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Identifying Emerging Phenomenon in Plant Long Temporal Phenotyping Experiments [article]

Jiajie Peng, Junya Lu, Donghee Hoh, Ayesha S Dina, Xuequn Shang, David M Kramer, Jin Chen
2018 bioRxiv   pre-print
To address this challenge, we developed a new algorithm to identify emerging phenomena from large-scale temporal plant phenotyping experiments.  ...  Then, emerging phenomena in different temporal scales are identified from dynamic phenotype network using a maximal clique based approach.  ...  Identifying Emerging Phenomenon in Plant Long Temporal Phenotyping Experiments Jiajie Peng, Junya Lu, Donghee Hoh, Ayesha S Dina, Xuequn Shang, David M Kramer, Jin Chen Abstract-The rapid improvement of  ... 
doi:10.1101/454686 fatcat:lgccu5fyw5f5fccjbuxozcfmna

The unforeseen challenge: from genotype-to-phenotype in cell populations

Erez Braun
2015 Reports on progress in physics (Print)  
I am also grateful to the referees that encouraged me in the process of publication and helped to improve the manuscript.  ...  Thus, the emerging phenotype depends on the spectrum of regulatory modes-temporal profiles of expressed genes.  ...  The issue of an emergent order-stable cell states-in essence is that of the genotype-to-phenotype associations.  ... 
doi:10.1088/0034-4885/78/3/036602 pmid:25719211 fatcat:e5zkideuonfyjhcik5hz3a42yi

Now You See It, Now You Don't—Closing in on Allostasis and Developmental Basis of Psychiatric Disorders

Barbara L. Thompson, Pat Levitt
2010 Neuron  
As the authors note, IUEP is useful for developing animal models that mimic (endo)phenotypic features of neurodevelomental disorders that emerge in childhood or even after puberty.  ...  With this current report by Niwa et al. and recent studies by other laboratories, the phenomenon has been demystified, and it appears that transient ontogenetic challenges of certain spatial and temporal  ... 
doi:10.1016/j.neuron.2010.02.010 pmid:20188647 fatcat:rh75dwrelbgczm5jqgv46kqbc4

What is the storage effect, why should it occur in cancers, and how can it inform cancer therapy? [article]

Anna K. Miller, Joel S. Brown, David Basanta, Nancy Huntly
2020 bioRxiv   pre-print
Three ingredients are required for there to be a storage effect: 1) temporal variability in the environment, 2) buffered population growth, and 3) species-specific environmental responses.  ...  Data that show the temporal variation within the tumor microenvironment is needed to quantify how cancer cells respond to fluctuations in the tumor microenvironment and what impact this has on interactions  ...  Temporal Variation in Nature and in the Tumor Microenvironment Very few, if any, ecological communities experience temporally constant environments.  ... 
doi:10.1101/2020.03.28.013557 fatcat:3fjzryik6zes3j4wrt7gnf44oi

Temporal environmental variation may impose differential selection on both genomic and ecological traits

Ludwig Leidinger, Daniel Vedder, Juliano Sarmento Cabral
2021 Oikos  
Which phenotypic and genomic traits enable survival in temporally variable environments?  ...  Nevertheless, in principle, our experiments demonstrate that GeMM can already be applied to the study of plant communities and, as long as the processes are similar, potentially to other organisms (e.g  ... 
doi:10.1111/oik.08172 fatcat:2olnhkuaqjadzhu5zw64fruzra

Taxonomic models of individual differences: a guide to transdisciplinary approaches

Jana Uher
2018 Philosophical Transactions of the Royal Society of London. Biological Sciences  
Instead, multiple models phenotypically taxonomizing different kinds of variability in different kinds of phenomena are needed to explore their causal and functional interrelations and ontogenetic development  ...  that are then modelled in integrative and explanatory taxonomies.  ...  But averages do not reveal how the identified components emerge, function and develop together in the individual.  ... 
doi:10.1098/rstb.2017.0171 pmid:29483354 fatcat:4r74gevperhnbdtmm66rpfyj2i

What Is the Storage Effect, Why Should It Occur in Cancers, and How Can It Inform Cancer Therapy?

Anna K. Miller, Joel S. Brown, David Basanta, Nancy Huntly
2020 Cancer Control: Journal of the Moffitt Cancer Cente  
Three ingredients are required for there to be a storage effect: (1) temporal variability in the environment, (2) buffered population growth, and (3) species-specific environmental responses.  ...  Data that show the temporal variation within the tumor microenvironment are needed to quantify how cancer cells respond to fluctuations in the tumor microenvironment and what impact this has on interactions  ...  Temporal Variation in Nature and the Tumor Microenvironment Very few, if any, ecological communities experience temporally constant environments.  ... 
doi:10.1177/1073274820941968 pmid:32723185 fatcat:2lrprxupgjdirnzhhmchxd26ha

Evolutionary conservation-evaluating the adaptive potential of species

Christophe Eizaguirre, Miguel Baltazar-Soares
2014 Evolutionary Applications  
To cease this phenomenon, we urgently need a better knowledge not only of the true extent of biodiversity, but also of the evolutionary potential of species to respond to environmental change.  ...  Hybridization is such a phenomenon and its outcome is unclear.  ...  , managing reintroductions and long-term monitoring.  ... 
doi:10.1111/eva.12227 pmcid:PMC4231588 fatcat:34jxmu3ysrcojb5pvkofgz6cim

