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Targeting autophagy as a novel strategy for facilitating the therapeutic action of potentiators on ΔF508 cystic fibrosis transmembrane conductance regulator

Alessandro Luciani, Valeria Rachela Villella, Speranza Esposito, Manuela Gavina, Ilaria Russo, Marco Silano, Stefano Guido, Massimo Pettoello-Mantovani, Rosa Carnuccio, Bob Scholte, Antonella De Matteis, Maria Chiara Maiuri (+4 others)
2012 Autophagy  
2012) Targeting autophagy as a novel strategy for facilitating the therapeutic action of potentiators on ∆F508 cystic fibrosis transmembrane conductance regulator, Autophagy, 8:11, These authors contributed equally to this work.
doi:10.4161/auto.21483 pmid:22874563 pmcid:PMC3494594 fatcat:crvvv5y4azd73by36o57w3jawi

Distributed Analysis in CMS

Alessandra Fanfani, Anzar Afaq, Jose Afonso Sanches, Julia Andreeva, Giusepppe Bagliesi, Lothar Bauerdick, Stefano Belforte, Patricia Bittencourt Sampaio, Ken Bloom, Barry Blumenfeld, Daniele Bonacorsi, Chris Brew (+67 others)
2010 Journal of Grid Computing  
The CMS experiment expects to manage several Pbytes of data each year during the LHC programme, distributing them over many A. Fanfani et al. location for physics analysis to support a wide community with thousands potential users. This represents an unprecedented experimental challenge in terms of the scale of distributed computing resources and number of user. An overview of the computing architecture, the software tools and the distributed infrastructure is reported. Summaries of the
more » ... ce in establishing efficient and scalable operations to get prepared for CMS distributed analysis are presented, followed by the user experience in their current analysis activities.
doi:10.1007/s10723-010-9152-1 fatcat:jvs2ccg7r5em7b3vringhmobye

IgE antibody repertoire in nasal secretions of children and adults with seasonal allergic rhinitis: A molecular analysis

Sveva Castelli, Stefania Arasi, Salvatore Tripodi, Danilo Villalta, Paola Martelli, Mariaelisabetta Conte, Valentina Panetta, Ilaria Simonelli, Alexander Rohrbach, Marco Di Fraia, Ifigenia Sfika, Valeria Villella (+6 others)
There is growing interest both in testing IgE in nasal secretions (NS) and in molecular diagnosis of seasonal allergic rhinitis (SAR). Yet, the reliability of nasal IgE detection with the newest molecular assays has never been assessed in a large cohort of pollen allergic patients. Objective: To investigate with microarray technology and compare the repertoires of specific IgE (sIgE) antibodies in NS and sera of a large population of children and adults with SAR. Methods: Nasal secretions were
more » ... ollected with an absorbent device (Merocel 2000®, Medtronic) and a minimal dilution procedure from 90 children and 71 adults with SAR. Total IgE (tIgE) (ImmunoCAP, Thermo Fisher Scientific (TFS)) and sIgE antibodies against 112 allergen molecules (ISAC-112, TFS) were measured in NS and serum. Results: Nasal sIgE was detectable in 68.3% of the patients. The detected nasal sIgE antibodies recognized airborne (88%), vegetable (10%), and animal food or other (<1%) allergen molecules. The prevalence and average levels of sIgE in NS and serum were highly interrelated at population level. A positive nasal sIgE antibody to a given molecule predicted the detection of the same antibody in the patient's serum with a specificity of 99.7% and a sensitivity of 40%. Conclusions: The concentration of sIgE is much lower in nasal secretions than in the serum. sIgE assays with very high analytical sensitivity and sampling methods with minimal dilution will be therefore needed to validate nasal secretions as alternative to serum in testing the sIgE repertoire.
doi:10.17169/refubium-34050 fatcat:wxnxct4xrjfydgamjss4spn7zi

Prognostic Impact of Diabetes and Prediabetes on Survival Outcomes in Patients With Chronic Heart Failure: A Post‐Hoc Analysis of the GISSI‐HF (Gruppo Italiano per lo Studio della Sopravvivenza nella Insufficienza Cardiaca‐Heart Failure) Trial

