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Identifying Emerging Phenomenon in Plant Long Temporal Phenotyping Experiments
[article]
2018
bioRxiv
pre-print
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To address this challenge, we developed a new algorithm to identify emerging phenomena from large-scale temporal plant phenotyping experiments. ...
Then, emerging phenomena in different temporal scales are identified from dynamic phenotype network using a maximal clique based approach. ...
Identifying Emerging Phenomenon in Plant Long Temporal Phenotyping Experiments Jiajie Peng, Junya Lu, Donghee Hoh, Ayesha S Dina, Xuequn Shang, David M Kramer, Jin Chen Abstract-The rapid improvement of ...
doi:10.1101/454686
fatcat:lgccu5fyw5f5fccjbuxozcfmna
The unforeseen challenge: from genotype-to-phenotype in cell populations
2015
Reports on progress in physics (Print)
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I am also grateful to the referees that encouraged me in the process of publication and helped to improve the manuscript. ...
Thus, the emerging phenotype depends on the spectrum of regulatory modes-temporal profiles of expressed genes. ...
The issue of an emergent order-stable cell states-in essence is that of the genotype-to-phenotype associations. ...
doi:10.1088/0034-4885/78/3/036602
pmid:25719211
fatcat:e5zkideuonfyjhcik5hz3a42yi
Now You See It, Now You Don't—Closing in on Allostasis and Developmental Basis of Psychiatric Disorders
2010
Neuron
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As the authors note, IUEP is useful for developing animal models that mimic (endo)phenotypic features of neurodevelomental disorders that emerge in childhood or even after puberty. ...
With this current report by Niwa et al. and recent studies by other laboratories, the phenomenon has been demystified, and it appears that transient ontogenetic challenges of certain spatial and temporal ...
doi:10.1016/j.neuron.2010.02.010
pmid:20188647
fatcat:rh75dwrelbgczm5jqgv46kqbc4
What is the storage effect, why should it occur in cancers, and how can it inform cancer therapy?
[article]
2020
bioRxiv
pre-print
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Three ingredients are required for there to be a storage effect: 1) temporal variability in the environment, 2) buffered population growth, and 3) species-specific environmental responses. ...
Data that show the temporal variation within the tumor microenvironment is needed to quantify how cancer cells respond to fluctuations in the tumor microenvironment and what impact this has on interactions ...
Temporal Variation in Nature and in the Tumor Microenvironment Very few, if any, ecological communities experience temporally constant environments. ...
doi:10.1101/2020.03.28.013557
fatcat:3fjzryik6zes3j4wrt7gnf44oi
Temporal environmental variation may impose differential selection on both genomic and ecological traits
2021
Oikos
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Which phenotypic and genomic traits enable survival in temporally variable environments? ...
Nevertheless, in principle, our experiments demonstrate that GeMM can already be applied to the study of plant communities and, as long as the processes are similar, potentially to other organisms (e.g ...
doi:10.1111/oik.08172
fatcat:2olnhkuaqjadzhu5zw64fruzra
Taxonomic models of individual differences: a guide to transdisciplinary approaches
2018
Philosophical Transactions of the Royal Society of London. Biological Sciences
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Instead, multiple models phenotypically taxonomizing different kinds of variability in different kinds of phenomena are needed to explore their causal and functional interrelations and ontogenetic development ...
that are then modelled in integrative and explanatory taxonomies. ...
But averages do not reveal how the identified components emerge, function and develop together in the individual. ...
doi:10.1098/rstb.2017.0171
pmid:29483354
fatcat:4r74gevperhnbdtmm66rpfyj2i
What Is the Storage Effect, Why Should It Occur in Cancers, and How Can It Inform Cancer Therapy?
2020
Cancer Control: Journal of the Moffitt Cancer Cente
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Three ingredients are required for there to be a storage effect: (1) temporal variability in the environment, (2) buffered population growth, and (3) species-specific environmental responses. ...
Data that show the temporal variation within the tumor microenvironment are needed to quantify how cancer cells respond to fluctuations in the tumor microenvironment and what impact this has on interactions ...
Temporal Variation in Nature and the Tumor Microenvironment Very few, if any, ecological communities experience temporally constant environments. ...
doi:10.1177/1073274820941968
pmid:32723185
fatcat:2lrprxupgjdirnzhhmchxd26ha
Evolutionary conservation-evaluating the adaptive potential of species
2014
Evolutionary Applications
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To cease this phenomenon, we urgently need a better knowledge not only of the true extent of biodiversity, but also of the evolutionary potential of species to respond to environmental change. ...
Hybridization is such a phenomenon and its outcome is unclear. ...
