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The genome-wide supported microRNA-137 variant predicts phenotypic heterogeneity within schizophrenia

T A Lett, M M Chakavarty, D Felsky, E J Brandl, A K Tiwari, V F Gonçalves, T K Rajji, Z J Daskalakis, H Y Meltzer, J A Lieberman, J P Lerch, B H Mulsant (+2 others)
<span title="2013-03-05">2013</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/ywuy2l3c7ngernsmmsbttqvzna" style="color: black;">Molecular Psychiatry</a> </i> &nbsp;
Mr Lett, Dr Kennedy, and  ...  ACKNOWLEDGEMENTS This work was supported by the Canadian Institutes of Health Research Clinician Scientist Award (ANV); NARSAD (ANV, TKR), Ontario Mental Health Foundation (ANV) and the CAMH and the CAMH  ...  the healthy control imaging sample, in line with the intermediate phenotype approach.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1038/mp.2013.17">doi:10.1038/mp.2013.17</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/23459466">pmid:23459466</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/k2tjjsi5dbffbfr7ulpkkirdiu">fatcat:k2tjjsi5dbffbfr7ulpkkirdiu</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20170830055504/http://www.psychiatry.utoronto.ca/wp-content/uploads/gravity_forms/9-9f8d9266964e45f94325cf2ebcf085db/2014/04/Voineskos-Stancer-Molecular-Psychiatry.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/f9/1f/f91f6f9ce1cbadfee3dc28089126cd29454d090b.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1038/mp.2013.17"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a>

Heterogeneity of Brain Structural Variation and the Structural Imaging Endophenotypes in Schizophrenia

Igor Nenadic, Christian Gaser, Heinrich Sauer
<span title="">2012</span> <i title="S. Karger AG"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/vofuivbe2va4jd53wqnysyzcam" style="color: black;">Neuropsychobiology</a> </i> &nbsp;
Similarly, Eugen Bleuler's conception of the 'group of schizophrenias' acknowledges the clinical (and putatively etiological) heterogeneity of schizophrenia.  ...  Clinical Heterogeneity and Subtypes of Schizophrenia Kraepelin's original concept of dementia praecox originates in a synthesis of the previously separately classified disorders of hebephrenia, catatonia  ...  As both the phenotype and genotype appear to be complex in nature, the heterogeneity of schizophrenia is one of the main problems in understanding the relation between putative genetic markers and their  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1159/000338547">doi:10.1159/000338547</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/22797276">pmid:22797276</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/xf6yw4gymvbqfij2k4vpg6bqjy">fatcat:xf6yw4gymvbqfij2k4vpg6bqjy</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20170809091522/http://dbm.neuro.uni-jena.de/pdf-files/Nenaidc-NPB12.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/49/2d/492dcbfec524ea04ee7c70a0b631142e170ff3ba.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1159/000338547"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a>

Shaping the Trans-Scale Properties of Schizophrenia via Cerebral Alterations on Magnetic Resonance Imaging and Single-Nucleotide Polymorphisms of Coding and Non-Coding Regions

Shu-Wan Zhao, Xian Xu, Xian-Yang Wang, Tian-Cai Yan, Yang Cao, Qing-Hong Yan, Kun Chen, Yin-Chuan Jin, Ya-Hong Zhang, Hong Yin, Long-Biao Cui
<span title="2021-09-09">2021</span> <i title="Frontiers Media SA"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/adcuz6lgabeidhngmk32v7egkq" style="color: black;">Frontiers in Human Neuroscience</a> </i> &nbsp;
Recently, the development of trans-scale and multi-omics methods that integrate gene and imaging information sheds new light on the nature of schizophrenia.  ...  Schizophrenia is a complex mental illness with genetic heterogeneity, which is often accompanied by alterations in brain structure and function.  ...  ACKNOWLEDGMENTS We are indebted to Xu-Sha Wu for her helpful suggestions and comments on the manuscript.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3389/fnhum.2021.720239">doi:10.3389/fnhum.2021.720239</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/34566604">pmid:34566604</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC8458928/">pmcid:PMC8458928</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/iqjwhqd4j5bo3d55wofw3nlmhi">fatcat:iqjwhqd4j5bo3d55wofw3nlmhi</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210914045312/https://fjfsdata01prod.blob.core.windows.net/articles/files/720239/pubmed-zip/.versions/2/.package-entries/fnhum-15-720239-r1/fnhum-15-720239.pdf?sv=2018-03-28&amp;sr=b&amp;sig=cAFptXYxpyb1WKqruaEBBqGmM8FOhYqr00cez3r018w%3D&amp;se=2021-09-14T04%3A53%3A41Z&amp;sp=r&amp;rscd=attachment%3B%20filename%2A%3DUTF-8%27%27fnhum-15-720239.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/fe/27/fe2748d0e8b6e951a25d44b026905e75c0c95d1d.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3389/fnhum.2021.720239"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> frontiersin.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8458928" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Basic helix–loop–helix transcription factor NEUROG1 and schizophrenia: Effects on illness susceptibility, MRI brain morphometry and cognitive abilities☆

