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Value of Functionalized Superparamagnetic Iron Oxide Nanoparticles in the Diagnosis and Treatment of Acute Temporal Lobe Epilepsy on MRI

Tingting Fu, Qingxia Kong, Huaqiang Sheng, Lingyun Gao
2016 Neural Plasticity  
Purpose.Although active targeting of drugs using a magnetic-targeted drug delivery system (MTDS) with superparamagnetic iron oxide nanoparticles (SPIONs) is a very effective treatment approach for tumors  ...  A hallmark in the neuropathology of TLE is brain inflammation, in particular the activation of interleukin-1β(IL-1β) induced by activated glial cells, which has been considered a new mechanistic target  ...  The particle consists of monocrystalline iron oxide cores of maghemite ( -Fe 2 O 3 ) coated with a PEG layer using a precipitation reaction, with an average diameter of 10-20 nm (an average iron-oxide  ... 
doi:10.1155/2016/2412958 pmid:26925269 pmcid:PMC4748095 fatcat:2iuq23uv25ahpgflf3nzwo3hqa

In Vivo MRI of Functionalized Iron Oxide Nanoparticles for Brain Inflammation

Tang Tang, Anthony Valenzuela, Fanny Petit, Sarah Chow, Kevin Leung, Fredric Gorin, Angelique Y. Louie, Marc Dhenain
2018 Contrast Media & Molecular Imaging  
The PET images obtained are not specific for microglia-driven inflammation.  ...  These sulfated dextran-coated iron oxide (SDIO) nanoparticles are avidly taken up by microglia and appear to be nontoxic when administered intravenously in a mouse model.  ...  Conclusions We demonstrated the ability of SDIO targeting SR-A to image microglia actively involved in brain inflammation. e functionalized iron oxide nanoparticles were proven to be nontoxic and were  ... 
doi:10.1155/2018/3476476 pmid:30079001 pmcid:PMC6036843 fatcat:4ty3e2y6zfewjj3bbzuftgnxni

Imaging Neuroinflammation – from Bench to Bedside

Benjamin Pulli John W Chen
2014 Journal of Clinical & Cellular Immunology  
These techniques enable us to image adhesion molecules to visualize endothelial cell activation, assess leukocyte functions such as oxidative stress, granule release, and phagocytosis, and label a variety  ...  Over the past decade, a plethora of molecular imaging agents have been developed and tested in animal models of (neuro)inflammation, and a few have been translated from bench to bedside.  ...  Using an oxidizable precursor sensor, increased levels of oxidative stress were detected in hippocampus and striatum in kainic acid induced seizure [59] .  ... 
doi:10.4172/2155-9899.1000226 pmid:25525560 pmcid:PMC4266918 fatcat:y4zr473jb5awvifelwhbo3pi5i

Superparamagnetic Iron Oxide Nanoparticles: Diagnostic Magnetic Resonance Imaging and Potential Therapeutic Applications in Neurooncology and Central Nervous System Inflammatory Pathologies, a Review

Jason S Weinstein, Csanad G Varallyay, Edit Dosa, Seymur Gahramanov, Bronwyn Hamilton, William D Rooney, Leslie L Muldoon, Edward A Neuwelt
2009 Journal of Cerebral Blood Flow and Metabolism  
They are useful as magnetic resonance imaging (MRI) contrast agents to evaluate: areas of blood-brain barrier (BBB) dysfunction related to tumors and other neuroinflammatory pathologies, the cerebrovasculature  ...  Superparamagnetic iron oxide nanoparticles have diverse diagnostic and potential therapeutic applications in the central nervous system (CNS).  ...  Molecular Imaging of Inflammation with Ultrasmall Superparamagnetic Iron Oxide Particles Molecular imaging is an important new diagnostic tool for studying in vivo cellular and molecular biology across  ... 
doi:10.1038/jcbfm.2009.192 pmid:19756021 pmcid:PMC2949106 fatcat:g7qwrdfrpjbynptzpbcwzrnjga

Molecular magnetic resonance imaging discloses endothelial activation after transient ischaemic attack

