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The novel p53 target gene IRF2BP2 participates in cell survival during the p53 stress response
2008
Nucleic Acids Research
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Here, we describe the interferon regulatory factor-2-binding protein-2 (IRF2BP2) as a new direct target gene of p53, influencing the p53-mediated cellular decision. ...
Analyzing the molecular functions of IRF2BP2, it appears to be able to impede on the p53-mediated transactivation of the p21-and the Bax-gene. ...
ACKNOWLEDGEMENTS We thank Stephen Goodbourn for IRF2BP2-constructs, Yugang Tu and Moshe Oren for the p53-responsive luciferase constructs and Karen Vousden for providing us with p53-expression plasmids ...
doi:10.1093/nar/gkn940
pmid:19042971
pmcid:PMC2632907
fatcat:tfso27afcbg5nidsdxpujk3wb4
Mutant p53 Protects Cells from 12-O-Tetradecanoylphorbol-13-Acetate-Induced Death by Attenuating Activating Transcription Factor 3 Induction
2006
Cancer Research
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Mutagenesis analysis of the ATF3 promoter identified the regulatory motifs cyclic AMP-responsive element binding protein/ATF and MEF2 as being responsible for the TPA-induced activation of ATF3. ...
Mutations in p53 are ubiquitous in human tumors. Some p53 mutations not only result in loss of wild-type (WT) activity but also grant additional functions, termed "gain of function." ...
Using the MatInspector database (39), we found that this promoter region harbors three known regu-latory motifs [i.e., MEF2, CREB/ATF, and CAAT/enhancer binding protein (C/EBP)]. ...
doi:10.1158/0008-5472.can-06-0916
pmid:17108111
fatcat:ryafxxo7abbv5id3neofj37qty
Naturally occurring germline and tumor-associated mutations within the ATP-binding motifs of PTEN lead to oxidative damage of DNA associated with decreased nuclear p53
2010
Human Molecular Genetics
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Recent identification of naturally occurring cancer and germline mutations within the ATP-binding motifs of PTEN (heretofore referred to as PTEN ATP-binding mutations) has revealed that these mutations ...
disrupted the subcellular localization and tumor-suppressor activity of PTEN. ...
Because tumor protein 53-induced nuclear protein 1 (TP53INP1) is a major mediator of p53 antioxidant function, we further compared TP53INP1 mRNA levels in MCF-7 cell lines expressing the FLAG-tagged PTEN ...
doi:10.1093/hmg/ddq434
pmid:20926450
pmcid:PMC3000677
fatcat:mkm6k6l5ejevpesfd35dqo5giy
Characterization of genome-wide p53-binding sites upon stress response
2008
Nucleic Acids Research
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Using this collection of genome-wide binding sites, a new high-confidence algorithm was developed, p53scan, to identify the p53 consensus-binding motif. ...
To understand p53's essential transcriptional functions, unbiased analysis of its DNA-binding repertoire is pivotal. ...
Vousden for p53-constructs; Dr H. van Bokhoven for p63-constructs and Drs Shinji Takagi and G. Melino for p73-constructs. ...
doi:10.1093/nar/gkn232
pmid:18474530
pmcid:PMC2441782
fatcat:rsjtbreldvhrbcz3qfltgmegue
Functional Characterization of Nupr1L, A Novel p53-Regulated Isoform of the High-Mobility Group (HMG)-Related Protumoral Protein Nupr1
2015
Journal of Cellular Physiology
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Experiments using reporter assays combined with site-directed mutagenesis and using cells with controllable p53 expression demonstrate that both of these sequences are responsible for the regulation of ...
We have previously demonstrated a crucial role of NUPR1 in tumor development and progression. ...
Acknowledgements This work was supported by La Ligue Contre le Cancer, INCa, Canceropole PACA, DGOS (labelization SIRIC) and INSERM (to JLI), National Institutes of Health Grants DK52913, the Mayo Clinic ...
doi:10.1002/jcp.25022
pmid:25899918
pmcid:PMC4778741
fatcat:jwksmcpjnbdrzdbfxhzgkxsxx4
EGR-1 forms a complex with YAP-1 and upregulates Bax expression in irradiated prostate carcinoma cells
2009
Oncogene
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Dominant-negative EGR-1 mutant (dnEGR-1) or repressor of EGR-1, NGFIA binding protein 1 (NAB1), increased radioresistance of these cells. ...
In this study, we investigated the functional role of early growth response-1 (Egr1 gene) in the regulation of radiation-induced clonogenic inhibition and apoptosis in p53 wild-type and mutant prostate ...
DK62345) and Pennsylvania Department of Health Grant (SAP4100037378) to MMS and Welch Foundation Grant (G-1495) to MTB. ...
doi:10.1038/onc.2008.461
pmid:19137013
fatcat:3s4r4q5ihfenfgoblzunqqmxmu
p53-repressed miRNAs are involved with E2F in a feed-forward loop promoting proliferation
2008
Molecular Systems Biology
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Indicative of their significance, expression of these miRNAs is downregulated in senescent cells and in breast cancers harboring wild-type p53. ...
Here we investigated the mammalian cell proliferation control network consisting of transcriptional regulators, E2F and p53, their targets and a family of 15 miRNAs. ...
