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A 12 W frequency-narrowed diode array was used for the optical pumping. The valved cells were studied at Amersham using a 60 W broad-band laser. ... The data were taken using a 60 W broad-band diode laser using high pressure cells and are representative of current spin-exchange practice. ...doi:10.1103/physrevlett.91.123003 pmid:14525358 fatcat:z4e7xg2iibbktg32q6axgo7wau
Reports suggest that two members of the novel immune-associated nucleotide (Ian) GTPase family, Ian1 and Ian5, play roles in T cell development. ... We performed real-time PCR analysis of the expression of Ian genes of the rat during T cell maturation, in macrophages and in cell lines. ... Ian-related genes. ...doi:10.1093/intimm/dxh302 pmid:16103028 fatcat:mru3t63umfb7haczf3bt7igjvu
SYNOPSIS. In reptiles, there is adequate evidence to indicate environmental control of the ovarian cycle through hypothalamic pathways and the subsequent release of tropic hormone (s) from the anterior pituitary. The role of the pineal-parietal complex still remains to be elucidated. In the hypothalamus there appear to be steroid sensitive areas, and both progesterone and estrogen appear to have important feedback influences upon gonadal growth, ovulation, and ovarian steroid production.doi:10.1093/icb/12.2.273 fatcat:d32366guyrb3voam56fwiifmyi
more »... ical studies of the reptilian pituitary indicate similar cell types to those observed in mammalian pituitaries, but thus far, two gonadotrophs cannot be identified with any certainty. Chemical and biological studies of the action of mammalian gonadotropins suggest that in reptiles hormones which are FSH-like in mammals are able to stimulate gonadal development, ovulation, and steroid biosynthesis under certain conditions. Preliminary studies of the chemistry of turtle gonadotropins have so far demonstrated only one active principle, which is chemically similar to mammalian LH, but is far more active than the latter hormone in reptilian systems. Further, the hormone also has FSH-like activity in the reptile. Thus, reptilian gonadal development can be stimulated by treatment with a variety of mammalian gonadotropins. Recent studies have indicated an important role for growth hormone, acting in concert with gonadotropin and estrogen in die regulation of vitellogenesis and ovarian growth. Prolactin appears to be an antigonadal agent in reptiles, as does progesterone. The exact manner in which these hormones exert their antigonadal action remains to be clarified, but at least one site of action is the central nervous system; other sites may be the liver and the fat depot. Ovarian tissue from reptiles is able to synthesize and secrete steroid hormones by pathways similar to those present in mammalian ovaries. Circulating levels of estrogen have not been measured, but progesterone levels in the blood show distinct changes associated with pregnancy and the presence of corpora lutea in the ovary. REPRODUCTIVE CYCLES AND ENVIRONMENTAL Phrynosoma comutum (Mellish, 1936; FACTORS Mellish and Meyer, 1937) or on Xantusia vigilis (Bartholomew, 1950 (Bartholomew, , 1953 . Howev-The ovarian cycle of a number of spe-er, in Chalcides ocellatus females exposed cies of reptiles has been described in some to 24 hours of light per day, mating and detail (Cieslak, 1945 ; Woodbury and the production of normal offspring occur
trust game (Moretto, Sellitto, & di Pellegrino, 2013) , and we have recently shown that vmPFC gray matter volume is associated with individual differences in the tendency to trust others (Haas, Ishak, Anderson ...doi:10.3758/s13415-015-0393-0 pmid:26567160 fatcat:hztzaek2jzaa5aqrlc5ppbybsy
loophole that treats flexible fuel vehicles capable of burning either gasoline or ethanol as though they run on ethanol 50 percent of the time even though, in practice, these vehicles rarely use ethanol (Anderson ... progress on developing fuel-saving technologies, could shift baseline demand toward more efficient vehicles, thereby reducing both the effectiveness and the costs of a given fuel economy standard. 10 Anderson ...doi:10.2139/ssrn.1691708 fatcat:k3tynkrilfbsbmwthggsmsroeu
doi:10.3389/fnhum.2013.00801 pmid:24348360 pmcid:PMC3842510 fatcat:zteobi5do5bgzpfdr2ewek3qna
The ability to empathize with other people is a critical component of human social relationships. Empathic processing varies across the human population, however it is currently unclear how personality traits are associated with empathic processing. This study was designed to test the hypothesis that specific personality traits are associated with behavioral and biological indicators of improved empathy. Extraversion and Agreeableness are personality traits designed to measure individualdoi:10.1371/journal.pone.0120639 pmid:25769028 pmcid:PMC4359130 fatcat:w3k4xit4mfg6jiw3nx4qctleeu
more »... nces in social-cognitive functioning, however each trait-dimension includes elements that represent interpersonal social functioning and elements that do not represent interpersonal social functioning. We tested the prediction that interpersonal elements of Extraversion (Warmth) and Agreeableness (Altruism) are associated with empathy and non-interpersonal elements of Extraversion and Agreeableness are not associated with empathy. We quantified empathic processing behaviorally (empathic accuracy task using video vignettes) and within the brain (fMRI and an emotional perspective taking task) in 50 healthy subjects. Converging evidence shows that highly warm and altruistic people are well skilled in recognizing the emotional states of other people and exhibit greater activity in brain regions important for empathy (temporoparietal junction and medial prefrontal cortex) during emotional perspective taking. A mediation analysis further supported the association between warm-altruistic personality and empathic processing; indicating that one reason why highly warm-altruistic individuals may be skilled empathizers is that they engage the temporoparietal junction and medial prefrontal cortex more. Together, these findings advance the way the behavioral and neural basis of empathy is understood and demonstrates the efficacy of personality scales to measure individual differences in interpersonal social function.
