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Collaborative effects of wavefront shaping and optical clearing agent in optical coherence tomography

Hyeonseung Yu, Peter Lee, YoungJu Jo, KyeoReh Lee, Valery V. Tuchin, Yong Jeong, YongKeun Park
2016 Journal of Biomedical Optics  
A tissue phantom study shows that concurrent applications of OCA and wavefront shaping successfully operate in OCT imaging.  ...  The penetration depth enhancement is further demonstrated for ex vivo mouse ears, revealing hidden structures inaccessible with conventional OCT imaging.  ...  The penetration depth can be extended at the expense of the tissue composition change.  ... 
doi:10.1117/1.jbo.21.12.121510 pmid:27792807 fatcat:wqajlqi5vvgencghei4xckfyae

Rapid ex vivo examination of Mohs specimens using optical coherence tomography

D. Rashed, D. Shah, A. Freeman, R.J. Cook, C. Hopper, CM. Perrett
2017 Photodiagnosis and Photodynamic Therapy  
Biopsies were scanned with the OCT instrument immediately ex vivo and processed to obtain horizontal Mohs frozen sections and compared with their corresponding OCT images.  ...  Optical coherence tomography (OCT) is a biomedical imaging modality that permits high-resolution imaging of the epidermis and dermis with the potential to detect both healthy tissue and tumour.  ...  The tissue penetration depth is around 1-2mm depending on the optical absorption and scattering properties of the tissue being imaged [12] .  ... 
doi:10.1016/j.pdpdt.2017.06.006 pmid:28619614 fatcat:vwadyt7j5vea5nuqlqbcdgp24e

Visualization and tissue classification of human breast cancer images using ultrahigh-resolution OCT

Xinwen Yao, Yu Gan, Ernest Chang, Hanina Hibshoosh, Sheldon Feldman, Christine Hendon
2017 Lasers in Surgery and Medicine  
UHR OCT images of a ‡ Correspondence to: variety of tissue types found in human breast tissue were presented.  ...  Classification in UHR OCT images achieved higher sensitivity (94%) and specificity (93%) of adipose tissue than the sensitivity (91%) and specificity (76%) in 1300 nm OCT images.  ...  Acknowledgments The authors would like to thank Syed Bin Amir for technical assistance on image acquisition, and the Columbia University Medical Center Histology Service for histology processing.  ... 
doi:10.1002/lsm.22654 pmid:28264146 pmcid:PMC5368015 fatcat:z3dcwyj7vzdvneao2jb2in5hrq

Evaluation of Radiation-Induced Oral Mucositis by Optical Coherence Tomography

T. M. Muanza
2005 Clinical Cancer Research  
images qualitatively compared with histologic findings and quantitative image analysis of the OCT images (effective light penetration depth) revealed significant changes 7 days post-irradiation compared  ...  Purpose: Optical coherence tomography (OCT) imaging was evaluated to determine if radiationinduced mucosal damage could be noninvasively monitored in real time and correlated with histopathologic findings  ...  A new, specialized, and fully automatic plug-in was developed to quantify the effective light penetration depth of the tissue of interest from the OCT images.  ... 
doi:10.1158/1078-0432.ccr-05-0403 pmid:16033826 fatcat:aogrvq43uzfirp2icknsh7gkmm

Long-wavelength optical coherence tomography at 17 μm for enhanced imaging depth

Utkarsh Sharma, Ernest W. Chang, Seok H. Yun
2008 Optics Express  
Multiple scattering in a sample presents a significant limitation to achieve meaningful structural information at deeper penetration depths in optical coherence tomography (OCT).  ...  Acknowledgment This work was supported in part by National Institute Health (Grant R33CA110130) and National Science Foundation (Grant ECCS-0801412). Authors are grateful to M. Suter, B. Vakoc, G.  ...  Bouma for access to the 1.3-μm system and P. Heim for helpful discussion.  ... 
doi:10.1364/oe.16.019712 pmid:19030057 pmcid:PMC2773451 fatcat:anlixgnyefcotaerprscuy3fmy

