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The Imaging and Cognition Genetics Conference 2011, ICG 2011: A Meeting of Minds

Stéphanie Le Hellard, Isabel Hanson
2012 Frontiers in Neuroscience  
The first is the importance of defining cognitive and imaging phenotypes and endophenotypes suitable for genetic analysis.  ...  These can come from differential psychology, cognitive science, structural MRI, tractography, and functional imaging.  ...  ACKNOWLEDGMENTS We thank the conference speakers whose talks are summarized in this report: Ian Deary (University of Edinburgh, UK), Thomas Espeseth (University of Oslo, Norway), Yulia Kovas We also gratefully  ... 
doi:10.3389/fnins.2012.00074 pmid:22654732 pmcid:PMC3359444 fatcat:nmzmmf33r5cpdh7im7pfm5biga

Cognitive, Genetic, Brain Volume, and Diffusion Tensor Imaging Markers as Early Indicators of Dementia

Theresa Müller, Nicola M. Payton, Grégoria Kalpouzos, Frank Jessen, Giulia Grande, Lars Bäckman, Erika J. Laukka
2020 Journal of Alzheimer's Disease  
, fluid-attenuated inversion recovery, diffusion tensor imaging), neuropsychological testing (perceptual speed, episodic memory, semantic memory, letter and category fluency), and genotyping (APOE).  ...  Objective: We aimed to evaluate the individual and combined effects of multiple markers, with special focus on microstructural white matter integrity, in detecting individuals with increased dementia risk  ...  In the cognitive domain, global cognitive ability, perceptual speed, executive function, and episodic memory are frequently affected [4] .  ... 
doi:10.3233/jad-200445 fatcat:6nctxnkq4rcwrccmbzcfchzcwq

Cognitive, Genetic, Brain Volume, and Diffusion Tensor Imaging Markers as Early Indicators of Dementia

Theresa Müller, Nicola M Payton, Grégoria Kalpouzos, Frank Jessen, Giulia Grande, Lars Bäckman, Erika J Laukka
2020 Journal of Alzheimer's Disease  
inversion recovery, diffusion tensor imaging), neuropsychological testing (perceptual speed, episodic memory, semantic memory, letter and category fluency), and genotyping (APOE).  ...  We aimed to evaluate the individual and combined effects of multiple markers, with special focus on microstructural white matter integrity, in detecting individuals with increased dementia risk.  ...  The best individual predictor was episodic 392 memory and the best combination of two spe-393 cific variables was obtained with episodic memory 394 and APOE (AUC = 0.910).  ... 
doi:10.3233/jad-200445 pmid:32925047 pmcid:PMC7683082 fatcat:qdqqiut36bbs3n6ntwnbzpedly

Genetic analysis of quantitative phenotypes in AD and MCI: imaging, cognition and biomarkers

Li Shen, Paul M. Thompson, Steven G. Potkin, Lars Bertram, Lindsay A. Farrer, Tatiana M. Foroud, Robert C. Green, Xiaolan Hu, Matthew J. Huentelman, Sungeun Kim, John S. K. Kauwe, Qingqin Li (+12 others)
2013 Brain Imaging and Behavior  
ADNI imaging genetics studies discovered novel findings (e.g., FRMD6 ) that were later replicated on different data sets.  ...  A complete listing of ADNI investigators can be found at: functional neuroimaging, fluid biomarker assays, and cognitive performance.  ...  One study identified a significant association of one coding variant in CR1 gene with episodic memory decline .  ... 
doi:10.1007/s11682-013-9262-z pmid:24092460 pmcid:PMC3976843 fatcat:a4ufw3rjcbbjzbzmeppuicws2a

