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Ictal propagation of high frequency activity is recapitulated in interictal recordings: Effective connectivity of epileptogenic networks recorded with intracranial EEG

A. Korzeniewska, M.C. Cervenka, C.C. Jouny, J.R. Perilla, J. Harezlak, G.K. Bergey, P.J. Franaszczuk, N.E. Crone
2014 NeuroImage  
the directionality and intensity of propagation of high frequency activity (70-175 Hz) during ictal and interictal recordings.  ...  We hypothesized that the patterns by which high frequency activity is propagated would help elucidate epileptogenic networks and thereby identify network nodes relevant for surgical planning.  ...  Conclusions SdDTF analysis of effective connectivity for high frequency activity (70-175 Hz) in ictal, pre-ictal and interictal recordings may help estimate the epileptogenic zone during invasive monitoring  ... 
doi:10.1016/j.neuroimage.2014.06.078 pmid:25003814 pmcid:PMC4165796 fatcat:gmsrldbgtrcd3f7ke3ycynfs5m

Defining the latent period of epileptogenesis and epileptogenic zone in a focal cortical dysplasia type II (FCDII) rat model

Hsin‐Yi Kao, Shuntong Hu, Temenuzhka Mihaylova, Julie Ziobro, EunSeon Ahn, Carli Fine, David Brang, Brendon O. Watson, Yu Wang
2021 Epilepsia  
We then took advantage of in vivo local field potential (LFP) recordings to localize the epileptogenic zone in these animals.  ...  Focal cortical dysplasia type II (FCDII) is one of the most common underlying pathologies in patients with drug-resistant epilepsy.  ...  AUTHOR CONTRIBUTIONS Y.W. contributed to the conception and design of this study. All authors contributed to the acquisition and analysis of data. Y.W drafted the text.  ... 
doi:10.1111/epi.16868 pmid:33735460 fatcat:4shpgw4ozneajdgj23any5qdrm

Mapping the epileptic brain with EEG dynamical connectivity: Established methods and novel approaches

Margarita Papadopoulou, Kristl Vonck, Paul Boon, Daniele Marinazzo
2012 The European Physical Journal Plus  
Some of these methods explore the dynamical connections between brain regions, exploiting the high temporal resolution of the electroencephalographic signals recorded at the scalp or directly from the  ...  region where the seizure originates from and of detecting upcoming seizure activity in order to trigger therapeutic neurostimulation devices.  ...  The sampling frequency of the recorded EEG signals is 256 Hz.  ... 
doi:10.1140/epjp/i2012-12144-5 fatcat:sygjnwec45dzvbyzilwhcyihpe

How do we use in vitro models to understand epileptiform and ictal activity? A report of the TASK1-WG4 group of the ILAE/AES Joint Translational Task Force

Chris G. Dulla, Damir Janigro, Premysl Jiruska, Joseph V. Raimondo, Akio Ikeda, Chou-Ching K. Lin, Howard P. Goodkin, Aristea S. Galanopoulou, Christophe Bernard, Marco de Curtis
2018 Epilepsia Open  
A great deal of knowledge about how brain networks generate various forms of epileptiform activity has been gained, but due to the multiple in vitro models and manipulations used, there is a need for a  ...  In vitro brain tissue preparations allow the convenient and affordable study of brain networks and have allowed us to garner molecular, cellular, and electrophysiologic insights into brain function with  ...  Uwe was a true leader in the field of epilepsy research. We would also like to acknowledge Lauren-Harte-Hargrove for assistance during the preparation of this manuscript.  ... 
doi:10.1002/epi4.12277 pmid:30525115 pmcid:PMC6276782 fatcat:3x5uyuq4qbfydn4ffjqip6or3u

Multimodal in vivo recording using transparent graphene microelectrodes illuminates spatiotemporal seizure dynamics at the microscale [article]

Nicolette Driscoll, Richard E Rosch, Brendan B. Murphy, Arian Ashourvan, Ramya Vishnubhotla, Olivia O. Dickens, A.T. Charlie Johnson, Kathryn A. Davis, Brian Litt, Danielle S Bassett, Hajime Takano, Flavia Vitale
2020 bioRxiv   pre-print
progression of ictal electrophysiology is linked to the spatial evolution of the recruited seizure core.  ...  Here we present a technique to map the onset and spatiotemporal spread of acute epileptic seizures in vivo by simultaneously recording high bandwidth microelectrocorticography and calcium fluorescence  ...  Any opinions, findings, conclusions, or recommendations expressed in this material are those of the authors and do not necessarily reflect the views of the National Science Foundation.  ... 
doi:10.1101/2020.06.04.134189 fatcat:bdax4w3gt5grzm7h27drq7xijq