Optical Coherence Tomography Technology and Quality Improvement Methods for Optical Coherence Tomography Images of Skin: A Short Review

Saba Adabi, Zahra Turani, Emad Fatemizadeh, Anne Clayton, Mohammadreza Nasiriavanaki
2017 Biomedical Engineering and Computational Biology  
similar to the ultrasound imaging, except that it uses light instead of sound. 7 Providing high-resolution images and a moderate penetration depth, ie, 1 to 3 mm, OCT is currently used in several medical  ...  . 5 Spectral domain OCT is a newer technology in which the scan rate is much faster than that in time domain, in addition to have a better penetration depth and signal-to-noise ratio.  ... 
doi:10.1177/1179597217713475 pmid:28638245 pmcid:PMC5470862 fatcat:2g6avfjwfrf4vnkg3hhy5fb4zi

Complex wavefront shaping for optimal depth-selective focusing in optical coherence tomography

Jaeduck Jang, Jaeguyn Lim, Hyeonseung Yu, Hyun Choi, Jinyong Ha, Jung-Hoon Park, Wang-Yuhl Oh, Wooyoung Jang, SeongDeok Lee, YongKeun Park
2013 Optics Express  
The proof-of-concept experiment demonstrates that this approach enhances depth-selective focusing in the presence of optical inhomogeneity, and thus extends the penetration depth in spectral domain-OCT  ...  Most of the reflected signal from biological tissue consists of multiply scattered light, which is regarded as noise in OCT.  ...  This results in a low signal-to-noise ratio (SNR) and limited penetration depth in deep tissue imaging.  ... 
doi:10.1364/oe.21.002890 pmid:23481747 fatcat:u5av7bthgfepblcgso6rxvg33e

Intracoronary imaging using attenuation-compensated optical coherence tomography allows better visualisation of coronary artery diseases

Nicolas Foin, Jean Martial Mari, Sukhjinder Nijjer, Sayan Sen, Ricardo Petraco, Matteo Ghione, Carlo Di Mario, Justin E. Davies, Michaël J.A. Girard
2013 Cardiovascular Revascularization Medicine  
Background: One of the major drawbacks of coronary OCT imaging is the rapid attenuation of the OCT signal, limiting penetration in tissue to only few millimetres.  ...  Methods: A compensation algorithm, previously developed to correct for light attenuation in soft tissues and to enhance contrast in ophthalmic OCT images, was applied to intracoronary plaque imaging using  ...  This approach was shown to drastically improve the penetration and contrast in ophthalmic OCT images.  ... 
doi:10.1016/j.carrev.2013.03.007 pmid:23632229 fatcat:fmkb6fcqazdddpjdxmtm6kkirq

Deep imaging in highly scattering media by combining reflection matrix measurement with Bessel-like beam based optical coherence tomography

Qiang Yang, Yusi Miao, Tiancheng Huo, Yan Li, Emon Heidari, Jiang Zhu, Zhongping Chen
2018 Applied Physics Letters  
Zhongping Chen has a financial interest in OCT Medical Imaging, Inc., which, however, did not support this work.  ...  digital pinhole) corresponding to the unfiltered residual multiple scattered light are effectively removed, resulting in a penetration depth enhancement of $2 times compared to conventional OCT.  ...  To retrieve depth-resolved images from the multi-scattering dominated background in the backward process, different techniques have been developed to minimize the detrimental effects of multiple scattering  ... 
doi:10.1063/1.5036661 pmid:30034015 fatcat:miyn4cmqv5cj5b4iaywnlodfty

Optical clearing for luminal organ imaging with ultrahigh-resolution optical coherence tomography

Yanmei Liang, Wu Yuan, Jessica Mavadia-Shukla, Xingde Li
2016 Journal of Biomedical Optics  
The imaging depth of optical coherence tomography (OCT) in highly scattering biological tissues (such as luminal organs) is limited, particularly for OCT operating at shorter wavelength regions (such as  ...  In contrast, no obvious optical clearing effect was identified on bronchus tissues.  ...  However, the limited imaging depth due to the high scattering of light in biological tissues hinders its potential applications, where a deeper imaging depth is desired.  ... 
doi:10.1117/1.jbo.21.8.081211 pmid:27335154 pmcid:PMC5994996 fatcat:nyxyec4x2vaajdvfzvumlo52yy

