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Decision-making under risk: A graph-based network analysis using functional MRI

Ludovico Minati, Marina Grisoli, Anil K. Seth, Hugo D. Critchley
2012 NeuroImage  
Connectivity graphs were constructed from analyses of psychophysiological interactions across a comprehensive atlas of brain regions.  ...  However, limited attention is given to how brain networks encode economic parameters in patterns of inter-regional interactions.  ...  Acknowledgments LM was wholly funded and employed by the Fondazione IRCCS Istituto Neurologico Carlo Besta (FINCB) during the core period of  ... 
doi:10.1016/j.neuroimage.2012.02.048 pmid:22387471 fatcat:u4rtcjqmand4zkfq5i5t2v3dpm

The power of using functional fMRI on small rodents to study brain pharmacology and disease

Elisabeth Jonckers, Disha Shah, Julie Hamaide, Marleen Verhoye, Annemie Van der Linden
2015 Frontiers in Pharmacology  
Respectively, these techniques permit the assessment of functional connectivity during rest as well as brain activation triggered by sensory stimulation and/or a pharmacological challenge.  ...  Functional magnetic resonance imaging (fMRI) is an excellent tool to study the effect of pharmacological modulations on brain function in a non-invasive and longitudinal manner.  ...  ACKNOWLEDGMENTS The authors acknowledge the Institute for the Promotion of Innovation by Science and Technology (IWT) in Flanders grant agreement 131060, Molecular Imaging of Brain Pathophysiology  ... 
doi:10.3389/fphar.2015.00231 pmid:26539115 pmcid:PMC4612660 fatcat:vxu45hrsn5hchn46yitjtt76my

Leveraging Neural Networks in Preclinical Alcohol Research

Lauren C. Smith, Adam Kimbrough
2020 Brain Sciences  
There is a plethora of neural imaging techniques available at the clinical and preclinical level, including magnetic resonance imaging and three-dimensional (3D) tissue imaging techniques.  ...  Network-based approaches can be applied to imaging data to create neural networks that model the functional and structural connectivity of the brain.  ...  Data from both of these methods can be interpreted using graph theory approaches to identify key brain regions, hubs, and global changes in neural networks during a given state. Table 3 .  ... 
doi:10.3390/brainsci10090578 pmid:32825739 pmcid:PMC7565429 fatcat:u34o4pn5afan7ouayjzpmxvigi

A set of functionally-defined brain regions with improved representation of the subcortex and cerebellum

Benjamin A. Seitzman, Caterina Gratton, Scott Marek, Ryan V. Raut, Nico U.F. Dosenbach, Bradley L. Schlaggar, Steven E. Petersen, Deanna J. Greene
2019 NeuroImage  
Two sets of functional brain nodes from our group are well represented in the literature: (1) 264 volumetric regions of interest (ROIs) reported in Power et al., 2011, and (2) 333 cortical surface parcels  ...  This new set of ROIs is made publicly available for general use, including a full list of MNI coordinates and functional network labels.  ...  Acknowledgements This work was supported by National Institutes of Health grants T32 NS073547 (BAS), F32 NS092290 (CG), T32 MH10001902 (SM), K23 NS088590 (NUFD), UL1 TR000448 (NUFD), R01 NS32979 (SEP),  ... 
doi:10.1016/j.neuroimage.2019.116290 pmid:31634545 pmcid:PMC6981071 fatcat:jj7befizebgr3fvnocxkw5fal4

Intrinsic functional connectivity of the central extended amygdala

Rachael M. Tillman, Melissa D. Stockbridge, Brendon M. Nacewicz, Salvatore Torrisi, Andrew S. Fox, Jason F. Smith, Alexander J. Shackman
2017 Human Brain Mapping  
Although it is widely thought that these disorders reflect the coordinated actions of large-scale functional circuits in the brain, the architecture of the EAc functional network, and the degree to which  ...  Using newly developed seed regions, whole-brain regression analyses revealed robust functional connectivity between the BST and Ce via the sublenticular extended amygdala ('substantia innominata'), the  ...  A key challenge for future research will be to use a combination of mechanistic (e.g., optogenetic) and whole-brain imaging techniques to clarify the specific causal contributions of the regions highlighted  ... 
doi:10.1002/hbm.23917 pmid:29235190 fatcat:2rfmxwbuibf6xg233zc6jc6lha