B HO, E EPPING, K WANG, N ANDREASEN, A LIBRANT, T WASSINK
<span title="2008-09-16">2008</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/n2tjigm4ejgmpavxgi3mqsqsfe" style="color: black;">Schizophrenia Research</a> </i> &nbsp;
The goal of this study is to investigate NEUROG1 effects on schizophrenia risk and on phenotypic features of schizophrenia.  ...  Consequently, transcription factor mutations can lead to phenotypic pleiotropy, and may be a candidate mechanism underlying the complex genetics and heterogeneous phenotype of schizophrenia.  ...  Acknowledgments This research was supported in part by NIMH Grants MH68380 and MH31593, andNARSAD Independent Investigator Award  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.schres.2008.08.009">doi:10.1016/j.schres.2008.08.009</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/18799289">pmid:18799289</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC2597152/">pmcid:PMC2597152</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/gwqswxl7k5ambgxey5v3evvsbe">fatcat:gwqswxl7k5ambgxey5v3evvsbe</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20191024054746/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC2597152&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/be/8f/be8f7bd66098dffdf038c8229040cf1928c7673e.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.schres.2008.08.009"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> elsevier.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2597152" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Effects of Neuregulin 3 Genotype on Human Prefrontal Cortex Physiology

Heike Tost, Joseph H. Callicott, Roberta Rasetti, Radhakrishna Vakkalanka, Venkata S. Mattay, Daniel R. Weinberger, Amanda J. Law
<span title="2014-01-15">2014</span> <i title="Society for Neuroscience"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/s7bticdwizdmhll4taefg57jde" style="color: black;">Journal of Neuroscience</a> </i> &nbsp;
These observed genotype-dependent effects in PFC were not explained by task performance and did not conform to established locales of prefrontal inefficiency linked to genetic risk for schizophrenia.  ...  genetic risk for schizophrenia and increased activation in some PFC areas has been established.  ...  Although the neural system link between NRG3 and risk for schizophrenia may not be based on prefrontal cortical physiologic inefficiency, other risk-associated imaging phenotypes [e.g., hippocampal-prefrontal  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1523/jneurosci.3496-13.2014">doi:10.1523/jneurosci.3496-13.2014</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/24431462">pmid:24431462</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3891948/">pmcid:PMC3891948</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/tx6d2djle5anfjbyhqvhrrdzdu">fatcat:tx6d2djle5anfjbyhqvhrrdzdu</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20170822082117/http://www.jneurosci.org/content/jneuro/34/3/1051.full.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/02/aa/02aa159d39834ef9104a2a4a47997fa9d32393ee.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1523/jneurosci.3496-13.2014"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3891948" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Functional variants of the dopamine receptor D2 gene modulate prefronto-striatal phenotypes in schizophrenia

Alessandro Bertolino, Leonardo Fazio, Grazia Caforio, Giuseppe Blasi, Antonio Rampino, Raffaella Romano, Annabella Di Giorgio, Paolo Taurisano, Audrey Papp, Julia Pinsonneault, Danxin Wang, Marcello Nardini (+2 others)
<span title="2008-10-01">2008</span> <i title="Oxford University Press (OUP)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/3yly6om4ynhcta4fdjenhrdk5y" style="color: black;">Brain</a> </i> &nbsp;
We performed a case-control study to determine association of these variants and of their main haplotypes with several schizophrenia-related phenotypes.  ...  We also would like to express our thanks to all patients and their families for having DRD2 functional variants and schizophrenia phenotypes Brain 2009: 132; 417-425 | 423 by guest on April 29, 2016 http  ...  Discussion The results of the present study indicate that DRD2 variants are associated with several schizophrenia phenotypes known to be and rs12364283 genotype on WM activity in the striatum (above).  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1093/brain/awn248">doi:10.1093/brain/awn248</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/18829695">pmid:18829695</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC2640212/">pmcid:PMC2640212</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/uiuihxjyhjaulas4bd7anj7cem">fatcat:uiuihxjyhjaulas4bd7anj7cem</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190304124134/http://pdfs.semanticscholar.org/c6a2/0e969b251c8f46051f2d0589d7e6e78e0780.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/c6/a2/c6a20e969b251c8f46051f2d0589d7e6e78e0780.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1093/brain/awn248"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> oup.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2640212" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Influence of ZNF804a on Brain Structure Volumes and Symptom Severity in Individuals With Schizophrenia

