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Immunization and Targeted Destruction of Networks using Explosive Percolation

Pau Clusella, Peter Grassberger, Francisco J. Pérez-Reche, Antonio Politi
2016 Physical Review Letters  
A new method ('explosive immunization' (EI)) is proposed for immunization and targeted destruction of networks.  ...  It combines the explosive percolation (EP) paradigm with the idea of maintaining a fragmented distribution of clusters.  ...  VP2-2014-043) and from Horizon2020 (Grant No. 642563 -COSMOS).  ... 
doi:10.1103/physrevlett.117.208301 pmid:27886508 fatcat:jqvsxnrtbvgs5cryp6uzxtvccu

Influencer identification in dynamical complex systems [article]

Sen Pei, Jiannan Wang, Flaviano Morone, Hernán A Makse
2019 arXiv   pre-print
In particular, we first discuss the problem of finding the minimal number of nodes whose removal would breakdown the network (i.e., the optimal percolation or network dismantle problem), and then survey  ...  The integrity and functionality of many real-world complex systems hinge on a small set of pivotal nodes, or influencers.  ...  In Section 3, we discuss the progresses in optimal percolation using collective influence, optimal decycling, explosive percolation and large deviations of percolation in details.  ... 
arXiv:1907.13017v3 fatcat:5lw7uebqqbht5bn5tjamjn7jau

Explosive phenomena in complex networks

Raissa M. D'Souza, Jesus Gómez-Gardeñes, Jan Nagler, Alex Arenas
2019 Advances in Physics  
Models of explosive synchronization provide an analytic framework for the dynamics of abrupt transitions and reveal the interplay between the distribution in natural frequencies and the network structure  ...  The emergence of large-scale connectivity and synchronization are crucial to the structure, function and failure of many complex socio-technical networks.  ...  ACKNOWLEDGMENTS We gratefully acknowledge support from funding agencies and the reviewers of this manuscript. In particular RMD acknowledges support from the U.  ... 
doi:10.1080/00018732.2019.1650450 fatcat:ggtqf675qjahrequpgz5gs44xu

Theories for influencer identification in complex networks [article]

Sen Pei, Flaviano Morone, Hernán A. Makse
2018 arXiv   pre-print
In social and biological systems, the structural heterogeneity of interaction networks gives rise to the emergence of a small set of influential nodes, or influencers, in a series of dynamical processes  ...  Finally, we present some applications of influencer identification in diverse real-world systems, including online social platforms, scientific publication, brain networks and socioeconomic systems.  ...  Acknowledgement We acknowledge funding from NIH-NIBIB 1R01EB022720, NIH-NCI U54CA137788 / U54CA132378 and nsf-iis 1515022.  ... 
arXiv:1707.01594v2 fatcat:j6je622mxffyxpgznciqdavo74

Challenges in network science: Applications to infrastructures, climate, social systems and economics

S. Havlin, D. Y. Kenett, E. Ben-Jacob, A. Bunde, R. Cohen, H. Hermann, J. W. Kantelhardt, J. Kertész, S. Kirkpatrick, J. Kurths, J. Portugali, S. Solomon
2012 The European Physical Journal Special Topics  
Network theory has become one of the most visible theoretical frameworks that can be applied to the description, analysis, understanding, design and repair of multi-level complex systems.  ...  Complex networks occur everywhere, in man-made and human social systems, in organic and inorganic matter, from nano to macro scales, and  ...  and robustness using scaling and percolation approaches.  ... 
doi:10.1140/epjst/e2012-01695-x fatcat:poyouxltpbcyflrcwaslew2dti

