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Identification of Characteristic Genes in Whole Blood of Intervertebral Disc Degeneration Patients by Weighted Gene Coexpression Network Analysis (WGCNA)

Xiaobo Ma, Junqiang Su, Bo Wang, Xiasheng Jin, Osamah Ibrahim Khalaf
2022 Computational and Mathematical Methods in Medicine  
Firstly, weighted gene coexpression network analysis (WGCNA) was used to screen IDD-related genes.  ...  Intervertebral disc degeneration (IDD) is a major cause of lower back pain. However, to date, the molecular mechanism of the IDD remains unclear.  ...  Computational and Mathematical Methods in Medicine  ... 
doi:10.1155/2022/6609901 pmid:35069789 pmcid:PMC8776439 fatcat:lq2uhjsgs5gr5fxgp5or32u2bq

Revealing the Key MSCs Niches and Pathogenic Genes in Influencing CEP Homeostasis: A Conjoint Analysis of Single-Cell and WGCNA

Weihang Li, Shilei Zhang, Yingjing Zhao, Dong Wang, Quan Shi, Ziyi Ding, Yongchun Wang, Bo Gao, Ming Yan
2022 Frontiers in Immunology  
Here, this study conducted a first conjoint analysis of weighted gene co-expression network analysis (WGCNA) and scRNA-seq in CEP, systematically analyzed the interested module, immune infiltration situation  ...  WGCNA and protein-protein interaction (PPI) network determined a group of gene signatures responsible for degenerative CEP, including BRD4, RAF1, ANGPT1, CHD7 and NOP56; differentially immune analysis  ...  Jiangming Zeng (University of Macau), and all the members of his bioinformatics team, biotrainee, for generously sharing their experiences and codes.  ... 
doi:10.3389/fimmu.2022.933721 pmid:35833124 pmcid:PMC9271696 fatcat:7c3iul7ntvhddftedvh2yuuwvq

New Insights into the Regulatory Role of Ferroptosis in Ankylosing Spondylitis via Consensus Clustering of Ferroptosis-Related Genes and Weighted Gene Co-Expression Network Analysis

Tianhua Rong, Ningyi Jia, Bingxuan Wu, Dacheng Sang, Baoge Liu
2022 Genes  
Weighted gene co-expression network analysis (WGCNA) of the intergroup differentially expressed genes (DEGs) and protein–protein interaction (PPI) analysis of the key module were used to screen out hub  ...  DEGs were mainly enriched in pathways related to mitochondria, ubiquitin, and neurodegeneration. Candidate hub genes, screened by PPI and WGCNA, were intersected.  ...  (A) Scatter plot of module membership and gene significance in the turquoise module in weighted gene co-expression network analysis (WGCNA).  ... 
doi:10.3390/genes13081373 pmid:36011284 pmcid:PMC9407156 fatcat:tvww7hgkunhxhat32qftjj227e

Computational Analysis of the Immune Infiltration Pattern and Candidate Diagnostic Biomarkers in Lumbar Disc Herniation

Kai Li, Shijue Li, Haojie Zhang, Di Lei, Wai Leung Ambrose Lo, Minghui Ding
The hub genes in the network were identified by the CIBERSORT tool and the Weighted Gene Coexpression Network Analysis (WGCNA).  ...  The whole-blood gene expression level profiles of GSE124272 and GSE150408 were downloaded from the Gene Expression Omnibus (GEO) database, including that of 25 patients with LDH and 25 healthy volunteers  ...  ACKNOWLEDGMENTS We would like to thank the Gene Expression Omnibus (GEO) network for its generous sharing of large amounts of data. We also would like to thank Dr.  ... 
doi:10.3389/fnmol.2022.846554 pmid:35531067 pmcid:PMC9069112 fatcat:w3au2ndcgrbsfjwld5fim4muo4

The 3rd National Festival & International Congress on Stem Cell & Regenerative Medicine

2018 BioImpacts  
Cells were exposed daily to 8 mT LMEMF for 20 min/d by using a magnetic device manufactured by the Research Center for New Technologies in Life Science Engineering, University of Tehran.  ...  In high cell density cultures, LMEMF slightly, but not significantly, increased G292 bone cell number at day 1 by 1.1-fold, at day 2 by 1.2-fold, and at day 3 by 1.1-fold.  ...  The herniation in the intervertebral disc and central degeneration of disc are two main causes of low back pain, which happen due to the structural defects of disc.  ... 
doi:10.15171/bi.2018.s1 pmid:30976575 pmcid:PMC6350633 fatcat:ygoicewggbeqtoehxttld3f2zi

American Association of Neuropathologists, Inc. Abstracts of the 93rd Annual Meeting June 8–11, 2017 Garden Grove, CA

2017 Journal of Neuropathology and Experimental Neurology  
Diagnosis of VWM was confirmed after demise by whole exome sequence analysis, which identified two pathologic variants in the EIF2B2 gene.  ...  WGCNA analysis using gene module eigengenes divided the schizophrenics into two groups, "type 1" and "type 2".  ...  The patient underwent whole brain radiation and is currently being treated with Avastin in addition to therapies for HIV and tuberculosis.  ... 
doi:10.1093/jnen/nlx029 fatcat:u42r2fehzfdrned7itfhkchpza