Thomas H. Wassink, Eric A. Epping, Danielle Rudd, Michael Axelsen, Stephen Ziebell, Frank W. Fleming, Eric Monson, Beng Choon Ho, Nancy C. Andreasen
<span title="2012-09-01">2012</span> <i title="American Medical Association (AMA)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/lybkshpjjfayvm4wxww2usbh6q" style="color: black;">Archives of General Psychiatry</a> </i> &nbsp;
Context: The single-nucleotide polymorphism rs1344706 in the gene ZNF804a has been associated with schizophrenia and with quantitative phenotypic features, including brain structure volume and the core  ...  Our study supports this assertion by finding that specific genotypes of the polymorphism are associated with brain structure volumes in individuals with schizophrenia and healthy volunteers and with symptom  ...  We find rs1344706 genotype to account for only 1.1% of total cortical WM volume variance in the combined sample and 2.0% in the schizophrenia group.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1001/archgenpsychiatry.2011.2116">doi:10.1001/archgenpsychiatry.2011.2116</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/22945618">pmid:22945618</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3852666/">pmcid:PMC3852666</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/66eaw3t64ncydjcx3vc4dmrqam">fatcat:66eaw3t64ncydjcx3vc4dmrqam</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190501160424/https://jamanetwork.com/journals/jamapsychiatry/articlepdf/1356404/yoa110075_885_892.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/9d/a9/9da95f48fd8cc7103b9c09142cefbf194d54b191.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1001/archgenpsychiatry.2011.2116"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3852666" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

No Effect of a Common Allelic Variant in the Reelin Gene on Intermediate Phenotype Measures of Brain Structure, Brain Function, and Gene Expression

Heike Tost, Barbara K. Lipska, Radhakrishna Vakkalanka, Herve Lemaitre, Joseph H. Callicott, Venkata S. Mattay, Joel E. Kleinman, Stefano Marenco, Daniel R. Weinberger
<span title="">2010</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/z5ukx73avrb57kufzzr36timya" style="color: black;">Biological Psychiatry</a> </i> &nbsp;
Background-A recent genome-wide association study linked a common variant in RELN (rs7341475G) with risk for schizophrenia in women.  ...  Methods-Brain structure was evaluated using voxel-based morphometry (VBM) and diffusion tensor imaging (DTI).  ...  Acknowledgments This research was supported by the Intramural Research Program of the National Institute of Mental Health, NIH, and a DFG-NIH scholarship grant to HT.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.biopsych.2010.02.023">doi:10.1016/j.biopsych.2010.02.023</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/20434133">pmid:20434133</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC2900542/">pmcid:PMC2900542</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/aybz7npguvcbrpue34al4d6cfy">fatcat:aybz7npguvcbrpue34al4d6cfy</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200504104719/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC2900542&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/fc/5f/fc5f3de57cb4c915a97d0c72349e9c9f05060501.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.biopsych.2010.02.023"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> elsevier.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2900542" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Effect of Schizophrenia Risk-Associated Alleles in SREB2 (GPR85) on Functional MRI Phenotypes in Healthy Volunteers