Aurélien Quenault, Sara Martinez de Lizarrondo, Olivier Etard, Maxime Gauberti, Cyrille Orset, Benoît Haelewyn, Helen C. Segal, Peter M. Rothwell, Denis Vivien, Emmanuel Touzé, Carine Ali
2016 Brain  
We thus developed ultra-sensitive molecular magnetic resonance imaging using antibody-based microparticles of iron oxide targeting P-selectin.  ...  We provide preclinical evidence that combining conventional magnetic resonance imaging with molecular magnetic resonance imaging targeting P-selectin might aid in the diagnosis of transient ischaemic attack  ...  We recently developed a new formulation of microsized particles of iron oxide (MPIO) targeted against VCAM1 to achieve ultra-sensitive molecular imaging of cerebrovascular inflammation in CNS disorders  ... 
doi:10.1093/brain/aww260 pmid:28031221 pmcid:PMC5226059 fatcat:pvpfgt35tzbsfi3pgdmheo7yrq

MRI/MRS in neuroinflammation: methodology and applications

Mario Quarantelli
2015 Clinical and translational imaging  
The complex interactions of immune, endothelial, and neuronal cells that take place during inflammation require an equivalent complexity of imaging approaches to be appropriately explored in vivo.  ...  Finally, both Gd-and USPIO-labeled MRI agents have been developed to target Integrin avb3, an adhesion molecule expressed on endothelial cells, macrophages, and platelets [41] , although their use has  ...  Blood-borne cell migration Iron oxide colloids to track phagocytic cells Non-specific labeling In-vivo labeling Pilot clinical studies Ex-vivo labeling Preclinical Iron oxide-labeled antibodies  ... 
doi:10.1007/s40336-015-0142-y pmid:26705534 pmcid:PMC4679099 fatcat:bozvrcnpfzd3jfy3wi2rj2jl3e

Monodisperse magnetic nanoparticles for biodetection, imaging, and drug delivery: a versatile and evolving technology

Shivang R. Dave, Xiaohu Gao
2009 Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology  
In particular, iron-oxide-based magnetic NPs have proved to be highly versatile deep-tissue imaging agents, having been incorporated into clinical applications due to their biocompatibility.  ...  Structure, magnetic characterization, and oxidation of colloidal iron dispersions. J Appl Phys 1979, 50(11):7108-7115. 47. Peng ZA, Peng XG.  ...  iron oxide and Gd agents.  ... 
doi:10.1002/wnan.51 pmid:20049819 fatcat:mxdtbv2k7bhydogvtdim2yxzom

Molecular imaging of inflammation - Current and emerging technologies for diagnosis and treatment

Neil MacRitchie, Marina Frleta-Gilchrist, Atsuko Sugiyama, Tristan Lawton, Iain B. McInnes, Pasquale Maffia
2020 Pharmacology and Therapeutics  
However, none of these have yet progressed to routine clinical use in the molecular imaging of inflammation, therefore new approaches are required to meet this goal.  ...  The optimum molecular imaging modality will possess high sensitivity and high resolution and be capable of non-invasive quantitative imaging of multiple disease biomarkers while maintaining an acceptable  ...  There also exists larger iron oxide-based contrast agents called micron-sized iron oxide particles (MPIOs) that are typically greater than 1 μM in diameter.  ... 
doi:10.1016/j.pharmthera.2020.107550 pmid:32325067 fatcat:gr3gwewrtnazdojcpg76mp4d7u

Traumatic injury to the immature brain: Inflammation, oxidative injury, and iron-mediated damage as potential therapeutic targets

Mathew B. Potts, Seong-Eun Koh, William D. Whetstone, Breset A. Walker, Tomoko Yoneyama, Catherine P. Claus, Hovhannes M. Manvelyan, Linda J. Noble-Haeusslein
2006 Neurotherapeutics  
In this review, we discuss three specific components of the secondary pathogenesis of pediatric TBIinflammation, oxidative injury, and iron-induced damage -and potential therapeutic strategies associated  ...  In addition, the developing brain is less able to detoxify free iron after TBI-induced hemorrhage and cell death.  ...  Here we consider three specific therapeutic targets based upon what is currently known about the unique vulnerability of the developing brain to injury -inflammation, oxidative injury, and iron-mediated  ... 
doi:10.1007/bf03207045 fatcat:zt6qjnupqnbzzdpbmz2qobnocq

Traumatic injury to the immature brain: Inflammation, oxidative injury, and iron-mediated damage as potential therapeutic targets

