patients.  ...  A Review of Molecular Genetic Studies of  ... 
doi:10.17863/cam.21939 fatcat:fnv2dvfy35etle3tsllyx74lcm

P.1.a.004 Chromosomal aberrations in an African schizophrenia population

L. Koen, D.J.H. Niehaus, G. De Jong, R.A. Emsley
2008 European Neuropsychopharmacology  
extent explicitly otherwise stated) and that I have not previously in its entirety or in part submitted it for obtaining any qualification.  ...  DECLARATION By submitting this dissertation electronically, I declare that the entirety of the work contained therein is my own, original work, that I am the owner of the copyright thereof (unless to the  ...  Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia. Proc Natl Acad Sci U S A. 2001;98:6917-6922. 116.  ... 
doi:10.1016/s0924-977x(08)70238-4 fatcat:v43yz5e27relnlanocbf43b6lu

The use of adjuvant L-arginine in schizophrenia: A behavioural and neurochemical analysis

Mary-Anne B MacKay
2016
Despite the availability of several neuroleptic medications on the market, many patients with schizophrenia remain symptomatic.  ...  Schizophrenia is a complex neurodevelopmental illness that often requires a combination of treatments to adequately control its symptoms.  ...  Effect of COMT Val108/158 met genotype on frontal lobe function and risk for schizophrenia. Proc Natl Acad Sci U S A 98(12): 6917-22.  ... 
doi:10.7939/r3zs2kq4m fatcat:j3zx2r36hzeqjif2gteou5w73i