Eugenia Radulescu, Fabio Sambataro, Venkata S Mattay, Joseph H Callicott, Richard E Straub, Mitsuyuki Matsumoto, Daniel R Weinberger, Stefano Marenco
<span title="2012-09-12">2012</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/zscwnf3bera7vcvkm7bgnh2sbu" style="color: black;">Neuropsychopharmacology</a> </i> &nbsp;
These data suggest that risk-associated variants in SREB2 are associated with phenotypes similar to those found in patients with schizophrenia in the DLPFC and the amygdala of males, while the pattern  ...  Genetic variants in GPR85 (SREB2: rs56080411 and rs56039557) have been associated with risk for schizophrenia.  ...  We tested for IQ effects and interactions with genotype in the corresponding imaging analyses.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1038/npp.2012.184">doi:10.1038/npp.2012.184</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/22968816">pmid:22968816</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3527120/">pmcid:PMC3527120</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/zaxx4yzcsnglngokiub35a4efm">fatcat:zaxx4yzcsnglngokiub35a4efm</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200510165610/https://www.nature.com/articles/npp2012184.pdf?error=cookies_not_supported&amp;code=2123a7f9-e872-4ee8-be24-2904c60aa2c3" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/27/d0/27d09d1af2425ecd8500c0ea55e086309a912b60.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1038/npp.2012.184"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3527120" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

ZNF804A and Cortical Structure in Schizophrenia: In Vivo and Postmortem Studies

Carl Christoph Schultz, Igor Nenadic, Brien Riley, Vladimir I. Vladimirov, Gerd Wagner, Kathrin Koch, Claudia Schachtzabel, Thomas W. Mühleisen, Buket Basmanav, Markus M. Nöthen, Thomas Deufel, Michael Kiehntopf (+5 others)
<span title="2013-09-27">2013</span> <i title="Oxford University Press (OUP)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/o67mrs6u45fmrmhkxo62gcvrli" style="color: black;">Schizophrenia Bulletin</a> </i> &nbsp;
Magnetic resonance imaging cortical thickness and folding were computed in 55 genotyped patients with schizophrenia and 40 healthy controls.  ...  other intermediate phenotypes.  ...  Acknowledgments The sponsor served no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the article for publication  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1093/schbul/sbt123">doi:10.1093/schbul/sbt123</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/24078172">pmid:24078172</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3984519/">pmcid:PMC3984519</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/vvrln4xs7vhirnlysviypteeaa">fatcat:vvrln4xs7vhirnlysviypteeaa</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190308062204/http://pdfs.semanticscholar.org/ee5b/c49e8f15fe2dbbee7d6b323d088bc9029d86.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/ee/5b/ee5bc49e8f15fe2dbbee7d6b323d088bc9029d86.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1093/schbul/sbt123"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> oup.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3984519" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Neuroimaging and molecular genetics of schizophrenia: pathophysiological advances and therapeutic potential

S M Lawrie, J Hall, A M McIntosh, D G Cunningham-Owens, E C Johnstone
<span title="2009-01-29">2009</span> <i title="Wiley"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/wsc2264oo5gpvk5scotezp75pu" style="color: black;">British Journal of Pharmacology</a> </i> &nbsp;
In a sample of young, initially healthy people at high genetic risk of schizophrenia brain structure was measured with structural magnetic resonance imaging (sMRI) and brain function was indexed with neuropsychological  ...  Examining their relationship with brain imaging indices is arguably the best currently available method of examining these effects in vivo.  ...  Acknowledgements SM Lawrie is supported by a charitable donation from the Dr Mortimer and Theresa Sackler Foundation. This work is funded by them and the Medical Research Council of Great Britain.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1038/sj.bjp.0707655">doi:10.1038/sj.bjp.0707655</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/18193072">pmid:18193072</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC2268055/">pmcid:PMC2268055</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/gvl5m4c3rnd6ljaqvhsvbj6c2m">fatcat:gvl5m4c3rnd6ljaqvhsvbj6c2m</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200501023812/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC2268055&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/e2/ad/e2ad363035c6be0119737b66177bad930238e40e.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1038/sj.bjp.0707655"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2268055" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Gene discovery through imaging genetics: identification of two novel genes associated with schizophrenia

S G Potkin, J A Turner, J A Fallon, A Lakatos, D B Keator, G Guffanti, F Macciardi
<span title="2008-12-09">2008</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/ywuy2l3c7ngernsmmsbttqvzna" style="color: black;">Molecular Psychiatry</a> </i> &nbsp;
We introduce the use of functional magnetic resonance imaging activation as a quantitative phenotype in conjunction with genome-wide association as a gene discovery tool. .  ...  We have discovered two genes, RSRC1 and ARHGAP18, associated with schizophrenia and in an independent study provided additional support for this association.  ...  the imaging phenotype in the discovery sample.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1038/mp.2008.127">doi:10.1038/mp.2008.127</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/19065146">pmid:19065146</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3254586/">pmcid:PMC3254586</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/zov6oarjuba5biiqchbomoatsi">fatcat:zov6oarjuba5biiqchbomoatsi</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20191023022921/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC3254586&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/f0/f7/f0f79c396223ba02fadb49b513dab3ec625d173d.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1038/mp.2008.127"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3254586" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Phenotype-Based Genetic Association Studies (PGAS)—Towards Understanding the Contribution of Common Genetic Variants to Schizophrenia Subphenotypes

