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The effects of Δ9-tetrahydrocannabinol on the dopamine system

Michael A. P. Bloomfield, Abhishekh H. Ashok, Nora D. Volkow, Oliver D. Howes
2016 Nature  
Altered architecture and functional consequences of the mesolimbic dopamine system in cannabis dependence.  ...  Sprague-Dawley Rats and Stimulation of in vivo Dopamine Transmission in the Nucleus Accumbens Shell.  ... 
doi:10.1038/nature20153 pmid:27853201 pmcid:PMC5123717 fatcat:4w7s542wvbbqhmdcbv46hpqtku

Cerebral glucose metabolism and D2/D3 receptor availability in young adults with cannabis dependence measured with positron emission tomography

Serge Sevy, Gwenn S. Smith, Yilong Ma, Vijay Dhawan, Thomas Chaly, Peter B. Kingsley, Sanjiv Kumra, Sherif Abdelmessih, David Eidelberg
2008 Psychopharmacology  
Compared to controls, subjects with cannabis dependence had lower normalized glucose metabolism in the right orbitofrontal cortex, putamen bilaterally, and precuneus.  ...  Materials and methods-Six 18-21-year-old male subjects with cannabis dependence in early full remission and six age-and sex-matched healthy subjects underwent PET scans for D 2 /D 3 receptor availability  ...  There do not appear to be any published imaging studies evaluating dopamine D 2 /D 3 receptor availability in cannabis-use disorders after prolonged periods of abstinence.  ... 
doi:10.1007/s00213-008-1075-1 pmid:18270689 pmcid:PMC5646272 fatcat:uz2gg3bbnnhrbeywmut2hk2joa

Dopaminergic Function in Cannabis Users and Its Relationship to Cannabis-Induced Psychotic Symptoms

Michael A.P. Bloomfield, Celia J.A. Morgan, Alice Egerton, Shitij Kapur, H. Valerie Curran, Oliver D. Howes
2014 Biological Psychiatry  
The group difference in dopamine synthesis capacity in cannabis users compared with control subjects was driven by those users meeting cannabis abuse or dependence criteria.  ...  Methods: We compared dopamine synthesis capacity in 19 regular cannabis users who experienced psychotic-like symptoms when they consumed cannabis with 19 nonuser sex-and age-matched control subjects.  ...  Striatal dopamine synthesis dopamine synthesis capacity in subjects who met DSM-IV criteria for a diagnosis of cannabis dependence or abuse (n ¼ 10), regular cannabis users who did not meet diagnostic  ... 
doi:10.1016/j.biopsych.2013.05.027 pmid:23820822 fatcat:u75i2uvvvfd4vhtja3lbtqrbze

A review of positron emission tomography studies exploring the dopaminergic system in substance use with a focus on tobacco as a co-variate

Thulasi Thiruchselvam, Saima Malik, Bernard Le Foll
2016 The American Journal of Drug and Alcohol Abuse  
A defined role for the dopaminergic system in cannabis and opiate use has yet to be elucidated.  ...  In this review, we summarize PET investigations from the last ten years that explore the dopaminergic system in tobacco, alcohol, stimulant, opiates and cannabis addiction.  ...  In Vivo Imaging of Cerebral Dopamine D3 receptors in Alcoholism. Neuropsychopharmacology. 2014 47.  ... 
doi:10.1080/00952990.2016.1257633 pmid:27901585 pmcid:PMC5584784 fatcat:rt3vznmey5corj47wss6x5fvwm

Salience attribution and its relationship to cannabis-induced psychotic symptoms

M. A. P. Bloomfield, E. Mouchlianitis, C. J. A. Morgan, T. P. Freeman, H. V. Curran, J. P. Roiser, O. D. Howes
2016 Psychological Medicine  
between cannabis dependency/abuse status and high implicit aberrant salience scores (F 1,15 = 5.8, p = 0.03).  ...  Conclusions Aberrant salience is positively associated with cannabis-induced psychotic symptom severity, but is not seen in cannabis users overall.  ...  Cannabis users are dose-dependently at increased risk of schizophrenia (Murray et al. in press) .  ... 
doi:10.1017/s0033291716002051 pmid:27628967 pmcid:PMC5122315 fatcat:lkhs4ltk7jdhvozuiipyikceq4

Dopamine Release in Chronic Cannabis Users: A [11C]Raclopride Positron Emission Tomography Study