Feasibility of ablative fractional laser-assisted drug delivery with optical coherence tomography

Chih-Hsun Yang, Meng-Tsan Tsai, Su-Chin Shen, Chau Yee Ng, Shih-Ming Jung
2014 Biomedical Optics Express  
Fractional resurfacing creates hundreds of microscopic wounds in the skin without injuring surrounding tissue.  ...  In conclusion, this study establishes OCT as an effective tool for the investigation of fractional photothermolysis and water/drug delivery through microscopic ablation channels after nail fractional laser  ...  OCT imaging enables to confirm the depth of penetration and density of these microscopic wound spots.  ... 
doi:10.1364/boe.5.003949 pmid:25426321 pmcid:PMC4242029 fatcat:tkn5d35txvf3tmokyno4ggvv24

Monitoring of wound healing process of human skin after fractional laser treatments with optical coherence tomography

Meng-Tsan Tsai, Chih-Hsun Yang, Su-Chin Shen, Ya-Ju Lee, Feng-Yu Chang, Cheng-Shin Feng
2013 Biomedical Optics Express  
To continue monitoring the wound healing process, the treated regions were scanned with OCT at different time points, and the en-face images at various tissue depths were extracted from three-dimensional  ...  OCT images.  ...  Moreover, Sattler et al. proposed the usage of 2D OCT images to visualize tissue changes after AFL treatments and to measure the penetration depths of MTZs after AFL exposures.  ... 
doi:10.1364/boe.4.002362 pmid:24298400 pmcid:PMC3829533 fatcat:jnrqxren3req7h4jbvubsqd7ra

Deep imaging of absorption and scattering features by multispectral multiple scattering low coherence interferometry

Yang Zhao, Jason R. Maher, Mohamed M. Ibrahim, Jennifer S. Chien, Howard Levinson, Adam Wax
2016 Biomedical Optics Express  
OCT at an imaging depth of 1 mm.  ...  Finally, healthy rat skin was imaged in vivo with both a commercial OCT instrument and our custom ms2/LCI system.  ...  The NIR optical window was chosen to provide increased penetration depth in tissue.  ... 
doi:10.1364/boe.7.003916 pmid:27867703 pmcid:PMC5102527 fatcat:aegjc5k5fbdm3nwgnmtszcpv2m

Spectrally encoded extended source optical coherence tomography

Xinyu Liu, Xiaojun Yu, Hongying Tang, Dongyao Cui, Meghna R. Beotra, Michael J. A. Girard, Ding Sun, Jun Gu, Linbo Liu
2014 Optics Letters  
The advantage of SEES-OCT in providing superior penetration depth over a point source system is demonstrated using swine eye tissues ex vivo.  ...  We have developed an extended source optical coherence tomography (SEES-OCT) technique in an attempt to improve signal strength for ophthalmic imaging.  ...  Therefore, an extended source OCT technology will effectively enhance the sensitivity thereby increasing the penetration depth.  ... 
doi:10.1364/ol.39.006803 pmid:25503001 fatcat:5sw4wtym3jeczmskdd6y4ys7ju

Effect of target biological tissue and choice of light source on penetration depth and resolution in optical coherence tomography

Ann W. Sainter, Terry A. King, Mark R. Dickinson
2004 Journal of Biomedical Optics  
The tissues studied include skin dermis, liver, and gallbladder. Sources at higher wavelengths are shown to be capable of high-resolution OCT imaging at greater depths.  ...  The resolution of OCT systems is not reduced significantly with imaging depth.  ...  It clearly shows a window of transmission in the tissues extending from approximately 600 to 1800 nm, with an interruption around 1400 nm, which shows that optimum OCT imaging depths are achieved using  ... 
doi:10.1117/1.1628243 pmid:14715073 fatcat:v6lrfrqr7bgfvfqwjlfvudcgkm
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