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The effects of Δ9-tetrahydrocannabinol on the dopamine system
2016
Nature
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Altered architecture and functional consequences of the mesolimbic dopamine system in cannabis dependence. ...
Sprague-Dawley Rats and Stimulation of in vivo Dopamine Transmission in the Nucleus Accumbens Shell. ...
doi:10.1038/nature20153
pmid:27853201
pmcid:PMC5123717
fatcat:4w7s542wvbbqhmdcbv46hpqtku
Cerebral glucose metabolism and D2/D3 receptor availability in young adults with cannabis dependence measured with positron emission tomography
2008
Psychopharmacology
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Compared to controls, subjects with cannabis dependence had lower normalized glucose metabolism in the right orbitofrontal cortex, putamen bilaterally, and precuneus. ...
Materials and methods-Six 18-21-year-old male subjects with cannabis dependence in early full remission and six age-and sex-matched healthy subjects underwent PET scans for D 2 /D 3 receptor availability ...
There do not appear to be any published imaging studies evaluating dopamine D 2 /D 3 receptor availability in cannabis-use disorders after prolonged periods of abstinence. ...
doi:10.1007/s00213-008-1075-1
pmid:18270689
pmcid:PMC5646272
fatcat:uz2gg3bbnnhrbeywmut2hk2joa
Dopaminergic Function in Cannabis Users and Its Relationship to Cannabis-Induced Psychotic Symptoms
2014
Biological Psychiatry
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The group difference in dopamine synthesis capacity in cannabis users compared with control subjects was driven by those users meeting cannabis abuse or dependence criteria. ...
Methods: We compared dopamine synthesis capacity in 19 regular cannabis users who experienced psychotic-like symptoms when they consumed cannabis with 19 nonuser sex-and age-matched control subjects. ...
Striatal dopamine synthesis dopamine synthesis capacity in subjects who met DSM-IV criteria for a diagnosis of cannabis dependence or abuse (n ¼ 10), regular cannabis users who did not meet diagnostic ...
doi:10.1016/j.biopsych.2013.05.027
pmid:23820822
fatcat:u75i2uvvvfd4vhtja3lbtqrbze
A review of positron emission tomography studies exploring the dopaminergic system in substance use with a focus on tobacco as a co-variate
2016
The American Journal of Drug and Alcohol Abuse
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A defined role for the dopaminergic system in cannabis and opiate use has yet to be elucidated. ...
In this review, we summarize PET investigations from the last ten years that explore the dopaminergic system in tobacco, alcohol, stimulant, opiates and cannabis addiction. ...
In Vivo Imaging of Cerebral Dopamine D3 receptors in Alcoholism. Neuropsychopharmacology. 2014 47. ...
doi:10.1080/00952990.2016.1257633
pmid:27901585
pmcid:PMC5584784
fatcat:rt3vznmey5corj47wss6x5fvwm
Salience attribution and its relationship to cannabis-induced psychotic symptoms
2016
Psychological Medicine
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between cannabis dependency/abuse status and high implicit aberrant salience scores (F 1,15 = 5.8, p = 0.03). ...
Conclusions Aberrant salience is positively associated with cannabis-induced psychotic symptom severity, but is not seen in cannabis users overall. ...
Cannabis users are dose-dependently at increased risk of schizophrenia (Murray et al. in press) . ...
doi:10.1017/s0033291716002051
pmid:27628967
pmcid:PMC5122315
fatcat:lkhs4ltk7jdhvozuiipyikceq4
Dopamine Release in Chronic Cannabis Users: A [11C]Raclopride Positron Emission Tomography Study
2012
Biological Psychiatry
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Less is known about the dopaminergic system in cannabis dependence. ...
Introduction-Low striatal dopamine 2/3 receptor (D2/3) availability and low ventrostriatal (VST) dopamine (DA) release have been observed in alcoholism, cocaine and heroin dependence. ...
Stimulant dependent participants with lower dopamine D2/3 receptor availability and lower dopamine transmission are more likely to relapse into drug use than those with higher dopamine activity [43, 44 ...
doi:10.1016/j.biopsych.2011.12.018
pmid:22290115
pmcid:PMC3314125
fatcat:53duuai2cvcv3g6ostzagn5jda
Deficits in striatal dopamine release in cannabis dependence
2016
Molecular Psychiatry
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To test whether cannabis dependence is associated with a similar dopaminergic deficit, we examined striatal and extrastriatal dopamine release in severely cannabis dependent participants (CD), free of ...
In conclusion, this study provides evidence that severe cannabis dependence -without the confounds of any comorbidity-is associated with a deficit in striatal dopamine release. ...
Dependence on dopamine-enhancing substances of abuse is associated with blunted striatal dopamine transmission 13, 14 . ...
doi:10.1038/mp.2016.21
pmid:27001613
pmcid:PMC5033654
fatcat:744tqga5kjghzo743drm5m5pyi
Δ9-Tetrahydrocannabinol Induces Dopamine Release in the Human Striatum
2008
Neuropsychopharmacology
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An increasing demand for treatment of cannabis dependence has refueled the discussion about the addictive potential of cannabis. ...
However, it is currently unknown if cannabis can stimulate striatal dopamine neurotransmission in humans. ...