Intrinsic functional connectivity of the central extended amygdala [article]

Rachael M. Tillman, Melissa D. Stockbridge, Brendon M. Nacewicz, Salvatore Torrisi, Andrew S. Fox, Jason F. Smith, Alexander Joseph Shackman
2017 bioRxiv   pre-print
Although it is widely thought that these disorders reflect the coordinated actions of large-scale functional circuits in the brain, the architecture of the EAc functional network, and the degree to which  ...  Using newly developed seed regions, whole-brain regression analyses revealed robust functional connectivity between the BST and Ce via the sublenticular extended amygdala (substantia innominata), the ribbon  ...  It is clear that the CM seeds encompass a substantial volume of extra-amygdalar tissue, including regions of white matter, globus pallidus, and putamen.  ... 
doi:10.1101/178533 fatcat:w3ci6dwk7fen5dzeu3ya2mzpo4

Selective septohippocampal – but not forebrain amygdalar – cholinergic dysfunction in diencephalic amnesia

Lisa M. Savage, Jessica Roland, Anna Klintsova
2007 Brain Research  
of the brain [4, 29, 45, 49, 53] .  ...  In-vivo acetylcholine (ACh) efflux, a marker of memory-related activation, was measured in the hippocampus and the amygdala of PTD-treated and pair-fed (PF) control rats while they were tested on a spontaneous  ...  Acknowledgements This work was supported by research grant NINDS 054272 to LMS.  ... 
doi:10.1016/j.brainres.2006.12.083 pmid:17289001 pmcid:PMC1868479 fatcat:aacc5sk4rnfupea5t3vszpm5cu

Rich-Club in the Brain's Macrostructure: Insights from Graph Theoretical Analysis

Dae-Jin Kim, Byoung-Kyong Min
2020 Computational and Structural Biotechnology Journal  
The brain is a complex network. Growing evidence supports the critical roles of a set of brain regions within the brain network, known as the brain's cores or hubs.  ...  The rich-club of the brain network is essential as it directly regulates functional integration across multiple segregated regions and helps to optimize cognitive processes.  ...  The structure of networks has been analyzed within a mathematical framework known as graph theory (Fig. 1) .  ... 
doi:10.1016/j.csbj.2020.06.039 pmid:32695269 pmcid:PMC7355726 fatcat:xd3o2bqpijakbktgtshythucy4

3D mapping reveals network-specific amyloid progression and subcortical susceptibility in mice

Rebecca Gail Canter, Wen-Chin Huang, Heejin Choi, Jun Wang, Lauren Ashley Watson, Christine G. Yao, Fatema Abdurrob, Stephanie M. Bousleiman, Jennie Z. Young, David A. Bennett, Ivana Delalle, Kwanghun Chung (+1 others)
2019 Communications Biology  
Prominent hypotheses suggest accumulation of beta-amyloid (Aβ) contributes to neurodegeneration and memory loss, however identifying brain regions with early susceptibility to Aβ remains elusive.  ...  Using SWITCH to immunolabel intact brain, we created a spatiotemporal map of Aβ deposition in the 5XFAD mouse.  ...  PPFE brain tissue for the optimized CLARITY protocol.  ... 
doi:10.1038/s42003-019-0599-8 pmid:31602409 pmcid:PMC6778135 fatcat:jzp576rzcva2fkh34emveo4un4

Multimodal fusion of structural and functional brain imaging in depression using linked independent component analysis

Luigi A. Maglanoc, Tobias Kaufmann, Rune Jonassen, Eva Hilland, Dani Beck, Nils Inge Landrø, Lars T. Westlye
2019 Human Brain Mapping  
Previous structural and functional neuroimaging studies have implicated distributed brain regions and networks in depression.  ...  A dimensional approach and fusion of imaging modalities may yield a more coherent view of the neuronal correlates of depression.  ...  Regional Health Authority (2014097, 2015073, 2015052), the Research Council of Norway (249795, 229135), and the Department of Psychology, University of Oslo.  ... 
doi:10.1002/hbm.24802 pmid:31571370 fatcat:g7y765irerdihhx4mx64nehug4