Multimodal in vivo recording using transparent graphene microelectrodes illuminates spatiotemporal seizure dynamics at the microscale

Nicolette Driscoll, Richard E. Rosch, Brendan B. Murphy, Arian Ashourvan, Ramya Vishnubhotla, Olivia O. Dickens, A. T. Charlie Johnson, Kathryn A. Davis, Brian Litt, Danielle S. Bassett, Hajime Takano, Flavia Vitale
2021 Communications Biology  
progression of ictal electrophysiology is linked to the spatial evolution of the recruited seizure core.  ...  Here we present a technique to map the onset and spatiotemporal spread of acute epileptic seizures in vivo by simultaneously recording high bandwidth microelectrocorticography and calcium fluorescence  ...  Acknowledgements This material is based upon work supported by the National Science Foundation Graduate Research Fellowship Program (DGE-1845298 to Driscoll, Murphy) and was carried out in part at the  ... 
doi:10.1038/s42003-021-01670-9 pmid:33514839 fatcat:sy4nsoxe6nhqtemdgif7oao564

High interictal connectivity within the resection zone is associated with favorable post-surgical outcomes in focal epilepsy patients

Preya Shah, John M. Bernabei, Lohith Kini, Arian Ashourvan, Jacqueline Boccanfuso, Ryan Archer, Kelly Oechsel, Sandhitsu R. Das, Joel M. Stein, Timothy H. Lucas, Danielle S. Bassett, Kathryn A. Davis (+1 others)
2019 NeuroImage: Clinical  
We generate interictal functional networks by calculating pairwise correlation of iEEG signals across different frequency bands.  ...  The goal of this study is to evaluate the utility of mapping interictal (non-seizure) iEEG networks to identify targets for surgical treatment.  ...  Acknowledgements This work was supported by National Institutes of Health grants 1R01NS099348 and K23-NS073801.  ... 
doi:10.1016/j.nicl.2019.101908 pmid:31491812 pmcid:PMC6617333 fatcat:ogah4tclirgkphyuhsfhhsgrmi

High interictal connectivity within the resection zone is associated with favorable post-surgical outcomes in focal epilepsy patients [article]

Preya Shah, John Bernabei, Lohith Kini, Arian Ashourvan, Jacqueline Boccanfuso, Ryan Archer, Kelly Oechsel, Timothy H Lucas, Danielle S Bassett, Kathryn Davis, Brian Litt
2018 bioRxiv   pre-print
We generate interictal functional networks by calculating pairwise correlation of iEEG signals across different frequency bands.  ...  The goal of this study is to evaluate the utility of mapping interictal (non-seizure) iEEG networks to identify targets for surgical treatment.  ...  is further supported by recent studies demonstrating that ictal and interictal iEEG network subgraphs are topologically similar, and that patterns of high frequency activity propagation during seizures  ... 
doi:10.1101/459008 fatcat:phgmqstk25hhbcvtb6bcsumheu

Low Consistency of Four Brain Connectivity Measures Derived from Intracranial Electrode Measurements

Stephen E. Jones, Erik B. Beall, Imad Najm, Ken E. Sakaie, Michael D. Phillips, Myron Zhang, Jorge A. Gonzalez-Martinez
2014 Frontiers in Neurology  
A second measure is the recent development of simultaneous BOLD fMRI and intracranial electrode stimulation. The resulting BOLD maps form a measure of effective connectivity.  ...  Using a group of eight epilepsy patients with intracranial electrodes, the connectivity from one method is compared to another method using all paired data points that are in common, yielding an overall  ...  One of the major problems in the process of the presurgical localization of the EZ through scalp EEG recordings is the issue of false localization of a surface activity that is the result of a network/  ... 
doi:10.3389/fneur.2014.00272 pmid:25566178 pmcid:PMC4271609 fatcat:e7qfc7lruncwxflv2ndcdrfmdy

On the nature of seizure dynamics

Viktor K. Jirsa, William C. Stacey, Pascale P. Quilichini, Anton I. Ivanov, Christophe Bernard
2014 Brain  
Seizure onset is reached upon the collision of normal brain trajectories with the separatrix.  ...  Seizures can occur spontaneously and in a recurrent manner, which defines epilepsy; or they can be induced in a normal brain under a variety of conditions in most neuronal networks and species from flies  ...  El Houssaini for help in preparing  ... 
doi:10.1093/brain/awu133 pmid:24919973 pmcid:PMC4107736 fatcat:6i353am36bajznhavdly5zlk4u

