Filters








211 Hits in 5.3 sec

Identification of Novel Predictor Classifiers for Inflammatory Bowel Disease by Gene Expression Profiling

Trinidad Montero-Meléndez, Xavier Llor, Esther García-Planella, Mauro Perretti, Antonio Suárez, Raffaele A. Calogero
<span title="2013-10-14">2013</span> <i title="Public Library of Science (PLoS)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/s3gm7274mfe6fcs7e3jterqlri" style="color: black;">PLoS ONE</a> </i> &nbsp;
Improvement of patient quality of life is the ultimate goal of biomedical research, particularly when dealing with complex, chronic and debilitating conditions such as inflammatory bowel disease (IBD).  ...  of IBD patients, a major step towards personalized therapy.  ...  The five algorithms implemented in Prophet were tested in all comparisons: support vector machine, k-nearest neighbor, diagonal linear discriminant analysis (DLDA), self-organizing maps and nearest shrunken  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1371/journal.pone.0076235">doi:10.1371/journal.pone.0076235</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/24155895">pmid:24155895</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3796518/">pmcid:PMC3796518</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/wrdsw4soo5frzivr5myd563f3i">fatcat:wrdsw4soo5frzivr5myd563f3i</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20171008160355/http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0076235&amp;type=printable" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/6c/7e/6c7eec11306e2fa1238563496176ab295ec8a379.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1371/journal.pone.0076235"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> plos.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3796518" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Gene Expression–Based Predictive Models of Graft Versus Host Disease–Associated Dry Eye

Lidia Cocho, Itziar Fernández, Margarita Calonge, Verónica Martínez, María J. González-García, Dolores Caballero, Lucía López-Corral, Carmen García-Vázquez, Lourdes Vázquez, Michael E. Stern, Amalia Enríquez-de-Salamanca
<span title="2015-07-17">2015</span> <i title="Association for Research in Vision and Ophthalmology (ARVO)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/bktgmrvaorcfle3nbaxcwpsb44" style="color: black;">Investigative Ophthalmology and Visual Science</a> </i> &nbsp;
Shrinkage discriminant analysis, support vector machine, and k-nearest neighbor classifier methods were used to develop predictive models that were validated considering accuracy, calibration, and discriminant  ...  To develop a predictive model based on inflammatory gene mRNA expression in conjunctival cells of graft versus host disease (GvHD)-associated dry eye (DE) patients, as well as to find meaningful correlations  ...  arthritis, or inflammatory bowel disease.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1167/iovs.15-16736">doi:10.1167/iovs.15-16736</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/26200497">pmid:26200497</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/3a6e62rhsfferc4xfsjjxpzala">fatcat:3a6e62rhsfferc4xfsjjxpzala</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20180722094329/https://iovs.arvojournals.org/data/journals/iovs/934219/i1552-5783-56-8-4570.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/25/73/2573b3c6bc07997e4020c6e47566b6aa1fcf1ea7.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1167/iovs.15-16736"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> Publisher / doi.org </button> </a>

Metaproteomics reveals associations between microbiome and intestinal extracellular vesicle proteins in pediatric inflammatory bowel disease

Xu Zhang, Shelley A. Deeke, Zhibin Ning, Amanda E. Starr, James Butcher, Jennifer Li, Janice Mayne, Kai Cheng, Bo Liao, Leyuan Li, Ruth Singleton, David Mack (+2 others)
<span title="2018-07-20">2018</span> <i title="Springer Nature America, Inc"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/a4wan6l5o5dfzn767kyz7jqevi" style="color: black;">Nature Communications</a> </i> &nbsp;
Alterations in gut microbiota have been implicated in the pathogenesis of inflammatory bowel disease (IBD), however factors that mediate the host-microbiota interactions remain largely unknown.  ...  Here we collected mucosal-luminal interface samples from a pediatric IBD inception cohort and characterized both the human and microbiota proteins using metaproteomics.  ...  For multivariate statistical analysis, only those protein groups with valid LFQ intensity values in ≥ 50% of the samples were used. Missing values were imputed with the K-nearest neighbors method.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1038/s41467-018-05357-4">doi:10.1038/s41467-018-05357-4</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/30030445">pmid:30030445</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC6054643/">pmcid:PMC6054643</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/tmdp2lk4sjghnjfc5mvqswqwwq">fatcat:tmdp2lk4sjghnjfc5mvqswqwwq</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200211124814/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC6054643&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/76/bc/76bc2e4f17904e49816e1d857c2c1373ab96ecdc.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1038/s41467-018-05357-4"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> nature.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054643" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Applications of Machine Learning in Human Microbiome Studies: A Review on Feature Selection, Biomarker Identification, Disease Prediction and Treatment