Assessing prefrontal cortex oxygenation after sport concussion with near-infrared spectroscopy

Scott A. Bishop, J. Patrick Neary
2017 Clinical Physiology and Functional Imaging  
The university and those conducting this project subscribe to the ethical conduct of research and to the protection at all time of the interests, comfort, and safety of participants, and this project has  ...  been approved the University of Regina Ethics Board  ...  -NIRS applications to brain injury.  ... 
doi:10.1111/cpf.12447 pmid:28626873 fatcat:ymldhodzvjg4lmtyhwb5v76fm4

Atypical Structural Connectome Organization and Cognitive Impairment in Young Survivors of Acute Lymphoblastic Leukemia

Shelli R. Kesler, Meike Gugel, Emily Huston-Warren, Christa Watson
2016 Brain Connectivity  
These findings provide further evidence of brain injury in young survivors of ALL, even those without a history of central nervous system (CNS) disease or cranial radiation.  ...  Regional analysis indicated that clustered connectivity in parietal, frontal, hippocampal, amygdalar, thalamic, and occipital regions was altered in the ALL group.  ...  Acknowledgment This research was supported by a grant from the National Institutes of Health (1K07CA134639 and 1R03CA191559 to S.R.K.).  ... 
doi:10.1089/brain.2015.0409 pmid:26850738 pmcid:PMC4876554 fatcat:qszcygvvcfdffpm2zntq434vuq

Multimodal image registration and connectivity analysis for integration of connectomic data from microscopy to MRI

Maged Goubran, Christoph Leuze, Brian Hsueh, Markus Aswendt, Li Ye, Qiyuan Tian, Michelle Y. Cheng, Ailey Crow, Gary K. Steinberg, Jennifer A. McNab, Karl Deisseroth, Michael Zeineh
2019 Nature Communications  
3D histology, slice-based connectivity atlases, and diffusion MRI are common techniques to map brain wiring.  ...  While there are many modality-specific tools to process these data, there is a lack of integration across modalities.  ...  Future studies will benefit from novel immunolabeling protocols applicable for the whole brain to include commonly used injury markers such as glial fibrillary acidic protein to visualize the formation  ... 
doi:10.1038/s41467-019-13374-0 pmid:31796741 pmcid:PMC6890789 fatcat:6amqk6fsojcgzjalhqvxp7wqym

The neurobiology of the emotional adolescent: From the inside out

Amanda E. Guyer, Jennifer S. Silk, Eric E. Nelson
2016 Neuroscience and Biobehavioral Reviews  
Research on the neural substrates of adolescent affective behavior is beginning to paint a more nuanced picture of how neurodevelopmental changes in brain function influence affective behavior, and how  ...  As the field progresses, it will be critical to test new hypotheses generated from the foundational empirical and conceptual work and to focus on identifying more precisely how and when neural networks  ...  Acknowledgments Financial support for the writing of the article was provided by the National Institutes of Health awards  ... 
doi:10.1016/j.neubiorev.2016.07.037 pmid:27506384 pmcid:PMC5074886 fatcat:ia4emy5otrgq3cmvcz4qabjhue

Affective Neuroscience Strategies for Understanding and Treating Depression

Jaak Panksepp, Jason S. Wright, Máté D. Döbrössy, Thomas E. Schlaepfer, Volker A. Coenen
2014 Clinical Psychological Science  
, such as affects, emotions, and feelings, and our rationale for going to a level of brain-mind analysis in animals, a strategy that has generally been deemed undoable and, thus, scientifically inappropriate  ...  for a fuller development of some of the arguments.  ...  That said, the assessment of a multitude of brain regions implicated in human clinical depression, permitted especially by modern functional brain imaging, is paralleled by nonhuman animal studies that  ... 
doi:10.1177/2167702614535913 fatcat:cwkajlu2krb2tfrhezhyo2gfdi
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