Dynamic Neurovascular Coupling and Uncoupling during Ictal Onset, Propagation, and Termination Revealed by Simultaneous In Vivo Optical Imaging of Neural Activity and Local Blood Volume

H. Ma, M. Zhao, T. H. Schwartz
2012 Cerebral Cortex  
Traditional models of ictal propagation involve the concept of an initiation site and a progressive outward march of activation.  ...  consist of multiple dynamic multidirectional waves of membrane potential change with variable onset sites that spread through a widespread network.  ...  Conflict of Interest : None declared.  ... 
doi:10.1093/cercor/bhs079 pmid:22499798 pmcid:PMC3593576 fatcat:ho6bwih445duhm3i4pizrzgck4

Commonalities in epileptogenic processes from different acute brain insults: Do they translate?

Pavel Klein, Raymond Dingledine, Eleonora Aronica, Christophe Bernard, Ingmar Blümcke, Detlev Boison, Martin J. Brodie, Amy R. Brooks-Kayal, Jerome Engel, Patrick A. Forcelli, Lawrence J. Hirsch, Rafal M. Kaminski (+14 others)
2017 Epilepsia  
In diverse human epilepsies and animal models, seizures appear to propagate within a limbic or thalamocortical/corticocortical network.  ...  Treatment is effective for only 60%-70% of patients and remains symptomatic despite decades of effort to develop epilepsy prevention therapies.  ...  these findings will predict later epilepsy, or whether detection of acute high-frequency oscillations (HFOs) with this type of recording will be as predictive as they are in animal models 20 , remains  ... 
doi:10.1111/epi.13965 pmid:29247482 pmcid:PMC5993212 fatcat:gpp6ve6akfcf7jvp3eplswo6ua

A taxonomy of seizure dynamotypes

Maria Luisa Saggio, Dakota Crisp, Jared M Scott, Philippa Karoly, Levin Kuhlmann, Mitsuyoshi Nakatani, Tomohiko Murai, Matthias Dümpelmann, Andreas Schulze-Bonhage, Akio Ikeda, Mark Cook, Stephen V Gliske (+4 others)
2020 eLife  
Seizures are a disruption of normal brain activity present across a vast range of species and conditions.  ...  The 'dynamotype' of a seizure is the dynamic composition that defines its observable characteristics, including how it starts, evolves and ends.  ...  This timeseries is high pass filtered to simulate the effect of AC recordings. The non-filtered simulation is shown in (C). (D) A portion of a long status epilepticus recorded in one patient.  ... 
doi:10.7554/elife.55632 pmid:32691734 fatcat:2qdvuqbc5bd5rbtcvd6bugm5ve

Epidynamics characterize and navigate the map of seizure dynamics [article]

Marisa Saggio, Dakota Crisp, Jared M Scott, Phillippa Karoly, Levin Kuhlmann, Mitsuyoshi Nakatani, Tomohiko Murai, Matthias Duempelmann, Andreas Schulze-Bonhage, Akio Ikeda, Mark Cook, Stephen V Gliske (+4 others)
2020 bioRxiv   pre-print
We provide the first objective taxonomy of seizures based on a straightforward analysis of EEG data.  ...  Seizures are a disruption of normal brain activity present across a vast range of species, diseases, and conditions.  ...  This timeseries is high pass filtered to simulate the effect of AC recordings. The non-filtered simulation is shown in C. D: A portion of a long status epilepticus recorded in one patient.  ... 
doi:10.1101/2020.02.08.940072 fatcat:nnejqsfjnrb63fnuxsodux32sm

29th Annual Computational Neuroscience Meeting: CNS*2020

2020 BMC Neuroscience  
by visual experience, and (iii) how patterns of neural activity in the zebrafish brain develop to facilitate precisely targeted hunting behaviour.  ...  Investigations of this question have, to date, focused largely on deep neural networks trained using supervised learning, in tasks such as image classification.  ...  Acknowledgements: This research is funded by the National Science Foundation (grants #1822517 and #1921515 to SJ), the National Institute of Mental Health (grant #MH117488 to SJ), the California Nano-Systems  ... 
doi:10.1186/s12868-020-00593-1 pmid:33342424 fatcat:edosycf35zfifm552a2aogis7a
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