Laura Judith Marcos-Zambrano, Kanita Karaduzovic-Hadziabdic, Tatjana Loncar Turukalo, Piotr Przymus, Vladimir Trajkovik, Oliver Aasmets, Magali Berland, Aleksandra Gruca, Jasminka Hasic, Karel Hron, Thomas Klammsteiner, Mikhail Kolev (+17 others)
<span title="2021-02-19">2021</span> <i title="Frontiers Media SA"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/67anf6qgandy5adz4rakospiuq" style="color: black;">Frontiers in Microbiology</a> </i> &nbsp;
The manual identification of data sources has been complemented with: (1) automated publication search through digital libraries of the three major publishers using natural language processing (NLP) Toolkit  ...  , and (2) an automated identification of relevant software repositories on GitHub and ranking of the related research papers relying on learning to rank approach.  ...  ML methods currently used in microbiome research during action workshops.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3389/fmicb.2021.634511">doi:10.3389/fmicb.2021.634511</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/33737920">pmid:33737920</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC7962872/">pmcid:PMC7962872</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/wbun4lkwwjen5ccdy4zb7mnz3q">fatcat:wbun4lkwwjen5ccdy4zb7mnz3q</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210427132356/https://fjfsdata01prod.blob.core.windows.net/articles/files/634511/pubmed-zip/.versions/2/.package-entries/fmicb-12-634511-r1/fmicb-12-634511.pdf?sv=2018-03-28&amp;sr=b&amp;sig=Q7zUO8omKcZdBcITJU4gjGbOS5YnWb6BuYJVTF8rSRg%3D&amp;se=2021-04-27T13%3A24%3A25Z&amp;sp=r&amp;rscd=attachment%3B%20filename%2A%3DUTF-8%27%27fmicb-12-634511.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/4d/bd/4dbdfcf09daf56bbabc84ab212c18c658b9f2c94.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3389/fmicb.2021.634511"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> frontiersin.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7962872" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

In Silicotarget fishing: addressing a "Big Data" problem by ligand-based similarity rankings with data fusion

Xian Liu, Yuan Xu, Shanshan Li, Yulan Wang, Jianlong Peng, Cheng Luo, Xiaomin Luo, Mingyue Zheng, Kaixian Chen, Hualiang Jiang
<span title="2014-06-18">2014</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/5aubiwi6v5beng6iqzj577kiaa" style="color: black;">Journal of Cheminformatics</a> </i> &nbsp;
The underlying principle of the approach is that known bioactive ligands can be used as reference to predict the targets for a new compound.  ...  For a given query molecule, its target profile is generated by similarity searching against the ligand sets assigned to each target, for which individual searches utilizing multiple reference structures  ...  Bronchodilator Adrenergic (β) Agonist 1 Linezolid Antibacterial Oxazolidinone MAO A Inhibitor 2 Loratadine Antihistaminic Inflammatory Bowel Disease Farnesyl Protein Transferase Inhibitor  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/1758-2946-6-33">doi:10.1186/1758-2946-6-33</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/24976868">pmid:24976868</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC4068908/">pmcid:PMC4068908</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/24p5anejznh7pms2gq6oc63dsq">fatcat:24p5anejznh7pms2gq6oc63dsq</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20170922012246/https://jcheminf.springeropen.com/track/pdf/10.1186/1758-2946-6-33?site=jcheminf.springeropen.com" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/d7/5a/d75a36ef5721ca28b4b6c47529bd7d3a3e3de36c.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/1758-2946-6-33"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> springer.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4068908" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Tejaas: reverse regression increases power for detecting trans-eQTLs