Marco Dauriz, Giovanni Targher, Pier Luigi Temporelli, Donata Lucci, Lucio Gonzini, Gian Luigi Nicolosi, Roberto Marchioli, Gianni Tognoni, Roberto Latini, Franco Cosmi, Luigi Tavazzi, Aldo Pietro Maggioni (+818 others)
2017 Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease  
on behalf of the GISSI-HF Investigators** Background--The independent prognostic impact of diabetes mellitus (DM) and prediabetes mellitus (pre-DM) on survival outcomes in patients with chronic heart failure has been investigated in observational registries and randomized, clinical trials, but the results have been often inconclusive or conflicting. We examined the independent prognostic impact of DM and pre-DM on survival outcomes in the GISSI-HF (Gruppo Italiano per lo Studio della
more » ... za nella Insufficienza Cardiaca-Heart Failure) trial. Methods and Results--We assessed the risk of all-cause death and the composite of all-cause death or cardiovascular hospitalization over a median follow-up period of 3.9 years among the 6935 chronic heart failure participants of the GISSI-HF trial, who were stratified by presence of DM (n=2852), pre-DM (n=2013), and non-DM (n=2070) at baseline. Compared with non-DM patients, those with DM had remarkably higher incidence rates of all-cause death (34.5% versus 24.6%) and the composite end point (63.6% versus 54.7%). Conversely, both event rates were similar between non-DM patients and those with pre-DM. Cox regression analysis showed that DM, but not pre-DM, was associated with an increased risk of all-cause death (adjusted hazard ratio, 1.43; 95% CI, 1.28-1.60) and of the composite end point (adjusted hazard ratio, 1.23; 95% CI, 1.13-1.32), independently of established risk factors. In the DM subgroup, higher hemoglobin A1c was also independently associated with increased risk of both study outcomes (all-cause death: adjusted hazard ratio, 1.21; 95% CI, 1.02-1.43; and composite end point: adjusted hazard ratio, 1.14; 95% CI, 1.01-1.29, respectively). Conclusions--Presence of DM was independently associated with poor long-term survival outcomes in patients with chronic heart failure. Clinical Trial Registration--URL: Unique identifier: NCT00336336. ( J Am Heart Assoc. 2017;6: e005156.
doi:10.1161/jaha.116.005156 pmid:28679559 pmcid:PMC5586270 fatcat:7aw3fdxhu5d4fffjgvqn56jskm

Anno III numero 5-maggio 2006

Direttore Responsabile, Roberto Bernabei, Vincenzo Canonico
Badini Ilaria Modena 4. Barbato Barbara Padova 5. Bedetta Samuele Civitanova Marche (MC) 6. Bellavia Massimo Palermo 7. Bianchini Cinzia Narni (Tr) 8. Caddeo Giuseppina Cagliari 9.  ...  Leandro Cascavilla Francesco Paris Piero D'Ambrosio Gino Pazienza Marilisa Franceschi Giovanni Pepe Alessandra Mangia Giuliana Placentino Valeria Niro Carlo Scarcelli Giuseppe Orsitto Massimo Villella  ... 

Measurement of the $pp -> ZZ$ production cross section and constraints on anomalous triple gauge couplings in four-lepton final states at $\sqrt s=$8 TeV