van Elsas et al ., 2000; Anderson et al ., 2003a) . ... Yeates and Gillings, 1998; Anderson et al ., 2003a,b; Ranjard et al ., 2003) . ...doi:10.1111/j.1462-2920.2004.00675.x pmid:15250879 fatcat:522jukx3p5bfjotm7ipqgo7rf4
Ian Sanders and Dr Lucy Gilbert for useful discussion, the editor (M-A. ... ., 1998; Anderson et al., 2001; Lian et al., 2006) . ... The internal transcribed spacer (ITS) region of the ribosomal RNA (rRNA) gene cluster has been the most widely targeted genomic region in molecular investigations of fungi (Horton & Bruns, 2001; Anderson ...doi:10.1111/j.1469-8137.2012.04087.x pmid:22489902 fatcat:r4gt6u2s5rfktjdgxm6nsemj7q
OBSTETRICS & GYNECOLOGY Anderson et al Who Will Be There When Women Deliver? OBSTETRICS & GYNECOLOGY ... Codes Related to Retention Code Explanation Training 1 Well prepared 2 Anderson et al Who Will Be There When Women Deliver? ...doi:10.1097/01.aog.0000287064.63051.1c pmid:17978113 fatcat:nj4wqskiqbbdhc5he4yilqi7ne
The underlying pathology of atopic dermatitis (AD) includes impaired skin barrier function, susceptibility to Staphylococcus aureus skin infection, immune dysregulation, and cutaneous dysbiosis. Our recent investigation into the potential role of Gram-negative skin bacteria in AD revealed that isolates of one particular commensal, Roseomonas mucosa, collected from healthy volunteers (HVs) improved outcomes in mouse and cell culture models of AD. In contrast, isolates of R. mucosa from patientsdoi:10.1172/jci.insight.120608 pmid:29720571 pmcid:PMC6012572 fatcat:smrwyijn55h6hpwjcmzq4z3cp4
more »... ith AD worsened outcomes in these models. These preclinical results suggested that interventions targeting the microbiome could provide therapeutic benefit for patients with AD. As a first test of this hypothesis in humans, 10 adult and 5 pediatric patients were enrolled in an open-label phase I/II safety and activity trial (the Beginning Assessment of Cutaneous Treatment Efficacy for Roseomonas in Atopic Dermatitis trial; BACTERiAD I/II). Treatment with R. mucosa was associated with significant decreases in measures of disease severity, topical steroid requirement, and S. aureus burden. There were no adverse events or treatment complications. We additionally evaluated differentiating bacterial metabolites and topical exposures that may contribute to the skin dysbiosis associated with AD and/or influence future microbiome-based treatments. These early results support continued evaluation of R. mucosa therapy with a placebo-controlled trial.