The Islamic State Threat to Western Homeland Security

Anthony NC
2017 Journal of Political Sciences & Public Affairs  
Likewise we renew our call to the muwahhidin in Europe and the disbelieving West and elsewhere, to target the crusaders in their own lands and wherever they are found.  ...  We will argue before Allah against any Muslim who has the ability to shed a single drop of crusader blood but does not do so, whether with an explosive device, a bullet, a knife, a car, a rock, or even  ...  42 Thomas Joscelyn, "The Future of Counterterrorism: Addressing the Evolving Threat to Domestic Security" February 28, 2017 Foundation for the Defense of Democracies accessed at:  ... 
doi:10.4172/2332-0761.1000259 fatcat:xr5hvpxnqzfsxdewudzwqysokm

Multilayer networks

M. Kivela, A. Arenas, M. Barthelemy, J. P. Gleeson, Y. Moreno, M. A. Porter
2014 Journal of Complex Networks  
In this paper, we discuss the history of multilayer networks (and related concepts) and review the exploding body of work on such networks.  ...  The origins of such efforts date back several decades and arose in multiple disciplines, and now the study of multilayer networks has become one of the most important directions in network science.  ...  explosion of papers on multilayer networks has produced an equally immense explosion of disparate terminology, and the lack of a consensus (or even generally accepted) set of terminology and mathematical  ... 
doi:10.1093/comnet/cnu016 fatcat:gkvuniqrdbgkpn22t7fkt7vdke

Immunology for physicists

Alan S. Perelson, Gérard Weisbuch
1997 Reviews of Modern Physics  
Sulzer and D. Sherrington for their careful comments on a draft of this manuscript, and B. Goldstein for help with the illustrations.  ...  Much of the work reported here was done in collaboration with Rob De Boer, Avidan Neumann, and Lee Segel.  ...  In the presence of percolation and large-scale fluctuations it is difficult to envision how immune memory might be maintained by a network.  ... 
doi:10.1103/revmodphys.69.1219 fatcat:w3dzlfuuqzdq5e27me7yb5u2ka

The structure and dynamics of multilayer networks

S. Boccaletti, G. Bianconi, R. Criado, C.I. del Genio, J. Gómez-Gardeñes, M. Romance, I. Sendiña-Nadal, Z. Wang, M. Zanin
2014 Physics reports  
the time-varying and multilayer nature of networks.  ...  redefinition of the basic structural measures, to understanding how the multilayer nature of the network affects processes and dynamics.  ...  132 Nation 2 Nation 1 Nation 1 SatCom Nation 1 UHF Network1 Nation 1 VHF Network Nation 1 UHF Network2 Nation 2 UHF Network Furthermore, a part of the material quoted in our presentation was taken from  ... 
doi:10.1016/j.physrep.2014.07.001 pmid:32834429 pmcid:PMC7332224 fatcat:5y6wdkop2nd75kwnla4by2icqy

Harnessing Novel Imaging Approaches to Guide HIV Prevention and Cure Discoveries—A National Institutes of Health and Global HIV Vaccine Enterprise 2017 Meeting Report

Brigitte E. Sanders-Beer, Yegor Voronin, David McDonald, Anjali Singh
2018 AIDS Research and Human Retroviruses  
In the HIV/SIV field, imaging has provided key insights into mucosal viral transmission, local and systemic virus spread, host-virus dynamics, and chronic inflammation/immune activation and the resultant  ...  The meeting covered applications of imaging in studies of early events and pathogenesis, reservoirs, and cure, as well as in vaccine development.  ...  The workshop was funded by the Global HIV Vaccine Enterprise and with federal funds from the National Institute of Allergies and Infectious Diseases, National Institutes of Health, Department of Health  ... 
doi:10.1089/aid.2017.0216 pmid:29145733 pmcid:PMC5824657 fatcat:nwmpbk7y2jfrvfgd2f74m4fbqy