Saikat Banerjee, Franco L Simonetti, Kira E Detrois, Anubhav Kaphle, Raktim Mitra, Rahul Nagial, Johannes Söding
<span title="2021-05-06">2021</span> <i title="BMC"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/6bzsiicmhvczjnsm7jbog7ysaa" style="color: black;">Genome Biology</a> </i> &nbsp;
Combined with a novel unsupervised k-nearest neighbor method to remove confounders, Tejaas predicts 18851 unique trans-eQTLs across 49 tissues from GTEx.  ...  Identifying trans-eQTLs is challenging because of small effect sizes, tissue specificity, and a severe multiple-testing burden.  ...  It uses a novel, nonlinear, nonparametric and unsupervised K-nearest neighbor clustering to correct for unknown confounder variables.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/s13059-021-02361-8">doi:10.1186/s13059-021-02361-8</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/33957961">pmid:33957961</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC8101255/">pmcid:PMC8101255</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/o47s2nnrivgxlfpajde76ogyfe">fatcat:o47s2nnrivgxlfpajde76ogyfe</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210508092941/https://genomebiology.biomedcentral.com/track/pdf/10.1186/s13059-021-02361-8.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/1a/55/1a5573442454caf9e0667c830558f4ff804a6e4d.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/s13059-021-02361-8"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8101255" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Elucidating the 'Jekyll and Hyde' Nature of PXR: The Case for Discovering Antagonists or Allosteric Antagonists

Arunima Biswas, Sridhar Mani, Matthew R. Redinbo, Matthew D. Krasowski, Hao Li, Sean Ekins
<span title="2009-05-05">2009</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/dcb2upqtxbevfpiacgnpgb6tnu" style="color: black;">Pharmaceutical Research</a> </i> &nbsp;
In summary, PXR has a multiplicity of roles in vivo and is being revealed as behaving like a "Jekyll and Hyde" nuclear hormone receptor.  ...  PXR was initially described as a xenobiotic sensor critical for the transcriptional regulation of  ...  diseases of the bowel (14) (15) (16) .  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s11095-009-9901-7">doi:10.1007/s11095-009-9901-7</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/19415465">pmid:19415465</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC2846309/">pmcid:PMC2846309</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/5qm4oudejbg7ppjwkjrsn5ty7y">fatcat:5qm4oudejbg7ppjwkjrsn5ty7y</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200211004452/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC2846309&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/31/33/31337e3c8c618e0185f5092d73fdd8151224041d.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s11095-009-9901-7"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> springer.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2846309" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Microbial network disturbances in relapsing refractory Crohn's disease

Bahtiyar Yilmaz, Pascal Juillerat, Ove Øyås, Charlotte Ramon, Francisco Damian Bravo, Yannick Franc, Nicolas Fournier, Pierre Michetti, Christoph Mueller, Markus Geuking, Valerie E. H. Pittet, Michel H. Maillard (+4 others)
<span title="2019-01-21">2019</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/aowhseoqprea3b5rljynk52q4m" style="color: black;">Nature Medicine</a> </i> &nbsp;
Bern City electronic search algorithm consisted of terms relating to key concepts of "inflammatory bowel disease", 818 "IBD", "microbiome", "gut microbiota", "metagenomic", "16S rDNA", "human",  ...  Fecal Microbiota in Pediatric Inflammatory Bowel Disease and Its Relation to 884 Inflammation. Am J Gastroenterol 110, 921-930 (2015). 885 22. Machiels, K., et al.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1038/s41591-018-0308-z">doi:10.1038/s41591-018-0308-z</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/ls6iakmbzjdmdgomzskyutq7uq">fatcat:ls6iakmbzjdmdgomzskyutq7uq</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20201104032519/https://boris.unibe.ch/132129/8/Yilmaz%20et%20al_2019.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/34/64/3464464d961f873ab1e77bedcceb222bb07a866f.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1038/s41591-018-0308-z"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> nature.com </button> </a>

