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Dynamic Neurotransmitter Interactions Measured with PET [chapter]

Wynne K. Schiffer, Stephen L. Dewey
2005 Handbook of Radiopharmaceuticals  
CRJ (1995) Serotonergic modulation of striatal dopamine measured with positron emission tomography (PET) and in vivo microdialysis. JNeurosci, 15, 821-9.  ...  and positron emission tomography.  ...  Positron emission tomography (PET) has become a valuable interdisciplinary tool forunderstanding physiological, biochemical and pharmacological functions at a molecular level in living humans, whether  ... 
doi:10.1002/0470846380.ch21 fatcat:ngfs67k6lraelctpr4rpvxi6kq

Imaging Transcranial Direct Current Stimulation (tDCS) with Positron Emission Tomography (PET)

Thorsten Rudroff, Craig D. Workman, Alexandra C. Fietsam, Laura L. Boles Ponto
2020 Brain Sciences  
One viable approach is positron emission tomography (PET) imaging.  ...  Consequently, it is essential to combine tDCS with human neuroimaging to complement animal and cadaver studies and clarify if and how tDCS can affect neural function.  ...  One viable alternative approach is positron emission tomography (PET) imaging.  ... 
doi:10.3390/brainsci10040236 pmid:32326515 fatcat:25oq35n77zhy3ngd4d3yywcxpq

Spatiotemporal Kernel Reconstruction for Linear Parametric Neurotransmitter PET Kinetic Modeling in Motion Correction Brain PET of Awake Rats

Alan Miranda, Daniele Bertoglio, Sigrid Stroobants, Steven Staelens, Jeroen Verhaeghe
2022 Frontiers in Neuroscience  
Finally, [11C]raclopride experiments were performed in anesthetized and awake rats, injecting cold raclopride at 20 min after scan start to simulate endogenous neurotransmitter release.  ...  The linear parametric neurotransmitter positron emission tomography (lp-ntPET) kinetic model can be used to detect transient changes (activation) in endogenous neurotransmitter levels.  ...  INTRODUCTION Transient changes in brain neurotransmitter levels can be investigated with dynamic positron emission tomography (PET) using for example the linear parametric neurotransmitter PET kinetic  ... 
doi:10.3389/fnins.2022.901091 fatcat:apo3lqpfdnb6bnifprh7ycxrl4

The pharmacology of amphetamine and methylphenidate: Relevance to the neurobiology of attention-deficit/hyperactivity disorder and other psychiatric comorbidities

Stephen V. Faraone
2018 Neuroscience and Biobehavioral Reviews  
and their use in managing individuals with ADHD who may have comorbid psychiatric conditions.  ...  Clinical implications of these actions in individuals with ADHD with comorbid depression, anxiety, substance use disorder, and sleep disturbances are discussed.  ...  Editorial assistance in the form of proofreading, copyediting, and fact checking was also provided by CHC.  ... 
doi:10.1016/j.neubiorev.2018.02.001 pmid:29428394 pmcid:PMC8063758 fatcat:pk4xnsjh2vgrrfnkdta4yaypzy

Sucrose intake lowers μ-opioid and dopamine D2/3 receptor availability in porcine brain

Michael Winterdahl, Ove Noer, Dariusz Orlowski, Anna C. Schacht, Steen Jakobsen, Aage K. O. Alstrup, Albert Gjedde, Anne M. Landau
2019 Scientific Reports  
We investigated the effects of sucrose using PET imaging with [11C]carfentanil (μ-opioid receptor agonist) and [11C]raclopride (dopamine D2/3 receptor antagonist) in seven female anesthetized Göttingen  ...  After a single exposure to sucrose, we found decreased binding of [11C]carfentanil in nucleus accumbens and cingulate cortex, consistent with opioid release.  ...  We are grateful for the technical support from the staff at the Aarhus University Hospital PET Centre and the Aarhus University Farm for help with the treatment of the animals.  ... 
doi:10.1038/s41598-019-53430-9 pmid:31729425 pmcid:PMC6858372 fatcat:tflc6guxyvesto52kutapvydoa

Allosteric Interactions between Adenosine A2A and Dopamine D2 Receptors in Heteromeric Complexes: Biochemical and Pharmacological Characteristics, and Opportunities for PET Imaging

