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Vancomycin-resistant Enterococcus faecium colonization in children

N Singh-Naz, A Sleemi, A Pikis, K M Patel, J M Campos
1999 Journal of Clinical Microbiology  
DNA analysis by this method identified two major clusters of VRE isolates.  ...  Risk factors associated with colonization with VRE identified by multiple logistic regression analysis included young age and chemotherapy with antineoplastic agents, cefotaxime, vancomycin, and ceftazidime  ...  e Underlying disease signifies malignancy or sickle cell disease.  ... 
pmid:9889230 pmcid:PMC84324 fatcat:2nrz5bj3wrdjjlidgg5o4ibwsa

Clinical and Molecular Characteristics of Invasive and Noninvasive Skin and Soft Tissue Infections Caused by Group A Streptococcus

J.-N. Lin, L.-L. Chang, C.-H. Lai, H.-H. Lin, Y.-H. Chen
2011 Journal of Clinical Microbiology  
Among these patients, 34 (46.6%) had invasive diseases. Diabetes mellitus, alcoholism, and hypertension were the most common underlying disorders.  ...  Of the 73 isolates, 93.2%, 97.3%, and 37% exhibited susceptibility to erythromycin, clindamycin, and tetracycline, respectively.  ...  The digested fragments of DNA were separated by contour-clamped homogeneous electric field (CHEF) Mapper XA Chiller system (Bio-Rad).  ... 
doi:10.1128/jcm.00531-11 pmid:21865425 pmcid:PMC3187321 fatcat:td5i4xeuineadanq4tzv7amrfa

Classification of rare missense substitutions, using risk surfaces, with genetic- and molecular-epidemiology applications

Sean V. Tavtigian, Graham B. Byrnes, David E. Goldgar, Alun Thomas
2008 Human Mutation  
Here, we used data from the Myriad Genetic Laboratories database of nearly 70,000 full-sequence tests plus two risk estimates, one approximating the odds ratio and the other reflecting strength of selection  ...  We abstracted contours from the surfaces and used the contours to define a sequence of missense substitution grades ordered from greatest risk to least risk.  ...  Acknowledgments We thank Amie Deffenbaugh and Lynne Ann Burbidge for compiling the BRCA1 and BRCA2 missense substitution dataset used in this analysis. We thank Paul B. Samollow and R.  ... 
doi:10.1002/humu.20896 pmid:18951461 pmcid:PMC3938023 fatcat:r55wpv73srgfrk3yfo4qkhqxc4

The Genetics of Multiple Sclerosis [chapter]

ALESSANDRO DIDONNA, JORGE R. OKSENBERG
2017 Multiple Sclerosis: Perspectives in Treatment and Pathogenesis  
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system, characterized by focal inflammation, demyelination, and axonal injury.  ...  In recent years, the advent of genome-wide association studies (GWAS) and collaborative efforts among international centers have fueled the characterization of several non-MHC loci associated with MS susceptibility  ...  The HLA-DRB1*15:01 allele has the strongest effect, with an average odds ratio (OR, a frequently used measure of effect size) of 3.08 and a clear dose response to 0, 1, or 2 allele copies the individual  ... 
doi:10.15586/codon.multiplesclerosis.2017.ch1 fatcat:tgswhjasfrc2toc5sguzz3rwrq

Pathogenicity of the BRCA1 missense variant M1775K is determined by the disruption of the BRCT phosphopeptide-binding pocket: a multi-modal approach

Marc Tischkowitz, Nancy Hamel, Marcelo A Carvalho, Gabriel Birrane, Aditi Soni, Erik H van Beers, Simon A Joosse, Nora Wong, David Novak, Louise A Quenneville, Scott A Grist, Petra M Nederlof (+5 others)
2008 European Journal of Human Genetics  
Here, we used a combination of functional, crystallographic, biophysical, molecular and evolutionary techniques, and classical genetic segregation analysis to demonstrate that the BRCA1 missense variant  ...  A number of germ-line mutations in the BRCA1 gene confer susceptibility to breast and ovarian cancer.  ...  This study was supported by grants DK062162 and AG021964 from the National Institutes of Health, and DAMD170210300 and DAMD170310563 from the US Department of  ... 
doi:10.1038/ejhg.2008.13 pmid:18285836 pmcid:PMC3905962 fatcat:7ptgjgbugje2for4qwcdsql2lu