Functional protein microarray as molecular decathlete: A versatile player in clinical proteomics

Heng Zhu, Eric Cox, Jiang Qian
<span title="2012-11-08">2012</span> <i title="Wiley"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/csxga5rwmjfw5dwl4y7mh7j4hu" style="color: black;">PROTEOMICS - Clinical Applications</a> </i> &nbsp;
modifications; 2) denaturing conditions were used to lyse the bacterial host, resulting in improperly folded proteins; 3) proteins of interest were not purified away from thousands of unwanted bacterial  ...  Therefore, protein microarrays were developed as a high-throughput tool to overcome the limitations of DNA microarrays, and to provide a versatile platform for protein functional analyses [4] [5] [6] .  ...  To determine the best classifiers and classification model, two different supervised analysis approaches, k nearest neighbor (k-NN) and logistics regression (LR) were applied, and the N protein of SARS  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1002/prca.201200041">doi:10.1002/prca.201200041</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/23027439">pmid:23027439</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3600421/">pmcid:PMC3600421</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/kggxox7pibesfiezl674tpagwm">fatcat:kggxox7pibesfiezl674tpagwm</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200209003342/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC3600421&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/45/63/45631bfc56b5179a37556cb0a060a1d7ce7ae7e4.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1002/prca.201200041"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> wiley.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3600421" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Identification of Restricted Subsets of Mature microRNA Abnormally Expressed in Inactive Colonic Mucosa of Patients with Inflammatory Bowel Disease

Magali Fasseu, Xavier Tréton, Cécile Guichard, Eric Pedruzzi, Dominique Cazals-Hatem, Christophe Richard, Thomas Aparicio, Fanny Daniel, Jean-Claude Soulé, Richard Moreau, Yoram Bouhnik, Marc Laburthe (+3 others)
<span title="2010-10-05">2010</span> <i title="Public Library of Science (PLoS)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/s3gm7274mfe6fcs7e3jterqlri" style="color: black;">PLoS ONE</a> </i> &nbsp;
Inflammatory Bowel Disease.  ...  Ulcerative Colitis (UC) and Crohn's Disease (CD) are two chronic Inflammatory Bowel Diseases (IBD) affecting the intestinal mucosa.  ...  When supervised class (UC or CD) prediction of individual patient's data was tested, we used a K Nearest Neighbors Classification algorithm with Leave-One-Out Cross-Validation (GenePattern ''KNNXValidation  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1371/journal.pone.0013160">doi:10.1371/journal.pone.0013160</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/20957151">pmid:20957151</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC2950152/">pmcid:PMC2950152</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/uy65l7euuzh7beo67mixv5yeuy">fatcat:uy65l7euuzh7beo67mixv5yeuy</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20170926115838/http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0013160&amp;type=printable" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/9e/a6/9ea61da37073ab2984430a70c93e52b20e87a712.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1371/journal.pone.0013160"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> plos.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2950152" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Identification of a biomarker panel for colorectal cancer diagnosis