Structural and Functional Brain Abnormalities in Schizophrenia

Katherine H. Karlsgodt, Daqiang Sun, Tyrone D. Cannon
2010 Current Directions in Psychological Science  
Here we review recent directions in structural and functional neuroimaging research on schizophrenia.  ...  Schizophrenia is associated with changes in the structure and functioning of a number of key brain systems, including prefrontal and medial temporal lobe regions involved in working memory and declarative  ...  Correspondingly, functional imaging techniques show abnormal neural activity when patients are engaged in various cognitive tasks, including those assessing short-term memory, long-term memory, decision  ... 
doi:10.1177/0963721410377601 pmid:25414548 pmcid:PMC4235761 fatcat:4az6j6yyebcb7nwm6mj25ue2fm

Genetics and Functional Imaging: Effects of APOE, BDNF, COMT, and KIBRA in Aging

Goran Papenberg, Alireza Salami, Jonas Persson, Ulman Lindenberger, Lars Bäckman
2015 Neuropsychology Review  
Increasing evidence from cross-sectional and longitudinal molecular-genetic studies suggests that effects of common genetic variations on cognitive functioning increase with aging.  ...  We review the influence of candidate genes on brain functioning in old age, focusing on four genetic variations that have been extensively investigated: APOE, BDNF, COMT, and KIBRA.  ...  Acknowledgments Preparation of this review was supported by grants from the Swedish Research Council, the Swedish Research Council for Health, Working Life, and Welfare, Swedish Brain Power, an Alexander  ... 
doi:10.1007/s11065-015-9279-8 pmid:25666727 fatcat:24x5ra55xrar7ifn4vljcjwava

What Is Normal Cognitive Aging? Evidence from Task-Based Functional Neuroimaging

Julie A. Dumas
2015 Current Behavioral Neuroscience Reports  
, working memory, and episodic memory and better on tests of general knowledge.  ...  More recent work in task-related functional neuroimaging has further elucidated the effects of aging on brain circuitry related to these cognitive processes.  ...  Functional Neuroimaging Studies of Attention, Working Memory, and Episodic Memory in Healthy Older Adults Older adults show impairments on tasks of attention, working memory, and episodic memory relative  ... 
doi:10.1007/s40473-015-0058-x pmid:26925366 pmcid:PMC4767530 fatcat:32wnktcvqnf2zbd4nupjgp52re

Large-Scale Functional Brain Network Abnormalities in Alzheimer's Disease: Insights from Functional Neuroimaging

Bradford C. Dickerson, Reisa A. Sperling
2009 Behavioural Neurology  
Since the medial temporal lobe (MTL) memory system is a site of very early pathology in AD, a number of studies have focused on this region of the brain.  ...  Functional MRI (fMRI) studies of mild cognitive impairment (MCI) and Alzheimer's disease (AD) have begun to reveal abnormalities in large-scale memory and cognitive brain networks.  ...  Large-scale brain networks supporting normal memory function Functional neuroimaging has made valuable contributions to the cognitive neuroscientific investigation of brain networks subserving episodic  ... 
doi:10.1155/2009/610392 fatcat:osv7fxlj4vegjmnm3n5xiyutt4

Age-related decline in brain resources magnifies genetic effects on cognitive functioning

Ulman Lindenberger
2008 Frontiers in Neuroscience  
We hypothesize that losses in neurochemical and anatomical brain resources in normal aging modulate the effects of common genetic variations on cognitive functioning.  ...  Our hypothesis is based on the assumption that the function relating brain resources to cognition is nonlinear, so that genetic differences exert increasingly large effects on cognition as resources recede  ...  Rather, to complement the focus of Nagel et al. (2008) on executive functioning and WM, we will selectively focus on four genes that are particularly relevant for episodic memory, namely GRM3, BDNF,  ... 
doi:10.3389/neuro.01.039.2008 pmid:19225597 pmcid:PMC2622748 fatcat:hfh2wmwnmzeg3p4fnv3an76cqe

Imaging markers of structural and functional brain changes that precede cognitive symptoms in risk for Alzheimer's disease