Hannelore Ehrenreich, Klaus-Armin Nave
<span title="2014-02-27">2014</span> <i title="MDPI AG"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/githwx23ynaxdoftesby3jya3y" style="color: black;">Genes</a> </i> &nbsp;
"Risk genotypes" of unknown significance with low odds ratios of mostly <1.2 were extracted and confirmed by including ever increasing numbers of individuals in large multicenter efforts.  ...  Deep phenotyping and comprehensive clinical data sets, however, are expensive and it may take years before PGAS will complement conventional GWAS approaches in psychiatric genetics.  ...  Acknowledgments This work has received continuous support by the Max Planck Society, the Max Planck Förderstiftung, and the DFG (CNMPB).  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/genes5010097">doi:10.3390/genes5010097</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/24705289">pmid:24705289</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3978514/">pmcid:PMC3978514</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/fndmjhwsmbfktjinmr7g56mcye">fatcat:fndmjhwsmbfktjinmr7g56mcye</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20150621011036/http://www.mdpi.com:80/2073-4425/5/1/97/pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/28/77/2877aad81e1813830caa1db07c034fd3121aa52f.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/genes5010097"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> mdpi.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978514" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

DTNBP1 is associated with imaging phenotypes in schizophrenia

Katherine L. Narr, Philip R. Szeszko, Todd Lencz, Roger P. Woods, Liberty S. Hamilton, Owen Phillips, Delbert Robinson, Katherine E. Burdick, Pamela DeRosse, Raju Kucherlapati, Paul M. Thompson, Arthur W. Toga (+2 others)
<span title="">2009</span> <i title="Wiley"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/wtsn7qcbmrhjppax2iuhu4xj2m" style="color: black;">Human Brain Mapping</a> </i> &nbsp;
We examined relationships between a previously implicated DTNBP1 risk variant [P1578] and global and segmented brain tissue volumes and regional cortical thickness in schizophrenia (n=62; 24 risk carriers  ...  Although DTNBP1 relates to cortical thinning in schizophrenia, morphological changes in the disorder are influenced by additional genetic and/or environmental factors.  ...  R01 MH060374, to RMB), the NIH Roadmap for Medical Research (U54 RR021813, Center for Computational Biology (CCB); and UL1 RR024911, Consortium for Neuropsychiatric Phenomics (CNP)).  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1002/hbm.20806">doi:10.1002/hbm.20806</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/19449336">pmid:19449336</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3176807/">pmcid:PMC3176807</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/hrqchakz5vbpncounramiciqoa">fatcat:hrqchakz5vbpncounramiciqoa</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200208035749/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC3176807&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/ec/11/ec1165852ecb3b6cad4d423c81a5bf1daba13b58.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1002/hbm.20806"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> wiley.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3176807" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

A Genotype-Phenotype Research Strategy for Schizophrenia*

W.G. Honer, A.S. Bassett, L. Kopala, J.L. Kennedy
<span title="">1990</span> <i title="SAGE Publications"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/fyebacrm4zchhbmzh26gtzhy3e" style="color: black;">Canadian journal of psychiatry</a> </i> &nbsp;
A research strategy which integrates known biological aspects of schizophrenia is proposed. The strategy includes genotype and phenotype components and emphasizes interactions.  ...  Clinical and laboratory based methodologies are applied within the genotype and phenotype components of the strategy.  ...  Honer and Kennedy), MRC Canada (Dr. Honer), the Keck Foundation, Scottish Rite Schizophrenia Research Program and Eli Lilly (Dr.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1177/070674379003500910">doi:10.1177/070674379003500910</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/2282633">pmid:2282633</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3176297/">pmcid:PMC3176297</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/gikq2dqcc5ezdb5cnualokb3am">fatcat:gikq2dqcc5ezdb5cnualokb3am</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20191013041950/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC3176297&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/00/a7/00a70e5cd6e8e6e8f6bc83b2c7b6d7eb53ce44ae.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1177/070674379003500910"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> sagepub.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3176297" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>
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