Amaia García-Bilbao, Rubén Armañanzas, Ziortza Ispizua, Begoña Calvo, Ana Alonso-Varona, Iñaki Inza, Pedro Larrañaga, Guillermo López-Vivanco, Blanca Suárez-Merino, Mónica Betanzos
<span title="2012-01-26">2012</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/hheklop5kbcmhawhlxc5lzh2sa" style="color: black;">BMC Cancer</a> </i> &nbsp;
Methods: A genomic study of human colorectal cancer has been carried out on a total of 31 tumoral samples, corresponding to different stages of the disease, and 33 non-tumoral samples.  ...  The study was carried out by hybridisation of the tumour samples against a reference pool of non-tumoral samples using Agilent Human 1A 60mer oligo microarrays.  ...  RA was supported by the Spanish Ministry of Science and Innovation through a Juan de la Cierva postdoctoral fellowship, TIN2010-20900-C04-04 and the Cajal Blue Brain Project.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/1471-2407-12-43">doi:10.1186/1471-2407-12-43</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/22280244">pmid:22280244</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3323359/">pmcid:PMC3323359</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/5pm2usg6dncona5esuzsomtew4">fatcat:5pm2usg6dncona5esuzsomtew4</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20170810223831/http://oa.upm.es/13937/1/INVE_MEM_2012_118986.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/2b/ac/2bac7943e02f92928c0fb769900ae1df6fca8627.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/1471-2407-12-43"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> springer.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3323359" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Novel Anti-inflammatory Activity of Epoxyazadiradione against Macrophage Migration Inhibitory Factor

Athar Alam, Saikat Haldar, Hirekodathakallu V. Thulasiram, Rahul Kumar, Manish Goyal, Mohd Shameel Iqbal, Chinmay Pal, Sumanta Dey, Samik Bindu, Souvik Sarkar, Uttam Pal, Nakul C. Maiti (+1 others)
<span title="2012-05-29">2012</span> <i title="American Society for Biochemistry &amp; Molecular Biology (ASBMB)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/mryncoafc5cxdicldzfm4vlsze" style="color: black;">Journal of Biological Chemistry</a> </i> &nbsp;
Significance: This novel molecule is a significant addition in the discovery of anti-inflammatory drugs. . 2 The abbreviations used are: MIF, macrophage migration inhibitory factor; NF-B, nuclear factor-B  ...  Results: Epoxyazadiradione, a limonoid, inhibits the tautomerase activity of both human and malarial MIF and prevents MIF-induced proinflammatory reactions.  ...  It is to be noted that these cytokines actively participate in inflammatory disease states such as arthritis, inflammatory bowel disease, shock, atherosclerosis, allergy, and some types of cancer (93,  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1074/jbc.m112.341321">doi:10.1074/jbc.m112.341321</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/22645149">pmid:22645149</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3397911/">pmcid:PMC3397911</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/6igjrlittnbvlgnud25jir3rmm">fatcat:6igjrlittnbvlgnud25jir3rmm</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20180724144837/http://www.jbc.org/content/287/29/24844.full.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/f1/88/f18898a41ce8470fa9a25962070c1a8117f41448.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1074/jbc.m112.341321"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397911" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Construction of Condition-Specific Gene Regulatory Network Using Kernel Canonical Correlation Analysis

Dabin Jeong, Sangsoo Lim, Sangseon Lee, Minsik Oh, Changyun Cho, Hyeju Seong, Woosuk Jung, Sun Kim
<span title="2021-05-20">2021</span> <i title="Frontiers Media SA"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/r7trx2kj6je5jhtaoy3rztibgy" style="color: black;">Frontiers in Genetics</a> </i> &nbsp;
Our method detected not only important regulatory interactions reported in previous studies but also novel TF–TG relations where a module of TF is regulating a module of TGs upon specific stress.  ...  To demonstrate the usefulness of our network construction method, we used the blood transcriptome data for the investigation on the response to high fat diet in a human and an arabidopsis data set for  ...  As a result, immune system related pathways-Th17 differentiation, Th1 and Th2 cell differentiation, and inflammatory bowel disease (IBD)were high ranked both in G 3h and G 6h .  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3389/fgene.2021.652623">doi:10.3389/fgene.2021.652623</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/34093651">pmid:34093651</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC8172963/">pmcid:PMC8172963</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/edg747sidrbjbkakwhhcgwbtom">fatcat:edg747sidrbjbkakwhhcgwbtom</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210521062203/https://fjfsdata01prod.blob.core.windows.net/articles/files/652623/pubmed-zip/.versions/1/.package-entries/fgene-12-652623/fgene-12-652623.pdf?sv=2018-03-28&amp;sr=b&amp;sig=Pd1Am6GEFZEFzjT1c0riVNgTqqZt%2FUPYnmoVhO%2FHb9g%3D&amp;se=2021-05-21T06%3A22%3A33Z&amp;sp=r&amp;rscd=attachment%3B%20filename%2A%3DUTF-8%27%27fgene-12-652623.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/a3/e7/a3e7da84db6d3873775af8f6fdb3986cc80b8253.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3389/fgene.2021.652623"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> frontiersin.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8172963" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Use of matching methods in observational studies with critical patients and renal outcomes. Scoping review