HPLC analysis of the urine of autistic subjects indicated the presence of an unidenti ed component in greatly increased concentrations. We have reported the isolation of this component by HPLC and its identi cation. Mass spectrometry, NMR and UV spectroscopy identi ed the peak as corresponding to indolyl-3-acryloylglycine (IAG, 3), and this has been con rmed by an independent synthesis.doi:10.1211/0022357021778349 pmid:11858215 fatcat:xttgolep2ja23flkwllu6733km
Background: There is ample evidence of adverse associations between short-term exposure to ambient particle mass concentrations and health but little is known about the relative contribution from various sources. Methods: We used air particle composition and number networks in London between 2011 and 2012 to derive six source-related factors for PM 10 and four factors for size distributions of ultrafine particles (NSD). We assessed the associations of these factors, at pre-specified lags, withdoi:10.1016/j.envint.2016.09.017 pmid:27692926 fatcat:l4lf2twmrndvrdknj36v3c5eny
more »... aily total, cardiovascular (CVD) and respiratory mortality and hospitalizations using Poisson regression. Relative risks and 95% confidence intervals (CI) were expressed as percentage change per interquartile range increment in source-factor mass or number concentration. We evaluated the sensitivity of associations to adjustment for multiple other factors and by season. Results: We found no evidence of associations between PM 10 or NSD source-related factors and daily mortality, as the direction of the estimates were variable with 95% CI spanning 0%. Traffic-related PM 10 and NSD displayed consistent associations with CVD admissions aged 15-64 years (1.01% (95%CI: 0.03%, 2.00%) and 1.04% (95%CI: − 0.62%, 2.72%) respectively) as did particles from background urban sources (0.36% for PM 10 and 0.81% for NSD). Most sources were positively associated with pediatric (0-14 years) respiratory hospitalizations, with stronger evidence for fuel oil PM 10 (3.43%, 95%CI: 1.26%, 5.65%). Our results did not suggest associations with cardiovascular admissions in 65+ or respiratory admissions in 15+ age groups. Effect estimates were generally robust to adjustment for other factors and by season. Conclusions: Our findings are broadly consistent with the growing evidence of the toxicity of traffic and combustion particles, particularly in relation to respiratory morbidity in children and cardiovascular morbidity in younger adults.
David Hill, Data curation, Writing-review and editing; Emma L Anderson, Eleanor Sanderson, Methodology, Writing-review and editing; Ian J Deary, Data curation, Funding acquisition, Writing-review and editing ... The relationships between intelligence and education and Alzheimer's disease was largely due to an effect of intelligence (Anderson et al., 2018) . ...doi:10.7554/elife.43990 pmid:31526476 pmcid:PMC6748790 fatcat:enyv5t7n2baadh67ao5xcw72se
Objective: There are no long-term medical treatments for uterine fibroids, and non-invasive biomarkers are needed to evaluate novel therapeutic interventions. The aim of this study was to determine whether serial dynamic contrast-enhanced MRI (DCE-MRI) and magnetization transfer MRI (MT-MRI) are able to detect changes that accompany volume reduction in patients administered GnRH analogue drugs, a treatment which is known to reduce fibroid volume and perfusion. Our secondary aim was to determinedoi:10.1371/journal.pone.0089809 pmid:24608161 pmcid:PMC3946427 fatcat:2q52nkxklfaftcic2jijubyzry
more »... whether rapid suppression of ovarian activity by combining GnRH agonist and antagonist therapies results in faster volume reduction. Methods: Forty women were assessed for eligibility at gynaecology clinics in the region, of whom thirty premenopausal women scheduled for hysterectomy due to symptomatic fibroids were randomized to three groups, receiving (1) GnRH agonist (Goserelin), (2) GnRH agonist+GnRH antagonist (Goserelin and Cetrorelix) or (3) no treatment. Patients were monitored by serial structural, DCE-MRI and MT-MRI, as well as by ultrasound and serum oestradiol concentration measurements from enrolment to hysterectomy (approximately 3 months). Results: A volumetric treatment effect assessed by structural MRI occurred by day 14 of treatment (9% median reduction versus 9% increase in untreated women; P = 0.022) and persisted throughout. Reduced fibroid perfusion and permeability assessed by DCE-MRI occurred later and was demonstrable by 2-3 months (43% median reduction versus 20% increase respectively; P = 0.0093). There was no apparent treatment effect by MT-MRI. Effective suppression of oestradiol was associated with early volume reduction at days 14 (P = 0.041) and 28 (P = 0.0061). Conclusion: DCE-MRI is sensitive to the vascular changes thought to accompany successful GnRH analogue treatment of uterine fibroids and should be considered for use in future mechanism/efficacy studies of proposed fibroid drug therapies. GnRH antagonist administration does not appear to accelerate volume reduction, though our data do support the role of oestradiol suppression in GnRH analogue treatment of fibroids. Trial Registration: ClinicalTrials.gov NCT00746031 Citation: Munro KI, Thrippleton MJ, Williams ARW, McKillop G, Walker J, et al. (2014) Quantitative Serial MRI of the Treated Fibroid Uterus. PLoS ONE 9(3): e89809.
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