Suicidal Behavior: A Developmental Perspective

Maria A. Oquendo, J. John Mann
2008 Psychiatric Clinics of North America  
The authors identify possible genetic and environmental explanations for this phenomenon.  ...  It has long been known that suicidal behavior varies strikingly across the life span.  ...  The authors identify possible genetic and environmental explanations for this phenomenon.  ... 
doi:10.1016/j.psc.2008.03.001 pmid:18439441 pmcid:PMC4302391 fatcat:bqnjrfdv5ndmzehp5gf5adogja

Genomics and Pain Research in Sickle Cell Disease: An Explanation of Heterogeneity?

Maxine Adegbola
2011 ISRN Nursing  
Previous research on the guanosine triphosphate cyclohydrolase (GCH1) gene suggests that in some cases, phenotypic heterogeneity in human sensitivity to pain correlates with underlying genotypic variations  ...  These findings imply that genotypic variations might also explain why some SCD patients experience more chronic pain than others.  ...  The functional impact of polymorphisms might identify one reason for variability or heterogeneity of pain phenotype in SCD.  ... 
doi:10.5402/2011/672579 pmid:21808743 pmcid:PMC3146762 fatcat:yjzvccouejbwvf6ufm4izkakeq

Application of Evolutionary Principles to Cancer Therapy

P. M. Enriquez-Navas, J. W. Wojtkowiak, R. A. Gatenby
2015 Cancer Research  
The dynamic cancer ecosystem, with its rich temporal and spatial diversity in environmental conditions and heritable cell phenotypes, is remarkably robust to therapeutic perturbations.  ...  Even when response to therapy is clinically complete, adaptive tumor strategies almost inevitably emerge and the tumor returns.  ...  Furthermore, many other mechanisms of de novo therapy resistance have been identified.  ... 
doi:10.1158/0008-5472.can-15-1337 pmid:26527288 pmcid:PMC4693617 fatcat:4zbdyldlkjbl7iimyvwhgcw6f4

The multitemporality of life: an analysis from Philosophy of Biology

Constanza Rendón, Nahuel Pallitto, Guillermo Folguera
2016 Manuscrito  
One possible way of approaching this subject is to examine the kinds of temporalities involved in biological processes.  ...  In that vein, the aim of this article is to analyze developmental and evolutionary processes' temporality in different biological fields of study, including a novel area (Evolutionary Developmental Biology  ...  This author postulated an explanatory model for the emergence of new phenotypes which combines the aforementioned processes.  ... 
doi:10.1590/0100-6045.2016.v39n3.cng fatcat:mcbhwfipkjcvzggfnpbwedyem4

Adaptive responses of the embryos of birds and reptiles to spatial and temporal variations in nest temperatures

Wei-Guo Du, Richard Shine, Liang Ma, Bao-Jun Sun
2019 Proceedings of the Royal Society of London. Biological Sciences  
Although relatively few taxa have been studied in detail, and proximate mechanisms remain unclear, our review identifies many cases in which natural selection appears to have fine-tuned embryogenesis to  ...  We review published literature on embryonic adaptations to spatio-temporal heterogeneity in nest temperatures.  ...  Li for their help in collecting data.  ... 
doi:10.1098/rspb.2019.2078 pmid:31744441 pmcid:PMC6892042 fatcat:jc45fssh2fgtjmiivxtrv7dufy

Temporal Population Genetics of Time Travelling Insects: A Long Term Study in a Seed-Specialized Wasp

Marie Suez, Cindy Gidoin, François Lefèvre, Jean-Noël Candau, Alain Chalon, Thomas Boivin, Hans Henrik Bruun
2013 PLoS ONE  
In this long-term study, we investigated how a particular pattern of prolonged diapause may influence the temporal population genetics of the invasive seed-specialized wasp Megastigmus schimitscheki (Hymenoptera  ...  We characterized the diapause strategy of M. schimitscheki using records of emergence from diapause in 97 larval cohorts, and we conducted a temporal population genetic study on a natural invasive wasp  ...  sampled during 10 consecutive years and for which the diapause phenotype (SD or PD) of emerging individuals was identified.  ... 
doi:10.1371/journal.pone.0070818 pmid:23936470 pmcid:PMC3732219 fatcat:p72phxxmyvdfxeazxppjxx2vzi

Influence of maternal care on the developing brain: Mechanisms, temporal dynamics and sensitive periods

James P. Curley, Frances A. Champagne
2016 Frontiers in neuroendocrinology (Print)  
Study of the long-term outcomes associated with mother-infant interactions suggests complex mechanisms linking the experience of variation in maternal care and these neurobiological consequences.  ...  Identifying the period of sensitivity to maternal care and the temporal dynamics of the molecular and neuroendocrine changes that are a consequence of maternal care represents a critical step in the study  ...  /gene targets so as to identify sex differences in response to this critical environmental experience.  ... 
doi:10.1016/j.yfrne.2015.11.001 pmid:26616341 pmcid:PMC4783284 fatcat:agugpphwvbhorcbtdoxviqsfnm
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