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Dynamic Neurotransmitter Interactions Measured with PET
[chapter]
2005
Handbook of Radiopharmaceuticals
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CRJ (1995) Serotonergic modulation of striatal dopamine measured with positron emission tomography (PET) and in vivo microdialysis. JNeurosci, 15, 821-9. ...
and positron emission tomography. ...
Positron emission tomography (PET) has become a valuable interdisciplinary tool forunderstanding physiological, biochemical and pharmacological functions at a molecular level in living humans, whether ...
doi:10.1002/0470846380.ch21
fatcat:ngfs67k6lraelctpr4rpvxi6kq
Imaging Transcranial Direct Current Stimulation (tDCS) with Positron Emission Tomography (PET)
2020
Brain Sciences
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One viable approach is positron emission tomography (PET) imaging. ...
Consequently, it is essential to combine tDCS with human neuroimaging to complement animal and cadaver studies and clarify if and how tDCS can affect neural function. ...
One viable alternative approach is positron emission tomography (PET) imaging. ...
doi:10.3390/brainsci10040236
pmid:32326515
fatcat:25oq35n77zhy3ngd4d3yywcxpq
Spatiotemporal Kernel Reconstruction for Linear Parametric Neurotransmitter PET Kinetic Modeling in Motion Correction Brain PET of Awake Rats
2022
Frontiers in Neuroscience
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Finally, [11C]raclopride experiments were performed in anesthetized and awake rats, injecting cold raclopride at 20 min after scan start to simulate endogenous neurotransmitter release. ...
The linear parametric neurotransmitter positron emission tomography (lp-ntPET) kinetic model can be used to detect transient changes (activation) in endogenous neurotransmitter levels. ...
INTRODUCTION Transient changes in brain neurotransmitter levels can be investigated with dynamic positron emission tomography (PET) using for example the linear parametric neurotransmitter PET kinetic ...
doi:10.3389/fnins.2022.901091
fatcat:apo3lqpfdnb6bnifprh7ycxrl4
The pharmacology of amphetamine and methylphenidate: Relevance to the neurobiology of attention-deficit/hyperactivity disorder and other psychiatric comorbidities
2018
Neuroscience and Biobehavioral Reviews
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and their use in managing individuals with ADHD who may have comorbid psychiatric conditions. ...
Clinical implications of these actions in individuals with ADHD with comorbid depression, anxiety, substance use disorder, and sleep disturbances are discussed. ...
Editorial assistance in the form of proofreading, copyediting, and fact checking was also provided by CHC. ...
doi:10.1016/j.neubiorev.2018.02.001
pmid:29428394
pmcid:PMC8063758
fatcat:pk4xnsjh2vgrrfnkdta4yaypzy
Sucrose intake lowers μ-opioid and dopamine D2/3 receptor availability in porcine brain
2019
Scientific Reports
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We investigated the effects of sucrose using PET imaging with [11C]carfentanil (μ-opioid receptor agonist) and [11C]raclopride (dopamine D2/3 receptor antagonist) in seven female anesthetized Göttingen ...
After a single exposure to sucrose, we found decreased binding of [11C]carfentanil in nucleus accumbens and cingulate cortex, consistent with opioid release. ...
We are grateful for the technical support from the staff at the Aarhus University Hospital PET Centre and the Aarhus University Farm for help with the treatment of the animals. ...
doi:10.1038/s41598-019-53430-9
pmid:31729425
pmcid:PMC6858372
fatcat:tflc6guxyvesto52kutapvydoa
Allosteric Interactions between Adenosine A2A and Dopamine D2 Receptors in Heteromeric Complexes: Biochemical and Pharmacological Characteristics, and Opportunities for PET Imaging
2021
International Journal of Molecular Sciences
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Positron emission tomography with suitable ligands may provide in vivo information about receptor crosstalk in the living organism. ...
Adenosine and dopamine interact antagonistically in living mammals. These interactions are mediated via adenosine A2A and dopamine D2 receptors (R). ...
emission tomography (PET) imaging of dopamine D 2/3 receptors. ...
doi:10.3390/ijms22041719
pmid:33572077
fatcat:dfp4ytziwjdffe27esnpbnqow4
Amphetamine Decreases 2C-Adrenoceptor Binding of [11C]ORM-13070: A PET Study in the Primate Brain
2014
International Journal of Neuropsychopharmacology
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Figure 2 . 2 Evaluation of the utility of [ 11 C]ORM-13070 as a positron emission tomography (PET) tracer in cynomolgus monkeys. ...
Positron emission tomography (PET) is a relatively non-invasive technique that has, in some cases, been applied to investigate changes in synaptic neurotransmitter concentrations in the living human brain ...
doi:10.1093/ijnp/pyu081
pmid:25522417
pmcid:PMC4360244
fatcat:gqlvmbqq7zghrbqwlbqbnvwqga
Sexual dimorphism in striatal dopaminergic responses promotes monogamy in social songbirds
2017
eLife
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In many songbird species, males sing to attract females and repel rivals. ...
Surprisingly, in unmated males but not in females, striatal dopamine neurotransmission was elevated after hearing songs. ...
We thank Michael Synan and Yeona Kang for help with PET image processing.