Mathew B. Potts, Seong-Eun Koh, William D. Whetstone, Breset A. Walker, Tomoko Yoneyama, Catherine P. Claus, Hovhannes M. Manvelyan, Linda J. Noble-Haeusslein
2006 NeuroRx  
In this review, we discuss three specific components of the secondary pathogenesis of pediatric TBIinflammation, oxidative injury, and iron-induced damage -and potential therapeutic strategies associated  ...  In addition, the developing brain is less able to detoxify free iron after TBI-induced hemorrhage and cell death.  ...  Here we consider three specific therapeutic targets based upon what is currently known about the unique vulnerability of the developing brain to injury -inflammation, oxidative injury, and iron-mediated  ... 
doi:10.1016/j.nurx.2006.01.006 pmid:16554253 pmcid:PMC3593438 fatcat:rxlt2syhkfan5msd5me5e6zmqy

Fleeting footprints: finding MRI biomarkers of transient ischaemic attack

Phillip Zhe Sun, Cenk Ayata, Eng H. Lo
2016 Brain  
The authors therefore developed antibody-based microparticles of iron oxide targeting P-selectin in an attempt to reveal this vascular footprint of TIA.  ...  P-selectintargeted contrast agents have previously been used for in vivo detection of endothelial activation and dysfunction associated with transient ischaemic injury and acute brain inflammation (Rouzet  ... 
doi:10.1093/brain/aww306 pmid:28031217 fatcat:mwepels55ze63fhrolxwtaqezq

WONOEP appraisal: Molecular and cellular biomarkers for epilepsy

Lauren E. Walker, Damir Janigro, Uwe Heinemann, Raili Riikonen, Christophe Bernard, Manisha Patel
2016 Epilepsia  
Peripheral biomarkers have myriad potential uses for treatment, prediction, prognostication, and pharmacovigilance in epilepsy.  ...  In this review, we discuss the major areas of focus including inflammation, blood-brain barrier dysfunction, redox alterations, metabolism, hormones and growth factors.  ...  Acknowledgments The review is devised as an extended account of the discussion that took place during the XIII WONOEP  ... 
doi:10.1111/epi.13460 pmid:27374986 pmcid:PMC5515385 fatcat:2aesj73gerealnjjjfevyxw3lm

Fabrication and evaluation of novel quercetin-conjugated Fe3O4–β-cyclodextrin nanoparticles for potential use in epilepsy disorder

Hashemian M, Ghasemi-Kasman M, Ghasemi S, Akbari A, Moalem-Banhangi M, Zare L, Ahmadian SR
2019 International Journal of Nanomedicine  
an iron oxide core coated with βCD and pluronic F68 polymer.  ...  In comparison to free quercetin, quercetin NPs markedly reduced seizure behavior, neuronal loss, and astrocyte activation in a PTZ-induced kindling model.Conclusion: Overall, quercetin–Fe3O4–βCD NPs might  ...  Methods: Quercetin-loaded NPs were prepared using an iron oxide core coated with βCD and pluronic F68 polymer.  ... 
doaj:7bd30611e74c40ceadf0e51270673ad5 fatcat:adz24epwqray3hjbx6k5oduizq

Current Approaches and Future Perspectives for Nanobodies in Stroke Diagnostic and Therapy

Larissa Jank, Carolina Pinto-Espinoza, Yinghui Duan, Friedrich Koch-Nolte, Tim Magnus, Björn Rissiek
2019 Antibodies  
Nanobodies (Nbs) are single domain antibodies derived from llama or shark heavy-chain antibodies and represent a new generation of biologics.  ...  In this review, we summarize recent findings on Nbs in preclinical stroke models and how they can be used as diagnostic and therapeutic reagents.  ...  For example, Quenault et al. used microparticle of iron oxide (MPIOs) coated with P-selectin-targeting antibodies to identify transient ischemic attacks and to exclude other differential diagnosis, such  ... 
doi:10.3390/antib8010005 pmid:31544811 pmcid:PMC6640704 fatcat:edzgc4nprjgs5b4kari42zlpg4

Impact of Nanoparticles on Brain Health: An Up to Date Overview

Daniel Teleanu, Cristina Chircov, Alexandru Grumezescu, Adrian Volceanov, Raluca Teleanu
2018 Journal of Clinical Medicine  
Due to their unique physical and chemical properties, nanoparticles are extensively used in a variety of fields, including medicine, pharmaceutics, and food industry.  ...  Hence, studies report the use of iron oxide nanoparticles functionalized with phosphonate polyethylene glycol and covalently coupled to the cyclo RGD peptide sequence as magnetic resonance imaging contrast  ...  inflammation, apoptosis, induced neural antioxidant responses, and immune cell infiltration [90] .  ... 
doi:10.3390/jcm7120490 pmid:30486404 fatcat:sit54iasaverxm5uni5xhjddhe
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