Vardan Khachatryan, Albert M. Sirunyan, Armen Tumasyan, Wolfgang Adam, Thomas Bergauer, Marko Dragicevic, Janos Erö, Christian Fabjan, Markus Friedl, Rudolf Fruehwirth, Vasile Mihai Ghete, Christian Hartl (+2124 others)
A measurement of the inclusive ZZ production cross section and constraints on anomalous triple gauge couplings in proton-proton collisions at √ s = 8 TeV are presented. The analysis is based on a data sample, corresponding to an integrated luminosity of 19.6 fb −1 , collected with the CMS experiment at the LHC. The measurements are performed in the leptonic decay modes ZZ → , where = e, µ and = e, µ, τ. The measured total cross section σ(pp → ZZ) = 7.7 ± 0.5 (stat) +0.5 −0.4 (syst) ± 0.4 (theo)
more » ... ± 0.2 (lumi) pb, for both Z bosons produced in the mass range 60 < m Z < 120 GeV, is consistent with standard model predictions. Differential cross sections are measured and well described by the theoretical predictions. The invariant mass distribution of the four-lepton system is used to set limits on anomalous ZZZ and ZZγ couplings at the 95% confidence level: −0.004 < f Z 4 < 0.004, −0.004 < f Z 5 < 0.004, −0.005 < f γ 4 < 0.005, and −0.005 < f γ 5 < 0.005. 3 Event reconstruction quartz-fiber Cherenkov calorimeter extends the coverage up to |η| < 5.0. Gas ionization muon detectors are embedded in the steel flux-return yoke outside the solenoid. A first level of the CMS trigger system, composed of custom hardware processors, is designed to select events of interest in less than 4 µs using information from the calorimeters and muon detectors. A highlevel-trigger processor farm reduces the event rate from 100 kHz delivered by the first level trigger to a few hundred hertz. Several Monte Carlo (MC) event generators are used to simulate the signal and background contributions. The qq → ZZ process is generated at next-to-leading order (NLO) with POWHEG 2.0 [9][10][11] or at leading-order (LO) with SHERPA [12]. The gg → ZZ process is simulated with GG2ZZ [13] at LO. Other diboson processes (WZ, Zγ ) and the Z+jets samples are generated at LO with MADGRAPH 5 [14]. Events from tt production are generated at NLO with POWHEG. The PYTHIA 6.4 [15] package is used for parton showering, hadronization, and the underlying event simulation. The default set of parton distribution functions (PDF) used for LO generators is CTEQ6L [16], whereas CT10 [17] is used for NLO generators. The ZZ yields from simulation are scaled according to the theoretical cross sections calculated with MCFM 6.0 [18] at NLO for qq → ZZ and at LO for gg → ZZ with the MSTW2008 PDF [19] with renormalization and factorization scales set to µ R = µ F = 91.2 GeV. The τ-lepton decays are simulated with TAUOLA [20] . For all processes, the detector response is simulated using a detailed description of the CMS detector based on the GEANT4 package [21] , and event reconstruction is performed with the same algorithms that are used for data. The simulated samples include multiple interactions per bunch crossing (pileup), such that the pileup distribution matches that of data, with an average value of about 21 interactions per bunch crossing.
doi:10.18154/rwth-2017-07658 fatcat:ci5y3fzbabaxvejf6kwkmdichu

The Right to Freedom of Religion in the Italian Experience of Secularism

Alberto Fabbri, Ilaria Pretelli
Giorgio Villella as legal representative of the Union.  ... 
doi:10.14276/1825-1676.1066 fatcat:d7z55r52mzhuflgs4unl4gqmru

Search for vector-like T quarks decaying to top quarks and Higgs bosons in the all-hadronic channel using jet substructure