Kavya Prasad, Erik F. J. de Vries, Philip H. Elsinga, Rudi A. J. O. Dierckx, Aren van Waarde
2021 International Journal of Molecular Sciences  
Positron emission tomography with suitable ligands may provide in vivo information about receptor crosstalk in the living organism.  ...  Adenosine and dopamine interact antagonistically in living mammals. These interactions are mediated via adenosine A2A and dopamine D2 receptors (R).  ...  emission tomography (PET) imaging of dopamine D 2/3 receptors.  ... 
doi:10.3390/ijms22041719 pmid:33572077 fatcat:dfp4ytziwjdffe27esnpbnqow4

Amphetamine Decreases 2C-Adrenoceptor Binding of [11C]ORM-13070: A PET Study in the Primate Brain

S. J. Finnema, Z. A. Hughes, M. Haaparanta-Solin, V. Stepanov, R. Nakao, K. Varnas, A. Varrone, E. Arponen, P. Marjamaki, K. Pohjanoksa, L. Vuorilehto, P. A. Babalola (+6 others)
2014 International Journal of Neuropsychopharmacology  
Figure 2 . 2 Evaluation of the utility of [ 11 C]ORM-13070 as a positron emission tomography (PET) tracer in cynomolgus monkeys.  ...  Positron emission tomography (PET) is a relatively non-invasive technique that has, in some cases, been applied to investigate changes in synaptic neurotransmitter concentrations in the living human brain  ... 
doi:10.1093/ijnp/pyu081 pmid:25522417 pmcid:PMC4360244 fatcat:gqlvmbqq7zghrbqwlbqbnvwqga

Sexual dimorphism in striatal dopaminergic responses promotes monogamy in social songbirds

Kirill Tokarev, Julia Hyland Bruno, Iva Ljubičić, Paresh J Kothari, Santosh A Helekar, Ofer Tchernichovski, Henning U Voss
2017 eLife  
In many songbird species, males sing to attract females and repel rivals.  ...  Surprisingly, in unmated males but not in females, striatal dopamine neurotransmission was elevated after hearing songs.  ...  We thank Michael Synan and Yeona Kang for help with PET image processing. Additional information  ... 
doi:10.7554/elife.25819 pmid:28826502 pmcid:PMC5584986 fatcat:iyqhnce63bfshnbxmblhpyotwa

[11C]AF150(S), an agonist PET ligand for M1 muscarinic acetylcholine receptors

Hans JC Buiter, Albert D Windhorst, Marc C Huisman, Maqsood Yaqub, Dirk L Knol, Abraham Fisher, Adriaan A Lammertsma, Josée E Leysen
2013 EJNMMI Research  
Moreover, BP ND was significantly reduced after pre-treatment with haloperidol, a dopamine D 2 receptor blocker that causes an increase in extracellular acetylcholine (ACh).  ...  Conclusions: The agonist PET ligand [ 11 C]AF150(S) was rapidly taken up in the brain and showed an apparent specific M1ACh-R-related signal in brain areas that are rich in M1ACh-R.  ...  A non-invasive molecular imaging technique such as positron emission tomography (PET) could be useful to elucidate the function of M1ACh-R in vivo.  ... 
doi:10.1186/2191-219x-3-19 pmid:23514539 pmcid:PMC3623648 fatcat:aofcqvzt7bcktfcvdg4ptpnzh4

Bayesian Estimation of the ntPET Model in Single-Scan Competition PET Studies

Zacharie Irace, Inés Mérida, Jérôme Redouté, Clara Fonteneau, Marie-Françoise Suaud-Chagny, Jérôme Brunelin, Benjamin Vidal, Luc Zimmer, Anthonin Reilhac, Nicolas Costes
2020 Frontiers in Physiology  
In human [11C]raclopride experiment, contrary to lp-ntPET, b-ntPET successfully detected significant endogenous dopamine releases induced by the stimulation.  ...  We then applied the model to experimental animal data acquired in pharmacological challenge studies and human data with endogenous releases induced by transcranial direct current stimulation.  ...  ZI wrote the manuscript and designed the figures with significant input from IM, AR, and NC. NC supervised this project and was in charge of overall direction.  ... 
doi:10.3389/fphys.2020.00498 pmid:32508679 pmcid:PMC7248280 fatcat:wahbkpkzlbau5aga62cmgzyxam