Recently, a substantial increase in the demand for treatment of cannabis dependence has intensified this discussion (Hall, 2006) . ...
doi:10.1038/npp.2008.138
pmid:18754005
fatcat:qcvna4yvgbbxhgjolvydjtuism
Δ 9-Tetrahydrocannabinol Toxicity and Validation of Cannabidiol on Brain Dopamine Levels: An Assessment on Cannabis Duplicity
2020
Natural Products and Bioprospecting
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Legal authorization of cannabis use and its analogs in most countries led to a drastic dispute in the elicitation of cannabis products. ...
With a recent increase in cannabis-induced disorder rates, the present review highlighted the detrimental effects of THC and the effects of CBD on THC induced alterations in DA synthesis and release. ...
Cannabis and Dopamine Vulnerability to DA-enhancing substances of abuse is analogous to impaired striatal DA transmission [22, 23] . ...
doi:10.1007/s13659-020-00263-z
pmid:32860199
fatcat:qgjutz7aabezffv3duedi5s7im
Effect of cannabis on glutamate signalling in the brain: A systematic review of human and animal evidence
2016
Neuroscience and Biobehavioral Reviews
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on the dopamine system in man is equivocal Chronic cannabis use reduces glutamate or its metabolites levels in human brain Δ9-THC alters glutamate signalling in animal brain 3 ABSTRACT Use of cannabis ...
In fact, it is thought that cannabis or Δ9-THC may not act on dopamine firing directly but indirectly by altering glutamate neurotransmission. ...
Previous reviews have mainly focused on the effects of cannabis use on dopamine transmission, in both animals (Kuepper et al., 2010) and humans (Ghazzaoui and Abi-Dargham, 2014; Sami et al., 2015; van ...
doi:10.1016/j.neubiorev.2016.03.010
pmid:26987641
fatcat:atecs5h3dnbcxjallh7qoyvcdu
Interaction Between Functional Genetic Variation of DRD2 and Cannabis Use on Risk of Psychosis
2015
Schizophrenia Bulletin
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Both cannabis use and the dopamine receptor (DRD2) gene have been associated with schizophrenia, psychosis-like experiences, and cognition. ...
In the case-control study, we found a significant interaction between the rs1076560 DRD2 genotype and cannabis use in influencing the likelihood of a psychotic disorder. ...
alteration in striatal dopamine. ...
doi:10.1093/schbul/sbv032
pmid:25829376
pmcid:PMC4535639
fatcat:tl7pjr4tdrbedpdhjf3sl3cd6e
Mechanisms contributing to prefrontal cortex maturation during adolescence
2016
Neuroscience and Biobehavioral Reviews
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Studies in animal models allow us to test the causal contribution of specific neural processes in the development of the prefrontal cortex and the acquisition of adult behavior. ...
These changes have been associated with the maturation of brain regions involved in the control of motivation, emotion, and cognition. ...
Dopamine D1 receptor stimulation in the adult PFC can elicit long-lasting plateau depolarizations in pyramidal neurons, an effect that requires NMDA receptor transmission and postsynaptic calcium-dependent ...
doi:10.1016/j.neubiorev.2016.05.013
pmid:27235076
pmcid:PMC5074870
fatcat:3cpny27hbfdfxjr7gfdxopyw4m
Cannabis and cocaine decrease cognitive impulse control and functional corticostriatal connectivity in drug users with low activity DBH genotypes
2015
Brain Imaging and Behavior
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The dopamine β-hydroxylase (DβH) enzyme transforms dopamine into noradrenaline. ...
It is concluded that interference of cannabis and cocaine with cognitive impulse control and functional corticostriatal connectivity depends on DBH genotype. ...
Leijtens and Cees van Leeuwen for their medical supervision and support in data collection, Marina Hakobjan for genotyping and all participants for their time and dedication. ...
doi:10.1007/s11682-015-9488-z
pmid:26667034
pmcid:PMC5167221
fatcat:r2esfitm4jg7ba3nf7p6bfbvdu
Pharmacological Treatment of Cannabis Dependence
2011
Current pharmaceutical design
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There is a significant increase in the number of treatment admissions for cannabis use disorders in the past few years, and the majority of cannabis-dependent individuals who enter treatment have difficulty ...
Buspirone is the only medication to date that has shown efficacy for cannabis dependence in a controlled clinical trial. ...
Weinstein is supported by the National Institute for Psychobiology in Israel that is funded by the Charles E. Smith Foundation. Dr. ...
doi:10.2174/138161211796150846
pmid:21524266
pmcid:PMC3171994
fatcat:xkq3wiyklrf5dmxxs7wo4iq3v4
Acute effects of cocaine and cannabis on reversal learning as a function of COMT and DRD2 genotype
2015
Psychopharmacology
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The effects of cocaine, but not cannabis, depend on interindividual genetic differences in the dopamine D2 receptor gene. ...
Effects of cocaine depended on the DRD2 genotype, as increases in proportion correct were seen only in the A1 carriers, and not in the A2/A2 homozygotes. ...
Acknowledgments We kindly thank the participants for taking part in the study and acknowledge the contribution of Jan Leijtens in data collection, and Michiel Kleinnijenhuis and Sean Fallon for providing ...
doi:10.1007/s00213-015-4141-5
pmid:26572896
pmcid:PMC4700084
fatcat:s5kbndms4vhhvbsgo6n4uukfhy
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