CMS Collaboration, Vardan Khachatryan, Albert M. Sirunyan, Armen Tumasyan, Wolfgang Adam, Thomas Bergauer, Marko Dragicevic, Janos Erö, Markus Friedl, Rudolf Fruehwirth, Vasile Mihai Ghete, Christian Hartl (+2127 others)
A search is performed for a vector-like heavy T quark that is produced in pairs and that decays to a top quark and a Higgs boson. The data analysed correspond to an integrated luminosity of 19.7 fb −1 collected with the CMS detector in proton-proton collisions at √ s = 8 TeV. For T quarks with large mass values the top quarks and Higgs bosons can have significant Lorentz boosts, so that their individual decay products often overlap and merge. Methods are applied to resolve the substructure of
more » ... ch merged jets. Upper limits on the production cross section of a T quark with mass between 500 and 1000 GeV/c 2 are derived. If the T quark decays exclusively to tH, the observed (expected) lower limit on the mass of the T quark is 745 (773) GeV/c 2 at 95% confidence level. For the first time an algorithm is used for tagging boosted Higgs bosons that is based on a combination of jet substructure information and b tagging. The central feature of the CMS apparatus is a superconducting solenoid of 6 m internal diameter. Within the superconducting solenoid volume are a silicon pixel and strip tracker, a lead tungstate crystal electromagnetic calorimeter (ECAL), and a brass and scintillator hadron calorimeter (HCAL), each composed of a barrel and two endcap sections. Muons are measured in gas-ionization detectors embedded in the steel flux-return yoke outside the solenoid. Extensive forward calorimetry complements the coverage provided by the barrel and endcap detectors. The energy resolution for photons with E T ≈60 GeV varies between 1.1 and 2.6% over the solid angle of the ECAL barrel, and from 2.2 to 5% in the endcaps. The HCAL, when combined with the ECAL, measures jets with a resolution In the region |η| < 1.74, the HCAL cells have widths of 0.087 in η and 0.087 in azimuth (φ). In the η-φ plane, and for |η| < 1.48, the HCAL cells map on to 5 × 5 ECAL crystal arrays to form calorimeter towers projecting radially outwards from close to the nominal interaction point. At larger values of |η|, the size of the towers increases and the matching ECAL arrays contain fewer crystals. Within each tower, the energy deposits in ECAL and HCAL cells are summed to define the calorimeter tower energies, subsequently used to provide the energies and directions of hadronic jets. The silicon tracker measures charged particles within the pseudorapidity range |η| < 2.5. It consists of 1440 silicon pixel and 15 148 silicon strip detector modules and is located in the 3.8 T field of the superconducting solenoid. For nonisolated particles of 1 < p T < 10 GeV/c and |η| < 1.4, the track resolutions are typically 1.5% in p T and 25-90 (45-150) µm in the transverse (longitudinal) impact parameter [24]. A more detailed description of the CMS detector, together with a definition of the coordinate system used and the relevant kinematic variables, can be found in ref. [25] . Event samples The data used for this analysis were collected by the CMS experiment using pp collisions provided by the CERN LHC with a centre-of-mass energy of 8 TeV, and correspond to an integrated luminosity of 19.7 fb −1 . Events are selected online by a trigger algorithm that requires H T , the scalar sum of the transverse momenta of reconstructed jets in the detector, to be greater than 750 GeV/c. The online H T is calculated from calorimeter jets with p T > 40 GeV/c. Calorimeter jets are reconstructed from the energy deposits in the calorimeter towers, clustered by the anti-k T algorithm [26, 27] with a size parameter of 0.5. Simulated samples are used to determine signal selection efficiencies as well as the background contribution from tt plus jets, ttH, and hadronically decaying W/Z plus b jet production. The background from QCD multijet production is derived from data. Events from T quark decays are generated for mass hypotheses between 500 and 1000 GeV/c 2 in steps of 100 GeV/c 2 . The inclusive cross sections for the signal samples and tt samples are calculated at next-to-next-to-leading order (NNLO) for the reaction gg → tt + X. The fixed order calculations are supplemented with soft-gluon resummation with next-to-next-to-leading logarithmic accuracy [28] . The tt cross sections are computed based on the Top++ v2.0 implementation using the MSTW2008nnlo68cl parton distribution functions (PDF) and the 5.9.0 version of LHAPDF [28, 29] . The evaluated -3 -
doi:10.18154/rwth-2016-04848 fatcat:wguhqec5bfellcyyf25ve2hjsy

Search for physics beyond the standard model in dilepton mass spectra in proton-proton collisions at √s = 8 TeV

Vardan Khachatryan, Albert M. Sirunyan, Armen Tumasyan, Wolfgang Adam, Thomas Bergauer, Marko Dragicevic, Janos Erö, Christian Fabjan, Markus Friedl, Rudolf Fruehwirth, Vasile Mihai Ghete, Christian Hartl (+2133 others)
Dimuon and dielectron mass spectra, obtained from data resulting from protonproton collisions at 8 TeV and recorded by the CMS experiment, are used to search for both narrow resonances and broad deviations from standard model predictions. The data correspond to an integrated luminosity of 20.6 (19.7) fb −1 for the dimuon (dielectron) channel. No evidence for non-standard-model physics is observed and 95% confidence level limits are set on parameters from a number of new physics models. The
more » ... w resonance analyses exclude a Sequential Standard Model Z SSM resonance lighter than 2.90 TeV, a superstring-inspired Z ψ lighter than 2.57 TeV, and Randall-Sundrum Kaluza-Klein gravitons with masses below 2.73, 2.35, and 1.27 TeV for couplings of 0.10, 0.05, and 0.01, respectively. A notable feature is that the limits have been calculated in a model-independent way to enable straightforward reinterpretation in any model predicting a resonance structure. The observed events are also interpreted within the framework of two non-resonant analyses: one based on a large extra dimensions model and one based on a quark and lepton compositeness model with a left-left isoscalar contact interaction. Lower limits are established on M S , the scale characterizing the onset of quantum gravity, which range from 4.9 to 3.3 TeV, where the number of additional spatial dimensions varies from 3 to 7. Similarly, lower limits on Λ, the energy scale parameter for the contact interaction, are found to be 12.0 (15.2) TeV for destructive (constructive) interference in the dimuon channel and 13.5 (18.3) TeV in the dielectron channel.
doi:10.18154/rwth-2016-04926 fatcat:hs72s7eowfczvbpmxuokiqxqyu