Coevolution spreading in complex networks

Wei Wang, Quan-Hui Liu, Junhao Liang, Yanqing Hu, Tao Zhou
2019 Physics reports  
To uncover the dynamical mechanisms, the evolving spatiotemporal patterns and critical phenomena of networked coevolution spreading are extremely important, which provide theoretical foundations for us  ...  In this review, we introduce recent progress in the study of coevolution spreading dynamics, emphasizing the contributions from the perspectives of statistical mechanics and network science.  ...  By using a generalized percolation theory, the fraction of nodes infected by each epidemic and both epidemics in the final state can be obtained.  ... 
doi:10.1016/j.physrep.2019.07.001 pmid:32308252 pmcid:PMC7154519 fatcat:zvkfs3pdondvbnxpdd43mm4tne

From Metabolite to Metabolome: Metabolomics Applications in Plasmodium Research

Xinyu Yu, Gaoqian Feng, Qingfeng Zhang, Jun Cao
2021 Frontiers in Microbiology  
Therefore, this review highlights the progress of metabolomics in malaria research, including metabolic mapping of Plasmodium vertebrate life cycle stages to investigate antimalarials mode of actions and  ...  This improves the investigation of varied metabolic requirements during life stages or when following transmission to their hosts, and fulfills the demand for improved diagnostics and precise therapeutics  ...  More recently, one rapid and easily to handle purification method for viable ring stage parasites using a combination of selective lysis property of Streptolysin-O and permeability of Percoll has been  ... 
doi:10.3389/fmicb.2020.626183 pmid:33505389 pmcid:PMC7829456 fatcat:zixjvxlvn5hdxke4qase7zmwma

AACR Cancer Progress Report 2013

C. L. Sawyers, C. Abate-Shen, K. C. Anderson, A. Barker, J. Baselga, N. A. Berger, M. Foti, A. Jemal, T. S. Lawrence, C. I. Li, E. R. Mardis, P. J. Neumann (+4 others)
2013 Clinical Cancer Research  
They operate, at least in part, by attaching to cancer cells expressing their target, flagging them for destruction by immune cells.  ...  Widespread use of these new technologies has led to an explosion of genetic information about cancers of different types.  ...  Immune system -A diffuse, complex network of interacting cells, cell products, and cell-forming tissues that protects the body from invading microorganisms and other foreign substances, destroys infected  ... 
doi:10.1158/1078-0432.ccr-13-2107 pmid:24045178 fatcat:hump63r4afczbby6cyxs74uj3a

Exploring the "Multiple-Hit Hypothesis" of Neurodegenerative Disease: Bacterial Infection Comes Up to Bat

Kristin L. Patrick, Samantha L. Bell, Chi G. Weindel, Robert O. Watson
2019 Frontiers in Cellular and Infection Microbiology  
This review will broadly explore the connections between bacterial infection, immune dysregulation, and CNS disorders.  ...  Recent data has begun to demonstrate roles for these genes (PARK2, PINK1, and LRRK2) in modulating innate immune outcomes, suggesting that immune dysregulation may play an even more important role in neurodegeneration  ...  Multiple studies have shown that macrophages use selective autophagy to tag and target a population (∼30%) of M. tuberculosis bacilli to autophagosomes.  ... 
doi:10.3389/fcimb.2019.00138 pmid:31192157 pmcid:PMC6546885 fatcat:pzyavbobx5hvrablkyxhivwqce

Structure and dynamics of molecular networks: A novel paradigm of drug discovery

Peter Csermely, Tamás Korcsmáros, Huba J.M. Kiss, Gábor London, Ruth Nussinov
2013 Pharmacology and Therapeutics  
The state-of-the-art use of chemical similarity, protein structure, protein-protein interaction, signaling, genetic interaction and metabolic networks in the discovery of drug targets is summarized.  ...  It is shown how network techniques can help in the identification of single-target, edgetic, multi-target and allo-network drug target candidates.  ...  Academy of Sciences, Szeged, Hungary) for the critical reading of Sections 1.3.3 and 3.6, respectively.  ... 
doi:10.1016/j.pharmthera.2013.01.016 pmid:23384594 pmcid:PMC3647006 fatcat:osjkz6kpr5gzxomqlyenla2fvq
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