Nina B.L. Urban, Mark Slifstein, Judy L. Thompson, Xiaoyan Xu, Ragy R. Girgis, Sonia Raheja, Margaret Haney, Anissa Abi-Dargham
2012 Biological Psychiatry  
Less is known about the dopaminergic system in cannabis dependence.  ...  Introduction-Low striatal dopamine 2/3 receptor (D2/3) availability and low ventrostriatal (VST) dopamine (DA) release have been observed in alcoholism, cocaine and heroin dependence.  ...  Stimulant dependent participants with lower dopamine D2/3 receptor availability and lower dopamine transmission are more likely to relapse into drug use than those with higher dopamine activity [43, 44  ... 
doi:10.1016/j.biopsych.2011.12.018 pmid:22290115 pmcid:PMC3314125 fatcat:53duuai2cvcv3g6ostzagn5jda

Deficits in striatal dopamine release in cannabis dependence

E van de Giessen, J J Weinstein, C M Cassidy, M Haney, Z Dong, R Ghazzaoui, N Ojeil, L S Kegeles, X Xu, N P Vadhan, N D Volkow, M Slifstein (+1 others)
2016 Molecular Psychiatry  
To test whether cannabis dependence is associated with a similar dopaminergic deficit, we examined striatal and extrastriatal dopamine release in severely cannabis dependent participants (CD), free of  ...  In conclusion, this study provides evidence that severe cannabis dependence -without the confounds of any comorbidity-is associated with a deficit in striatal dopamine release.  ...  Dependence on dopamine-enhancing substances of abuse is associated with blunted striatal dopamine transmission 13, 14 .  ... 
doi:10.1038/mp.2016.21 pmid:27001613 pmcid:PMC5033654 fatcat:744tqga5kjghzo743drm5m5pyi

Δ9-Tetrahydrocannabinol Induces Dopamine Release in the Human Striatum

Matthijs G Bossong, Bart NM van Berckel, Ronald Boellaard, Lineke Zuurman, Robert C Schuit, Albert D Windhorst, Joop M A van Gerven, Nick F Ramsey, Adriaan A Lammertsma, René S Kahn
2008 Neuropsychopharmacology  
An increasing demand for treatment of cannabis dependence has refueled the discussion about the addictive potential of cannabis.  ...  However, it is currently unknown if cannabis can stimulate striatal dopamine neurotransmission in humans.  ...  Recently, a substantial increase in the demand for treatment of cannabis dependence has intensified this discussion (Hall, 2006) .  ... 
doi:10.1038/npp.2008.138 pmid:18754005 fatcat:qcvna4yvgbbxhgjolvydjtuism

Δ 9-Tetrahydrocannabinol Toxicity and Validation of Cannabidiol on Brain Dopamine Levels: An Assessment on Cannabis Duplicity

Swapnali Chetia, Gaurab Borah
2020 Natural Products and Bioprospecting  
Legal authorization of cannabis use and its analogs in most countries led to a drastic dispute in the elicitation of cannabis products.  ...  With a recent increase in cannabis-induced disorder rates, the present review highlighted the detrimental effects of THC and the effects of CBD on THC induced alterations in DA synthesis and release.  ...  Cannabis and Dopamine Vulnerability to DA-enhancing substances of abuse is analogous to impaired striatal DA transmission [22, 23] .  ... 
doi:10.1007/s13659-020-00263-z pmid:32860199 fatcat:qgjutz7aabezffv3duedi5s7im

Effect of cannabis on glutamate signalling in the brain: A systematic review of human and animal evidence

Marco Colizzi, Philip McGuire, Roger G. Pertwee, Sagnik Bhattacharyya
2016 Neuroscience and Biobehavioral Reviews  
on the dopamine system in man is equivocal  Chronic cannabis use reduces glutamate or its metabolites levels in human brain  Δ9-THC alters glutamate signalling in animal brain 3 ABSTRACT Use of cannabis  ...  In fact, it is thought that cannabis or Δ9-THC may not act on dopamine firing directly but indirectly by altering glutamate neurotransmission.  ...  Previous reviews have mainly focused on the effects of cannabis use on dopamine transmission, in both animals (Kuepper et al., 2010) and humans (Ghazzaoui and Abi-Dargham, 2014; Sami et al., 2015; van  ... 
doi:10.1016/j.neubiorev.2016.03.010 pmid:26987641 fatcat:atecs5h3dnbcxjallh7qoyvcdu

