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Immune system simulation online
2011
Bioinformatics
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In current mesoscopic-scale simulators of the immune system, this crucial step has been modeled in a very approximated way. ...
Results: We have equipped an agent-based model of the immune system with immuno-informatics methods to allow the simulation of the cardinal events of the antigenic recognition, going from single peptides ...
The immune system simulation server presented here consists of a simple interface to the simulation method mentioned above where the user can specify the antigen injection schedule , the haplotype of the ...
doi:10.1093/bioinformatics/btr335
pmid:21685045
fatcat:yfpulxapo5attnaizmkrq2nbse
Novel Control Scheme for Helicopter Flight: Fuzzy Immune Adaptive Model Inversion Control
2008
IFAC Proceedings Volumes
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Simulation results comparing with the neural network adaptive control method show the system based on the proposed scheme has better real-time performance. ...
It could achieve effective control throughout large flight envelope curve via the design of fuzzy immune online-compensation element, only needing a static inverse model on the basis of a single flight ...
FIOCE DESIGN As the core of whole system, FIOCE will simulate biology immune response mechanism and counteract the inversion error brought by RDIP in time. ...
doi:10.3182/20080706-5-kr-1001.02546
fatcat:yrjtblzj6bd37izbbgzz4jumh4
Two-Way Mutual-Structure-Based Public Opinion Communication System: An Analysis with Simulation
2019
Tehnički Vjesnik
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The multi-agent simulation platform Netlogo is used to simulate a constructed public opinion evolution model, and the law of public opinion evolution under the resonance path is analyzed. ...
Taking Stephen Hawking's death in 2018 as a sample case, simulation results are verified through data collection and collation; additionally, the law of the evolution of public opinion in the two-way mutual ...
The state of online media outlet k (whether concerning a diffuser or immunizer) depends on clique, denoting the number of distributors in the system space at time t. ...
doi:10.17559/tv-20181122070039
fatcat:brvabpqpujgo7mxlaoawrizgju
Page 1991 of International Pharmaceutical Abstracts Vol. 35, Issue 18
[page]
1998
International Pharmaceutical Abstracts
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The Internet Archive has digitized a microfilm copy of this work. It may be possible to borrow a copy for reading.
3511202 IMPACT OF A SIMULATED IMMUNIZATION REGISTRY ON PERCEIVED CHILDHOOD IMMUNIZATION STATUS Yawn, B. P. (Dept. of Res., Olmsted Med. Ctr., 210 Ninth St. ...
The perceived rate was compared to the rate obtained by combining all recorded immunizations from all facilities (simulated registry). ...
Integrated Systems View on Networking by Hormones in Arabidopsis Immunity Reveals Multiple Crosstalk for Cytokinin
2012
The Plant Cell
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Our dynamic simulation is instrumental in predicting system effects of individual components in complex hormone disease networks and synergism or antagonism between pathways. ...
Dynamic modeling and system analysis identified multiple cytokinin-mediated regulatory interactions in plant disease networks. ...
Table 2 online for simulation validation). ...
doi:10.1105/tpc.112.098335
pmid:22643121
pmcid:PMC3442570
fatcat:vbolq5by3jhvha6vvohphvadru
Immune Signaling Networks: Sources of Robustness and Constrained Evolvability during Coevolution
2017
Molecular biology and evolution
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Here, we use a theoretical simulation model to examine how underlying network architectures constrain the evolution of immune strategies, and how these network architectures account for desirable immune ...
This is because evolution proceeds via mutational changes to the protein interaction networks underlying immune responses, not by changes to an immune strategy directly. ...
immune systems. ...
doi:10.1093/molbev/msx321
pmid:29294066
fatcat:i62e2tc4s5aubbx5wttu6crvx4
Systems biology model repository for macrophage pathway simulation
2011
Bioinformatics
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The Macrophage Pathway Knowledgebase (MACPAK) is a computational system that allows biomedical researchers to query and study the dynamic behaviors of macrophage molecular pathways. ...
MACPAK comprises a total of 24 009 entities and 12 774 processes and is described in the Cell System Markup Language (CSML), an XML format that runs on the Cell Illustrator platform and can be visualized ...
INTRODUCTION The immune system has evolved as a defense mechanism against pathogenic microbes. ...
doi:10.1093/bioinformatics/btr173
pmid:21505034
fatcat:vxxnphdk5zcutam4f2sv6dwpou
Immune Loss as a Driver of Coexistence During Host-Phage Coevolution
[article]
2017
bioRxiv
pre-print
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We pair a general model of immunity with an experimental and theoretical case study of the CRISPR-Cas immune system to contrast the behavior of tradeoff and loss mechanisms in well-mixed systems. ...
Despite this prediction, in many systems host and pathogen coexist with minimal coevolution even when well-mixed. ...
402 of spacers (Semenova et al., 2016) .