Additional information ...
doi:10.7554/elife.25819
pmid:28826502
pmcid:PMC5584986
fatcat:iyqhnce63bfshnbxmblhpyotwa
[11C]AF150(S), an agonist PET ligand for M1 muscarinic acetylcholine receptors
2013
EJNMMI Research
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Moreover, BP ND was significantly reduced after pre-treatment with haloperidol, a dopamine D 2 receptor blocker that causes an increase in extracellular acetylcholine (ACh). ...
Conclusions: The agonist PET ligand [ 11 C]AF150(S) was rapidly taken up in the brain and showed an apparent specific M1ACh-R-related signal in brain areas that are rich in M1ACh-R. ...
A non-invasive molecular imaging technique such as positron emission tomography (PET) could be useful to elucidate the function of M1ACh-R in vivo. ...
doi:10.1186/2191-219x-3-19
pmid:23514539
pmcid:PMC3623648
fatcat:aofcqvzt7bcktfcvdg4ptpnzh4
Bayesian Estimation of the ntPET Model in Single-Scan Competition PET Studies
2020
Frontiers in Physiology
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In human [11C]raclopride experiment, contrary to lp-ntPET, b-ntPET successfully detected significant endogenous dopamine releases induced by the stimulation. ...
We then applied the model to experimental animal data acquired in pharmacological challenge studies and human data with endogenous releases induced by transcranial direct current stimulation. ...
ZI wrote the manuscript and designed the figures with significant input from IM, AR, and NC. NC supervised this project and was in charge of overall direction. ...
doi:10.3389/fphys.2020.00498
pmid:32508679
pmcid:PMC7248280
fatcat:wahbkpkzlbau5aga62cmgzyxam
Optimisation of synthesis, purification and reformulation of (R)-[N-Methyl-11C]PK11195 for in vivo PET imaging studies
2013
2013 IEEE 3rd Portuguese Meeting in Bioengineering (ENBENG)
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The (R)-enantiomer radiolabelled with Carbon-11, (R)-[N-Methyl-11 C]PK11195, is the most widely used radiotracer for in vivo TSPO imaging with PET. ...
In this work we report on the optimisation of the synthesis, purification and reformulation of (R)- [N-methyl-11 C]PK11195 by the captive solvent method with the aim of being used for in vivo PET imaging ...
), which can be detected in vivo by positron emission tomography (PET) imaging using a selective TSPO radioligand [3] . ...
doi:10.1109/enbeng.2013.6518428
fatcat:cw3nxf5b35cdxhmkvunkwdneii
Hypothesizing Balancing Endorphinergic and Glutaminergic Systems to Treat and Prevent Relapse to Reward Deficiency Behaviors: Coupling D-Phenylalanine and N-Acetyl-L-Cysteine (NAC) as a Novel Therapeutic Modality
2015
Clinical Medical Reviews and Case Reports
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In these trials, subjects were situated under a positron emission tomography (PET) camera and administered a dopamine receptor ligand 11C-raclopride intravenously. ...
These brain regions were also consistent with changes observed in metabolic activity following optogenetic stimulation of the rat NAc using small animal positron emission tomography (PET) and [18F] deoxyglucose ...
pmid:26900600
pmcid:PMC4760695
fatcat:ym43lkufmnecrbz3fyose4pfsu
Imaging the Role of Inflammation in Mood and Anxiety-related Disorders
2018
Current Neuropharmacology
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anxiety-related disorders in patients with high inflammation. ...
Of relevance to mood and anxiety-related disorders, biomarkers of inflammation such as inflammatory cytokines and acute-phase proteins are reliably elevated in a significant proportion of patients with ...
Positron emission tomography imaging of neuroinflammation. Neurotherapeutics, 2007, 4(3), 443-452. ...
doi:10.2174/1570159x15666171123201142
pmid:29173175
pmcid:PMC5997866
fatcat:lid3x2ztlva3zeyiqytzs43k6a
Music-Evoked Emotions—Current Studies
2017
Frontiers in Neuroscience
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musical stimuli and the basic features of tomographic imaging of emotional activation in the brain, such as functional magnetic resonance imaging (fMRI) and positron emission tomography (PET), which offer ...
The progress in correlating activation imaging in the brain to the psychological understanding of music-evoked emotion is demonstrated and some prospects for future research are outlined. ...
ACKNOWLEDGMENTS The present study has been stimulated by a discussion with
SUPPLEMENTARY MATERIAL The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles ...
doi:10.3389/fnins.2017.00600
pmid:29225563
pmcid:PMC5705548
fatcat:3m3vfvvjd5g3hds57jvcfsrh54
Type of Anesthesia Influences Positron Emission Tomography Measurements of Dopamine D2/3 Receptor Binding in the Rat Brain
2014
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Rats are often anesthetized prior to positron emission tomography (PET) brain imaging in order to prevent head movements. ...
The aim of this study was to compare the effects of inhalation and injection anesthesia on the binding potential of the dopaminergic D2/3 tracer [11C]raclopride used for PET brain imaging in human and ...
Introduction Positron emission tomography (PET) brain imaging can be performed in humans and non-human primates in an awake state, however, this is much more difficult with small animals. ...
doi:10.23675/sjlas.v38i3.240
fatcat:7gwamnssibamnnrudyqlx7ytka
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