, managing reintroductions and long-term monitoring. ...
doi:10.1111/eva.12227
pmcid:PMC4231588
fatcat:34jxmu3ysrcojb5pvkofgz6cim
Suicidal Behavior: A Developmental Perspective
2008
Psychiatric Clinics of North America
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The authors identify possible genetic and environmental explanations for this phenomenon. ...
It has long been known that suicidal behavior varies strikingly across the life span. ...
The authors identify possible genetic and environmental explanations for this phenomenon. ...
doi:10.1016/j.psc.2008.03.001
pmid:18439441
pmcid:PMC4302391
fatcat:bqnjrfdv5ndmzehp5gf5adogja
Genomics and Pain Research in Sickle Cell Disease: An Explanation of Heterogeneity?
2011
ISRN Nursing
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Previous research on the guanosine triphosphate cyclohydrolase (GCH1) gene suggests that in some cases, phenotypic heterogeneity in human sensitivity to pain correlates with underlying genotypic variations ...
These findings imply that genotypic variations might also explain why some SCD patients experience more chronic pain than others. ...
The functional impact of polymorphisms might identify one reason for variability or heterogeneity of pain phenotype in SCD. ...
doi:10.5402/2011/672579
pmid:21808743
pmcid:PMC3146762
fatcat:yjzvccouejbwvf6ufm4izkakeq
Application of Evolutionary Principles to Cancer Therapy
2015
Cancer Research
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The dynamic cancer ecosystem, with its rich temporal and spatial diversity in environmental conditions and heritable cell phenotypes, is remarkably robust to therapeutic perturbations. ...
Even when response to therapy is clinically complete, adaptive tumor strategies almost inevitably emerge and the tumor returns. ...
Furthermore, many other mechanisms of de novo therapy resistance have been identified. ...
doi:10.1158/0008-5472.can-15-1337
pmid:26527288
pmcid:PMC4693617
fatcat:4zbdyldlkjbl7iimyvwhgcw6f4
The multitemporality of life: an analysis from Philosophy of Biology
2016
Manuscrito
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One possible way of approaching this subject is to examine the kinds of temporalities involved in biological processes. ...
In that vein, the aim of this article is to analyze developmental and evolutionary processes' temporality in different biological fields of study, including a novel area (Evolutionary Developmental Biology ...
This author postulated an explanatory model for the emergence of new phenotypes which combines the aforementioned processes. ...
doi:10.1590/0100-6045.2016.v39n3.cng
fatcat:mcbhwfipkjcvzggfnpbwedyem4
Adaptive responses of the embryos of birds and reptiles to spatial and temporal variations in nest temperatures
2019
Proceedings of the Royal Society of London. Biological Sciences
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Although relatively few taxa have been studied in detail, and proximate mechanisms remain unclear, our review identifies many cases in which natural selection appears to have fine-tuned embryogenesis to ...
We review published literature on embryonic adaptations to spatio-temporal heterogeneity in nest temperatures. ...
Li for their help in collecting data. ...
doi:10.1098/rspb.2019.2078
pmid:31744441
pmcid:PMC6892042
fatcat:jc45fssh2fgtjmiivxtrv7dufy
Temporal Population Genetics of Time Travelling Insects: A Long Term Study in a Seed-Specialized Wasp
2013
PLoS ONE
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In this long-term study, we investigated how a particular pattern of prolonged diapause may influence the temporal population genetics of the invasive seed-specialized wasp Megastigmus schimitscheki (Hymenoptera ...
We characterized the diapause strategy of M. schimitscheki using records of emergence from diapause in 97 larval cohorts, and we conducted a temporal population genetic study on a natural invasive wasp ...
sampled during 10 consecutive years and for which the diapause phenotype (SD or PD) of emerging individuals was identified. ...
doi:10.1371/journal.pone.0070818
pmid:23936470
pmcid:PMC3732219
fatcat:p72phxxmyvdfxeazxppjxx2vzi
Influence of maternal care on the developing brain: Mechanisms, temporal dynamics and sensitive periods
2016
Frontiers in neuroendocrinology (Print)
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Study of the long-term outcomes associated with mother-infant interactions suggests complex mechanisms linking the experience of variation in maternal care and these neurobiological consequences. ...
Identifying the period of sensitivity to maternal care and the temporal dynamics of the molecular and neuroendocrine changes that are a consequence of maternal care represents a critical step in the study ...
/gene targets so as to identify sex differences in response to this critical environmental experience. ...
doi:10.1016/j.yfrne.2015.11.001
pmid:26616341
pmcid:PMC4783284
fatcat:agugpphwvbhorcbtdoxviqsfnm
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