Interaction Between Functional Genetic Variation of DRD2 and Cannabis Use on Risk of Psychosis

Marco Colizzi, Conrad Iyegbe, John Powell, Gianluca Ursini, Annamaria Porcelli, Aurora Bonvino, Paolo Taurisano, Raffaella Romano, Rita Masellis, Giuseppe Blasi, Craig Morgan, Katherine Aitchison (+7 others)
2015 Schizophrenia Bulletin  
Both cannabis use and the dopamine receptor (DRD2) gene have been associated with schizophrenia, psychosis-like experiences, and cognition.  ...  In the case-control study, we found a significant interaction between the rs1076560 DRD2 genotype and cannabis use in influencing the likelihood of a psychotic disorder.  ...  alteration in striatal dopamine.  ... 
doi:10.1093/schbul/sbv032 pmid:25829376 pmcid:PMC4535639 fatcat:tl7pjr4tdrbedpdhjf3sl3cd6e

Mechanisms contributing to prefrontal cortex maturation during adolescence

Adriana Caballero, Rachel Granberg, Kuei Y. Tseng
2016 Neuroscience and Biobehavioral Reviews  
Studies in animal models allow us to test the causal contribution of specific neural processes in the development of the prefrontal cortex and the acquisition of adult behavior.  ...  These changes have been associated with the maturation of brain regions involved in the control of motivation, emotion, and cognition.  ...  Dopamine D1 receptor stimulation in the adult PFC can elicit long-lasting plateau depolarizations in pyramidal neurons, an effect that requires NMDA receptor transmission and postsynaptic calcium-dependent  ... 
doi:10.1016/j.neubiorev.2016.05.013 pmid:27235076 pmcid:PMC5074870 fatcat:3cpny27hbfdfxjr7gfdxopyw4m

Cannabis and cocaine decrease cognitive impulse control and functional corticostriatal connectivity in drug users with low activity DBH genotypes

J. G. Ramaekers, J. H. van Wel, D. Spronk, B. Franke, G. Kenis, S. W. Toennes, K. P. C. Kuypers, E. L. Theunissen, P. Stiers, R. J. Verkes
2015 Brain Imaging and Behavior  
The dopamine β-hydroxylase (DβH) enzyme transforms dopamine into noradrenaline.  ...  It is concluded that interference of cannabis and cocaine with cognitive impulse control and functional corticostriatal connectivity depends on DBH genotype.  ...  Leijtens and Cees van Leeuwen for their medical supervision and support in data collection, Marina Hakobjan for genotyping and all participants for their time and dedication.  ... 
doi:10.1007/s11682-015-9488-z pmid:26667034 pmcid:PMC5167221 fatcat:r2esfitm4jg7ba3nf7p6bfbvdu

Pharmacological Treatment of Cannabis Dependence

A. M. Weinstein, David A. Gorelick
2011 Current pharmaceutical design  
There is a significant increase in the number of treatment admissions for cannabis use disorders in the past few years, and the majority of cannabis-dependent individuals who enter treatment have difficulty  ...  Buspirone is the only medication to date that has shown efficacy for cannabis dependence in a controlled clinical trial.  ...  Weinstein is supported by the National Institute for Psychobiology in Israel that is funded by the Charles E. Smith Foundation. Dr.  ... 
doi:10.2174/138161211796150846 pmid:21524266 pmcid:PMC3171994 fatcat:xkq3wiyklrf5dmxxs7wo4iq3v4

Acute effects of cocaine and cannabis on reversal learning as a function of COMT and DRD2 genotype

Desirée B. Spronk, Marieke E. Van der Schaaf, Roshan Cools, Ellen R. A. De Bruijn, Barbara Franke, Janelle H. P. van Wel, Johannes G. Ramaekers, Robbert J. Verkes
2015 Psychopharmacology  
The effects of cocaine, but not cannabis, depend on interindividual genetic differences in the dopamine D2 receptor gene.  ...  Effects of cocaine depended on the DRD2 genotype, as increases in proportion correct were seen only in the A1 carriers, and not in the A2/A2 homozygotes.  ...  Acknowledgments We kindly thank the participants for taking part in the study and acknowledge the contribution of Jan Leijtens in data collection, and Michiel Kleinnijenhuis and Sean Fallon for providing  ... 
doi:10.1007/s00213-015-4141-5 pmid:26572896 pmcid:PMC4700084 fatcat:s5kbndms4vhhvbsgo6n4uukfhy
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