403 While we conclude that immune loss plays a key role in our system, it is not 404 immediately clear why bacterial immune systems would lose functionality ...
doi:10.1101/105908
fatcat:dyqrxurysnenripc6s3v2qz4wa
Rational design of chimeric Multiepitope Based Vaccine (MEBV) against human T-cell lymphotropic virus type 1: An integrated vaccine informatics and molecular docking based approach
2021
PLoS ONE
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Repeated-exposure simulations and Immune simulations ensured the rapid antigen clearance and higher levels of cell-mediated immunity, respectively. ...
Additionally, Molecular docking analysis and Molecular Dynamics (MD) simulations confirmed the strong association between MEBV construct and human pathogenic immune receptor TLR-3. ...
systems were simulated for 20ns. ...
doi:10.1371/journal.pone.0258443
pmid:34705829
pmcid:PMC8550388
fatcat:pnxh6zxterc6xalvlj6aejpfxq
A Hybrid Algorithm Between the Artificial Immunological Network and the ANFIS Technique with Application
2018
Al-Kitab Journal for Pure Sciences
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the Artificial Immune Network, was developed using the Adaptive Neuro Fuzzy Inference System (ANFIS) by using the Immune Memory, The immunological network as an input to ANFIS technology to increase the ...
The proposed algorithm proved to have better and more efficient results rack on the patterns compared with the usual artificial immune system. ...
EFF (Decision Boundary) Efficiency Scale ANFIS ANFIS Artificial Immune System Ag Clonal If Then) MSE Selection ANFIS 5 Time Artificial Immune Systems (Ab Triangular Function (Affinity Degree AIN_ANFIS ...
doi:10.32441/kjps.02.02.p22
fatcat:pyl3fsuwpbge5oylvu7kk6vage
Progress Towards an Open Source PhysiCell Ecosystem
[article]
2019
Figshare
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of systems (e.g., immune system) In cancer, these systems become dysregulated. ...
Treatments target parts of these systems. Cancer is a complex system: changing one part can have surprising effects! Modeling can help understand this system. This is multicellular systems biology. ...
doi:10.6084/m9.figshare.9934469.v1
fatcat:b6n6wc7nsnepthm26yy2tfbx4q
Immune loss as a driver of coexistence during host-phage coevolution
2018
The ISME Journal
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We pair a general model of immunity with an 9 experimental and theoretical case study of the CRISPR-Cas immune system to contrast 10 the behavior of tradeoff and loss mechanisms in well-mixed systems. ...
Despite this prediction, in many systems host and pathogen coexist with 5 minimal coevolution even when well-mixed. ...
402 of spacers (Semenova et al., 2016) .
403 While we conclude that immune loss plays a key role in our system, it is not 404 immediately clear why bacterial immune systems would lose functionality ...
doi:10.1038/ismej.2017.194
pmid:29328063
pmcid:PMC5776473
fatcat:s4b3dyhq5rbjxfqv35vn52zqkq
A tipping point in cancer-immune dynamics leads to divergent immunotherapy responses and hampers biomarker discovery
2021
Journal for ImmunoTherapy of Cancer
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and molecular approaches, only a limited number of candidate biomarkers eventually enter clinical practice.MethodsA computational modeling approach based on ordinary differential equations was used to simulate ...
the fundamental mechanisms that dictate tumor-immune dynamics and to investigate its implications on responses to immune checkpoint inhibition (ICI) and patient survival. ...
To illustrate this, we simulated twenty patients with identical immune systems (ie, identical T cell killing rates). ...
doi:10.1136/jitc-2020-002032
pmid:34059522
pmcid:PMC8169479
fatcat:yqegut6fv5bfxopjhx3zakq34q
Toward computational modelling on immune system function
2020
BMC Bioinformatics
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AbstractThe 3rd edition of the computational methods for the immune system function workshop has been held in San Diego, CA, in conjunction with the IEEE International Conference on Bioinformatics and ...
System Function (CMISF 2019). ...
About this supplement This article has been published as part of BMC Bioinformatics Volume 21 Supplement 17 2020: Selected papers from the 3rd International Workshop on Computational Methods for the Immune ...
doi:10.1186/s12859-020-03897-5
pmid:33308137
fatcat:nkcsqmolsjholihix7ajahg2ry
High-throughput cancer hypothesis testing with an integrated PhysiCell-EMEWS workflow
[article]
2017
bioRxiv
pre-print
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Cancer is a complex, multiscale dynamical system, with interactions between tumor cells and non-cancerous host systems. ...
Therapies act on this combined cancer-host system, sometimes with unexpected results. ...
The copyright holder for this preprint . http://dx.doi.org/10.1101/196709 doi: bioRxiv preprint first posted online Sep. 30, 2017; Figure 1 Sample 3-D cancer-immune simulation. 3-D simulation of adaptive ...
doi:10.1101/196709
fatcat:uk4522iosraf5mlthxpkodnnym
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