Performance of photon reconstruction and identification with the CMS detector in proton-proton collisions at √s = 8 TeV

CMS Collaboration, Vardan Khachatryan, Albert M. Sirunyan, Armen Tumasyan, Wolfgang Adam, Thomas Bergauer, Marko Dragicevic, Janos Erö, Markus Friedl, Rudolf Fruehwirth, Vasile Mihai Ghete, Christian Hartl (+2134 others)
Performance of electron reconstruction and selection with the CMS detector in proton-proton collisions at s = 8 TeV -The diphoton resonance and Higgs results from the CMS Detector of the LHC M.I. Pedraza-Morales - Recent citations ABSTRACT: A description is provided of the performance of the CMS detector for photon reconstruction and identification in proton-proton collisions at a centre-of-mass energy of 8 TeV at the CERN LHC. Details are given on the reconstruction of photons from energy
more » ... its in the electromagnetic calorimeter (ECAL) and the extraction of photon energy estimates. The reconstruction of electron tracks from photons that convert to electrons in the CMS tracker is also described, as is the optimization of the photon energy reconstruction and its accurate modelling in simulation, in the analysis of the Higgs boson decay into two photons. In the barrel section of the ECAL, an energy resolution of about 1% is achieved for unconverted or late-converting photons from H → γγ decays. Different photon identification methods are discussed and their corresponding selection efficiencies in data are compared with those found in simulated events. JINST 10 P08010 are included. The interactions used to simulate pileup are generated with PYTHIA 6.426 [6], the same version that is used for other purposes as described below. Samples of simulated Higgs boson events produced in gluon-gluon and vector-boson fusion processes are obtained using the next-to-leading-order matrix-element generator POWHEG (version 1.0) [7-11] interfaced with PYTHIA. For the associated Higgs boson production with W and Z bosons, and with tt pairs, PYTHIA is used alone. Direct-photon production in γ + jet processes is simulated using PYTHIA alone. Nonresonant diphoton processes involving two prompt photons are simulated using SHERPA 1.4.2 [12] . The SHERPA samples are found to give a good description of diphoton continuum events accompanied by one or two jets. To complete the description of the diphoton background in the H → γγ channel, the remaining processes where one of the photon candidates arises from misidentified jet fragments are simulated with PYTHIA. The cross sections for these processes are scaled to match their values measured in data, using the K-factors at 8 TeV that were obtained at 7 TeV [13, 14] . Simulated samples of Z → e + e − and Z → µ + µ − γ events, generated with MADGRAPH 5.1 [15], SHERPA, and POWHEG [16], are used for some tests, for comparison with data, and for the derivation of energy scale corrections in data and resolution corrections in the simulations. The simulation of the ECAL response has been tuned to match test beam results, and uses a detailed simulation of the 40 MHz digitization based on an accurate model of the signal pulse as a function of time. The effects of electronics noise, fluctuations due to the number of photoelectrons, and the amplification process of the photodetectors are included. The simulation also includes a spread of the single-channel response corresponding to the estimated intercalibration precision, an additional 0.3% constant term to account for longitudinal nonuniformity of light collection, and the few nonresponding channels identified in data. The measured intercalibration uncertainties range from 0.35% in most of the barrel, to 0.9% at the end of the fourth barrel module, and 1.6% in most of the region covered by the endcaps with a steep rise for |η| > 2.3. As a general rule, for the simulation of data taken at 7 and 8 TeV, the response variation with time is not simulated. However, for the simulation of photon signals and Z-boson background samples used for data-MC comparisons of the photon energy scale, energy resolution, and photon selection, two refinements are implemented: the changes in the energy-equivalent noise in the electromagnetic calorimeter during the data-taking period are simulated, and a significantly increased time window (starting 300 ns before the triggering bunch crossing) is used to simulate out-of-time pileup. These refinements improve the agreement between data and simulated events, seen when comparing distributions of shower shape variables, and they provide improved corrections to the energy measurement. Photon reconstruction Photons for use as signals or signatures in measurements and searches, rather than for use in the construction of jets or missing transverse energy, are reconstructed from energy deposits in the ECAL using algorithms that constrain the clusters to the size and shape expected for electrons and photons with p T 15 GeV. The algorithms do not use any hypothesis as to whether the particle originating from the interaction point is a photon or an electron, consequently electrons from Z → e + e − events, for which pure samples with a well defined invariant mass can be selected, can provide -4 -2015 JINST 10 P08010 excellent measurements of the photon trigger, reconstruction, and identification efficiencies, and of the photon energy scale and resolution. The reconstructed showers are generally limited to a fiducial region excluding the last two crystals at each end of the barrel (|η| < 1.4442). The outer circumferences of the endcaps are obscured by services passing between the barrel and the endcaps, and this area is removed from the fiducial region by excluding the first ring of trigger towers of the endcaps (|η| > 1.566). The fiducial region terminates at |η| = 2.5 where the tracker coverage ends. The photon reconstruction proceeds through several steps. Sections 4.1, 4.2, and 4.3 cover the intercalibration of the individual channels, the clustering of recorded energy signals resulting from showers in the calorimeter, and the energy assignment to a cluster. Section 4.4 discusses the procedure used in the H → γγ analysis to (i) obtain corrections for fine-tuning the photon energy assignment in data, and (ii) tune the resolution of simulated photons reconstructed in MC samples. Section 4.5 examines the resulting photon resolution in data and in simulation. Section 4.6 discusses the estimation of the uncertainty in the energy scale after implementing the corrections obtained in section 4.4.
doi:10.18154/rwth-2016-01494 fatcat:eeou4vbqubelniexyilx755drm