Genetic determinants of risk and progression in multiple sclerosis

Alessandro Didonna, Jorge R. Oksenberg
2015 Clinica Chimica Acta  
However, none convincingly alters the long-term prognosis of the disease.  ...  Thus, the biggest challenge for the next era of MS research will consist in identifying and characterizing the molecular mechanisms and the cellular pathways in which these risk variants play a role. neuronal  ...  HLA-DRB1*15:01 has the strongest effect with an average odds ratio (OR; a measure of association) of 3.08.  ... 
doi:10.1016/j.cca.2015.01.034 pmid:25661088 pmcid:PMC4524789 fatcat:u6g4rcji4jf5xg46h4uk4d7u2m

Cytokine-Induced Monocyte Characteristics in SLE

Zhe Zhang, Kelly Maurer, Juan C. Perin, Li Song, Kathleen E. Sullivan
2010 Journal of Biomedicine and Biotechnology  
We examined gene expression and used a genome-wide approach to study the posttranslational histone mark, H4 acetylation, to examine epigenetic changes in SLE monocytes.  ...  Group 1 Group 0 Correlation (r) Top 200 overlap * Num gene (up) Odds Ratio (up) Num gene (down) Odds Ratio (down) Healthy GST 0.39 8 1.99 17 4.65 SLE GST 0.44 10 2.54 24 7.11 NoRx  ...  The numbers of overlapped genes and the odds ratios calculated by Fisher's test are also listed in Table 3 .  ... 
doi:10.1155/2010/507475 pmid:20625490 pmcid:PMC2896681 fatcat:7nkfzldkwfhinduhzqe273mb4y

Preferential Binding to Elk-1 by SLE-Associated IL10 Risk Allele Upregulates IL10 Expression

Daisuke Sakurai, Jian Zhao, Yun Deng, Jennifer A. Kelly, Elizabeth E. Brown, John B. Harley, Sang-Cheol Bae, Marta E. Alarcόn-Riquelme, Jeffrey C. Edberg, Robert P. Kimberly, Rosalind Ramsey-Goldman, Michelle A. Petri (+33 others)
2013 PLoS Genetics  
The established association of IL10 with SLE and other autoimmune diseases led us to fine map causal variant(s) and to explore underlying mechanisms.  ...  Using nuclear extracts of peripheral blood cells from SLE patients for electrophoretic mobility shift assays, we identified specific binding of transcription factor Elk-1 to oligodeoxynucleotides containing  ...  Some of the samples used in this study were provided by the Lupus Family Registry and Repository (LFRR). The  ... 
doi:10.1371/journal.pgen.1003870 pmid:24130510 pmcid:PMC3794920 fatcat:fgq54qyg4ne6hb4xuuapdykh7a

Non-alcoholic fatty liver disease (NAFLD) and MTHFR 1298A > C gene polymorphism

D Catalano, G M Trovato, A Ragusa, G F Martines, A Tonzuso, C Pirri, M A Buccheri, F M Trovato
2014 European Review for Medical and Pharmacological Sciences  
Non-Alcoholic Fatty Liver Disease (NAFLD) is related to unhealthy habits, mainly to unfavorable dietary profiles.  ...  This mutation occurs frequently in populations with low prevalence of overall mortality and of atherosclerosis-associated disease: it could have maintained and maintain its persistence by an heterozygosis  ...  They were tested for both MTHFR C677T and A1298C polymorphisms, with the purpose of excluding C677T polymorphisms from data analysis, and identifying MTHFR Wild genotype subjects.  ... 
pmid:24488901 fatcat:n4m6y4z3dzcl7cssfjg2ijqvja

Large Dissemination of VIM-2-Metallo- -Lactamase-Producing Pseudomonas aeruginosa Strains Causing Health Care-Associated Community-Onset Infections

A. Tsakris, A. Poulou, I. Kristo, T. Pittaras, N. Spanakis, S. Pournaras, F. Markou
2009 Journal of Clinical Microbiology  
The high rate of recurrent infections in the community underlies the difficulty of constraining infections caused by such microorganisms in the extrahospital setting.  ...  to healthcare facilities, while the predominant clonal type was also identified to cause infections in hospitalized patients.  ...  Odds ratios (OR) and 95% confidence intervals (CI) were calculated.  ... 
doi:10.1128/jcm.01099-09 pmid:19776233 pmcid:PMC2772580 fatcat:a7uveguxijb2vbl227skmb4kze

Association of KRAS polymorphisms with risk for lung adenocarcinoma accompanied by atypical adenomatous hyperplasias