Henry Oliveros Rodríguez, Giancarlo Buitrago, Paola Castellanos Saavedra
<span title="2020-09-16">2020</span> <i title="Sociedad Colombiana de Anestesiologia y Reanimacion (SCARE)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/awxa57hdrzfdxp74y2y7isrycm" style="color: black;">Colombian Journal of Anesthesiology</a> </i> &nbsp;
A summary is made of the aspects to be considered in the use of the methods and reporting of the findings with the matching by propensity index.  ...  Objective: Through a scoping review, determine the available evidence on the use of matching methods in studies involving critically ill patients and assessing renal outcomes.  ...  Data confidentiality The authors declare that the protocols of their center pertaining to patient data were followed.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.5554/22562087.e944">doi:10.5554/22562087.e944</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/klidf4bm7neulk3rnuptpeb37e">fatcat:klidf4bm7neulk3rnuptpeb37e</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210429124803/https://www.revcolanest.com.co/index.php/rca/article/download/944/1538" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/ad/06/ad0685353576f0eca5d32a26626692fee8fb1bbb.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.5554/22562087.e944"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> Publisher / doi.org </button> </a>

Plasma Protein and MicroRNA Biomarkers of Insulin Resistance: A Network-Based Integrative -Omics Analysis

Hyungwon Choi, Hiromi W. L. Koh, Lihan Zhou, He Cheng, Tze Ping Loh, Ehsan Parvaresh Rizi, Sue Anne Toh, Gabriele V. Ronnett, Bevan E. Huang, Chin Meng Khoo
<span title="2019-04-05">2019</span> <i title="Frontiers Media SA"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/evju7ot335gbrctgmomg4gg6je" style="color: black;">Frontiers in Physiology</a> </i> &nbsp;
In summary, our integrative analysis provides a network of elevated plasma markers of OIR and a global shift of microRNA secretome composition in the blood plasma.  ...  Combined with tissue of origin information, the integrative analysis allowed us to nominate obesity-dependent and obesity-independent protein markers, along with potential sites of post-transcriptional  ...  After crosssample alignment by chromatographic retention time, peptides with 25% or higher frequency of missing data were removed, and the missing peptide intensities were imputed using the K-nearest neighbors  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3389/fphys.2019.00379">doi:10.3389/fphys.2019.00379</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/31024340">pmid:31024340</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC6460474/">pmcid:PMC6460474</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/52v2afvfajbpxlrxnoxlcxp7ty">fatcat:52v2afvfajbpxlrxnoxlcxp7ty</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200210180538/https://fjfsdata01prod.blob.core.windows.net/articles/files/423569/pubmed-zip/.versions/1/.package-entries/fphys-10-00379/fphys-10-00379.pdf?sv=2015-12-11&amp;sr=b&amp;sig=SzPV6%2F94q2yOz2Z9lzNxbc5Fk5lDr%2BUW%2FNcEYvV2Fwk%3D&amp;se=2020-02-10T18%3A06%3A07Z&amp;sp=r&amp;rscd=attachment%3B%20filename%2A%3DUTF-8%27%27fphys-10-00379.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/82/be/82beabc9a6536e3cb6b0e59d5865a0bc98a8958c.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3389/fphys.2019.00379"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> frontiersin.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460474" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>
&laquo; Previous Showing results 1 &mdash; 15 out of 211 results