Performance of Electron Reconstruction and Selection with the CMS Detector in Proton-Proton Collisions at √s = 8 TeV

CMS Collaboration, Vardan Khachatryan, Albert M. Sirunyan, Armen Tumasyan, Wolfgang Adam, Thomas Bergauer, Marko Dragicevic, Janos Erö, Markus Friedl, Rudolf Fruehwirth, Vasile Mihai Ghete, Christian Hartl (+2132 others)
The performance and strategies used in electron reconstruction and selection at CMS are presented based on data corresponding to an integrated luminosity of 19.7 fb −1 , collected in proton-proton collisions at √ s = 8 TeV at the CERN LHC. The paper focuses on prompt isolated electrons with transverse momenta ranging from about 5 to a few 100 GeV. A detailed description is given of the algorithms used to cluster energy in the electromagnetic calorimeter and to reconstruct electron trajectories
more » ... n the tracker. The electron momentum is estimated by combining the energy measurement in the calorimeter with the momentum measurement in the tracker. Benchmark selection criteria are presented, and their performances assessed using Z, ϒ, and J/ψ decays into e + + e − pairs. The spectra of the observables relevant to electron reconstruction and selection as well as their global efficiencies are well reproduced by Monte Carlo simulations. The momentum scale is calibrated with an uncertainty smaller than 0.3%. The momentum resolution for electrons produced in Z boson decays ranges from 1.7 to 4.5%, depending on electron pseudorapidity and energy loss through bremsstrahlung in the detector material.
doi:10.18154/rwth-2016-05201 fatcat:tjivwdgqpjcwtcm4f23xiejxn4

Seconda Relazione Semestrale sulle attività svolte dal Commissario unico per il superamento degli Ospedali Psichiatrici Giudiziari

Franco Corleone
2016 unpublished
Corrado Villella Dott.ssa Arianna Piermarini, dott.  ...  Dott.sse Ilaria Santini, Domenica Canna e Melissa Cornelio Calabria -Santa Sofia D'Epiro La nostra è una esperienza giovane avendo aperto la REMS nel mese di ottobre 2016.  ... 