Alison Burggren, Jesse Brown
2013 Brain Imaging and Behavior  
Focusing on prodromal subjects, we will discuss structural changes to hippocampal subregions, alterations to functional activity both within the hippocampus and elsewhere in the cortex, as well as changes  ...  to structural white matter connectivity and changes to functionally correlated patterns during memory performance.  ...  This node, therefore, became the primary focus early on of many imaging studies in at-risk, but cognitively intact subjects at elevated risk for future cognitive decline in AD.  ... 
doi:10.1007/s11682-013-9278-4 pmid:24317680 pmcid:PMC4012007 fatcat:fth5gb2f7zcbbkdswjt7c7hwx4

Research progress in China on the assessment of cognitive function in schizophrenia

Dengtang Liu, Yingchan Wang, Yifeng Xu, Kaida Jiang
2013 Shanghai Archives of Psychiatry  
Cognitive impairment - one of the core symptoms of schizophrenia - has become a focus of research about schizophrenia in China and elsewhere.  ...  The first study on cognitive function in schizophrenia in China was conducted in the late 1970s; more recently there has been a resurgence of interest in the area because of new information that has emerged  ...  Conflict of interest All authors declare that they have no conflict of interest.  ... 
doi:10.3969/j.issn.1002-0829.2013.05.002 pmid:24991166 pmcid:PMC4054565 fatcat:47uomh5k4bbqvperhd6cjxdlaa

Hippocampal function, declarative memory, and schizophrenia: Anatomic and functional neuroimaging considerations

Alison R. Preston, Daphna Shohamy, Carol A. Tamminga, Anthony D. Wagner
2005 Current Neurology and Neuroscience Reports  
Thus, some of the broader disturbances in cognitive function associated with schizophrenia, including impaired performance on tasks that focus on abstraction or associative memory processing, may result  ...  are functionally disconnected during performance on some cognitive tasks [14] .  ... 
doi:10.1007/s11910-005-0067-3 pmid:15987607 fatcat:vgfwspnotvehtpiedxrotd2isq

Functional magnetic resonance imaging: Emerging clinical applications

Heather A. Wishart, Andrew J. Saykin, Thomas W. McAllister
2002 Current Psychiatry Reports  
Acknowledgments The authors thank the agencies supporting imaging research in our laboratory, including the Hitchcock Foundation, the National Multiple Sclerosis Society, the National Institutes of Aging  ...  (AG19771), the National Institute of Neurological Disorders and Stroke (NS 40472), the National Institute of Disability and Rehabilitation Research (H133G000136), the Alzheimer's Association and the Ira  ...  Mild Cognitive Impairment and Alzheimer's Disease A hallmark cognitive feature of Alzheimer's disease (AD) is episodic memory impairment.  ... 
doi:10.1007/s11920-002-0081-y pmid:12230962 fatcat:5ik57unrcjeltkdaqzrhtjcbmm

Functional magnetic resonance imaging as a dynamic candidate biomarker for Alzheimer's disease

David Prvulovic, Arun L.W. Bokde, Frank Faltraco, Harald Hampel
2011 Progress in Neurobiology  
Potential caveats of functional imaging are critically reviewed with focus on confound variables such as altered neurovascular coupling as well as parameters related to task-and study design. 1.  ...  During the last two decades, imaging of neural activation has become an invaluable tool for assessing the functional organization of the human brain in vivo.  ...  for use in genetic imaging than functional activation imaging based on cognitive tasks.  ... 
doi:10.1016/j.pneurobio.2011.05.008 pmid:21722703 fatcat:qanvaqdw35dspgcr47k4o6iuqi

Cognitive Function in Schizophrenia: A Review

2015 Journal of Psychiatry  
Though not described as diagnostic criteria, cognitive dysfunction is the strongest determinant of functional recovery as it has a gradual deteriorating effect on social and occupational functioning.  ...  Among different cognitive abilities it affects attention, memory, processing speed, social cognition and executive function most.  ...  Neuropsychological test batteries typically focus on assessment of multiple cognitive abilities, such as memory, executive functions, attention, visuospatial ability etc. and these include a strong component  ... 
doi:10.4172/psychiatry.1000187 fatcat:akvgo43g55b43mjir3d7dwt6p4
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