Takashi Kohno, Hideo Kunitoh, Kenji Suzuki, Seiichiro Yamamoto, Aya Kuchiba, Yoshihiro Matsuno, Noriko Yanagitani, Jun Yokota
2008 Carcinogenesis  
However, minor allele carriers for two polymorphisms in the KRAS gene, KRAS-1 and -6, showed significantly increased odds ratios (ORs) for ADC accompanied by multiple AAHs [OR 5 3.0; 95% confidence interval  ...  The pulmonary adenoma susceptibility 1 (Pas1) gene affects susceptibility to the development of lung adenomas in mice with a subset of the adenomas progressing to adenocarcinoma (ADC).  ...  The KRAS-6 polymorphism is located in a 94 kb LD region covering introns and the 3#-UTR of the KRAS gene (Figure 1 ), and 10 of other polymorphisms have been identified in this region.  ... 
doi:10.1093/carcin/bgn048 pmid:18299280 fatcat:7bi3iveervedpjpoigua23inoa

Biologic susceptibility of hepatocellular carcinoma patients treated with radiotherapy to radiation-induced liver disease

Jason Chia-Hsien Cheng, Jian-Kuen Wu, Patricia Chiao-Tzu Lee, Hua-Shan Liu, James Jer-Min Jian, Yu-Mong Lin, Juei-Low Sung, Gwo-Jen Jan
2004 International Journal of Radiation Oncology, Biology, Physics  
On multivariate analysis, HBV carrier status (odds ratio, 9.26; p ‫؍‬ 0.04) and Child-Pugh B cirrhosis of the liver (odds ratio, 3.65; p ‫؍‬ 0.04) remained statistically significant.  ...  Purpose: To identify the factors associated with radiation-induced liver disease (RILD) and to describe the difference in normal tissue complication probability (NTCP) between subgroups of hepatocellular  ...  in the univariate test for the model, the correlation of HBV carrier (odds ratio, 9.26; p ϭ 0.040) and Child-Pugh B classification (odds ratio, 3.65; p ϭ 0.036) with RILD remained statistically significant  ... 
doi:10.1016/j.ijrobp.2004.05.048 pmid:15590181 fatcat:hki5ej5noramnmdq74who5scdm

Preliminary association of microsatellite heterozygosity with footrot in domestic sheep

Edward M. Smith, Joseph I. Hoffman, Laura E. Green, William Amos
2012 Livestock Science  
However, little is known about the relationship between heterozygosity and disease susceptibility in domesticated livestock, where disease resistance has the potential to improve animal welfare and productivity  ...  The use of gene ontology codes might prove a useful strategy to target selection of candidate markers in future studies.  ...  of footrot (n = 34), sheep homozygous at BMC5221 (n = 15) had an odds ratio (OR) of 12.0 (95% CI = 1.2-119.1; Fig. 1 ) for having virulent footrot in both years.  ... 
doi:10.1016/j.livsci.2011.10.009 fatcat:2octnu2rebdyrp7vqpnxm2bvwq

Brain Function in Carriers of a Genome-wide Supported Bipolar Disorder Variant

Susanne Erk, Andreas Meyer-Lindenberg, Knut Schnell, Carola Opitz von Boberfeld, Christine Esslinger, Peter Kirsch, Oliver Grimm, Claudia Arnold, Leila Haddad, Stephanie H. Witt, Sven Cichon, Markus M. Nöthen (+2 others)
2010 Archives of General Psychiatry  
Context: The neural abnormalities underlying genetic risk for bipolar disorder, a severe, common, and highly heritable psychiatric condition, are largely unknown.  ...  and diminished functional coupling between left and right hippocampal regions.  ...  *114205) on chromosome 12p13 (combined P=7.0ϫ10 −8 , odds ratio,1.21)  ... 
doi:10.1001/archgenpsychiatry.2010.94 pmid:20679588 fatcat:dw6thqidzfhedkmyjenspjo6ti

Myocardial Metabolic Response Predicts Chemotherapy Curative Potential on Hodgkin Lymphoma: A Proof-of-Concept Study

Cecilia Marini, Matteo Bauckneht, Anna Borra, Rita Lai, Maria Isabella Donegani, Alberto Miceli, Cristina Campi, Vanessa Cossu, Daniela Schenone, Silvia Morbelli, Stephane Chauvie, Michele Piana (+2 others)
2021 Biomedicines  
The independent nature and additive predictive value of their risk prediction were confirmed by the multivariate Cox regression analysis.  ...  Genome sharing between cancer and normal tissues might imply a similar susceptibility to chemotherapy toxicity.  ...  At chi-square analysis, this response was independent of age (p = ns, odds ratio 0.91; 95% CI: 0.38-2.15), and tumor bulk as evaluated by metabolic tumor volume (MTV) (p = ns, odds ratio 1.62; 95% CI:  ... 
doi:10.3390/biomedicines9080971 fatcat:zqn3y6kox5bdhirrerihlaxaey
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