Providing further support, the promoters of the mRNAs from the 'cell-cycle-associated co-cluster' are highly enriched with E2F-binding motifs ( Figure 3F ), and in particular, a conserved E2F-binding ...
doi:10.1038/msb.2008.65
pmid:19034270
pmcid:PMC2600669
fatcat:khhyqv5cebe6platqirkohmdt4
The N-terminal Interferon-binding Domain (IBiD) Homology Domain of p300 Binds to Peptides with Homology to the p53 Transactivation Domain
2004
Journal of Biological Chemistry
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This minimal IHD miniprotein can function in vivo as a p53-binding polypeptide in assays including: (i) complex formation with VP16-LXXLL peptide motifs in the two-hybrid assay; (ii) action as a dominant ...
negative inhibitor of p53 from p21 luciferase templates; and (iii) attenuation of endogenous p21 protein levels. ...
of p53 and loss of proliferative control (19) , thereby supporting the notion that T-antigen has another mechanism of disrupting the critical activities of tumor suppressor proteins. ...
doi:10.1074/jbc.m405974200
pmid:15337767
fatcat:3eohgxs4izcctn5tsypotmu4qm
A Genomic Map of p53 Binding Sites Identifies Novel p53 Targets Involved in an Apoptotic Network
2005
Cancer Research
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The transcriptional activity of the p53 protein is central to its role in tumor suppression. ...
Using a computational approach, we generated a genome-wide map of p53 binding sites (p53BS) to identify novel p53 target genes. ...
Acknowledgments The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. ...
doi:10.1158/0008-5472.can-04-4232
pmid:15958553
fatcat:gxuhcvjsanbrrkjksbbfnj4iei
Phosphorylation-Dependent PIH1D1 Interactions Define Substrate Specificity of the R2TP Cochaperone Complex
2014
Cell Reports
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motif within TEL2, are essential and sufficient for binding. ...
Here, we describe a phosphopeptide binding domain (PIH-N) in the PIH1D1 subunit of the R2TP complex that preferentially binds to highly acidic phosphorylated proteins. ...
S.J.S is grateful to the MRC for its continuing support (U117584228) and to Philip Walker and the staff at Diamond Light Source (UK) for assistance with X-ray data collection. ...
doi:10.1016/j.celrep.2014.03.013
pmid:24656813
pmcid:PMC3989777
fatcat:p4qulxmqhvblld5mlakwrnptky
Regulation of the MicroRNA Processor DGCR8 by the Tumor Suppressor ING1
2010
Cancer Research
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ING proteins are functionally linked to the p53 pathway, and they participate in transcriptional control via the recognition of histone marks and recruitment of protein complexes with chromatin-modifying ...
The ING family of tumor suppressor proteins controls several cellular functions relevant to antitumor protection, such as cell cycle control, apoptosis, senescence, or migration. ...
Grant Support ...
doi:10.1158/0008-5472.can-09-2088
pmid:20179197
fatcat:vmblztjakbf3rohlckiu7pbi7m
Crosstalk between c-Jun and TAp73α/β contributes to the apoptosis–survival balance
2011
Nucleic Acids Research
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We identified a specific p73 consensus binding motif and found a strong enrichment of AP1 motifs in close proximity to binding sites for TAp73a. ...
The p53-family member p73 plays a role in various cellular signaling pathways during development and growth control and it can have tumor suppressor properties. ...
Besides its function as a pro-apoptotic protein, several reports have also described an inhibition of apoptosis or a support of growth by TAp73 in certain cell lines under specific conditions (19, 20) ...
doi:10.1093/nar/gkr028
pmid:21459846
pmcid:PMC3152320
fatcat:gtgoveyo5ff6pesvzzjryz3lga
Ionizing Radiation-inducible Apoptosis in the Absence of p53 Linked to Transcription Factor EGR-1
1997
Journal of Biological Chemistry
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The tumor suppressor protein p53 is a pivotal regulator of apoptosis, and prostate cancer cells that lack p53 protein are moderately resistant to apoptotic death by ionizing radiation. ...
Induction of the TNF-␣ gene by ionizing radiation and EGR-1 was mediated via a GC-rich EGR-1-binding motif in the TNF-␣ promoter. ...
Because p53 protein is mutated and non-functional in a large number of prostate tumors (14, 15) , it is imperative to identify other proapoptotic genes that can function via a p53-independent mechanism ...
doi:10.1074/jbc.272.52.33056
pmid:9407088
fatcat:ckaamesacnemrfufgywg7io6mu
MSK1 functions as a transcriptional coactivator of p53 in the regulation of p21 gene expression
2018
Experimental and Molecular Medicine
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Here, using in vitro and cell-based transcription assays, we show that MSK1 functions as a transcriptional coactivator of p53 in p21 expression, an action associated with MAPK-dependent phosphorylation ...
The kinase activity of MSK1 is activated by intramolecular autophosphorylation, which is initially triggered by the activation of upstream mitogen-activated protein kinases (MAPKs), such as p38 and ERK1 ...
Our findings support a novel connection between MSK1 and p53, showing that p53 has a direct role in the recruitment of MSK1 to p53-binding sites in the p21 locus, and further warrant a future genome-wide ...
doi:10.1038/s12276-018-0160-8
pmid:30305627
pmcid:PMC6180136
fatcat:xd5mct34czdannb6z25qcs452e
DNA-dependent Acetylation of p53 by the Transcription Coactivator p300
2002
Journal of Biological Chemistry
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The IHD or IBiD minidomains can bind to the p53 activation domain in vivo as determined using the mammalian two-hybrid VP16-GAL4 luciferase reporter assay. ...
Co-transfection into cells of the p53 gene and plasmid DNA containing the consensus DNA binding site of p53 activated DNAdependent acetylation of p53 in vivo. ...
Deborah French (University of Strathclyde, UK) for critical reading of the manuscript and helpful discussions. ...
doi:10.1074/jbc.m211460200
pmid:12499368
fatcat:3vel4zbwurcs7d2obqq33fmn3y
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