Description and performance of track and primary-vertex reconstruction with the CMS tracker

CMS Collaboration, Serguei Chatrchyan, Vardan Khachatryan, Albert M. Sirunyan, Armen Tumasyan, Wolfgang Adam, Thomas Bergauer, Marko Dragicevic, Janos Erö, Christian Fabjan, Markus Friedl, Rudolf Fruehwirth (+2401 others)
Commissioning and performance of the CMS silicon strip tracker with cosmic ray muons CMS Collaboration -Commissioning and performance of the CMS pixel tracker with cosmic ray muons CMS Collaboration -Operation and performance of the ATLAS semiconductor tracker The ATLAS collaboration -Recent citations Lepton-number violation in Bs meson decays induced by an on-shell Majorana neutrino Jhovanny Mejía-Guisao et al -Search for massive resonances decaying into WW , WZ , ZZ , qW , and qZ with dijet
more » ... nal states at s=13 TeV A. M. Sirunyan et al -Suppression of Excited States Relative to the Ground State in Pb-Pb Collisions at sNN=5.02 TeV A. M. Sirunyan et al -This content was downloaded from IP address 134.130.185. ABSTRACT: A description is provided of the software algorithms developed for the CMS tracker both for reconstructing charged-particle trajectories in proton-proton interactions and for using the resulting tracks to estimate the positions of the LHC luminous region and individual primaryinteraction vertices. Despite the very hostile environment at the LHC, the performance obtained with these algorithms is found to be excellent. For tt events under typical 2011 pileup conditions, the average track-reconstruction efficiency for promptly-produced charged particles with transverse momenta of p T > 0.9 GeV is 94% for pseudorapidities of |η| < 0.9 and 85% for 0.9 < |η| < 2.5. The inefficiency is caused mainly by hadrons that undergo nuclear interactions in the tracker material. For isolated muons, the corresponding efficiencies are essentially 100%. For isolated muons of p T = 100 GeV emitted at |η| < 1.4, the resolutions are approximately 2.8% in p T , and respectively, 10 µm and 30 µm in the transverse and longitudinal impact parameters. The position resolution achieved for reconstructed primary vertices that correspond to interesting pp collisions is 10-12 µm in each of the three spatial dimensions. The tracking and vertexing software is fast and flexible, and easily adaptable to other functions, such as fast tracking for the trigger, or dedicated tracking for electrons that takes into account bremsstrahlung.
doi:10.18154/rwth-2015-06639 fatcat:xkumijoi3zcsloe5adp4xlwzeq


Laura Di Bona, Marco Cangiotti, Gabriele Fattori, Lanfranco Ferroni, Henry Frendo, Giuseppe Giliberti, Anna Giomaro, Guido Guidi, Giulio Illuminati, Andrea Lovato, Luigi Mari, Remo Martini (+13 others)
d'impresa come stato di non insolvenza (irreversibile), 181 MARIA LUISA BICCARI, Sul titolo De Iniuriis del Codice Giustinianeo: le costituzioni di Diocle-ziano e il diritto classico, 203 ALBERTO FABBRI, ILARIA  ...  Giorgio Villella as legal representative of the Union.  ...  ALBERTO FABBRI *, ILARIA PRETELLI * * The Right to Freedom of Religion in the Italian Experience of Secularism ABSTRACT  Nell'esperienza italiana, il principio di laicità va misurato con gli altri principi  ... 

The ubiquitin pathway in host-parasite interactions during infection by Trichinella spiralis

Rhiannon Rose White, Katerina Artavanis-Tsakonas, Niki Gounaris, Medical Research Council (Great Britain)
Drawing by Villella, J.B., 1970, Life cycle and morphology, in: Trichinosis in Man and Animals (S.E. Gould, ed.), Charles C.  ...  The first lentiviral vector to be tested was the HIV-derived pCSGW tdTomato, kindly provided by Ilaria Nisoli and Hugh Brady (Imperial College).  ... 
doi:10.25560/30661 fatcat:xf73lym5cncg7ftqljntowbkoi