Optimisation of synthesis, purification and reformulation of (R)-[N-Methyl-11C]PK11195 for in vivo PET imaging studies

Vitor H. Alves, Antero J. Abrunhosa, Miguel Castelo-Branco
2013 2013 IEEE 3rd Portuguese Meeting in Bioengineering (ENBENG)  
The (R)-enantiomer radiolabelled with Carbon-11, (R)-[N-Methyl-11 C]PK11195, is the most widely used radiotracer for in vivo TSPO imaging with PET.  ...  In this work we report on the optimisation of the synthesis, purification and reformulation of (R)- [N-methyl-11 C]PK11195 by the captive solvent method with the aim of being used for in vivo PET imaging  ...  ), which can be detected in vivo by positron emission tomography (PET) imaging using a selective TSPO radioligand [3] .  ... 
doi:10.1109/enbeng.2013.6518428 fatcat:cw3nxf5b35cdxhmkvunkwdneii

Hypothesizing Balancing Endorphinergic and Glutaminergic Systems to Treat and Prevent Relapse to Reward Deficiency Behaviors: Coupling D-Phenylalanine and N-Acetyl-L-Cysteine (NAC) as a Novel Therapeutic Modality

Kenneth Blum, Marcelo Febo, Claudia Fahlke, Trevor Archer, U Berggren, Zsolt Demetrovics, Kristina Dushaj, Rajendra D Badgaiyan
2015 Clinical Medical Reviews and Case Reports  
In these trials, subjects were situated under a positron emission tomography (PET) camera and administered a dopamine receptor ligand 11C-raclopride intravenously.  ...  These brain regions were also consistent with changes observed in metabolic activity following optogenetic stimulation of the rat NAc using small animal positron emission tomography (PET) and [18F] deoxyglucose  ... 
pmid:26900600 pmcid:PMC4760695 fatcat:ym43lkufmnecrbz3fyose4pfsu

Imaging the Role of Inflammation in Mood and Anxiety-related Disorders

Jennifer C. Felger
2018 Current Neuropharmacology  
anxiety-related disorders in patients with high inflammation.  ...  Of relevance to mood and anxiety-related disorders, biomarkers of inflammation such as inflammatory cytokines and acute-phase proteins are reliably elevated in a significant proportion of patients with  ...  Positron emission tomography imaging of neuroinflammation. Neurotherapeutics, 2007, 4(3), 443-452.  ... 
doi:10.2174/1570159x15666171123201142 pmid:29173175 pmcid:PMC5997866 fatcat:lid3x2ztlva3zeyiqytzs43k6a

Music-Evoked Emotions—Current Studies

Hans-Eckhardt Schaefer
2017 Frontiers in Neuroscience  
musical stimuli and the basic features of tomographic imaging of emotional activation in the brain, such as functional magnetic resonance imaging (fMRI) and positron emission tomography (PET), which offer  ...  The progress in correlating activation imaging in the brain to the psychological understanding of music-evoked emotion is demonstrated and some prospects for future research are outlined.  ...  ACKNOWLEDGMENTS The present study has been stimulated by a discussion with SUPPLEMENTARY MATERIAL The Supplementary Material for this article can be found online at:  ... 
doi:10.3389/fnins.2017.00600 pmid:29225563 pmcid:PMC5705548 fatcat:3m3vfvvjd5g3hds57jvcfsrh54

Type of Anesthesia Influences Positron Emission Tomography Measurements of Dopamine D2/3 Receptor Binding in the Rat Brain

Aage Kristian Olsen Alstrup, Mette Simonsen, Anne M Landau
Rats are often anesthetized prior to positron emission tomography (PET) brain imaging in order to prevent head movements.  ...  The aim of this study was to compare the effects of inhalation and injection anesthesia on the binding potential of the dopaminergic D2/3 tracer [11C]raclopride used for PET brain imaging in human and  ...  Introduction Positron emission tomography (PET) brain imaging can be performed in humans and non-human primates in an awake state, however, this is much more difficult with small animals.  ... 
doi:10.23675/sjlas.v38i3.240 fatcat:7gwamnssibamnnrudyqlx7ytka
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